• 7979 Citations
  • 39 h-Index
19952020

Research output per year

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Research Output

Short survey

Double indemnity: p53, BRCA and cancer

Brugarolas, J. & Jacks, T., Jul 1 1997, In : Nature medicine. 3, 7, p. 721-722 2 p.

Research output: Contribution to journalShort survey

99 Scopus citations

Succination of Keap1 and Activation of Nrf2-Dependent Antioxidant Pathways in FH-Deficient Papillary Renal Cell Carcinoma Type 2

Kinch, L., Grishin, N. V. & Brugarolas, J., Oct 18 2011, In : Cancer Cell. 20, 4, p. 418-420 3 p.

Research output: Contribution to journalShort survey

54 Scopus citations
Review article

Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine

Carbone, M., Amelio, I., Affar, E. B., Brugarolas, J., Cannon-Albright, L. A., Cantley, L. C., Cavenee, W. K., Chen, Z., Croce, C. M., Andrea, A. D., Gandara, D., Giorgi, C., Jia, W., Lan, Q., Mak, T. W., Manley, J. L., Mikoshiba, K., Onuchic, J. N., Pass, H. I., Pinton, P. & 8 others, Prives, C., Rothman, N., Sebti, S. M., Turkson, J., Wu, X., Yang, H., Yu, H. & Melino, G., Nov 1 2018, In : Cell Death and Differentiation. 25, 11, p. 1885-1904 20 p.

Research output: Contribution to journalReview article

7 Scopus citations

Cooperation and antagonism among cancer genes: The renal cancer paradigm

Peña-Llopis, S., Christie, A., Xie, X. J. & Brugarolas, J., Jul 15 2013, In : Cancer Research. 73, 14, p. 4173-4179 7 p.

Research output: Contribution to journalReview article

46 Scopus citations

Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes

Brugarolas, J. & Kaelin, W. G., Jul 2004, In : Cancer Cell. 6, 1, p. 7-10 4 p.

Research output: Contribution to journalReview article

134 Scopus citations

Familial Kidney Cancer: Implications of New Syndromes and Molecular Insights

Carlo, M. I., Hakimi, A. A., Stewart, G. D., Bratslavsky, G., Brugarolas, J. B., Chen, Y. B., Linehan, W. M., Maher, E. R., Merino, M. J., Offit, K., Reuter, V. E., Shuch, B. & Coleman, J. A., Jan 1 2019, In : European urology.

Research output: Contribution to journalReview article

7 Scopus citations

Metabolism of kidney cancer: From the lab to clinical practice

Sudarshan, S., Karam, J. A., Brugarolas, J., Thompson, R. H., Uzzo, R., Rini, B., Margulis, V., Patard, J. J., Escudier, B. & Linehan, W. M., Feb 1 2013, In : European urology. 63, 2, p. 244-251 8 p.

Research output: Contribution to journalReview article

45 Scopus citations

PBRM1 and BAP1 as novel targets for renal cell carcinoma

Brugarolas, J., Jul 1 2013, In : Cancer Journal (United States). 19, 4, p. 324-332 9 p.

Research output: Contribution to journalReview article

58 Scopus citations

Personalized Management of Advanced Kidney Cancer

Graham, J., Heng, D. Y. C., Brugarolas, J. B. & Vaishampayan, U., May 23 2018, In : American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting. 38, p. 330-341 12 p.

Research output: Contribution to journalReview article

5 Scopus citations

Perspectives in immunotherapy: Meeting report from the Immunotherapy Bridge (29-30 November, 2017, Naples, Italy)

Ascierto, P. A., Brugarolas, J., Buonaguro, L., Butterfield, L. H., Carbone, D., Daniele, B., Ferris, R., Fox, B. A., Galon, J., Gridelli, C., Kaufman, H. L., Klebanoff, C. A., Melero, I., Nathan, P., Paulos, C. M., Ruella, M., Sullivan, R., Zarour, H. & Puzanov, I., Jul 11 2018, In : Journal for ImmunoTherapy of Cancer. 6, 1, 69.

