• 36419 Citations
  • 95 h-Index
1992 …2020

Research output per year

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Research Output

2020

Leptin: Less is more

Zhao, S., Kusminski, C. M., Elmquist, J. K. & Scherer, P. E., May 1 2020, In : Diabetes. 69, 5, p. 823-829 7 p.

Research output: Contribution to journalArticle

Melanocortin regulation of histaminergic neurons via perifornical lateral hypothalamic melanocortin 4 receptors

Michael, N. J., Caron, A., Lee, C. E., Castorena, C. M., Lee, S., Zigman, J. M., Williams, K. W. & Elmquist, J. K., May 2020, In : Molecular Metabolism. 35, 100956.

Research output: Contribution to journalArticle

Open Access
2019

Adipocyte Gs but not Gi signaling regulates whole-body glucose homeostasis

Caron, A., Reynolds, R. P., Castorena, C. M., Michael, N. J., Lee, C. E., Lee, S., Berdeaux, R., Scherer, P. E. & Elmquist, J. K., Sep 2019, In : Molecular Metabolism. 27, p. 11-21 11 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Erratum: Distinct Hypothalamic Neurons Mediate Estrogenic Effects on Energy Homeostasis and Reproduction (Distinct Hypothalamic Neurons Mediate Estrogenic Effects on Energy Homeostasis and Reproduction (2011) 14(4) (453–465), (S1550413111003391), (10.1016/j.cmet.2011.08.009))

Xu, Y., Nedungadi, T. P., Zhu, L., Sobhani, N., Irani, B. G., Davis, K. E., Zhang, X., Zou, F., Gent, L. M., Hahner, L. D., Khan, S. A., Elias, C. F., Elmquist, J. K. & Clegg, D. J., May 7 2019, In : Cell Metabolism. 29, 5, 1 p.

Research output: Contribution to journalComment/debate

Open Access

NURR1 activation in skeletal muscle controls systemic energy homeostasis

Amoasii, L., Sanchez-Ortiz, E., Fujikawa, T., Elmquist, J. K., Bassel-Duby, R. S. & Olson, E. N., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 166, 23, p. 11299-11308 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy

Zhao, S., Zhu, Y., Schultz, R. D., Li, N., He, Z., Zhang, Z., Caron, A., Zhu, Q., Sun, K., Xiong, W., Deng, H., Sun, J., Deng, Y., Kim, M., Lee, C. E., Gordillo, R., Liu, T., Odle, A. K., Childs, G. V., Zhang, N. & 5 others, Kusminski, C. M., Elmquist, J. K., Williams, K. W., An, Z. & Scherer, P. E., Oct 1 2019, In : Cell Metabolism. 30, 4, p. 706-719.e6

Research output: Contribution to journalArticle

10 Scopus citations

Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver

Cappel, D. A., Deja, S., Duarte, J. A. G., Kucejova, B., Iñigo, M., Fletcher, J. A., Fu, X., Berglund, E. D., Liu, T., Elmquist, J. K., Hammer, S., Mishra, P., Browning, J. D. & Burgess, S. C., Jun 4 2019, In : Cell Metabolism. 29, 6, p. 1291-1305.e8

Research output: Contribution to journalArticle

7 Scopus citations
2018

Desacetyl-α-melanocyte stimulating hormone and α-melanocyte stimulating hormone are required to regulate energy balance

Mountjoy, K. G., Caron, A., Hubbard, K., Shome, A., Grey, A. C., Sun, B., Bould, S., Middleditch, M., Pontré, B., McGregor, A., Harris, P. W. R., Kowalczyk, R., Brimble, M. A., Botha, R., Tan, K. M. L., Piper, S. J., Buchanan, C., Lee, S., Coll, A. P. & Elmquist, J. K., Mar 2018, In : Molecular Metabolism. 9, p. 207-216 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Ghrelin mediates exercise endurance and the feeding response post-exercise

Mani, B. K., Castorena, C. M., Osborne-Lawrence, S., Vijayaraghavan, P., Metzger, N. P., Elmquist, J. K. & Zigman, J. M., Jan 1 2018, (Accepted/In press) In : Molecular Metabolism.

