• 2243 Citations
  • 12 h-Index
20082020

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Article
2020

A-kinase anchoring protein 8L interacts with mTORC1 and promotes cell growth

Melick, C. H., Meng, D. & Jewell, J. L., Apr 2020, In : Journal of Biological Chemistry. 295, 23

Research output: Contribution to journalArticle

Amino Acid Sensing: Architecture of mTORC1 on the Lysosome Surface

Peng, W. & Jewell, J. L., Jan 20 2020, In : Current Biology. 30, 2, p. R89-R91

Research output: Contribution to journalArticle

1 Scopus citations

Small molecule H89 renders the phosphorylation of S6K1 and AKT resistant to mTOR inhibitors

Melick, C. H. & Jewell, J. L., May 29 2020, In : The Biochemical journal. 477, 10, p. 1847-1863 17 p.

Research output: Contribution to journalArticle

Open Access
2019

GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor

Jewell, J. L., Fu, V., Hong, A. W., Yu, F. X., Meng, D., Melick, C. H., Wang, H., Lam, W. L. M., Yuan, H. X., Taylor, S. S. & Guan, K. L., May 21 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2015

Differential regulation of mTORC1 by leucine and glutamine

Jewell, J. L., Kim, Y. C., Russell, R. C., Yu, F. X., Park, H. W., Plouffe, S. W., Tagliabracci, V. S. & Guan, K. L., Jan 9 2015, In : Science. 347, 6218, p. 194-198 5 p.

Research output: Contribution to journalArticle

293 Scopus citations

NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition

Yuan, H. X., Wang, Z., Yu, F. X., Li, F., Russell, R. C., Jewell, J. L. & Guan, K. L., Nov 15 2015, In : Genes and Development. 29, 22, p. 2362-2376 15 p.

Research output: Contribution to journalArticle

20 Scopus citations
2014

Rag GTPases are cardioprotective by regulating lysosomal function

Kim, Y. C., Park, H. W., Sciarretta, S., Mo, J. S., Jewell, J. L., Russell, R. C., Wu, X., Sadoshima, J. & Guan, K. L., Jul 1 2014, In : Nature communications. 5, 4241.

Research output: Contribution to journalArticle

44 Scopus citations
2013

Amino acid signalling upstream of mTOR

Jewell, J. L., Russell, R. C. & Guan, K. L., Mar 1 2013, In : Nature Reviews Molecular Cell Biology. 14, 3, p. 133-139 7 p.

Research output: Contribution to journalArticle

460 Scopus citations

Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation

Yu, F. X., Zhang, Y., Park, H. W., Jewell, J. L., Chen, Q., Deng, Y., Pan, D., Taylor, S. S., Lai, Z. C. & Guan, K. L., Feb 1 2013, In : Genes and Development. 27, 11, p. 1223-1232 10 p.

Research output: Contribution to journalArticle

162 Scopus citations
2012

Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling

Yu, F. X., Zhao, B., Panupinthu, N., Jewell, J. L., Lian, I., Wang, L. H., Zhao, J., Yuan, H., Tumaneng, K., Li, H., Fu, X. D., Mills, G. B. & Guan, K. L., Aug 17 2012, In : Cell. 150, 4, p. 780-791 12 p.

Research output: Contribution to journalArticle

770 Scopus citations
2011

Munc18c phosphorylation by the insulin receptor links cell signaling directly to SNARE exocytosis

Jewell, J. L., Oh, E., Ramalingam, L., Kalwat, M. A., Tagliabracci, V. S., Tackett, L., Elmendorf, J. S. & Thurmond, D. C., Apr 4 2011, In : Journal of Cell Biology. 193, 1, p. 185-199 15 p.

Research output: Contribution to journalArticle

48 Scopus citations
2008

Filamentous actin regulates insulin exocytosis through direct interaction with Syntaxin 4

Jewell, J. L., Luo, W., Oh, E., Wang, Z. & Thurmond, D. C., Apr 18 2008, In : Journal of Biological Chemistry. 283, 16, p. 10716-10726 11 p.

Research output: Contribution to journalArticle

76 Scopus citations

The tyrosine phosphorylation of Munc18c induces a switch in binding specificity from syntaxin 4 to Doc2β

Jewell, J. L., Oh, E., Bennett, S. M., Meroueh, S. O. & Thurmond, D. C., Aug 1 2008, In : Journal of Biological Chemistry. 283, 31, p. 21734-21746 13 p.

Research output: Contribution to journalArticle

36 Scopus citations