Research output: Contribution to journalReview article

5 Scopus citations

State of the science: An update on renal cell carcinoma

Jonasch, E., Futreal, P. A., Davis, I. J., Bailey, S. T., Kim, W. Y., Brugarolas, J., Giaccia, A. J., Kurban, G., Pause, A., Frydman, J., Zurita, A. J., Rini, B. I., Sharma, P., Atkins, M. B., Walker, C. L. & Rathmell, W. K., Jul 1 2012, In : Molecular Cancer Research. 10, 7, p. 859-880 22 p.

Research output: Contribution to journalReview article

113 Scopus citations

The complex relationship between TFEB transcription factor phosphorylation and subcellular localization

Puertollano, R., Ferguson, S. M., Brugarolas, J. & Ballabio, A., Jun 1 2018, In : EMBO Journal. 37, 11, e98804.

Research output: Contribution to journalReview article

51 Scopus citations
Letter

In reply

Brugarolas, J., Dec 1 2008, In : Journal of Clinical Oncology. 26, 34, p. 5653-5654 2 p.

Research output: Contribution to journalLetter

Radiation-induced cell cycle arrest compromised by p21 deficiency

Brugarolas, J., Chandrasekaran, C., Gordon, J. I., Beach, D., Jacks, T. & Hannon, G. J., Oct 12 1995, In : Nature. 377, 6549, p. 552-557 6 p.

Research output: Contribution to journalLetter

1083 Scopus citations
Editorial

Renal-cell carcinoma - Molecular pathways and therapies

Brugarolas, J., Jan 11 2007, In : New England Journal of Medicine. 356, 2, p. 185-187 3 p.

Research output: Contribution to journalEditorial

218 Scopus citations

TFEB, a novel mTORC1 effector implicated in lysosome biogenesis, endocytosis and autophagy

Peña-Llopis, S. & Brugarolas, J., Dec 1 2011, In : Cell Cycle. 10, 23, p. 3987-3988 2 p.

Research output: Contribution to journalEditorial

24 Scopus citations
Comment/debate
3 Scopus citations

Towards a genomic-based diagnosis

Brugarolas, J., Haynes, B. F. & Nevins, J. R., Jan 27 2001, In : Lancet. 357, 9252, p. 249-250 2 p.

Research output: Contribution to journalComment/debate

13 Scopus citations

Using "rationally designed drugs" rationally

Brugarolas, J., Clark, J. W. & Chabner, B., May 24 2003, In : Lancet. 361, 9371, p. 1758-1759 2 p.

Research output: Contribution to journalComment/debate

6 Scopus citations
Chapter

Research translation and personalized medicine

Brugarolas, J., Nov 1 2012, Renal Cell Carcinoma: Translational Biology, Personalized Medicine, and Novel Therapeutic Targets. Springer US, Vol. 9781461424000. p. 161-191 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations
Article

Ablation of a site of progression with stereotactic body radiation therapy extends sunitinib treatment from 14 to 22 months

Straka, C., Kim, D. W. N., Timmerman, R. D., Pedrosa, I., Jacobs, C. & Brugarolas, J., Aug 10 2013, In : Journal of Clinical Oncology. 31, 23, p. e401-e403

Research output: Contribution to journalArticle

21 Scopus citations

Addressing metabolic heterogeneity in clear cell renal cell carcinoma with quantitative Dixon MRI

Zhang, Y., Udayakumar, D., Cai, L., Hu, Z., Kapur, P., Kho, E. Y., Pavía-Jiménez, A., Fulkerson, M., de Leon, A. D., Yuan, Q., Dimitrov, I. E., Yokoo, T., Ye, J., Mitsche, M. A., Kim, H., McDonald, J. G., Xi, Y., Madhuranthakam, A. J., Dwivedi, D. K., Lenkinski, R. E. & 5 others, Cadeddu, J. A., Margulis, V., Brugarolas, J., DeBerardinis, R. J. & Pedrosa, I., Aug 3 2017, In : JCI Insight. 2, 15

