• 11409 Citations
  • 57 h-Index
1977 …2020

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Article
2020
Open Access
2019

Defective FasL expression is associated with increased resistance to melanoma liver metastases and enhanced natural killer cell activity

Neelam, S., Mellon, J., Wilkerson, A. & Niederkorn, J. Y., Aug 1 2019, In : Melanoma research. 29, 4, p. 401-412 12 p.

Research output: Contribution to journalArticle

The eye sees eye to eye with the immune system: The 2019 Proctor lecture

Niederkorn, J. Y., Oct 1 2019, In : Investigative Ophthalmology and Visual Science. 60, 13, p. 4489-4495 7 p.

Research output: Contribution to journalArticle

Open Access
2018

Induction of contrasuppressor cells and loss of immune privilege produced by corneal nerve ablation

Neelam, S., Mellon, J., Wilkerson, A. & Niederkorn, J. Y., Sep 1 2018, In : Investigative Ophthalmology and Visual Science. 59, 11, 1 p.

Research output: Contribution to journalArticle

6 Scopus citations
2017

Effect of corneal nerve ablation on immune tolerance induced by corneal allografts, oral immunization, or anterior chamber injection of antigens

Mo, J., Neelam, S., Mellon, J., Brown, J. R. & Niederkorn, J. Y., Jan 1 2017, In : Investigative Ophthalmology and Visual Science. 58, 1, p. 137-148 12 p.

Research output: Contribution to journalArticle

9 Scopus citations
2016

Growth and metastasis of intraocular tumors in aged mice

Han, Z., Brown, J. R. & Niederkorn, J. Y., May 2016, In : Investigative Ophthalmology and Visual Science. 57, 6, p. 2366-2376 11 p.

Research output: Contribution to journalArticle

4 Scopus citations
2 Scopus citations

Role of interferon-γ and cytotoxic T lymphocytes in intraocular tumor rejection

Ligocki, A. J., Brown, J. R. & Niederkorn, J. Y., May 1 2016, In : Journal of Leukocyte Biology. 99, 5, p. 735-747 13 p.

Research output: Contribution to journalArticle

3 Scopus citations
2015

Advances on non-CD4 + Foxp3+ T regulatory cells: CD8+, type 1, and double negative T regulatory cells in organ transplantation

Ligocki, A. J. & Niederkorn, J. Y., Aug 1 2015, In : Transplantation. 99, 8, p. 1553-1559 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

NKT cells act through third party bone marrow-derived cells to suppress NK cell activity in the liver and exacerbate hepatic melanoma metastases

Sadegh, L., Chen, P. W., Brown, J. R., Han, Z. & Niederkorn, J. Y., Sep 1 2015, In : International Journal of Cancer. 137, 5, p. 1085-1094 10 p.

Research output: Contribution to journalArticle

14 Scopus citations
36 Scopus citations
2014

CD8+ cells regulate the T helper-17 response in an experimental murine model of sjögren syndrome

Zhang, X., Schaumburg, C. S., Coursey, T. G., Siemasko, K. F., Volpe, E. A., Gandhi, N. B., Li, D. Q., Niederkorn, J. Y., Stern, M. E., Pflugfelder, S. C. & De Paiva, C. S., Mar 2014, In : Mucosal Immunology. 7, 2, p. 417-427 11 p.

Research output: Contribution to journalArticle

23 Scopus citations
2013

Allergic conjunctivitis renders CD4+ T cells resistant to T regulatory cells and exacerbates corneal allograft rejection

Reyes, N. J., Chen, P. W. & Niederkorn, J. Y., May 1 2013, In : American Journal of Transplantation. 13, 5, p. 1181-1192 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Development, alteration and real time dynamics of conjunctiva-associated lymphoid tissue

Siebelmann, S., Gehlsen, U., Hüttmann, G., Koop, N., Bölke, T., Gebert, A., Stern, M. E., Niederkorn, J. Y. & Steven, P., Dec 20 2013, In : PloS one. 8, 12, e82355.

Research output: Contribution to journalArticle

22 Scopus citations

Epigenetic regulation of CXCR4 expression by the ocular microenvironment

Li, H., Niederkorn, J. Y., Sadegh, L., Mellon, J. & Chen, P. W., Jan 1 2013, In : Investigative Ophthalmology and Visual Science. 54, 1, p. 234-243 10 p.