Research output: Contribution to journalArticle

8 Scopus citations

Hepatocyte toll-like receptor 4 deficiency protects against alcohol-induced fatty liver disease

Jia, L., Chang, X., Qian, S., Liu, C., Lord, C. C., Ahmed, N., Lee, C. E., Lee, S., Gautron, L., Mitchell, M. C., Horton, J. D., Scherer, P. E. & Elmquist, J. K., Aug 1 2018, In : Molecular Metabolism. 14, p. 121-129 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Leptin and brain-adipose crosstalks

Caron, A., Lee, S., Elmquist, J. K. & Gautron, L., Feb 16 2018, In : Nature Reviews Neuroscience. 19, 3, p. 153-165 13 p.

Research output: Contribution to journalReview article

33 Scopus citations

POMC neurons expressing leptin receptors coordinate metabolic responses to fasting via suppression of leptin levels

Caron, A., Lemko, H. M. D., Castorena, C. M., Fujikawa, T., Lee, S., Lord, C. C., Ahmed, N., Lee, C. E., Holland, W. L., Liu, C. & Elmquist, J. K., Mar 12 2018, In : eLife. 7, e33710.

Research output: Contribution to journalArticle

18 Scopus citations
2017

An adipo-biliary-uridine axis that regulates energy homeostasis

Deng, Y., Wang, Z., Gordillo, R., An, Y., Zhang, C., Liang, Q., Yoshino, J., Cautivo, K. M., De Brabander, J. K., Elmquist, J. K., Horton, J. D., Hill, J. A., Klein, S. & Scherer, P. E., Mar 17 2017, In : Science. 355, 6330, eaaf5375.

Research output: Contribution to journalArticle

34 Scopus citations

Brain nuclear receptors and body weight regulation

Xu, Y., O'Malley, B. W. & Elmquist, J. K., Apr 3 2017, In : Journal of Clinical Investigation. 127, 4, p. 1172-1180 9 p.

Research output: Contribution to journalReview article

7 Scopus citations

Nav1.8 neurons are involved in limiting acute phase responses to dietary fat

Udit, S., Burton, M., Rutkowski, J. M., Lee, S., Bookout, A. L., Scherer, P. E., Elmquist, J. K. & Gautron, L., 2017, (Accepted/In press) In : Molecular Metabolism.

Research output: Contribution to journalArticle

4 Scopus citations

Serotonergic control of metabolic homeostasis

Wyler, S. C., Lord, C. C., Lee, S., Elmquist, J. K. & Liu, C., Sep 20 2017, In : Frontiers in Cellular Neuroscience. 11, 277.

Research output: Contribution to journalShort survey

13 Scopus citations

Short-term versus long-term effects of adipocyte toll-like receptor 4 activation on insulin resistance in male mice

Tao, C., Holland, W. L., Wang, Q. A., Shao, M., Jia, L., Sun, K., Lin, X., Kuo, Y. C., Johnson, J. A., Gordillo, R., Elmquist, J. K. & Scherer, P. E., May 1 2017, In : Endocrinology. 158, 5, p. 1260-1270 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

The atypical antipsychotic olanzapine causes weight gain by targeting serotonin receptor 2C

Lord, C. C., Wyler, S. C., Wan, R., Castorena, C. M., Ahmed, N., Mathew, D., Lee, S., Liu, C. & Elmquist, J. K., Sep 1 2017, In : Journal of Clinical Investigation. 127, 9, p. 3402-3406 5 p.

Research output: Contribution to journalArticle

38 Scopus citations

The hypothalamic regulation of metabolic adaptations to exercise

Fujikawa, T., Castorena, C. M., Lee, S. & Elmquist, J. K., Oct 1 2017, In : Journal of Neuroendocrinology. 29, 10, e12533.

Research output: Contribution to journalReview article

4 Scopus citations
2016

Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals

Zhu, Y., Gao, Y., Tao, C., Shao, M., Zhao, S., Huang, W., Yao, T., Johnson, J. A., Liu, T., Cypess, A. M., Gupta, O., Holland, W. L., Gupta, R. K., Spray, D. C., Tanowitz, H. B., Cao, L., Lynes, M. D., Tseng, Y. H., Elmquist, J. K., Williams, K. W. & 2 others, Lin, H. V. & Scherer, P. E., Sep 13 2016, In : Cell Metabolism. 24, 3, p. 420-433 14 p.

