Research Output per year
Research Output
2020
Interrogation of enhancer function by enhancer-targeting CRISPR epigenetic editing
Li, K., Liu, Y., Cao, H., Zhang, Y., Gu, Z., Liu, X., Yu, A., Kaphle, P., Dickerson, K. E., Ni, M. & Xu, J., Dec 1 2020, In : Nature communications. 11, 1, 485.Research output: Contribution to journal › Article
Open Access
Multiplexed capture of spatial configuration and temporal dynamics of locus-specific 3D chromatin by biotinylated dCas9
Liu, X., Chen, Y., Zhang, Y., Liu, Y., Liu, N., Botten, G. A., Cao, H., Orkin, S. H., Zhang, M. Q. & Xu, J., Mar 5 2020, In : Genome biology. 21, 1, 59.Research output: Contribution to journal › Article
Open Access
Noncoding Variants Connect Enhancer Dysregulation with Nuclear Receptor Signaling in Hematopoietic Malignancies
Li, K., Zhang, Y., Liu, X., Liu, Y., Gu, Z., Cao, H., Dickerson, K., Chen, M., Chen, W., Shao, Z., Ni, M. & Xu, J., May 1 2020, In : Cancer discovery. 10, 5, p. 724-745 22 p.Research output: Contribution to journal › Article
2019
Author Correction: CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells (Nature, (2017), 546, 7656, (168-172), 10.1038/nature22359)
Kim, J., Hu, Z., Cai, L., Li, K., Choi, E., Faubert, B., Bezwada, D., Rodriguez-Canales, J., Villalobos, P., Lin, Y. F., Ni, M., Huffman, K. E., Girard, L., Byers, L. A., Unsal-Kacmaz, K., Peña, C. G., Heymach, J. V., Wauters, E., Vansteenkiste, J., Castrillon, D. H. & 6 others, , May 16 2019, In : Nature. 569, 7756, p. E4Research output: Contribution to journal › Comment/debate
Open Access
Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation
Gu, Z., Liu, Y., Cai, F., Patrick, M., Zmajkovic, J., Cao, H., Zhang, Y., Tasdogan, A., Chen, M., Qi, L., Liu, X., Li, K., Lyu, J., Dickerson, K. E., Chen, W., Ni, M., Merritt, M. E., Morrison, S. J., Skoda, R. C., DeBerardinis, R. J. & 1 others, , Sep 1 2019, In : Cancer discovery. 9, 9, p. 1228-1247 20 p.Research output: Contribution to journal › Article
14
Scopus
citations
MAP: model-based analysis of proteomic data to detect proteins with significant abundance changes
Li, M., Tu, S., Li, Z., Tan, F., Liu, J., Wang, Q., Zhang, Y., Xu, J., Zhang, Y., Zhou, F. & Shao, Z., Dec 1 2019, In : Cell Discovery. 5, 1, 40.Research output: Contribution to journal › Article
Open Access
2018
CAPTURE: In Situ Analysis of Chromatin Composition of Endogenous Genomic Loci by Biotinylated dCas9
Liu, X., Zhang, Y., Chen, Y., Li, M., Shao, Z., Zhang, M. Q. & Xu, J., Jul 2018, In : Current Protocols in Molecular Biology. 123, 1, e64.Research output: Contribution to journal › Article
3
Scopus
citations
Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch
Liu, N., Hargreaves, V. V., Zhu, Q., Kurland, J. V., Hong, J., Kim, W., Sher, F., Macias-Trevino, C., Rogers, J. M., Kurita, R., Nakamura, Y., Yuan, G. C., Bauer, D. E., Xu, J., Bulyk, M. L. & Orkin, S. H., Apr 5 2018, In : Cell. 173, 2, p. 430-442.e17Research output: Contribution to journal › Article
56
Scopus
citations
Dissecting super-enhancer hierarchy based on chromatin interactions
Huang, J., Li, K., Cai, W., Liu, X., Zhang, Y., Orkin, S. H., Xu, J. & Yuan, G. C., Dec 1 2018, In : Nature Communications. 9, 1, 943.Research output: Contribution to journal › Article
38
Scopus
citations
GATA/Heme Multi-omics Reveals a Trace Metal-Dependent Cellular Differentiation Mechanism
Tanimura, N., Liao, R., Wilson, G. M., Dent, M. R., Cao, M., Burstyn, J. N., Hematti, P., Liu, X., Zhang, Y., Zheng, Y., Keles, S., Xu, J., Coon, J. J. & Bresnick, E. H., Sep 10 2018, In : Developmental cell. 46, 5, p. 581-594.e4Research output: Contribution to journal › Article
