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Research Output 1993 2019

  • 25210 Citations
  • 66 h-Index
  • 97 Article
  • 2 Comment/debate
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Article
2019

SREBP-regulated adipocyte lipogenesis is dependent on substrate availability and redox modulation of mTORC1

Crewe, C., Zhu, Y., Paschoal, V. A., Joffin, N., Ghaben, A. L., Gordillo, R., Oh, D. Y., Liang, G., Horton, J. D. & Scherer, P. E., Aug 8 2019, In : JCI Insight. 4, 15, e129397.

Research output: Contribution to journalArticle

Open Access
Lipogenesis
Adipocytes
Oxidation-Reduction
Adipose Tissue
Response Elements
2018
4 Citations (Scopus)

Adipocyte Xbp1s overexpression drives uridine production and reduces obesity

Deng, Y., Wang, Z., Gordillo, R., Zhu, Y., Ali, A., Zhang, C., Wang, X., Shao, M., Zhang, Z., Iyengar, P., Gupta, R. K., Horton, J. D., Hill, J. A. & Scherer, P. E., Jan 1 2018, (Accepted/In press) In : Molecular Metabolism.

Research output: Contribution to journalArticle

Uridine
Adipocytes
Obesity
Lipolysis
Dihydroorotase
6 Citations (Scopus)

Hepatocyte toll-like receptor 4 deficiency protects against alcohol-induced fatty liver disease

Jia, L., Chang, X., Qian, S., Liu, C., Lord, C. C., Ahmed, N., Lee, C. E., Lee, S., Gautron, L., Mitchell, M. C., Horton, J. D., Scherer, P. E. & Elmquist, J. K., Aug 1 2018, In : Molecular Metabolism. 14, p. 121-129 9 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Fatty Liver
Liver Diseases
Hepatocytes
Alcohols
27 Citations (Scopus)

Interplay between ChREBP and SREBP-1c coordinates postprandial glycolysis and lipogenesis in livers of mice

Linden, A. G., Li, S., Choi, H. Y., Fang, F., Fukasawa, M., Uyeda, K., Hammer, R. E., Horton, J. D., Engelking, L. & Liang, G., Jan 1 2018, In : Journal of Lipid Research. 59, 3, p. 475-487 13 p.

Research output: Contribution to journalArticle

Sterol Regulatory Element Binding Protein 1
Lipogenesis
Glycolysis
Liver
Carrier Proteins
2017
48 Citations (Scopus)

Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation

Kim, C. W., Addy, C., Kusunoki, J., Anderson, N. N., Deja, S., Fu, X., Burgess, S. C., Li, C., Chakravarthy, M., Previs, S., Milstein, S., Fitzgerald, K., Kelley, D. E. & Horton, J. D., Aug 1 2017, In : Cell Metabolism. 26, 2, p. 394-406.e6

Research output: Contribution to journalArticle

Acetyl-CoA Carboxylase
Lipogenesis
Triglycerides
Liver
Unsaturated Fatty Acids
104 Citations (Scopus)

A highly durable RNAi therapeutic inhibitor of PCSK9

Fitzgerald, K., White, S., Borodovsky, A., Bettencourt, B. R., Strahs, A., Clausen, V., Wijngaard, P., Horton, J. D., Taubel, J., Brooks, A., Fernando, C., Kauffman, R. S., Kallend, D., Vaishnaw, A. & Simon, A., Jan 5 2017, In : New England Journal of Medicine. 376, 1, p. 41-51 11 p.

Research output: Contribution to journalArticle

RNA Interference
LDL Cholesterol
Least-Squares Analysis
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Therapeutics
29 Citations (Scopus)

An adipo-biliary-uridine axis that regulates energy homeostasis

Deng, Y., Wang, Z., Gordillo, R., An, Y., Zhang, C., Liang, Q., Yoshino, J., Cautivo, K. M., De Brabander, J. K., Elmquist, J. K., Horton, J. D., Hill, J. A., Klein, S. & Scherer, P. E., Mar 17 2017, In : Science. 355, 6330, eaaf5375.

Research output: Contribution to journalArticle

Uridine
Homeostasis
Fasting
Body Temperature Regulation
Leptin
31 Citations (Scopus)

Expression of SREBP-1c requires SREBP-2-mediated generation of a sterol ligand for LXR in livers of mice

Rong, S., Cortés, V. A., Rashid, S., Anderson, N. N., McDonald, J. G., Liang, G., Moon, Y. A., Hammer, R. E. & Horton, J. D., Feb 28 2017, In : eLife. 6, e25015.

