• 25402 Citations
  • 66 h-Index
1993 …2019

Research output per year

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Research Output

  • 25402 Citations
  • 66 h-Index
  • 97 Article
  • 2 Comment/debate
2019

Intravascular triglyceride lipolysis becomes crystal clear

Horton, J. D., Jan 29 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 5, p. 1480-1482 3 p.

Research output: Contribution to journalComment/debate

2 Scopus citations

SREBP-regulated adipocyte lipogenesis is dependent on substrate availability and redox modulation of mTORC1

Crewe, C., Zhu, Y., Paschoal, V. A., Joffin, N., Ghaben, A. L., Gordillo, R., Oh, D. Y., Liang, G., Horton, J. D. & Scherer, P. E., Aug 8 2019, In : JCI Insight. 4, 15, e129397.

Research output: Contribution to journalArticle

Open Access
2018

Adipocyte Xbp1s overexpression drives uridine production and reduces obesity

Deng, Y., Wang, Z., Gordillo, R., Zhu, Y., Ali, A., Zhang, C., Wang, X., Shao, M., Zhang, Z., Iyengar, P., Gupta, R. K., Horton, J. D., Hill, J. A. & Scherer, P. E., Jan 1 2018, (Accepted/In press) In : Molecular Metabolism.

Research output: Contribution to journalArticle

7 Scopus citations

Hepatocyte toll-like receptor 4 deficiency protects against alcohol-induced fatty liver disease

Jia, L., Chang, X., Qian, S., Liu, C., Lord, C. C., Ahmed, N., Lee, C. E., Lee, S., Gautron, L., Mitchell, M. C., Horton, J. D., Scherer, P. E. & Elmquist, J. K., Aug 1 2018, In : Molecular Metabolism. 14, p. 121-129 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Interplay between ChREBP and SREBP-1c coordinates postprandial glycolysis and lipogenesis in livers of mice

Linden, A. G., Li, S., Choi, H. Y., Fang, F., Fukasawa, M., Uyeda, K., Hammer, R. E., Horton, J. D., Engelking, L. & Liang, G., Jan 1 2018, In : Journal of Lipid Research. 59, 3, p. 475-487 13 p.

Research output: Contribution to journalArticle

27 Scopus citations
2017

Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation

Kim, C. W., Addy, C., Kusunoki, J., Anderson, N. N., Deja, S., Fu, X., Burgess, S. C., Li, C., Chakravarthy, M., Previs, S., Milstein, S., Fitzgerald, K., Kelley, D. E. & Horton, J. D., Aug 1 2017, In : Cell Metabolism. 26, 2, p. 394-406.e6

Research output: Contribution to journalArticle

52 Scopus citations

A highly durable RNAi therapeutic inhibitor of PCSK9

Fitzgerald, K., White, S., Borodovsky, A., Bettencourt, B. R., Strahs, A., Clausen, V., Wijngaard, P., Horton, J. D., Taubel, J., Brooks, A., Fernando, C., Kauffman, R. S., Kallend, D., Vaishnaw, A. & Simon, A., Jan 5 2017, In : New England Journal of Medicine. 376, 1, p. 41-51 11 p.

Research output: Contribution to journalArticle

108 Scopus citations

An adipo-biliary-uridine axis that regulates energy homeostasis

Deng, Y., Wang, Z., Gordillo, R., An, Y., Zhang, C., Liang, Q., Yoshino, J., Cautivo, K. M., De Brabander, J. K., Elmquist, J. K., Horton, J. D., Hill, J. A., Klein, S. & Scherer, P. E., Mar 17 2017, In : Science. 355, 6330, eaaf5375.

Research output: Contribution to journalArticle

31 Scopus citations

Erratum: Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation (Cell Metabolism (2017) 26 (394–406.e6) (S1550413117304308) (10.1016/j.cmet.2017.07.009))

Kim, C. W., Addy, C., Kusunoki, J., Anderson, N. N., Deja, S., Fu, X., Burgess, S. C., Li, C., Ruddy, M., Chakravarthy, M., Previs, S., Milstein, S., Fitzgerald, K., Kelley, D. E. & Horton, J. D., Sep 5 2017, In : Cell Metabolism. 26, 3, p. 576 1 p.

