• 11409 Citations
  • 57 h-Index
1977 …2020

Research output per year

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Research Output

2010

Spontaneous autoimmune dacryoadenitis in aged CD25KO mice

Rahimy, E., Pitcher, J. D., Pangelinan, S. B., Chen, W., Farley, W. J., Niederkorn, J. Y., Stern, M. E., Li, D. Q., Pflugfelder, S. C. & De Paiva, C. S., Aug 2010, In : American Journal of Pathology. 177, 2, p. 744-753 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Transgenic mice expressing variants of complement factor H develop AMD-like retinal findings

Ufret-Vincenty, R. L., Aredo, B., Liu, X., McMahon, A., Chen, P. W., Sun, H., Niederkorn, J. Y. & Kedzierski, W., Nov 1 2010, In : Investigative Ophthalmology and Visual Science. 51, 11, p. 5878-5887 10 p.

Research output: Contribution to journalArticle

70 Scopus citations

Two different regulatory T cell populations that promote corneal allograft survival

Cunnusamy, K., Paunicka, K., Reyes, N., Yang, W., Chen, P. W. & Niederkorn, J. Y., Dec 1 2010, In : Investigative Ophthalmology and Visual Science. 51, 12, p. 6566-6574 9 p.

Research output: Contribution to journalArticle

31 Scopus citations
2009

Allergic airway hyperreactivity increases the risk for corneal allograft rejection

Niederkorn, J. Y., Chen, P. W., Mellon, J., Stevens, C. & Mayhew, E., May 1 2009, In : American Journal of Transplantation. 9, 5, p. 1017-1026 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

IL-17 disrupts corneal barrier following desiccating stress

De Paiva, C. S., Chotikavanich, S., Pangelinan, S. B., Pitcher, J. D., Fang, B., Zheng, X., Ma, P., Farley, W. J., Siemasko, K. F., Niederkorn, J. Y., Stern, M. E., Li, D. Q. & Pflugfelder, S. C., May 7 2009, In : Mucosal Immunology. 2, 3, p. 243-253 11 p.

Research output: Contribution to journalArticle

237 Scopus citations

Immune escape mechanisms of intraocular tumors

Niederkorn, J. Y., Sep 1 2009, In : Progress in Retinal and Eye Research. 28, 5, p. 329-347 19 p.

Research output: Contribution to journalReview article

47 Scopus citations

Immunoregulation on the ocular surface: 2nd cullen symposium

Pflugfelder, S. C., Stern, M. E., Beutler, B. A., Burns, A. R., Calonge, M., Chodosh, J., Dana, M. R., De Paiva, C. S., Fleiszig, S., Hazlett, L. D., Huang, A. J., Jones, D. B., Liu, Y. J., McDermott, A. M., Mircheff, A. K., Niederkorn, J. Y., Perez, V., Perlman, E., Rosenbaum, J., Theofilopoulus, A. & 1 others, Wilhelmu, K., Jan 1 2009, In : Ocular Surface. 7, 2, p. 67-77 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

Inhibition of chemokine receptor expression on uveal melanomas by CXCR4 siRNA and its effect on uveal melanoma liver metastases

Li, H., Yang, W., Chen, P. W., Alizadeh, H. & Niederkorn, J. Y., Dec 1 2009, In : Investigative Ophthalmology and Visual Science. 50, 12, p. 5522-5528 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

PD-L1 expression on human ocular cells and its possible role in regulating immune-mediated ocular inflammation

Yang, W., Li, H., Chen, P. W., Alizadeh, H., He, Y., Hogan, R. N. & Niederkorn, J. Y., Jan 1 2009, In : Investigative Ophthalmology and Visual Science. 50, 1, p. 273-280 8 p.

Research output: Contribution to journalArticle

44 Scopus citations

Role of NKT cells in anterior chamber-associated immune deviation

Niederkorn, J. Y., Dec 1 2009, In : Expert review of clinical immunology. 5, 2, p. 137-144 8 p.

Research output: Contribution to journalReview article

11 Scopus citations
2008

CD4+ T-cell-dependent tumour rejection in an immune-privileged environment requires macrophages

Dace, D. S., Chen, P. W. & Niederkorn, J. Y., Mar 1 2008, In : Immunology. 123, 3, p. 367-377 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Differential expression of chemokine receptors on uveal melanoma cells and their metastases

Li, H., Alizadeh, H. & Niederkorn, J. Y., Feb 1 2008, In : Investigative Ophthalmology and Visual Science. 49, 2, p. 636-643 8 p.

Research output: Contribution to journalArticle

34 Scopus citations

Emerging concepts in CD8+ T regulatory cells

Niederkorn, J. Y., Jun 1 2008, In : Current Opinion in Immunology. 20, 3, p. 327-331 5 p.

Research output: Contribution to journalReview article

60 Scopus citations
31 Scopus citations

Immune System and the Eye

Niederkorn, J. Y. & Dana, M. R., Dec 1 2008, Ocular Therapeutics. Elsevier Ltd, p. 199-237 39 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Innate and adaptive immune responses to ocular Acanthamoeba infections

Niederkorn, J. Y., Dec 1 2008, In : Expert Review of Ophthalmology. 3, 6, p. 665-672 8 p.