Research output: Contribution to journalArticle

Sterol Regulatory Element Binding Protein 1
Sterols
Liver
Hepatocytes
Ligands
17 Citations (Scopus)

Inhibition of PCSK9 does not improve lipopolysaccharide-induced mortality in mice

Berger, J. M., Valdes, A. L., Gromada, J., Anderson, N. & Horton, J. D., 2017, In : Journal of Lipid Research. 58, 8, p. 1661-1669 9 p.

Research output: Contribution to journalArticle

Proprotein Convertases
Subtilisin
Lipopolysaccharides
Mortality
Endotoxemia
23 Citations (Scopus)

Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism

Ferris, H. A., Perry, R. J., Moreira, G. V., Shulman, G. I., Horton, J. D. & Kahn, C. R., Jan 31 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 5, p. 1189-1194 6 p.

Research output: Contribution to journalArticle

Astrocytes
Cholesterol
Brain
Sterols
Proteins
429 Citations (Scopus)

Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement fromthe European Atherosclerosis Society Consensus Panel

Ference, B. A., Ginsberg, H. N., Graham, I., Ray, K. K., Packard, C. J., Bruckert, E., Hegele, R. A., Krauss, R. M., Raal, F. J., Schunkert, H., Watt, G. F., Borén, J., Fazio, S., Horton, J. D., Masana, L., Nicholls, S. J., Nordestgaard, B. G., Van De Sluis, B., Taskinen, M. R., Tokgözoǧlu, L. & 6 others, Landmesser, U., Laufs, U., Wiklund, O., Stock, J. K., Chapman, M. J. & Catapano, A. L., Aug 21 2017, In : European Heart Journal. 38, 32, p. 2459-2472 14 p.

Research output: Contribution to journalArticle

LDL Lipoproteins
Epidemiologic Studies
Cardiovascular Diseases
Random Allocation
Clinical Studies
2016
9 Citations (Scopus)

AGPAT2 is essential for postnatal development and maintenance of white and brown adipose tissue

Cautivo, K. M., Lizama, C. O., Tapia, P. J., Agarwal, A. K., Garg, A., Horton, J. D. & Cortés, V. A., Feb 13 2016, (Accepted/In press) In : Molecular Metabolism.

Research output: Contribution to journalArticle

White Adipose Tissue
Brown Adipose Tissue
Maintenance
Adipose Tissue
Fibroblasts
43 Citations (Scopus)

CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL

Bartuzi, P., Billadeau, D. D., Favier, R., Rong, S., Dekker, D., Fedoseienko, A., Fieten, H., Wijers, M., Levels, J. H., Huijkman, N., Kloosterhuis, N., Van Der Molen, H., Brufau, G., Groen, A. K., Elliott, A. M., Kuivenhoven, J. A., Plecko, B., Grangl, G., McGaughran, J., Horton, J. D. & 3 others, Burstein, E., Hofker, M. H. & Van De Sluis, B., Mar 11 2016, In : Nature Communications. 7, 10961.

Research output: Contribution to journalArticle

Wiskott-Aldrich Syndrome Protein
lipoproteins
LDL Receptors
clearances
classifying
13 Citations (Scopus)

MOGAT1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2-/-) or obese (ob/ob) mice

Agarwal, A. K., Tunison, K., Dalal, J. S., Yen, C. L. E., Farese, R. V., Horton, J. D. & Garg, A., Apr 1 2016, In : Journal of Lipid Research. 57, 4, p. 616-630 15 p.

Research output: Contribution to journalArticle

Triglycerides
Liver
Monoglycerides
Knockout Mice
1-Acylglycerol-3-Phosphate O-Acyltransferase
2015
54 Citations (Scopus)

A high-fat diet suppresses de novo lipogenesis and desaturation but not elongation and triglyceride synthesis in mice

Duarte, J. A. G., Carvalho, F., Pearson, M., Horton, J. D., Browning, J. D., Jones, J. G. & Burgess, S. C., Jan 1 2015, In : Journal of Lipid Research. 55, 12, p. 2541-2553 13 p., A11.