2
Scopus
citations
Quantitative integration of epigenomic variation and transcription factor binding using MAmotif toolkit identifies an important role of IRF2 as transcription activator at gene promoters
Sun, H., Wang, J., Gong, Z., Yao, J., Wang, Y., Xu, J., Yuan, G. C., Zhang, Y. & Shao, Z., Dec 1 2018, In : Cell Discovery. 4, 1, 38.Research output: Contribution to journal › Letter
4
Scopus
citations
Regulation of embryonic haematopoietic multipotency by EZH1
Vo, L. T., Kinney, M. A., Liu, X., Zhang, Y., Barragan, J., Sousa, P. M., Jha, D. K., Han, A., Cesana, M., Shao, Z., North, T. E., Orkin, S. H., Doulatov, S., Xu, J. & Daley, G. Q., Jan 25 2018, In : Nature. 553, 7689, p. 506-510 5 p.Research output: Contribution to journal › Article
22
Scopus
citations
2017
CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells
Kim, J., Hu, Z., Cai, L., Li, K., Choi, E., Faubert, B., Bezwada, D., Rodriguez-Canales, J., Villalobos, P., Lin, Y. F., Ni, M., Huffman, K. E., Girard, L., Byers, L. A., Unsal-Kacmaz, K., Peña, C. G., Heymach, J. V., Wauters, E., Vansteenkiste, J., Castrillon, D. H. & 6 others, , Jun 1 2017, In : Nature. 546, 7656, p. 168-172 5 p.Research output: Contribution to journal › Article
63
Scopus
citations
In Situ Capture of Chromatin Interactions by Biotinylated dCas9
Liu, X., Zhang, Y., Chen, Y., Li, M., Zhou, F., Li, K., Cao, H., Ni, M., Liu, Y., Gu, Z., Dickerson, K. E., Xie, S., Hon, G. C., Xuan, Z., Zhang, M. Q., Shao, Z. & Xu, J., Aug 24 2017, In : Cell. 170, 5, p. 1028-1043.e19Research output: Contribution to journal › Article
77
Scopus
citations
Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation
Liu, X., Zhang, Y., Ni, M., Cao, H., Signer, R. A. J., Li, D., Li, M., Gu, Z., Hu, Z., Dickerson, K. E., Weinberg, S. E., Chandel, N. S., Deberardinis, R. J., Zhou, F., Shao, Z. & Xu, J., May 31 2017, In : Nature cell biology. 19, 6, p. 626-638 13 p.Research output: Contribution to journal › Article
40
Scopus
citations
Temporal dynamics of cardiac hypertrophic growth in response to pressure overload
Wang, Y., Zhang, Y., Ding, G., May, H. I., Xu, J., Gillette, T. G., Wang, H. & Wang, Z. V., Dec 1 2017, In : American Journal of Physiology - Heart and Circulatory Physiology. 313, 6, p. H1119-H1129Research output: Contribution to journal › Article
7
Scopus
citations
The mitochondrial respiratory chain is essential for haematopoietic stem cell function
Ansó, E., Weinberg, S. E., Diebold, L. P., Thompson, B. J., Malinge, S., Schumacker, P. T., Liu, X., Zhang, Y., Shao, Z., Steadman, M., Marsh, K. M., Xu, J., Crispino, J. D. & Chandel, N. S., May 31 2017, In : Nature Cell Biology. 19, 6, p. 614-625 12 p.Research output: Contribution to journal › Article
73
Scopus
citations
2016
Bcl11a Deficiency Leads to Hematopoietic Stem Cell Defects with an Aging-like Phenotype
Luc, S., Huang, J., McEldoon, J. L., Somuncular, E., Li, D., Rhodes, C., Mamoor, S., Hou, S., Xu, J. & Orkin, S. H., Sep 20 2016, In : Cell Reports. 16, 12, p. 3181-3194 14 p.Research output: Contribution to journal › Article
25
Scopus
citations
Dynamic Control of Enhancer Repertoires Drives Lineage and Stage-Specific Transcription during Hematopoiesis
Huang, J., Liu, X., Li, D., Shao, Z., Cao, H., Zhang, Y., Trompouki, E., Bowman, T. V., Zon, L. I., Yuan, G. C., Orkin, S. H. & Xu, J., Jan 11 2016, In : Developmental Cell. 36, 1, p. 9-23 15 p.Research output: Contribution to journal › Article
85
Scopus
citations
Gene regulation: Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin
Masuda, T., Wang, X., Maeda, M., Canver, M. C., Sher, F., Funnell, A. P. W., Fisher, C., Suciu, M., Martyn, G. E., Norton, L. J., Zhu, C., Kurita, R., Nakamura, Y., Xu, J., Higgs, D. R., Crossley, M., Bauer, D. E., Orkin, S. H., Kharchenko, P. V. & Maeda, T., Jan 15 2016, In : Science. 351, 6270, p. 285-289 5 p.Research output: Contribution to journal › Article
89
Scopus
citations
Genetic inactivation of calpain-1 attenuates pain sensitivity in a humanized mouse model of sickle cell disease
Nwankwo, J. O., Lei, J., Xu, J., Rivera, A., Gupta, K. & Chishti, A. H., Sep 30 2016, In : Haematologica. 101, 10, p. e397-e400Research output: Contribution to journal › Letter
8
Scopus
citations
Suppression of the SWI/SNF Component Arid1a Promotes Mammalian Regeneration
Sun, X., Chuang, J. C., Kanchwala, M., Wu, L., Celen, C., Li, L., Liang, H., Zhang, S., Maples, T., Nguyen, L. H., Wang, S. C., Signer, R. A. J., Sorouri, M., Nassour, I., Liu, X., Xu, J., Wu, M., Zhao, Y., Kuo, Y. C., Wang, Z. & 2 others, , Apr 7 2016, In : Cell Stem Cell. 18, 4, p. 456-466 11 p.Research output: Contribution to journal › Article
48
Scopus
citations
2015
Developmental control of polycomb subunit composition by GATA factors mediates a switch to non-canonical functions
Xu, J., Shao, Z., Li, D., Xie, H., Kim, W., Huang, J., Taylor, J. E., Pinello, L., Glass, K., Jaffe, J. D., Yuan, G. C. & Orkin, S. H., Jan 22 2015, In : Molecular cell. 57, 2, p. 304-316 13 p.Research output: Contribution to journal › Article
67
Scopus
citations
PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells
Das, P. P., Hendrix, D. A., Apostolou, E., Buchner, A. H., Canver, M. C., Beyaz, S., Ljuboja, D., Kuintzle, R., Kim, W., Karnik, R., Shao, Z., Xie, H., Xu, J., De Los Angeles, A., Zhang, Y., Choe, J., Jun, D. L. J., Shen, X., Gregory, R. I., Daley, G. Q. & 5 others, , Sep 1 2015, In : Cell Reports. 12, 9, p. 1456-1470 15 p., 1953.Research output: Contribution to journal › Article
28
Scopus
citations
Role of the clathrin adaptor PICALM in normal hematopoiesis and polycythemia vera pathophysiology
Ishikawa, Y., Maeda, M., Pasham, M., Aguet, F., Tacheva-Grigorova, S. K., Masuda, T., Yi, H., Lee, S. U., Xu, J., Teruya-Feldstein, J., Ericsson, M., Mullally, A., Heuser, J., Kirchhausen, T. & Maeda, T., Jan 1 2015, In : Haematologica. 100, 4, p. 439-451 13 p.Research output: Contribution to journal › Article
14
Scopus
citations
2014
Analysis of chromatin-state plasticity identifies cell-type-specific regulators of H3K27me3 patterns
Pinello, L., Xu, J., Orkin, S. H. & Yuan, G. C., Jan 21 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 3, p. E344-E353Research output: Contribution to journal › Article
Open Access
42
Scopus
citations
GATA1s induces hyperproliferation of eosinophil precursors in Down syndrome transient leukemia
Maroz, A., Stachorski, L., Emmrich, S., Reinhardt, K., Xu, J., Shao, Z., Käbler, S., Dertmann, T., Hitzler, J., Roberts, I., Vyas, P., Juban, G., Hennig, C., Hansen, G., Li, Z., Orkin, S., Reinhardt, D. & Klusmann, J. H., Jun 2014, In : Leukemia. 28, 6, p. 1259-1270 12 p.Research output: Contribution to journal › Article
18
Scopus
citations
Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production
Li, Y., Esain, V., Teng, L., Xu, J., Kwan, W., Frost, I. M., Yzaguirre, A. D., Cai, X., Cortes, M., Maijenburg, M. W., Tober, J., Dzierzak, E., Orkin, S. H., Tan, K., North, T. E. & Speck, N. A., Dec 1 2014, In : Genes and Development. 28, 23, p. 2597-2612 16 p.Research output: Contribution to journal › Article
118
Scopus
citations