Research output: Contribution to journalArticle

9 Scopus citations
11 Scopus citations
2012

Autoantibodies contribute to the immunopathogenesis of experimental dry eye disease.

Stern, M. E., Schaumburg, C. S., Siemasko, K. F., Gao, J., Wheeler, L. A., Grupe, D. A., De Paiva, C. S., Calder, V. L., Calonge, M., Niederkorn, J. Y. & Pflugfelder, S. C., Apr 2012, In : Investigative ophthalmology & visual science. 53, 4, p. 2062-2075 14 p.

Research output: Contribution to journalArticle

Open Access
35 Scopus citations

Ifn-γ-independent intraocular tumor rejection is mediated by a macrophage-ependent process that leaves the eye intact

Coursey, T. G., Chen, P. W. & Niederkorn, J. Y., Nov 1 2012, In : Journal of Leukocyte Biology. 92, 5, p. 939-950 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

NK cells promote Th-17 mediated corneal barrier disruption in dry eye

Zhang, X., Volpe, E. A., Gandhi, N. B., Schaumburg, C. S., Siemasko, K. F., Pangelinan, S. B., Kelly, S. D., Hayday, A. C., Li, D. Q., Stern, M. E., Niederkorn, J. Y., Pflugfelder, S. C. & de Paiva, C. S., May 8 2012, In : PloS one. 7, 5, e36822.

Research output: Contribution to journalArticle

47 Scopus citations

Role of IFN-γ in the establishment of anterior chamber-associated immune deviation (ACAID)-induced CD8 + T regulatory cells

Paunicka, K., Chen, P. W. & Niederkorn, J. Y., Mar 1 2012, In : Journal of Leukocyte Biology. 91, 3, p. 475-483 9 p.

Research output: Contribution to journalArticle

13 Scopus citations
2011

Abrogating TNF-α expression prevents bystander destruction of normal tissues during iNOS-mediated elimination of intraocular tumors

Coursey, T. G., Chen, P. W. & Niederkorn, J. Y., Apr 1 2011, In : Cancer Research. 71, 7, p. 2445-2454 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Desiccating stress induces CD4 + T-cell-mediated Sjögren's syndrome-like corneal epithelial apoptosis via activation of the extrinsic apoptotic pathway by interferon-γ

Zhang, X., Chen, W., De Paiva, C. S., Volpe, E. A., Gandhi, N. B., Farley, W. J., Li, D. Q., Niederkorn, J. Y., Stern, M. E. & Pflugfelder, S. C., Oct 1 2011, In : American Journal of Pathology. 179, 4, p. 1807-1814 8 p.

Research output: Contribution to journalArticle

45 Scopus citations

Disruption of TGF-β signaling improves ocular surface epithelial disease in experimental autoimmune keratoconjunctivitis sicca

de Paiva, C. S., Volpe, E. A., Gandhi, N. B., Zhang, X., Zheng, X., Pitcher, J. D., Farley, W. J., Stern, M. E., Niederkorn, J. Y., Li, D. Q., Flavell, R. A. & Pflugfelder, S. C., Dec 14 2011, In : PloS one. 6, 12, e29017.

Research output: Contribution to journalArticle

37 Scopus citations

IL-17A-dependent CD4+CD25+ regulatory T cells promote immune privilege of corneal allografts

Cunnusamy, K., Chen, P. W. & Niederkorn, J. Y., Jun 15 2011, In : Journal of Immunology. 186, 12, p. 6737-6745 9 p.

Research output: Contribution to journalArticle

40 Scopus citations

IL-17-dependent, IFN-γ-independent tumor rejection is mediated by cytotoxic T lymphocytes and occurs at extraocular sites, but is excluded from the eye

Coursey, T. G., Chen, P. W. & Niederkorn, J. Y., Oct 15 2011, In : Journal of Immunology. 187, 8, p. 4219-4228 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

NKT cell exacerbation of liver metastases arising from melanomas transplanted into either the eyes or spleens of mice

Yang, W., Li, H., Mayhew, E., Mellon, J., Chen, P. W. & Niederkorn, J. Y., May 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 6, p. 3094-3102 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Ocular surface APCs are necessary for autoreactive T cell-mediated experimental autoimmune lacrimal keratoconjunctivitis

Schaumburg, C. S., Siemasko, K. F., De Paiva, C. S., Wheeler, L. A., Niederkorn, J. Y., Pflugfelder, S. C. & Stern, M. E., Oct 1 2011, In : Journal of Immunology. 187, 7, p. 3653-3662 10 p.