Research output: Contribution to journalArticle

28 Scopus citations

Leptin and insulin engage specific PI3K subunits in hypothalamic SF1 neurons

Sohn, J. W., Oh, Y., Kim, K. W., Lee, S., Williams, K. W. & Elmquist, J. K., Aug 1 2016, In : Molecular Metabolism. 5, 8, p. 669-679 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Mechanisms of homeostatically regulated behaviors

Elmquist, J. K., Zigman, J. M. & Saper, C. B., Jan 1 2016, Neuroscience in the 21st Century: From Basic to Clinical, Second Edition. Springer New York, p. 2087-2116 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nutritional conditions regulate transcriptional activity of SF-1 by controlling sumoylation and ubiquitination

Lee, J., Yang, D. J., Lee, S., Hammer, G. D., Kim, K. W. & Elmquist, J. K., Jan 11 2016, In : Scientific Reports. 6, 19143.

Research output: Contribution to journalArticle

4 Scopus citations

SF-1 expression in the hypothalamus is required for beneficial metabolic effects of exercise

Fujikawa, T., Castorena, C. M., Pearson, M., Kusminski, C., Ahmed, N., Battiprolu, P. K., Kim, K. W., Lee, S., Hill, J. A., Scherer, P. E., Holland, W. L. & Elmquist, J. K., Nov 22 2016, In : eLife. 5, NOVEMBER2016, e18206.

Research output: Contribution to journalArticle

13 Scopus citations
2015

A neural basis for melanocortin-4 receptor-regulated appetite

Garfield, A. S., Li, C., Madara, J. C., Shah, B. P., Webber, E., Steger, J. S., Campbell, J. N., Gavrilova, O., Lee, C. E., Olson, D. P., Elmquist, J. K., Tannous, B. A., Krashes, M. J. & Lowell, B. B., Jun 28 2015, In : Nature neuroscience. 18, 6, p. 863-871 9 p.

Research output: Contribution to journalArticle

158 Scopus citations

Development of neuroendocrine systems governing energy homeostasis

Elmquist, J. K., Oct 1 2015, In : Frontiers in Neuroendocrinology. 39, p. 1-2 2 p.

Research output: Contribution to journalArticle

Hypothalamic POMC neurons promote cannabinoid-induced feeding

Koch, M., Varela, L., Kim, J. G., Kim, J. D., Hernández-Nuño, F., Simonds, S. E., Castorena, C. M., Vianna, C. R., Elmquist, J. K., Morozov, Y. M., Rakic, P., Bechmann, I., Cowley, M. A., Szigeti-Buck, K., Dietrich, M. O., Gao, X. B., Diano, S. & Horvath, T. L., Mar 5 2015, In : Nature. 519, 7541, p. 45-50 6 p.

Research output: Contribution to journalArticle

183 Scopus citations

Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions

Arble, D. M., Bass, J., Behn, C. D., Butler, M. P., Challet, E., Czeisler, C., Depner, C. M., Elmquist, J., Franken, P., Grandner, M. A., Hanlon, E. C., Keene, A. C., Joyner, M. J., Karatsoreos, I., Kern, P. A., Klein, S., Morris, C. J., Pack, A. I., Panda, S., Ptacek, L. J. & 8 others, Punjabi, N. M., Sassone-Corsi, P., Scheer, F. A., Saxena, R., Seaquest, E. R., Thimgan, M. S., Van Cauter, E. & Wright, K. P., Dec 1 2015, In : Sleep. 38, 12, p. 1849-1860 12 p.

Research output: Contribution to journalArticle

51 Scopus citations

Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure

Mansuy-Aubert, V., Gautron, L., Lee, S., Bookout, A. L., Kusminski, C. M., Sun, K., Zhang, Y., Scherer, P. E., Mangelsdorf, D. J. & Elmquist, J. K., Jun 15 2015, In : eLife. 4, JUNE, e06667.