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

An empirical approach leveraging tumorgrafts to dissect the tumor microenvironment in renal cell carcinoma identifies missing link to prognostic inflammatory factors

Wang, T., Lu, R., Kapur, P., Jaiswal, B. S., Hannan, R., Zhang, Z., Pedrosa, I., Luke, J. J., Zhang, H., Goldstein, L. D., Yousuf, Q., Gu, Y. F., McKenzie, T., Joyce, A., Kim, M. S., Wang, X., Luo, D., Onabolu, O., Stevens, C., Xie, Z. & 11 others, Chen, M., Filatenkov, A., Torrealba, J., Luo, X., Guo, W., He, J., Stawiski, E., Modrusan, Z., Durinck, S., Seshagiri, S. & Brugarolas, J., Sep 1 2018, In : Cancer Discovery. 8, 9, p. 1142-1155 14 p.

Research output: Contribution to journalArticle

16 Scopus citations

A novel germline mutation in BAP1 predisposes to familial clear-cell renal cell carcinoma

Farley, M. N., Schmidt, L. S., Mester, J. L., Peña-Llopis, S., Pavia-Jimenez, A., Christie, A., Vocke, C. D., Ricketts, C. J., Peterson, J., Middelton, L., Kinch, L., Grishin, N., Merino, M. J., Metwalli, A. R., Xing, C., Xie, X. J., Dahia, P. L. M., Eng, C., Linehan, W. M. & Brugarolas, J., Sep 1 2013, In : Molecular Cancer Research. 11, 9, p. 1061-1071 11 p.

Research output: Contribution to journalArticle

99 Scopus citations

A validated tumorgraft model reveals activity of dovitinib against renal cell carcinoma

Sivanand, S., Peña-Llopis, S., Zhao, H., Kucejova, B., Spence, P., Pavia-Jimenez, A., Yamasaki, T., McBride, D. J., Gillen, J., Wolff, N. C., Morlock, L., Lotan, Y., Raj, G., Sagalowsky, A. I., Margulis, V., Cadeddu, J. A., Ross, M. T., Bentley, D. R., Kabbani, W., Xie, X-J. & 3 others, Kapur, P., Williams, N. S. & Brugarolas, J. B., Jun 6 2012, In : Science Translational Medicine. 4, 137, 137ra75.

Research output: Contribution to journalArticle

113 Scopus citations

BAP1 and PBRM1 in metastatic clear cell renal cell carcinoma: tumor heterogeneity and concordance with paired primary tumor

Eckel-Passow, J. E., Serie, D. J., Cheville, J. C., Ho, T. H., Kapur, P., Brugarolas, J., Thompson, R. H., Leibovich, B. C., Kwon, E. D., Joseph, R. W. & Parker, A. S., Mar 21 2017, In : BMC Urology. 17, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

BAP1 immunohistochemistry predicts outcomes in a multi-institutional cohort with clear cell renal cell carcinoma

Kapur, P., Christie, A., Raman, J. D., Then, M. T., Nuhn, P., Buchner, A., Bastian, P., Seitz, C., Shariat, S. F., Bensalah, K., Rioux-Leclercq, N., Xie, X-J., Lotan, Y., Margulis, V. & Brugarolas, J. B., Mar 1 2014, In : Journal of Urology. 191, 3, p. 603-610 8 p.

Research output: Contribution to journalArticle

46 Scopus citations

Bap1 is essential for kidney function and cooperates with Vhl in renal tumorigenesis

Wang, S. S., Gu, Y. F., Wolff, N., Stefanius, K., Christie, A., Dey, A., Hammer, R. E., Xie, X-J., Rakheja, D., Pedrosa, I., Carroll, T. J., McKay, R. M., Kapur, P. & Brugarolas, J. B., Nov 18 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 46, p. 16538-16543 6 p.