Research output: Contribution to journalComment/debate

11 Scopus citations

Expression of SREBP-1c requires SREBP-2-mediated generation of a sterol ligand for LXR in livers of mice

Rong, S., Cortés, V. A., Rashid, S., Anderson, N. N., McDonald, J. G., Liang, G., Moon, Y. A., Hammer, R. E. & Horton, J. D., Feb 28 2017, In : eLife. 6, e25015.

Research output: Contribution to journalArticle

34 Scopus citations

Inhibition of PCSK9 does not improve lipopolysaccharide-induced mortality in mice

Berger, J. M., Valdes, A. L., Gromada, J., Anderson, N. & Horton, J. D., 2017, In : Journal of Lipid Research. 58, 8, p. 1661-1669 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism

Ferris, H. A., Perry, R. J., Moreira, G. V., Shulman, G. I., Horton, J. D. & Kahn, C. R., Jan 31 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 5, p. 1189-1194 6 p.

Research output: Contribution to journalArticle

23 Scopus citations

Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement fromthe European Atherosclerosis Society Consensus Panel

Ference, B. A., Ginsberg, H. N., Graham, I., Ray, K. K., Packard, C. J., Bruckert, E., Hegele, R. A., Krauss, R. M., Raal, F. J., Schunkert, H., Watt, G. F., Borén, J., Fazio, S., Horton, J. D., Masana, L., Nicholls, S. J., Nordestgaard, B. G., Van De Sluis, B., Taskinen, M. R., Tokgözoǧlu, L. & 6 others, Landmesser, U., Laufs, U., Wiklund, O., Stock, J. K., Chapman, M. J. & Catapano, A. L., Aug 21 2017, In : European Heart Journal. 38, 32, p. 2459-2472 14 p.

Research output: Contribution to journalArticle

447 Scopus citations
2016

AGPAT2 is essential for postnatal development and maintenance of white and brown adipose tissue

Cautivo, K. M., Lizama, C. O., Tapia, P. J., Agarwal, A. K., Garg, A., Horton, J. D. & Cortés, V. A., Feb 13 2016, (Accepted/In press) In : Molecular Metabolism.

Research output: Contribution to journalArticle

9 Scopus citations

CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL

Bartuzi, P., Billadeau, D. D., Favier, R., Rong, S., Dekker, D., Fedoseienko, A., Fieten, H., Wijers, M., Levels, J. H., Huijkman, N., Kloosterhuis, N., Van Der Molen, H., Brufau, G., Groen, A. K., Elliott, A. M., Kuivenhoven, J. A., Plecko, B., Grangl, G., McGaughran, J., Horton, J. D. & 3 others, Burstein, E., Hofker, M. H. & Van De Sluis, B., Mar 11 2016, In : Nature Communications. 7, 10961.

Research output: Contribution to journalArticle

45 Scopus citations

MOGAT1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2-/-) or obese (ob/ob) mice

Agarwal, A. K., Tunison, K., Dalal, J. S., Yen, C. L. E., Farese, R. V., Horton, J. D. & Garg, A., Apr 1 2016, In : Journal of Lipid Research. 57, 4, p. 616-630 15 p.

Research output: Contribution to journalArticle

13 Scopus citations
2015

A high-fat diet suppresses de novo lipogenesis and desaturation but not elongation and triglyceride synthesis in mice

Duarte, J. A. G., Carvalho, F., Pearson, M., Horton, J. D., Browning, J. D., Jones, J. G. & Burgess, S. C., Jan 1 2015, In : Journal of Lipid Research. 55, 12, p. 2541-2553 13 p., A11.

Research output: Contribution to journalArticle

54 Scopus citations

Deletion of ELOVL6 blocks the synthesis of oleic acid but does not prevent the development of fatty liver or insulin resistance

Moon, Y. A., Ochoa, C. R., Mitsche, M. A., Hammer, R. E. & Horton, J. D., Jan 1 2015, In : Journal of Lipid Research. 55, 12, p. 2597-2605 9 p., A16.