Research output: Contribution to journalArticle

Lipogenesis
High Fat Diet
Nutrition
Elongation
Triglycerides
33 Citations (Scopus)

Deletion of ELOVL6 blocks the synthesis of oleic acid but does not prevent the development of fatty liver or insulin resistance

Moon, Y. A., Ochoa, C. R., Mitsche, M. A., Hammer, R. E. & Horton, J. D., Jan 1 2015, In : Journal of Lipid Research. 55, 12, p. 2597-2605 9 p., A16.

Research output: Contribution to journalArticle

Fatty Liver
Oleic Acid
Liver
Insulin Resistance
Fatty Acids
89 Citations (Scopus)

MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels

Goedeke, L., Rotllan, N., Canfrán-Duque, A., Aranda, J. F., Ramírez, C. M., Araldi, E., Lin, C. S., Anderson, N. N., Wagschal, A., De Cabo, R., Horton, J. D., Lasunción, M. A., Näär, A. M., Suárez, Y. & Fernández-Hernando, C., Nov 1 2015, In : Nature Medicine. 21, 11, p. 1280-1288 9 p.

Research output: Contribution to journalArticle

LDL Receptors
MicroRNAs
Lipoproteins
Adenosine Triphosphate
LDL Cholesterol
2014
238 Citations (Scopus)

Acetate dependence of tumors

Comerford, S. A., Huang, Z., Du, X., Wang, Y., Cai, L., Witkiewicz, A., Walters, H., Tantawy, M. N., Fu, A., Manning, H. C., Horton, J. D., Hammer, R. E., McKnight, S. L. & Tu, B. P., Dec 18 2014, In : Cell. 159, 7, p. 1591-1602 12 p.

Research output: Contribution to journalArticle

Tumors
Acetates
Acetyl Coenzyme A
Neoplasms
Carbon
32 Citations (Scopus)

An acetate switch regulates stress erythropoiesis.

Xu, M., Nagati, J. S., Xie, J., Li, J., Walters, H., Moon, Y. A., Gerard, R. D., Huang, C-L., Comerford, S. A., Hammer, R. E., Horton, J. D., Chen, R. & Garcia, J. A., 2014, In : Nature Medicine. 20, 9, p. 1018-1026 9 p.

Research output: Contribution to journalArticle

Erythropoiesis
Erythropoietin
Acetates
Switches
Acetate-CoA Ligase
318 Citations (Scopus)

Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: A randomised, single-blind, placebo-controlled, phase 1 trial

Fitzgerald, K., Frank-Kamenetsky, M., Shulga-Morskaya, S., Liebow, A., Bettencourt, B. R., Sutherland, J. E., Hutabarat, R. M., Clausen, V. A., Karsten, V., Cehelsky, J., Nochur, S. V., Kotelianski, V., Horton, J., Mant, T., Chiesa, J., Ritter, J., Munisamy, M., Vaishnaw, A. K., Gollob, J. A. & Simon, A., 2014, In : The Lancet. 383, 9911, p. 60-68 9 p.

Research output: Contribution to journalArticle

RNA Interference
LDL Cholesterol
Healthy Volunteers
Placebos
Serum
8 Citations (Scopus)
Phosphatidic Acids
Gluconeogenesis
Insulin
Hyperglycemia
Liver
21 Citations (Scopus)
Leptin Receptors
Leptin
Insulin Resistance
Hepatocytes
Insulin
2013
12 Citations (Scopus)

Metabolic response to high-carbohydrate and low-carbohydrate meals in a nonhuman primate model

Fabbrini, E., Higgins, P. B., Magkos, F., Bastarrachea, R. A., Saroja Voruganti, V., Comuzzie, A. G., Shade, R. E., Gastaldelli, A., Horton, J. D., Omodei, D., Patterson, B. W. & Klein, S., Feb 15 2013, In : American Journal of Physiology - Endocrinology and Metabolism. 304, 4

Research output: Contribution to journalArticle

Primates
Meals
Carbohydrates
Glucose
Portal Vein
1 Citation (Scopus)

Opening up new fronts in the fight against cholesterol

DeBose-Boyd, R. A. & Horton, J. D., Apr 9 2013, In : eLife. 2013, 2, e00663.