Research output: Contribution to journalReview article

1 Scopus citations

In vitro expanded CD4+CD25+Foxp3+ regulatory T cells maintain a normal phenotype and suppress immune-mediated ocular surface inflammation

Siemasko, K. F., Gao, J., Calder, V. L., Hanna, R., Calonge, M., Pflugfelder, S. C., Niederkorn, J. Y. & Stern, M. E., Dec 1 2008, In : Investigative Ophthalmology and Visual Science. 49, 12, p. 5434-5440 7 p.

Research output: Contribution to journalArticle

45 Scopus citations

Modulation of corneal and stromal matrix metalloproteinase by the mannose-induced Acanthamoeba cytolytic protein

Alizadeh, H., Li, H., Neelam, S. & Niederkorn, J. Y., Sep 1 2008, In : Experimental Eye Research. 87, 3, p. 286-291 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

PD-L1: PD-1 interaction contributes to the functional suppression of T-cell responses to human uveal melanoma cells in vitro

Yang, W., Chen, P. W., Li, H., Alizadeh, H. & Niederkorn, J. Y., Jun 1 2008, In : Investigative Ophthalmology and Visual Science. 49, 6, p. 2518-2525 8 p.

Research output: Contribution to journalArticle

81 Scopus citations
2007

CD8+ T cells circumvent immune privilege in the eye and mediate intraocular tumor rejection by a TNF-α-dependent mechanism

Dace, D. S., Chen, P. W. & Niederkorn, J. Y., May 15 2007, In : Journal of Immunology. 178, 10, p. 6115-6122 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by interferon-γ

De Paiva, C. S., Villarreal, A. L., Corrales, R. M., Rahman, H. T., Chang, V. Y., Farley, W. J., Stern, M. E., Niederkorn, J. Y., Li, D. Q. & Pflugfelder, S. C., Jun 1 2007, In : Investigative Ophthalmology and Visual Science. 48, 6, p. 2553-2560 8 p.

Research output: Contribution to journalArticle

187 Scopus citations
18 Scopus citations
23 Scopus citations

Immune mechanisms of corneal allograft rejection

Niederkorn, J. Y., Dec 1 2007, In : Current Eye Research. 32, 12, p. 1005-1016 12 p.

Research output: Contribution to journalShort survey

91 Scopus citations

Immunogenicity and immune privilege of corneal allografts

Hori, J. & Niederkorn, J. Y., Jul 30 2007, Immune Response and the Eye. Niederkorn, J. & Kaplan, H. (eds.). p. 290-299 10 p. (Chemical Immunology and Allergy; vol. 92).

Research output: Chapter in Book/Report/Conference proceedingChapter

29 Scopus citations

Induction of anterior chamber-associated immune deviation requires an intact, functional spleen

Streilein, J. W. & Niederkorn, J. Y., May 1 2007, In : Ocular Immunology and Inflammation. 15, 3, p. 187-194 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Ocular immune privilege is circumvented by CD4+ T cells, leading to the rejection of intraocular tumors in an IFN-γ-dependent manner

Dace, D. S., Chen, P. W., Alizadeh, H. & Niederkorn, J. Y., Feb 1 2007, In : Journal of Leukocyte Biology. 81, 2, p. 421-429 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Rationale for immune response and the eye

Niederkorn, J. Y. & Kaplan, H. J., 2007, In : Chemical Immunology and Allergy. 92, p. 1-3 3 p.

Research output: Contribution to journalArticle

5 Scopus citations

Regional immunity and immune privilege

Kaplan, H. J. & Niederkorn, J. Y., Jul 30 2007, Immune Response and the Eye. Niederkorn, J. & Kaplan, H. (eds.). p. 11-26 16 p. (Chemical Immunology and Allergy; vol. 92).

Research output: Chapter in Book/Report/Conference proceedingChapter

23 Scopus citations

Regulatory T cells and the eye

Niederkorn, J. Y., Jul 30 2007, Immune Response and the Eye. Niederkorn, J. & Kaplan, H. (eds.). p. 131-139 9 p. (Chemical Immunology and Allergy; vol. 92).

Research output: Chapter in Book/Report/Conference proceedingChapter

20 Scopus citations

Role of activated macrophages in Acanthamoeba keratitis

Alizadeh, H., Neelam, S. & Niederkorn, J. Y., Oct 1 2007, In : Journal of Parasitology. 93, 5, p. 1114-1120 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

The induction of anterior chamber-associated immune deviation

Niederkorn, J. Y., Jul 30 2007, Immune Response and the Eye. Niederkorn, J. & Kaplan, H. (eds.). p. 27-35 9 p. (Chemical Immunology and Allergy; vol. 92).