Polycomb repressive complex 2 regulates normal hematopoietic stem cell function in a developmental-stage-specific manner
Xie, H., Xu, J., Hsu, J. H., Nguyen, M., Fujiwara, Y., Peng, C. & Orkin, S. H., Jan 2 2014, In : Cell Stem Cell. 14, 1, p. 68-80 13 p.Research output: Contribution to journal › Article
165
Scopus
citations
2013
An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level
Bauer, D. E., Kamran, S. C., Lessard, S., Xu, J., Fujiwara, Y., Lin, C., Shao, Z., Canver, M. C., Smith, E. C., Pinello, L., Sabo, P. J., Vierstra, J., Voit, R. A., Yuan, G. C., Porteus, M. H., Stamatoyannopoulos, J. A., Lettre, G. & Orkin, S. H., Jan 1 2013, In : Science. 342, 6155, p. 253-257 5 p.Research output: Contribution to journal › Article
301
Scopus
citations
Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A
Xu, J., Bauer, D. E., Kerenyi, M. A., Vo, T. D., Hou, S., Hsu, Y. J., Yao, H., Trowbridge, J. J., Mandel, G. & Orkin, S. H., Apr 16 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 16, p. 6518-6523 6 p.Research output: Contribution to journal › Article
97
Scopus
citations
Mapping cellular hierarchy by single-cell analysis of the cell surface repertoire
Guo, G., Luc, S., Marco, E., Lin, T. W., Peng, C., Kerenyi, M. A., Beyaz, S., Kim, W., Xu, J., Das, P. P., Neff, T., Zou, K., Yuan, G. C. & Orkin, S. H., Oct 3 2013, In : Cell Stem Cell. 13, 4, p. 492-505 14 p.Research output: Contribution to journal › Article
148
Scopus
citations
2012
Combinatorial Assembly of Developmental Stage-Specific Enhancers Controls Gene Expression Programs during Human Erythropoiesis
Xu, J., Shao, Z., Glass, K., Bauer, D. E., Pinello, L., Van Handel, B., Hou, S., Stamatoyannopoulos, J. A., Mikkola, H. K. A., Yuan, G. C. & Orkin, S. H., Oct 16 2012, In : Developmental cell. 23, 4, p. 796-811 16 p.Research output: Contribution to journal › Article
106
Scopus
citations
Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number
Sankaran, V. G., Ludwig, L. S., Sicinska, E., Xu, J., Bauer, D. E., Eng, J. C., Patterson, H. C., Metcalf, R. A., Natkunam, Y., Orkin, S. H., Sicinski, P., Lander, E. S. & Lodish, H. F., Sep 15 2012, In : Genes and Development. 26, 18, p. 2075-2087 13 p.Research output: Contribution to journal › Article
59
Scopus
citations
Designing an enhancer landscape
Xu, J. & Smale, S. T., Nov 21 2012, In : Cell. 151, 5, p. 929-931 3 p.Research output: Contribution to journal › Short survey
9
Scopus
citations
Generation of a genomic reporter assay system for analysis of γ- and β-globin gene regulation
Chan, K. S. K., Xu, J., Wardan, H., McColl, B., Orkin, S. & Vadolas, J., Apr 1 2012, In : FASEB Journal. 26, 4, p. 1736-1744 9 p.Research output: Contribution to journal › Article
17
Scopus
citations
2011
A functional element necessary for fetal hemoglobin silencing
Sankaran, V. G., Xu, J., Byron, R., Greisman, H. A., Fisher, C., Weatherall, D. J., Sabath, D. E., Groudine, M., Orkin, S. H., Premawardhena, A. & Bender, M. A., Sep 1 2011, In : New England Journal of Medicine. 365, 9, p. 807-814 8 p.Research output: Contribution to journal › Article
102
Scopus
citations
Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing
Xu, J., Peng, C., Sankaran, V. G., Shao, Z., Esrick, E. B., Chong, B. G., Ippolito, G. C., Fujiwara, Y., Ebert, B. L., Tucker, P. W. & Orkin, S. H., Nov 18 2011, In : Science. 334, 6058, p. 993-996 4 p.Research output: Contribution to journal › Article
186
Scopus
citations
Role of ZBP-89 in human globin gene regulation and erythroid differentiation
Woo, A. J., Kim, J., Xu, J., Huang, H. & Cantor, A. B., Sep 29 2011, In : Blood. 118, 13, p. 3684-3693 10 p.Research output: Contribution to journal › Article