Research output: Contribution to journalArticle

Serine Endopeptidases
Vesicular Transport Proteins
COP-Coated Vesicles
Proprotein Convertases
Dyslipidemias
20 Citations (Scopus)

Temporal regulation of nuclear factor one occupancy by calcineurin/NFAT governs a voltage-sensitive developmental switch in late maturing neurons

Ding, B., Wang, W., Selvakumar, T., Xi, H. S., Zhu, H., Chow, C. W., Horton, J. D., Gronostajski, R. M. & Kilpatrick, D. L., Feb 13 2013, In : Journal of Neuroscience. 33, 7, p. 2860-2872 13 p.

Research output: Contribution to journalArticle

NFI Transcription Factors
Calcineurin
Neurons
Genes
Dendrites
74 Citations (Scopus)

The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism

Deng, Y., Wang, Z., Tao, C., Gao, N., Holland, W. L., Ferdous, A., Repa, J., Liang, G., Ye, J., Lehrman, M. A., Hill, J. A., Horton, J. D. & Scherer, P. E., Jan 2 2013, In : Journal of Clinical Investigation. 123, 1, p. 455-468 14 p.

Research output: Contribution to journalArticle

Unfolded Protein Response
Liver
UDPglucose 4-Epimerase
Glucose
Protein Biosynthesis
2012
24 Citations (Scopus)

Enhanced fatty acid flux triggered by adiponectin overexpression

Shetty, S., Ramos-Roman, M. A., Cho, Y. R., Brown, J., Plutzky, J., Muise, E. S., Horton, J. D., Scherer, P. E. & Parks, E. J., Jan 2012, In : Endocrinology. 153, 1, p. 113-122 10 p.

Research output: Contribution to journalArticle

Adiponectin
Retinoids
Fatty Acids
Peroxisome Proliferator-Activated Receptors
Nonesterified Fatty Acids
99 Citations (Scopus)

Regulation of hepatic LDL receptors by mTORC1 and PCSK9 in mice

Ai, D., Chen, C., Han, S., Ganda, A., Murphy, A. J., Haeusler, R., Thorp, E., Accili, D., Horton, J. D. & Tall, A. R., Apr 2 2012, In : Journal of Clinical Investigation. 122, 4, p. 1262-1270 9 p.

Research output: Contribution to journalArticle

LDL Receptors
Liver
Sirolimus
LDL Cholesterol
Type 2 Diabetes Mellitus
170 Citations (Scopus)

The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals

Moon, Y. A., Liang, G., Xie, X., Frank-Kamenetsky, M., Fitzgerald, K., Koteliansky, V., Brown, M. S., Goldstein, J. L. & Horton, J. D., Feb 8 2012, In : Cell Metabolism. 15, 2, p. 240-246 7 p.

Research output: Contribution to journalArticle

Hypertriglyceridemia
Fatty Liver
Carbohydrates
Sucrose
Insulin Resistance
2011
40 Citations (Scopus)

Human 1-Acylglycerol-3-phosphate O-Acyltransferase isoforms 1 and 2: Biochemical characterization and inability to rescue hepatic steatosis in Agpat2 -/- gene lipodystrophic mice

Agarwal, A. K., Sukumaran, S., Cortés, V. A., Tunison, K., Mizrachi, D., Sankella, S., Gerard, R. D., Horton, J. D. & Garg, A., Oct 28 2011, In : Journal of Biological Chemistry. 286, 43, p. 37676-37691 16 p.

Research output: Contribution to journalArticle

1-Acylglycerol-3-Phosphate O-Acyltransferase
Liver
Protein Isoforms
Genes
Tissue
1146 Citations (Scopus)

Human fatty liver disease: Old questions and new insights

Cohen, J. C., Horton, J. D. & Hobbs, H. H., Jun 24 2011, In : Science. 332, 6037, p. 1519-1523 5 p.

Research output: Contribution to journalArticle

Fatty Liver
Liver Diseases
Medical Genetics
Liver Neoplasms
Developed Countries
81 Citations (Scopus)

Integrated expression profiling and Genome-Wide analysis of ChREBP targets reveals the dual role for ChREBP in Glucose-Regulated gene expression

Jeong, Y. S., Kim, D., Lee, Y. S., Kim, H. J., Han, J. Y., Im, S. S., Chong, H. K., Kwon, J. K., Cho, Y. H., Kim, W. K., Osborne, T. F., Horton, J. D., Jun, H. S., Ahn, Y. H., Ahn, S. M. & Cha, J. Y., 2011, In : PLoS One. 6, 7, e22544.