Research output: Contribution to journalArticle

35 Scopus citations

MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels

Goedeke, L., Rotllan, N., Canfrán-Duque, A., Aranda, J. F., Ramírez, C. M., Araldi, E., Lin, C. S., Anderson, N. N., Wagschal, A., De Cabo, R., Horton, J. D., Lasunción, M. A., Näär, A. M., Suárez, Y. & Fernández-Hernando, C., Nov 1 2015, In : Nature Medicine. 21, 11, p. 1280-1288 9 p.

Research output: Contribution to journalArticle

92 Scopus citations
2014

Acetate dependence of tumors

Comerford, S. A., Huang, Z., Du, X., Wang, Y., Cai, L., Witkiewicz, A., Walters, H., Tantawy, M. N., Fu, A., Manning, H. C., Horton, J. D., Hammer, R. E., McKnight, S. L. & Tu, B. P., Dec 18 2014, In : Cell. 159, 7, p. 1591-1602 12 p.

Research output: Contribution to journalArticle

243 Scopus citations

An acetate switch regulates stress erythropoiesis.

Xu, M., Nagati, J. S., Xie, J., Li, J., Walters, H., Moon, Y. A., Gerard, R. D., Huang, C-L., Comerford, S. A., Hammer, R. E., Horton, J. D., Chen, R. & Garcia, J. A., 2014, In : Nature Medicine. 20, 9, p. 1018-1026 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: A randomised, single-blind, placebo-controlled, phase 1 trial

Fitzgerald, K., Frank-Kamenetsky, M., Shulga-Morskaya, S., Liebow, A., Bettencourt, B. R., Sutherland, J. E., Hutabarat, R. M., Clausen, V. A., Karsten, V., Cehelsky, J., Nochur, S. V., Kotelianski, V., Horton, J., Mant, T., Chiesa, J., Ritter, J., Munisamy, M., Vaishnaw, A. K., Gollob, J. A. & Simon, A., 2014, In : The Lancet. 383, 9911, p. 60-68 9 p.

Research output: Contribution to journalArticle

322 Scopus citations
8 Scopus citations
21 Scopus citations
2013

Metabolic response to high-carbohydrate and low-carbohydrate meals in a nonhuman primate model

Fabbrini, E., Higgins, P. B., Magkos, F., Bastarrachea, R. A., Saroja Voruganti, V., Comuzzie, A. G., Shade, R. E., Gastaldelli, A., Horton, J. D., Omodei, D., Patterson, B. W. & Klein, S., Feb 15 2013, In : American Journal of Physiology - Endocrinology and Metabolism. 304, 4

Research output: Contribution to journalArticle

12 Scopus citations

Opening up new fronts in the fight against cholesterol

DeBose-Boyd, R. A. & Horton, J. D., Apr 9 2013, In : eLife. 2013, 2, e00663.

Research output: Contribution to journalArticle

2 Scopus citations

Temporal regulation of nuclear factor one occupancy by calcineurin/NFAT governs a voltage-sensitive developmental switch in late maturing neurons

Ding, B., Wang, W., Selvakumar, T., Xi, H. S., Zhu, H., Chow, C. W., Horton, J. D., Gronostajski, R. M. & Kilpatrick, D. L., Feb 13 2013, In : Journal of Neuroscience. 33, 7, p. 2860-2872 13 p.

Research output: Contribution to journalArticle

20 Scopus citations

The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism

Deng, Y., Wang, Z., Tao, C., Gao, N., Holland, W. L., Ferdous, A., Repa, J., Liang, G., Ye, J., Lehrman, M. A., Hill, J. A., Horton, J. D. & Scherer, P. E., Jan 2 2013, In : Journal of Clinical Investigation. 123, 1, p. 455-468 14 p.