13
Scopus
citations
The erythroid/myeloid lineage fate paradigm takes a new player
Xu, J. & Orkin, S. H., Mar 16 2011, In : EMBO Journal. 30, 6, p. 983-985 3 p.Research output: Contribution to journal › Article
1
Scopus
citations
2010
Advances in the understanding of haemoglobin switching: Review
Sankaran, V. G., Xu, J. & Orkin, S. H., Apr 1 2010, In : British Journal of Haematology. 149, 2, p. 181-194 14 p.Research output: Contribution to journal › Review article
125
Scopus
citations
Sumoylation regulates interaction of FOG1 with C-terminal-binding protein (CTBP)
Snow, J. W., Kim, J., Currie, C. R., Xu, J. & Orkin, S. H., Sep 3 2010, In : Journal of Biological Chemistry. 285, 36, p. 28064-28075 12 p.Research output: Contribution to journal › Article
16
Scopus
citations
Transcriptional silencing of fetal hemoglobin by BCL11A
Sankaran, V. G., Xu, J. & Orkin, S. H., Aug 2010, Cooley's Anemia: Ninth Symposium. Blackwell Publishing Inc., p. 64-68 5 p. (Annals of the New York Academy of Sciences; vol. 1202).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
29
Scopus
citations
Transcriptional silencing of γ-globin by BCL11A involves long-range interactions and cooperation with SOX6
Xu, J., Sankaran, V. G., Ni, M., Menne, T. F., Puram, R. V., Kim, W. & Orkin, S. H., Apr 15 2010, In : Genes and Development. 24, 8, p. 783-789 7 p.Research output: Contribution to journal › Article
215
Scopus
citations
2009
Developmental and species-divergent globin switching are driven by BCL11A
Sankaran, V. G., Xu, J., Ragoczy, T., Ippolito, G. C., Walkley, C. R., Maika, S. D., Fujiwara, Y., Ito, M., Groudine, M., Bender, M. A., Tucker, P. W. & Orkin, S. H., Aug 27 2009, In : Nature. 460, 7259, p. 1093-1097 5 p.Research output: Contribution to journal › Article
251
Scopus
citations
Evaluation of the long-term reconstituting subset of hematopoietic stem cells with CD150
Papathanasiou, P., Attema, J. L., Karsunky, H., Jian, X., Smale, S. T. & Weissman, I. L., Oct 1 2009, In : STEM CELLS. 27, 10, p. 2498-2508 11 p.Research output: Contribution to journal › Article
36
Scopus
citations
Transcriptional competence and the active marking of tissue-specific enhancers by defined transcription factors in embryonic and induced pluripotent stem cells
Xu, J., Watts, J. A., Pope, S. D., Gadue, P., Kamps, M., Plath, K., Zaret, K. S. & Smale, S. T., Dec 15 2009, In : Genes and Development. 23, 24, p. 2824-2838 15 p.Research output: Contribution to journal › Article
123
Scopus
citations
2008
Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A
Sankaran, V. G., Menne, T. F., Xu, J., Akie, T. E., Lettre, G., Van Handel, B., Mikkola, H. K. A., Hirschhorn, J. N., Cantor, A. B. & Orkin, S. H., Dec 19 2008, In : Science. 322, 5909, p. 1839-1842 4 p.Research output: Contribution to journal › Article
485
Scopus
citations
Pioneer factors, genetic competence, and inductive signaling: Programming liver and pancreas progenitors from the endoderm
Zaret, K. S., Watts, J., Xu, J., Wandzioch, E., Smale, S. T. & Sekiya, T., Dec 1 2008, In : Cold Spring Harbor symposia on quantitative biology. 73, p. 119-126 8 p.Research output: Contribution to journal › Article
104
Scopus
citations
2007
An inducible enhancer required for Il12b promoter activity in an insulated chromatin environment
Zhou, L., Nazarian, A. A., Xu, J., Tantin, D., Corcoran, L. M. & Smale, S. T., Apr 1 2007, In : Molecular and cellular biology. 27, 7, p. 2698-2712 15 p.Research output: Contribution to journal › Article
36
Scopus
citations