Research output: Contribution to journalArticle

response elements
Response Elements
Gene expression
binding proteins
Carrier Proteins
14 Citations (Scopus)

Lack of a relationship between plasma PCSK9 concentrations and hepatic lipoprotein kinetics in obese people

Sullivan, S., Fabbrini, E., Horton, J. D., Korenblat, K., Patterson, B. W. & Klein, S., Nov 2011, In : Translational Research. 158, 5, p. 302-306 5 p.

Research output: Contribution to journalArticle

Lipoproteins
Blood Proteins
Kinetics
Liver
LDL Cholesterol
2010
35 Citations (Scopus)

Crystal structure of Spot 14, a modulator of fatty acid synthesis

Colbert, C. L., Kim, C. W., Moon, Y. A., Henry, L., Palnitkar, M., McKean, W. B., Fitzgerald, K., Deisenhofer, J., Horton, J. D. & Kwon, H. J., Nov 2 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 44, p. 18820-18825 6 p.

Research output: Contribution to journalArticle

Acetyl-CoA Carboxylase
Fatty Acids
Polymerization
Breast
Lipids
69 Citations (Scopus)
Proprotein Convertases
Subtilisin
Biosynthesis
Fasting
Cholesterol
69 Citations (Scopus)
Acetyl-CoA Carboxylase
Polymerization
Fatty Acids
Citric Acid
Phosphorylation
233 Citations (Scopus)

Tauroursodeoxycholic acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women

Kars, M., Yang, L., Gregor, M. F., Mohammed, B. S., Pietka, T. A., Finck, B. N., Patterson, B. W., Horton, J. D., Mittendorfer, B., Hotamisligil, G. S. & Klein, S., Aug 2010, In : Diabetes. 59, 8, p. 1899-1905 7 p.

Research output: Contribution to journalArticle

Insulin Resistance
Adipose Tissue
Endoplasmic Reticulum Stress
Muscles
Liver
2009
109 Citations (Scopus)

Antagonism of secreted PCSK9 increases low density lipoprotein receptor expression in HepG2 cells

McNutt, M. C., Kwon, H. J., Chen, C., Chen, J. R., Horton, J. D. & Lagace, T. A., Apr 17 2009, In : Journal of Biological Chemistry. 284, 16, p. 10561-10570 10 p.

Research output: Contribution to journalArticle

LDL Receptors
Hep G2 Cells
Epidermal Growth Factor
Degradation
Hyperlipoproteinemia Type II
103 Citations (Scopus)

Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice

Moon, Y. A., Hammer, R. E. & Horton, J. D., Apr 2009, In : Journal of Lipid Research. 50, 3, p. 412-423 12 p.

Research output: Contribution to journalArticle

Sterol Regulatory Element Binding Protein 1
Fatty Liver
Liver
Fatty Acids
Chemical activation
299 Citations (Scopus)

Genetic and metabolic determinants of plasma PCSK9 levels

Lakoski, S. G., Lagace, T. A., Cohen, J. C., Horton, J. D. & Hobbs, H. H., Jul 2009, In : Journal of Clinical Endocrinology and Metabolism. 94, 7, p. 2537-2543 7 p.

Research output: Contribution to journalArticle

Plasmas
LDL Cholesterol
Lipoproteins
Plasma (human)
Sampling Studies
140 Citations (Scopus)

Molecular Mechanisms of Hepatic Steatosis and Insulin Resistance in the AGPAT2-Deficient Mouse Model of Congenital Generalized Lipodystrophy

Cortés, V. A., Curtis, D. E., Sukumaran, S., Shao, X., Parameswara, V., Rashid, S., Smith, A. R., Ren, J., Esser, V., Hammer, R. E., Agarwal, A. K., Horton, J. D. & Garg, A., Feb 4 2009, In : Cell Metabolism. 9, 2, p. 165-176 12 p.

Research output: Contribution to journalArticle

1-Acylglycerol-3-Phosphate O-Acyltransferase
Congenital Generalized Lipodystrophy
Insulin Resistance
Liver
Monoglycerides
357 Citations (Scopus)

PCSK9: A convertase that coordinates LDL catabolism

Horton, J. D., Cohen, J. C. & Hobbs, H. H., Apr 2009, In : Journal of Lipid Research. 50, SUPPL.