Research output: Contribution to journalArticle

76 Scopus citations
2012

Enhanced fatty acid flux triggered by adiponectin overexpression

Shetty, S., Ramos-Roman, M. A., Cho, Y. R., Brown, J., Plutzky, J., Muise, E. S., Horton, J. D., Scherer, P. E. & Parks, E. J., Jan 2012, In : Endocrinology. 153, 1, p. 113-122 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Regulation of hepatic LDL receptors by mTORC1 and PCSK9 in mice

Ai, D., Chen, C., Han, S., Ganda, A., Murphy, A. J., Haeusler, R., Thorp, E., Accili, D., Horton, J. D. & Tall, A. R., Apr 2 2012, In : Journal of Clinical Investigation. 122, 4, p. 1262-1270 9 p.

Research output: Contribution to journalArticle

99 Scopus citations

The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals

Moon, Y. A., Liang, G., Xie, X., Frank-Kamenetsky, M., Fitzgerald, K., Koteliansky, V., Brown, M. S., Goldstein, J. L. & Horton, J. D., Feb 8 2012, In : Cell Metabolism. 15, 2, p. 240-246 7 p.

Research output: Contribution to journalArticle

171 Scopus citations
2011

Human 1-Acylglycerol-3-phosphate O-Acyltransferase isoforms 1 and 2: Biochemical characterization and inability to rescue hepatic steatosis in Agpat2 -/- gene lipodystrophic mice

Agarwal, A. K., Sukumaran, S., Cortés, V. A., Tunison, K., Mizrachi, D., Sankella, S., Gerard, R. D., Horton, J. D. & Garg, A., Oct 28 2011, In : Journal of Biological Chemistry. 286, 43, p. 37676-37691 16 p.

Research output: Contribution to journalArticle

41 Scopus citations

Human fatty liver disease: Old questions and new insights

Cohen, J. C., Horton, J. D. & Hobbs, H. H., Jun 24 2011, In : Science. 332, 6037, p. 1519-1523 5 p.

Research output: Contribution to journalArticle

1160 Scopus citations

Integrated expression profiling and Genome-Wide analysis of ChREBP targets reveals the dual role for ChREBP in Glucose-Regulated gene expression

Jeong, Y. S., Kim, D., Lee, Y. S., Kim, H. J., Han, J. Y., Im, S. S., Chong, H. K., Kwon, J. K., Cho, Y. H., Kim, W. K., Osborne, T. F., Horton, J. D., Jun, H. S., Ahn, Y. H., Ahn, S. M. & Cha, J. Y., 2011, In : PLoS One. 6, 7, e22544.

Research output: Contribution to journalArticle

81 Scopus citations

Lack of a relationship between plasma PCSK9 concentrations and hepatic lipoprotein kinetics in obese people

Sullivan, S., Fabbrini, E., Horton, J. D., Korenblat, K., Patterson, B. W. & Klein, S., Nov 2011, In : Translational Research. 158, 5, p. 302-306 5 p.

Research output: Contribution to journalArticle

15 Scopus citations
2010

Crystal structure of Spot 14, a modulator of fatty acid synthesis

Colbert, C. L., Kim, C. W., Moon, Y. A., Henry, L., Palnitkar, M., McKean, W. B., Fitzgerald, K., Deisenhofer, J., Horton, J. D. & Kwon, H. J., Nov 2 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 44, p. 18820-18825 6 p.

Research output: Contribution to journalArticle

35 Scopus citations
69 Scopus citations
69 Scopus citations

Tauroursodeoxycholic acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women

Kars, M., Yang, L., Gregor, M. F., Mohammed, B. S., Pietka, T. A., Finck, B. N., Patterson, B. W., Horton, J. D., Mittendorfer, B., Hotamisligil, G. S. & Klein, S., Aug 2010, In : Diabetes. 59, 8, p. 1899-1905 7 p.

Research output: Contribution to journalArticle

233 Scopus citations
2009

Antagonism of secreted PCSK9 increases low density lipoprotein receptor expression in HepG2 cells

McNutt, M. C., Kwon, H. J., Chen, C., Chen, J. R., Horton, J. D. & Lagace, T. A., Apr 17 2009, In : Journal of Biological Chemistry. 284, 16, p. 10561-10570 10 p.

