• 2046 Citations
  • 12 h-Index
20082019
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Research Output 2008 2019

2019

Clearing debris

Meng, D. & Jewell, J. L., Aug 1 2019, In : Nature chemical biology. 15, 8, p. 760-761 2 p.

Research output: Contribution to journalComment/debate

Vacuolar Proton-Translocating ATPases
Poisons
Autophagy
Neurodegenerative Diseases
mechanistic target of rapamycin complex 1

GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor

Jewell, J. L., Fu, V., Hong, A. W., Yu, F. X., Meng, D., Melick, C. H., Wang, H., Lam, W. L. M., Yuan, H. X., Taylor, S. S. & Guan, K. L., May 21 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
Raptors
Phosphorylation
G-Protein-Coupled Receptors
Cyclic AMP-Dependent Protein Kinases
mechanistic target of rapamycin complex 1
2018
30 Citations (Scopus)

mTOR signaling in stem and progenitor cells

Meng, D., Frank, A. R. & Jewell, J. L., Jan 1 2018, In : Development (Cambridge). 145, 1, dev152595.

Research output: Contribution to journalReview article

Sirolimus
Stem Cells
Multipotent Stem Cells
Adult Stem Cells
Autophagy
2015
258 Citations (Scopus)

Differential regulation of mTORC1 by leucine and glutamine

Jewell, J. L., Kim, Y. C., Russell, R. C., Yu, F. X., Park, H. W., Plouffe, S. W., Tagliabracci, V. S. & Guan, K. L., Jan 9 2015, In : Science. 347, 6218, p. 194-198 5 p.

Research output: Contribution to journalArticle

Glutamine
Leucine
GTP Phosphohydrolases
Adenosine Triphosphatases
Amino Acids
3 Citations (Scopus)

Micro(RNA) managing by mTORC1

Jewell, J. L., Flores, F. & Guan, K. L., Jan 1 2015, In : Molecular Cell. 57, 4, p. 575-576 2 p.

Research output: Contribution to journalShort survey

Ubiquitin-Protein Ligases
MicroRNAs
Food
mechanistic target of rapamycin complex 1
17 Citations (Scopus)

NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition

Yuan, H. X., Wang, Z., Yu, F. X., Li, F., Russell, R. C., Jewell, J. L. & Guan, K. L., Nov 15 2015, In : Genes and Development. 29, 22, p. 2362-2376 15 p.

Research output: Contribution to journalArticle

Raptors
Phosphotransferases
Osmotic Pressure
mechanistic target of rapamycin complex 1
GTP Phosphohydrolases
2014

Rag GTPases

Jewell, J. L. & Guan, K. L., May 1 2014, Ras Superfamily Small G Proteins: Biology and Mechanisms 2: Transport. Springer International Publishing, p. 277-292 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

GTP Phosphohydrolases
Amino Acids
Availability
GTPase-Activating Proteins
Guanine Nucleotide Exchange Factors
42 Citations (Scopus)

Rag GTPases are cardioprotective by regulating lysosomal function

Kim, Y. C., Park, H. W., Sciarretta, S., Mo, J. S., Jewell, J. L., Russell, R. C., Wu, X., Sadoshima, J. & Guan, K. L., Jul 1 2014, In : Nature Communications. 5, 4241.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
lysosomes
activation
Chemical activation
knockout mice
2013
432 Citations (Scopus)

Amino acid signalling upstream of mTOR

Jewell, J. L., Russell, R. C. & Guan, K. L., Mar 1 2013, In : Nature Reviews Molecular Cell Biology. 14, 3, p. 133-139 7 p.

Research output: Contribution to journalArticle

Sirolimus
Amino Acids
Vacuolar Proton-Translocating ATPases
GTP Phosphohydrolases
Autophagy
199 Citations (Scopus)

Nutrient signaling to mTOR and cell growth

Jewell, J. L. & Guan, K. L., May 1 2013, In : Trends in Biochemical Sciences. 38, 5, p. 233-242 10 p.

Research output: Contribution to journalReview article

Cell growth
Sirolimus
Nutrients
Food
Growth
142 Citations (Scopus)

Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation

Yu, F. X., Zhang, Y., Park, H. W., Jewell, J. L., Chen, Q., Deng, Y., Pan, D., Taylor, S. S., Lai, Z. C. & Guan, K. L., Feb 1 2013, In : Genes and Development. 27, 11, p. 1223-1232 10 p.

Research output: Contribution to journalArticle

Cyclic AMP-Dependent Protein Kinases
Cell Differentiation
Cell Proliferation
Phosphotransferases
Adenosine Kinase
2012
695 Citations (Scopus)

Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling

Yu, F. X., Zhao, B., Panupinthu, N., Jewell, J. L., Lian, I., Wang, L. H., Zhao, J., Yuan, H., Tumaneng, K., Li, H., Fu, X. D., Mills, G. B. & Guan, K. L., Aug 17 2012, In : Cell. 150, 4, p. 780-791 12 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Phosphotransferases
Glucagon Receptors
Sphingosine
Organ Size
2011
46 Citations (Scopus)

Munc18c phosphorylation by the insulin receptor links cell signaling directly to SNARE exocytosis

Jewell, J. L., Oh, E., Ramalingam, L., Kalwat, M. A., Tagliabracci, V. S., Tackett, L., Elmendorf, J. S. & Thurmond, D. C., Apr 4 2011, In : Journal of Cell Biology. 193, 1, p. 185-199 15 p.

Research output: Contribution to journalArticle

SNARE Proteins
Insulin Receptor
Exocytosis
Qa-SNARE Proteins
Phosphorylation
2010
72 Citations (Scopus)
Qa-SNARE Proteins
Exocytosis
SNARE Proteins
Insulin
Glucose
2008
75 Citations (Scopus)

Filamentous actin regulates insulin exocytosis through direct interaction with Syntaxin 4

Jewell, J. L., Luo, W., Oh, E., Wang, Z. & Thurmond, D. C., Apr 18 2008, In : Journal of Biological Chemistry. 283, 16, p. 10716-10726 11 p.

Research output: Contribution to journalArticle

Qa-SNARE Proteins
Exocytosis
Actins
Insulin
Glucose
35 Citations (Scopus)

The tyrosine phosphorylation of Munc18c induces a switch in binding specificity from syntaxin 4 to Doc2β

Jewell, J. L., Oh, E., Bennett, S. M., Meroueh, S. O. & Thurmond, D. C., Aug 1 2008, In : Journal of Biological Chemistry. 283, 31, p. 21734-21746 13 p.

Research output: Contribution to journalArticle

Qa-SNARE Proteins
Phosphorylation
Tyrosine
Switches
SNARE Proteins