Research output: Contribution to journalArticle

70 Scopus citations

BAP1 loss defines a new class of renal cell carcinoma

Peña-Llopis, S., Vega-Rubín-De-Celis, S., Liao, A., Leng, N., Pavía-Jiménez, A., Wang, S., Yamasaki, T., Zhrebker, L., Sivanand, S., Spence, P., Kinch, L., Hambuch, T., Jain, S., Lotan, Y., Margulis, V., Sagalowsky, A. I., Summerour, P. B., Kabbani, W., Wong, S. W. W., Grishin, N. V. & 7 others, Laurent, M., Xie, X-J., Haudenschild, C. D., Ross, M. T., Bentley, D. R., Kapur, P. & Brugarolas, J. B., Jul 1 2012, In : Nature genetics. 44, 7, p. 751-759 9 p.

Research output: Contribution to journalArticle

483 Scopus citations

Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia

Wolff, N. C., Vega-Rubin-de-Celis, S., Xie, X. J., Castrillon, D. H., Kabbani, W. & Brugarolas, J., May 2011, In : Molecular and cellular biology. 31, 9, p. 1870-1884 15 p.

Research output: Contribution to journalArticle

49 Scopus citations

Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor

Mata, M. A., Satterly, N., Versteeg, G. A., Frantz, D., Wei, S., Williams, N., Schmolke, M., Peña-Llopis, S., Brugarolas, J., Forst, C. V., White, M. A., García-Sastre, A., Roth, M. G. & Fontoura, B. M. A., Oct 2011, In : Nature chemical biology. 7, 10, p. 712-719 8 p.

Research output: Contribution to journalArticle

51 Scopus citations

Clear Cell Renal Cell Carcinoma Subtypes Identified by BAP1 and PBRM1 Expression

Joseph, R. W., Kapur, P., Serie, D. J., Parasramka, M., Ho, T. H., Cheville, J. C., Frenkel, E., Parker, A. S. & Brugarolas, J., Jan 1 2016, In : Journal of Urology. 195, 1, p. 180-187 8 p.

Research output: Contribution to journalArticle

61 Scopus citations

DEFOR: Depth- and frequency-based somatic copy number alteration detector

Zhang, H., Zhan, X., Brugarolas, J. & Xie, Y., Oct 1 2019, In : Bioinformatics. 35, 19, p. 3824-3825 2 p.

Research output: Contribution to journalArticle

Open Access

Deletion of p21 cannot substitute for p53 loss in rescue of mdm2 null lethality

Montes de Oca Luna, R., Amelse, L. L., Chavez-Reyes, A., Evans, S. C., Brugarolas, J., Jacks, T. & Lozano, G., Aug 1 1997, In : Nature genetics. 16, 4, p. 336-337 2 p.

Research output: Contribution to journalArticle

16 Scopus citations
11 Scopus citations

Discontinuing VEGF-targeted Therapy for Progression Versus Toxicity Affects Outcomes of Second-line Therapies in Metastatic Renal Cell Carcinoma

De Velasco, G., Xie, W., Donskov, F., Albiges, L., Beuselinck, B., Srinivas, S., Agarwal, N., Lee, J. L., Brugarolas, J., Wood, L. A., Rha, S. Y., Kollmannsberger, C., North, S., Kanesvaran, R., Rini, B. I., Broom, R., Yamamoto, H., Kaymakcalan, M. D., Heng, D. Y. C. & Choueiri, T. K., Nov 7 2016, (Accepted/In press) In : Clinical Genitourinary Cancer.

Research output: Contribution to journalArticle

6 Scopus citations

Downregulation of human DAB2IP gene expression in renal cell carcinoma results in resistance to ionizing radiation

Yun, E. J., Lin, C. J., Dang, A., Hernandez, E., Guo, J., Chen, W. M., Allison, J., Kim, N., Kapur, P., Brugarolas, J., Wu, K., He, D., Lai, C. H., Lin, H., Saha, D., Baek, S. T., Chen, B. P. C. & Hsieh, J. T., Jan 1 2019, In : Clinical Cancer Research. 25, 14, p. 4542-4551 10 p.