Research output: Contribution to journalArticle

73 Scopus citations

γδ T cells are required for maximal expression of allergic conjunctivitis

Reyes, N. J., Mayhew, E., Chen, P. W. & Niederkorn, J. Y., Apr 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 5, p. 2211-2216 6 p.

Research output: Contribution to journalArticle

10 Scopus citations
2010

Age-related T-cell cytokine profile parallels corneal disease severity in Sjögren's syndrome-like keratoconjunctivitis sicca in CD25KO mice

de Paiva, C. S., Hwang, C. S., Pitcher, J. D., Pangelinan, S. B., Rahimy, E., Chen, W., Yoon, K. C., Farley, W. J., Niederkorn, J. Y., Stern, M. E., Li, D. Q. & Pflugfelder, S. C., Feb 2010, In : Rheumatology. 49, 2, p. 246-258 13 p., kep357.

Research output: Contribution to journalArticle

60 Scopus citations

Allergic conjunctivitis exacerbates corneal allograft rejection by activating Th1 and Th2 alloimmune responses

Niederkorn, J. Y., Chen, P. W., Mellon, J., Stevens, C. & Mayhew, E., Jun 1 2010, In : Journal of Immunology. 184, 11, p. 6076-6083 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

History and physiology of immune privilege

Niederkorn, J. Y. & Stein-Streilein, J., Jan 1 2010, In : Ocular Immunology and Inflammation. 18, 1, p. 19-23 5 p.

Research output: Contribution to journalArticle

38 Scopus citations

IL-17 promotes immune privilege of corneal allografts

Cunnusamy, K., Chen, P. W. & Niederkorn, J. Y., Oct 15 2010, In : Journal of Immunology. 185, 8, p. 4651-4658 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

NKT cells are necessary for maximal expression of allergic conjunctivitis

Reyes, N. J., Mayhew, E., Chen, P. W. & Niederkorn, J. Y., May 26 2010, In : International Immunology. 22, 8, p. 627-636 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Paradigm shifts in the role of CD4+ T cells in keratoplasty.

Cunnusamy, K., Chen, P. W. & Niederkorn, J. Y., Nov 2010, In : Discovery Medicine. 10, 54, p. 452-461 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Spontaneous autoimmune dacryoadenitis in aged CD25KO mice

Rahimy, E., Pitcher, J. D., Pangelinan, S. B., Chen, W., Farley, W. J., Niederkorn, J. Y., Stern, M. E., Li, D. Q., Pflugfelder, S. C. & De Paiva, C. S., Aug 2010, In : American Journal of Pathology. 177, 2, p. 744-753 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Transgenic mice expressing variants of complement factor H develop AMD-like retinal findings

Ufret-Vincenty, R. L., Aredo, B., Liu, X., McMahon, A., Chen, P. W., Sun, H., Niederkorn, J. Y. & Kedzierski, W., Nov 1 2010, In : Investigative Ophthalmology and Visual Science. 51, 11, p. 5878-5887 10 p.

Research output: Contribution to journalArticle

70 Scopus citations

Two different regulatory T cell populations that promote corneal allograft survival

Cunnusamy, K., Paunicka, K., Reyes, N., Yang, W., Chen, P. W. & Niederkorn, J. Y., Dec 1 2010, In : Investigative Ophthalmology and Visual Science. 51, 12, p. 6566-6574 9 p.

Research output: Contribution to journalArticle

31 Scopus citations
2009

Allergic airway hyperreactivity increases the risk for corneal allograft rejection

Niederkorn, J. Y., Chen, P. W., Mellon, J., Stevens, C. & Mayhew, E., May 1 2009, In : American Journal of Transplantation. 9, 5, p. 1017-1026 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

IL-17 disrupts corneal barrier following desiccating stress

De Paiva, C. S., Chotikavanich, S., Pangelinan, S. B., Pitcher, J. D., Fang, B., Zheng, X., Ma, P., Farley, W. J., Siemasko, K. F., Niederkorn, J. Y., Stern, M. E., Li, D. Q. & Pflugfelder, S. C., May 7 2009, In : Mucosal Immunology. 2, 3, p. 243-253 11 p.