Research output: Contribution to journalArticle

12 Scopus citations

Meta-chlorophenylpiperazine enhances leptin sensitivity in diet-induced obese mice

Yan, C., Yang, Y., Saito, K., Xu, P., Wang, C., Hinton, A. O., Yan, X., Wu, Q., Tong, Q., Elmquist, J. K., Fukuda, M. & Xu, Y., Jul 1 2015, In : British Journal of Pharmacology. 172, 14, p. 3510-3521 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Neural control of energy balance: Translating circuits to therapies

Gautron, L., Elmquist, J. K. & Williams, K. W., Mar 26 2015, In : Cell. 161, 1, p. 133-145 13 p., 8054.

Research output: Contribution to journalReview article

105 Scopus citations
2014

Arcuate AgRP neurons mediate orexigenic and glucoregulatory actions of ghrelin

Wang, Q., Liu, C., Uchida, A., Chuang, J. C., Walker, A., Liu, T., Osborne-Lawrence, S., Mason, B. L., Mosher, C., Berglund, E. D., Elmquist, J. K. & Zigman, J. M., Feb 1 2014, In : Molecular Metabolism. 3, 1, p. 64-72 9 p.

Research output: Contribution to journalArticle

115 Scopus citations

Circuits controlling energy balance and mood: Inherently intertwined or just complicated intersections?

Liu, C., Lee, S. & Elmquist, J. K., Jun 3 2014, In : Cell Metabolism. 19, 6, p. 902-909 8 p.

Research output: Contribution to journalReview article

16 Scopus citations

Dnmt3a in sim1 neurons is necessary for normal energy homeostasis

Kohno, D., Lee, S., Harper, M. J., Kim, K. W., Sone, X., Sasaki, T., Kitamura, T., Fan, G. & Elmquist, J. K., Nov 12 2014, In : Journal of Neuroscience. 34, 46, p. 15288-15296 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Elevated resistin levels induce central leptin resistance and increased atherosclerotic progression in mice

Asterholm, I. W., Rutkowski, J. M., Fujikawa, T., Cho, Y. R., Fukuda, M., Tao, C., Wang, Z., Gupta, R. K., Elmquist, J. K. & Scherer, P. E., Jun 2014, In : Diabetologia. 57, 6, p. 1209-1218 10 p.

Research output: Contribution to journalArticle

26 Scopus citations
3 Scopus citations

Foreword

Gautron, L. & Elmquist, J. K., 2014, In : Frontiers of Hormone Research. 42

Research output: Contribution to journalArticle

Foreword

Gautron, L. & Elmquist, J. K., Apr 10 2014, In : Unknown Journal. 42, p. vii-viii

Research output: Contribution to journalArticle

Hepatocyte toll-like receptor 4 regulates obesity-induced inflammation and insulin resistance

Jia, L., Vianna, C. R., Fukuda, M., Berglund, E. D., Liu, C., Tao, C., Sun, K., Liu, T., Harper, M. J., Lee, C. E., Lee, S., Scherer, P. E. & Elmquist, J. K., May 12 2014, In : Nature communications. 5, 3878.

Research output: Contribution to journalArticle

121 Scopus citations

Hyperphagia: current concepts and future directions proceedings of the 2nd international conference on hyperphagia.

Heymsfield, S. B., Avena, N. M., Baier, L., Brantley, P., Bray, G. A., Burnett, L. C., Butler, M. G., Driscoll, D. J., Egli, D., Elmquist, J., Forster, J. L., Goldstone, A. P., Gourash, L. M., Greenway, F. L., Han, J. C., Kane, J. G., Leibel, R. L., Loos, R. J. F., Scheimann, A. O., Roth, C. L. & 9 others, Seeley, R. J., Sheffield, V., Tauber, M., Vaisse, C., Wang, L., Waterland, R. A., Wevrick, R., Yanovski, J. A. & Zinn, A. R., Feb 2014, In : Obesity (Silver Spring, Md.). 22 Suppl 1, p. S1-S17

Research output: Contribution to journalArticle

23 Scopus citations

Leptin mediates the increase in blood pressure associated with obesity

Simonds, S. E., Pryor, J. T., Ravussin, E., Greenway, F. L., Dileone, R., Allen, A. M., Bassi, J., Elmquist, J. K., Keogh, J. M., Henning, E., Myers, M. G., Licinio, J., Brown, R. D., Enriori, P. J., O'Rahilly, S., Sternson, S. M., Grove, K. L., Spanswick, D. C., Farooqi, I. S. & Cowley, M. A., Dec 4 2014, In : Cell. 159, 6, p. 1404-1416 13 p.