Research output: Contribution to journalArticle

Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: A retrospective analysis with independent validation

Kapur, P., Peña-Llopis, S., Christie, A., Zhrebker, L., Pavía-Jiménez, A., Rathmell, W. K., Xie, X. J. & Brugarolas, J., Feb 1 2013, In : The Lancet Oncology. 14, 2, p. 159-167 9 p.

Research output: Contribution to journalArticle

242 Scopus citations

Establishing a human renal cell carcinoma tumorgraft platform for preclinical drug testing

Pavía-Jiménez, A., Tcheuyap, V. T. & Brugarolas, J., Aug 2014, In : Nature Protocols. 9, 8, p. 1848-1859 12 p.

Research output: Contribution to journalArticle

29 Scopus citations

Exploring a glycolytic inhibitor for the treatment of an FH-deficient type-2 papillary RCC

Yamasaki, T., Tran, T. A. T., Oz, O. K., Raj, G. V., Schwarz, R. E., DeBerardinis, R. J., Zhang, X. & Brugarolas, J., Apr 1 2011, In : Nature Reviews Urology. 8, 3, p. 165-171 7 p.

Research output: Contribution to journalArticle

28 Scopus citations

Fibroblast growth factor receptor-dependent and -independent paracrine signaling by sunitinib-resistant renal cell carcinoma

Tran, T. A., Leong, H. S., Pavia-Jimenez, A., Fedyshyn, S., Yang, J., Kucejova, B., Sivanand, S., Spence, P., Xie, X. J., Peña-Llopis, S., Power, N. & Brugarolas, J., 2016, In : Molecular and Cellular Biology. 36, 13, p. 1836-1855 20 p.

Research output: Contribution to journalArticle

16 Scopus citations

Hepatic mTORC1 Opposes Impaired Insulin Action to Control Mitochondrial Metabolism in Obesity

Kucejova, B., Duarte, J., Satapati, S., Fu, X., Ilkayeva, O., Newgard, C. B., Brugarolas, J. & Burgess, S. C., Jul 12 2016, In : Cell Reports. 16, 2, p. 508-519 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

High-throughput simultaneous screen and counterscreen identifies homoharringtonine as synthetic lethal with von Hippel-Lindau loss in renal cell carcinoma

Wolff, N. C., Pavía-Jiménez, A., Tcheuyap, V. T., Alexander, S., Vishwanath, M., Christie, A., Xie, X. J., Williams, N. S., Kapur, P., Posner, B., McKay, R. M. & Brugarolas, J., Jan 1 2015, In : Oncotarget. 6, 19, p. 16951-16962 12 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations
15 Scopus citations

Identification of CREB3L1 as a biomarker predicting doxorubicin treatment outcome

Denard, B., Pavia-Jimenez, A., Chen, W., Williams, N. S., Naina, H., Collins, R., Brugarolas, J. & Ye, J., Jun 25 2015, In : PLoS One. 10, 6, e0129233.

Research output: Contribution to journalArticle

7 Scopus citations
3 Scopus citations

Incidence and Outcomes of Delayed Targeted Therapy After Cytoreductive Nephrectomy for Metastatic Renal-Cell Carcinoma: A Nationwide Cancer Registry Study

Woldu, S. L., Matulay, J. T., Clinton, T. N., Singla, N., Freifeld, Y., Sanli, O. M., Krabbe, L. M., Hutchinson, R. C., Lotan, Y., Hammers, H., Hannan, R., Brugarolas, J. B., Bagrodia, A. & Margulis, V., Jan 1 2018, (Accepted/In press) In : Clinical Genitourinary Cancer.

Research output: Contribution to journalArticle

2 Scopus citations

Inflammatory Reaction Secondary to Immune Checkpoint Inhibitor Therapy Mimicking a Post-Operative Brain Abscess

Patel, A. R., Connors, S., Wardak, Z., Brugarolas, J. B. & Patel, T. R., Sep 1 2019, In : World Neurosurgery. 129, p. 354-358 5 p.

Research output: Contribution to journalArticle

1 Scopus citations