Research output: Contribution to journalArticle

237 Scopus citations

Immunoregulation on the ocular surface: 2nd cullen symposium

Pflugfelder, S. C., Stern, M. E., Beutler, B. A., Burns, A. R., Calonge, M., Chodosh, J., Dana, M. R., De Paiva, C. S., Fleiszig, S., Hazlett, L. D., Huang, A. J., Jones, D. B., Liu, Y. J., McDermott, A. M., Mircheff, A. K., Niederkorn, J. Y., Perez, V., Perlman, E., Rosenbaum, J., Theofilopoulus, A. & 1 others, Wilhelmu, K., Jan 1 2009, In : Ocular Surface. 7, 2, p. 67-77 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

Inhibition of chemokine receptor expression on uveal melanomas by CXCR4 siRNA and its effect on uveal melanoma liver metastases

Li, H., Yang, W., Chen, P. W., Alizadeh, H. & Niederkorn, J. Y., Dec 1 2009, In : Investigative Ophthalmology and Visual Science. 50, 12, p. 5522-5528 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

PD-L1 expression on human ocular cells and its possible role in regulating immune-mediated ocular inflammation

Yang, W., Li, H., Chen, P. W., Alizadeh, H., He, Y., Hogan, R. N. & Niederkorn, J. Y., Jan 1 2009, In : Investigative Ophthalmology and Visual Science. 50, 1, p. 273-280 8 p.

Research output: Contribution to journalArticle

44 Scopus citations
2008

CD4+ T-cell-dependent tumour rejection in an immune-privileged environment requires macrophages

Dace, D. S., Chen, P. W. & Niederkorn, J. Y., Mar 1 2008, In : Immunology. 123, 3, p. 367-377 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Differential expression of chemokine receptors on uveal melanoma cells and their metastases

Li, H., Alizadeh, H. & Niederkorn, J. Y., Feb 1 2008, In : Investigative Ophthalmology and Visual Science. 49, 2, p. 636-643 8 p.

Research output: Contribution to journalArticle

34 Scopus citations

In vitro expanded CD4+CD25+Foxp3+ regulatory T cells maintain a normal phenotype and suppress immune-mediated ocular surface inflammation

Siemasko, K. F., Gao, J., Calder, V. L., Hanna, R., Calonge, M., Pflugfelder, S. C., Niederkorn, J. Y. & Stern, M. E., Dec 1 2008, In : Investigative Ophthalmology and Visual Science. 49, 12, p. 5434-5440 7 p.

Research output: Contribution to journalArticle

45 Scopus citations

Modulation of corneal and stromal matrix metalloproteinase by the mannose-induced Acanthamoeba cytolytic protein

Alizadeh, H., Li, H., Neelam, S. & Niederkorn, J. Y., Sep 1 2008, In : Experimental Eye Research. 87, 3, p. 286-291 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

PD-L1: PD-1 interaction contributes to the functional suppression of T-cell responses to human uveal melanoma cells in vitro

Yang, W., Chen, P. W., Li, H., Alizadeh, H. & Niederkorn, J. Y., Jun 1 2008, In : Investigative Ophthalmology and Visual Science. 49, 6, p. 2518-2525 8 p.

Research output: Contribution to journalArticle

81 Scopus citations
2007

CD8+ T cells circumvent immune privilege in the eye and mediate intraocular tumor rejection by a TNF-α-dependent mechanism

Dace, D. S., Chen, P. W. & Niederkorn, J. Y., May 15 2007, In : Journal of Immunology. 178, 10, p. 6115-6122 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by interferon-γ

De Paiva, C. S., Villarreal, A. L., Corrales, R. M., Rahman, H. T., Chang, V. Y., Farley, W. J., Stern, M. E., Niederkorn, J. Y., Li, D. Q. & Pflugfelder, S. C., Jun 1 2007, In : Investigative Ophthalmology and Visual Science. 48, 6, p. 2553-2560 8 p.

Research output: Contribution to journalArticle

187 Scopus citations
18 Scopus citations