Research output: Contribution to journalArticle

Proprotein Convertases
Coronary Disease
Degradation
LDL Receptors
Metabolism
2008
103 Citations (Scopus)

Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice

Minehira, K., Young, S. G., Villanueva, C. J., Yetukuri, L., Oresic, M., Hellerstein, M. K., Farese, R. V., Horton, J. D., Preitner, F., Thorens, B. & Tappy, L., Sep 2008, In : Journal of Lipid Research. 49, 9, p. 2038-2044 7 p.

Research output: Contribution to journalArticle

Insulin Resistance
Triglycerides
Insulin
Lipids
Liver
240 Citations (Scopus)

Molecular basis for LDL receptor recognition by PCSK9

Hyock, J. K., Lagace, T. A., McNutt, M. C., Horton, J. D. & Deisenhofer, J., Feb 12 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 6, p. 1820-1825 6 p.

Research output: Contribution to journalArticle

LDL Receptors
Epidermal Growth Factor
LDL Cholesterol
Catalytic Domain
Binding Sites
9 Citations (Scopus)

Physiology: Unfolding lipid metabolism

Horton, J. D., Jun 13 2008, In : Science. 320, 5882, p. 1433-1434 2 p.

Research output: Contribution to journalArticle

Lipid Metabolism
Transcription Factors
Lipids
Genes
Proteins
129 Citations (Scopus)

Plasma PCSK9 preferentially reduces liver LDL receptors in mice

Grefhorst, A., McNutt, M. C., Lagace, T. A. & Horton, J. D., Jun 1 2008, In : Journal of Lipid Research. 49, 6, p. 1303-1311 9 p.

Research output: Contribution to journalArticle

Proprotein Convertases
Subtilisin
LDL Receptors
Liver
Plasmas
441 Citations (Scopus)

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

Frank-Kamenetsky, M., Grefhorst, A., Anderson, N. N., Racie, T. S., Bramlage, B., Akinc, A., Butler, D., Charisse, K., Dorkin, R., Fan, Y., Gamba-Vitalo, C., Hadwiger, P., Jayaraman, M., John, M., Jayaprakash, K. N., Maier, M., Nechev, L., Rajeev, K. G., Read, T., Röhl, I. & 13 others, Soutschek, J., Tan, P., Wong, J., Wang, G., Zimmermann, T., De Fougerolles, A., Vornlocher, H. P., Langer, R., Anderson, D. G., Manoharan, M., Koteliansky, V., Horton, J. D. & Fitzgerald, K., Aug 19 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 33, p. 11915-11920 6 p.

Research output: Contribution to journalArticle

LDL Cholesterol
Primates
Rodentia
Cholesterol
Small Interfering RNA
2007
472 Citations (Scopus)

Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation

Zhang, D. W., Lagace, T. A., Garuti, R., Zhao, Z., McDonald, M., Horton, J. D., Cohen, J. C. & Hobbs, H. H., Jun 22 2007, In : Journal of Biological Chemistry. 282, 25, p. 18602-18612 11 p.

Research output: Contribution to journalArticle

Proprotein Convertases
Subtilisin
LDL Receptors
Epidermal Growth Factor
Recycling
172 Citations (Scopus)

Catalytic activity is not required for secreted PCSK9 to reduce low density lipoprotein receptors in HepG2 cells

McNutt, M. C., Lagace, T. A. & Horton, J. D., Jul 20 2007, In : Journal of Biological Chemistry. 282, 29, p. 20799-20803 5 p.

Research output: Contribution to journalArticle

Proprotein Convertases
Subtilisin
LDL Receptors
Hep G2 Cells
Catalyst activity
128 Citations (Scopus)

Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway

John, M., Constien, R., Akinc, A., Goldberg, M., Moon, Y. A., Spranger, M., Hadwiger, P., Soutschek, J., Vornlocher, H. P., Manoharan, M., Stoffel, M., Langer, R., Anderson, D. G., Horton, J. D., Koteliansky, V. & Bumcrot, D., Oct 11 2007, In : Nature. 449, 7163, p. 745-747 3 p.

Research output: Contribution to journalArticle

Gene Silencing
RNA Interference
MicroRNAs
Small Interfering RNA
Hepatocytes