• 2083 Citations
  • 12 h-Index
20082019

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Article
2019

GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor

Jewell, J. L., Fu, V., Hong, A. W., Yu, F. X., Meng, D., Melick, C. H., Wang, H., Lam, W. L. M., Yuan, H. X., Taylor, S. S. & Guan, K. L., May 21 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2015

Differential regulation of mTORC1 by leucine and glutamine

Jewell, J. L., Kim, Y. C., Russell, R. C., Yu, F. X., Park, H. W., Plouffe, S. W., Tagliabracci, V. S. & Guan, K. L., Jan 9 2015, In : Science. 347, 6218, p. 194-198 5 p.

Research output: Contribution to journalArticle

260 Scopus citations

NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition

Yuan, H. X., Wang, Z., Yu, F. X., Li, F., Russell, R. C., Jewell, J. L. & Guan, K. L., Nov 15 2015, In : Genes and Development. 29, 22, p. 2362-2376 15 p.

Research output: Contribution to journalArticle

17 Scopus citations
2014

Rag GTPases are cardioprotective by regulating lysosomal function

Kim, Y. C., Park, H. W., Sciarretta, S., Mo, J. S., Jewell, J. L., Russell, R. C., Wu, X., Sadoshima, J. & Guan, K. L., Jul 1 2014, In : Nature Communications. 5, 4241.

Research output: Contribution to journalArticle

43 Scopus citations
2013

Amino acid signalling upstream of mTOR

Jewell, J. L., Russell, R. C. & Guan, K. L., Mar 1 2013, In : Nature Reviews Molecular Cell Biology. 14, 3, p. 133-139 7 p.

Research output: Contribution to journalArticle

436 Scopus citations

Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation

Yu, F. X., Zhang, Y., Park, H. W., Jewell, J. L., Chen, Q., Deng, Y., Pan, D., Taylor, S. S., Lai, Z. C. & Guan, K. L., Feb 1 2013, In : Genes and Development. 27, 11, p. 1223-1232 10 p.

Research output: Contribution to journalArticle

146 Scopus citations
2012

Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling

Yu, F. X., Zhao, B., Panupinthu, N., Jewell, J. L., Lian, I., Wang, L. H., Zhao, J., Yuan, H., Tumaneng, K., Li, H., Fu, X. D., Mills, G. B. & Guan, K. L., Aug 17 2012, In : Cell. 150, 4, p. 780-791 12 p.

Research output: Contribution to journalArticle

717 Scopus citations
2011

Munc18c phosphorylation by the insulin receptor links cell signaling directly to SNARE exocytosis

Jewell, J. L., Oh, E., Ramalingam, L., Kalwat, M. A., Tagliabracci, V. S., Tackett, L., Elmendorf, J. S. & Thurmond, D. C., Apr 4 2011, In : Journal of Cell Biology. 193, 1, p. 185-199 15 p.

Research output: Contribution to journalArticle

46 Scopus citations
2008

Filamentous actin regulates insulin exocytosis through direct interaction with Syntaxin 4

Jewell, J. L., Luo, W., Oh, E., Wang, Z. & Thurmond, D. C., Apr 18 2008, In : Journal of Biological Chemistry. 283, 16, p. 10716-10726 11 p.

Research output: Contribution to journalArticle

75 Scopus citations

The tyrosine phosphorylation of Munc18c induces a switch in binding specificity from syntaxin 4 to Doc2β

Jewell, J. L., Oh, E., Bennett, S. M., Meroueh, S. O. & Thurmond, D. C., Aug 1 2008, In : Journal of Biological Chemistry. 283, 31, p. 21734-21746 13 p.

Research output: Contribution to journalArticle

35 Scopus citations