Research output: Contribution to journalArticle

111 Scopus citations

Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice

Moon, Y. A., Hammer, R. E. & Horton, J. D., Apr 2009, In : Journal of Lipid Research. 50, 3, p. 412-423 12 p.

Research output: Contribution to journalArticle

105 Scopus citations

Genetic and metabolic determinants of plasma PCSK9 levels

Lakoski, S. G., Lagace, T. A., Cohen, J. C., Horton, J. D. & Hobbs, H. H., Jul 2009, In : Journal of Clinical Endocrinology and Metabolism. 94, 7, p. 2537-2543 7 p.

Research output: Contribution to journalArticle

303 Scopus citations

Molecular Mechanisms of Hepatic Steatosis and Insulin Resistance in the AGPAT2-Deficient Mouse Model of Congenital Generalized Lipodystrophy

Cortés, V. A., Curtis, D. E., Sukumaran, S., Shao, X., Parameswara, V., Rashid, S., Smith, A. R., Ren, J., Esser, V., Hammer, R. E., Agarwal, A. K., Horton, J. D. & Garg, A., Feb 4 2009, In : Cell Metabolism. 9, 2, p. 165-176 12 p.

Research output: Contribution to journalArticle

143 Scopus citations

PCSK9: A convertase that coordinates LDL catabolism

Horton, J. D., Cohen, J. C. & Hobbs, H. H., Apr 2009, In : Journal of Lipid Research. 50, SUPPL.

Research output: Contribution to journalArticle

360 Scopus citations
2008

Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice

Minehira, K., Young, S. G., Villanueva, C. J., Yetukuri, L., Oresic, M., Hellerstein, M. K., Farese, R. V., Horton, J. D., Preitner, F., Thorens, B. & Tappy, L., Sep 2008, In : Journal of Lipid Research. 49, 9, p. 2038-2044 7 p.

Research output: Contribution to journalArticle

104 Scopus citations

Molecular basis for LDL receptor recognition by PCSK9

Hyock, J. K., Lagace, T. A., McNutt, M. C., Horton, J. D. & Deisenhofer, J., Feb 12 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 6, p. 1820-1825 6 p.

Research output: Contribution to journalArticle

246 Scopus citations

Physiology: Unfolding lipid metabolism

Horton, J. D., Jun 13 2008, In : Science. 320, 5882, p. 1433-1434 2 p.

Research output: Contribution to journalArticle

9 Scopus citations

Plasma PCSK9 preferentially reduces liver LDL receptors in mice

Grefhorst, A., McNutt, M. C., Lagace, T. A. & Horton, J. D., Jun 1 2008, In : Journal of Lipid Research. 49, 6, p. 1303-1311 9 p.

Research output: Contribution to journalArticle

132 Scopus citations

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

Frank-Kamenetsky, M., Grefhorst, A., Anderson, N. N., Racie, T. S., Bramlage, B., Akinc, A., Butler, D., Charisse, K., Dorkin, R., Fan, Y., Gamba-Vitalo, C., Hadwiger, P., Jayaraman, M., John, M., Jayaprakash, K. N., Maier, M., Nechev, L., Rajeev, K. G., Read, T., Röhl, I. & 13 others, Soutschek, J., Tan, P., Wong, J., Wang, G., Zimmermann, T., De Fougerolles, A., Vornlocher, H. P., Langer, R., Anderson, D. G., Manoharan, M., Koteliansky, V., Horton, J. D. & Fitzgerald, K., Aug 19 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 33, p. 11915-11920 6 p.

Research output: Contribution to journalArticle

443 Scopus citations
2007

Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation

Zhang, D. W., Lagace, T. A., Garuti, R., Zhao, Z., McDonald, M., Horton, J. D., Cohen, J. C. & Hobbs, H. H., Jun 22 2007, In : Journal of Biological Chemistry. 282, 25, p. 18602-18612 11 p.

Research output: Contribution to journalArticle

480 Scopus citations