Research output: Chapter in Book/Report/Conference proceedingChapter

51 Scopus citations

Therapeutic manipulation of ocular antigen-presenting cells in corneal transplantation

Niederkorn, J. Y., Jan 1 2007, Antigen-Presenting Cells and the Eye. CRC Press, p. 157-164 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Uveal melanoma expression of indoleamine 2,3-deoxygenase: Establishment of an immune privileged environment by tryptophan depletion

Chen, P. W., Mellon, J. K., Mayhew, E., Wang, S., He, Y. G., Hogan, N. & Niederkorn, J. Y., Nov 1 2007, In : Experimental Eye Research. 85, 5, p. 617-625 9 p.

Research output: Contribution to journalArticle

41 Scopus citations
2006

Anterior chamber-associated immune deviation and its impact on corneal allograft survival

Niederkorn, J. Y., Aug 1 2006, In : Current Opinion in Organ Transplantation. 11, 4, p. 360-365 6 p.

Research output: Contribution to journalReview article

25 Scopus citations

CD4+ T-cell-independent rejection of corneal allografts

Niederkorn, J. Y., Stevens, C., Mellon, J. & Mayhew, E., Apr 1 2006, In : Transplantation. 81, 8, p. 1171-1178 8 p.

Research output: Contribution to journalArticle

34 Scopus citations

Desiccating stress induces T cell-mediated Sjögren's syndrome-like lacrimal keratoconjunctivitis

Niederkorn, J. Y., Stern, M. E., Plugfelder, S. C., De Paiva, C. S., Corrales, R. M., Gao, J. & Siemasko, K., Apr 1 2006, In : Journal of Immunology. 176, 7, p. 3950-3957 8 p.

Research output: Contribution to journalArticle

Open Access
232 Scopus citations

Differential roles of CD8+ and CD8- T lymphocytes in corneal allograft rejection in 'high-risk' hosts

Niederkorn, J. Y., Stevens, C., Mellon, J. & Mayhew, E., Apr 1 2006, In : American Journal of Transplantation. 6, 4, p. 705-713 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Downregulation of survivin expression enhances sensitivity of cultured uveal melanoma cells to cisplatin treatment

Li, H., Niederkorn, J. Y., Neelam, S. & Alizadeh, H., Jul 1 2006, In : Experimental Eye Research. 83, 1, p. 176-182 7 p.

Research output: Contribution to journalArticle

18 Scopus citations
19 Scopus citations

Intracorneal instillation of latex beads induces macrophage-dependent protection against Acanthamoeba keratitis

Clarke, D. W., Alizadeh, H. & Niederkorn, J. Y., Nov 1 2006, In : Investigative Ophthalmology and Visual Science. 47, 11, p. 4917-4925 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Oral immunization with Acanthamoeba castellanii mannose-binding protein ameliorates amoebic keratitis

Garate, M., Alizadeh, H., Neelam, S., Niederkorn, J. Y. & Panjwani, N., Dec 1 2006, In : Infection and immunity. 74, 12, p. 7032-7034 3 p.

Research output: Contribution to journalArticle

20 Scopus citations

Peripheral tolerance via the anterior chamber of the eye: Role of B cells in MHC class I and II antigen presentation

Ashour, H. M. & Niederkorn, J. Y., May 15 2006, In : Journal of Immunology. 176, 10, p. 5950-5957 8 p.

Research output: Contribution to journalArticle

Open Access
43 Scopus citations

See no evil, hear no evil, do no evil: The lessons of immune privilege

Niederkorn, J. Y., Apr 1 2006, In : Nature immunology. 7, 4, p. 354-359 6 p.

Research output: Contribution to journalReview article

312 Scopus citations

The immunobiology of Acanthamoeba keratitis

Clarke, D. W. & Niederkorn, J. Y., Apr 1 2006, In : Microbes and Infection. 8, 5, p. 1400-1405 6 p.

Research output: Contribution to journalShort survey

36 Scopus citations

The pathophysiology of Acanthamoeba keratitis

Clarke, D. W. & Niederkorn, J. Y., Apr 1 2006, In : Trends in Parasitology. 22, 4, p. 175-180 6 p.

Research output: Contribution to journalReview article

162 Scopus citations

γδ T cells promote anterior chamber-associated immune deviation and immune privilege through their production of IL-10

Ashour, H. M. & Niederkorn, J. Y., Dec 15 2006, In : Journal of Immunology. 177, 12, p. 8331-8337 7 p.

Research output: Contribution to journalArticle

Open Access
47 Scopus citations
2005

A renewed appreciation for ocular immune privilege.

Niederkorn, J. Y., Aug 2005, In : Archivos de la Sociedad Española de Oftalmología. 80, 8, p. 437-438; 439-440

Research output: Contribution to journalEditorial

Open Access
3 Scopus citations

CD4+ T-cell-mediated mechanisms of corneal allograft rejection: Role of Fas-induced apoptosis

Hegde, S., Beauregard, C., Mayhew, E. & Niederkorn, J. Y., Jan 15 2005, In : Transplantation. 79, 1, p. 23-31 9 p.

Research output: Contribution to journalArticle

72 Scopus citations

Corneal immune privilege

Niederkorn, J. Y., Oct 1 2005, In : Ocular Surface. 3, 4, p. S158-S160

Research output: Contribution to journalArticle

3 Scopus citations