Research output: Contribution to journalArticle

155 Scopus citations

MC4R-expressing glutamatergic neurons in the paraventricular hypothalamus regulate feeding and are synaptically connected to the parabrachial nucleus

Shah, B. P., Vong, L., Olson, D. P., Koda, S., Krashes, M. J., Ye, C., Yang, Z., Fuller, P. M., Elmquist, J. K. & Lowell, B. B., Jan 1 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 36, p. 13193-13198 6 p.

Research output: Contribution to journalArticle

85 Scopus citations

Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia

Berglund, E. D., Liu, T., Kong, X., Sohn, J. W., Vong, L., Deng, Z., Lee, C. E., Lee, S., Williams, K. W., Olson, D. P., Scherer, P. E., Lowell, B. B. & Elmquist, J. K., Jul 2014, In : Nature neuroscience. 17, 7, p. 911-913 3 p.

Research output: Contribution to journalArticle

72 Scopus citations

PPARγ in vagal neurons regulates high-fat diet induced thermogenesis

Liu, C., Bookout, A. L., Lee, S., Sun, K., Jia, L., Lee, C., Udit, S., Deng, Y., Scherer, P. E., Mangelsdorf, D. J., Gautron, L. & Elmquist, J. K., Apr 1 2014, In : Cell Metabolism. 19, 4, p. 722-730 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

Shp2 signaling in POMC neurons is important for leptin’s actions on blood pressure, Energy balance, And glucose regulation

Do Carmo, J. M., Da Silva, A. A., Ebaady, S. E., Sessums, P. O., Abraham, R. S., Elmquist, J. K., Lowell, B. B. & Hall, J. E., Dec 15 2014, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 307, 12, p. R1438-R1447

Research output: Contribution to journalArticle

18 Scopus citations

Xbp1s in pomc neurons connects ER stress with energy balance and glucose homeostasis

Williams, K. W., Liu, T., Kong, X., Fukuda, M., Deng, Y., Berglund, E. D., Deng, Z., Gao, Y., Liu, T., Sohn, J. W., Jia, L., Fujikawa, T., Kohno, D., Scott, M. M., Lee, S., Lee, C. E., Sun, K., Chang, Y., Scherer, P. E. & Elmquist, J. K., Sep 2 2014, In : Cell Metabolism. 20, 3, p. 471-482 12 p.

Research output: Contribution to journalArticle

126 Scopus citations
2013

Discrete melanocortin-sensitive neuroanatomical pathway linking the ventral premmamillary nucleus to the paraventricular hypothalamus

Gautron, L., Cravo, R. M., Elmquist, J. K. & Elias, C. F., Jun 14 2013, In : Neuroscience. 240, p. 70-82 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

FGF21 regulates metabolism and circadian behavior by acting on the nervous system

Bookout, A. L., De Groot, M. H. M., Owen, B. M., Lee, S., Gautron, L., Lawrence, H. L., Ding, X., Elmquist, J. K., Takahashi, J. S., Mangelsdorf, D. J. & Kliewer, S. A., Sep 1 2013, In : Nature medicine. 19, 9, p. 1147-1152 6 p.

Research output: Contribution to journalArticle

238 Scopus citations

Leptin Engages a Hypothalamic Neurocircuitry to Permit Survival in the Absence of Insulin

Fujikawa, T., Berglund, E. D., Patel, V. R., Ramadori, G., Vianna, C. R., Vong, L., Thorel, F., Chera, S., Herrera, P. L., Lowell, B. B., Elmquist, J. K., Baldi, P. & Coppari, R., Sep 3 2013, In : Cell Metabolism. 18, 3, p. 431-444 14 p.

Research output: Contribution to journalArticle

70 Scopus citations

Mechanisms of homeostatically regulated behaviors

Elmquist, J. K., Zigman, J. M. & Saper, C. B., Nov 1 2013, Neuroscience in the 21st Century: From Basic to Clinical. Springer New York, p. 1753-1782 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations