• 3051 Citations
  • 30 h-Index
19992019
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Research Output 1999 2019

  • 3051 Citations
  • 30 h-Index
  • 62 Article
  • 2 Review article
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Article
21 Citations (Scopus)

[3 + 2]-Cycloadditions of Azomethine Imines and Ynolates

Winterton, S. E. & Ready, J. M., Jun 3 2016, In : Organic Letters. 18, 11, p. 2608-2611 4 p.

Research output: Contribution to journalArticle

Imines
Cycloaddition
Cycloaddition Reaction
cycloaddition
Lithium
13 Citations (Scopus)

A Concise Total Synthesis of Dictyodendrins F, H, and i Using Aryl Ynol Ethers as Key Building Blocks

Zhang, W. & Ready, J. M., Aug 24 2016, In : Journal of the American Chemical Society. 138, 33, p. 10684-10692 9 p.

Research output: Contribution to journalArticle

Ethers
Oxidative Coupling
Acylation
Cycloaddition Reaction
Cycloaddition
14 Citations (Scopus)

A high throughput screen identifies benzoquinoline compounds as inhibitors of Ebola virus replication

Luthra, P., Liang, J., Pietzsch, C. A., Khadka, S., Edwards, M. R., Wei, S., De, S., Posner, B., Bukreyev, A., Ready, J. M. & Basler, C. F., Feb 1 2018, In : Antiviral Research. 150, p. 193-201 9 p.

Research output: Contribution to journalArticle

Ebolavirus
Virus Replication
Antiviral Agents
RNA Viruses
RNA
75 Citations (Scopus)

Allenes in asymmetric catalysis: Asymmetric ring opening of meso-epoxides catalyzed by allene-containing phosphine oxides

Pu, X., Qi, X. & Ready, J. M., Aug 5 2009, In : Journal of the American Chemical Society. 131, 30, p. 10364-10365 2 p.

Research output: Contribution to journalArticle

phosphine
Epoxy Compounds
Catalysis
Oxides
Ligands
69 Citations (Scopus)

A mild and efficient synthesis of oxindoles: Progress towards the synthesis of welwitindolinone A isonitrile

Ready, J. M., Reisman, S. E., Hirata, M., Weiss, M. M., Tamaki, K., Ovaska, T. V. & Wood, J. L., Feb 27 2004, In : Angewandte Chemie - International Edition. 43, 10, p. 1270-1272 3 p.

Research output: Contribution to journalArticle

Isocyanates
Cycloaddition
Cyclization
Carbon
1,8-diazabicyclo(5.4.0)undec-7-ene
219 Citations (Scopus)

A practical oligomeric [(salen)Co] catalyst for asymmetric epoxide ring-opening reactions

Ready, J. M. & Jacobsen, E. N., Apr 15 2002, In : Angewandte Chemie - International Edition. 41, 8, p. 1374-1377 4 p.

Research output: Contribution to journalArticle

Catalyst selectivity
Epoxy Compounds
Chromatography
Dimers
Catalyst activity

A second-generation 15-PGDH inhibitor promotes bone marrow transplant recovery independently of age, transplant dose and granulocyte colony-stimulating factor support

Desai, A., Zhang, Y., Park, Y., Dawson, D. M., Larusch, G. A., Kasturi, L., Wald, D., Ready, J. M., Gerson, S. L. & Markowitz, S. D., Jun 3 2018, In : Haematologica. 103, 6, p. 1054-1064 11 p.

Research output: Contribution to journalArticle

15-hydroxyprostaglandin dehydrogenase
Granulocyte Colony-Stimulating Factor
Bone Marrow
Transplants
Dinoprostone
179 Citations (Scopus)
Phenols
Epoxy Compounds
Alcohols
Kinetics
13 Citations (Scopus)

Asymmetric synthesis of tertiary benzylic alcohols

Antczak, M. I., Cai, F. & Ready, J. M., Jan 21 2011, In : Organic Letters. 13, 2, p. 184-187 4 p.

Research output: Contribution to journalArticle

sulfoxide
ketones
alcohols
Alcohols
Organometallics
53 Citations (Scopus)

Catalytic cross-coupling of alkylzinc halides with α-chloroketones

Malosh, C. F. & Ready, J. M., Aug 25 2004, In : Journal of the American Chemical Society. 126, 33, p. 10240-10241 2 p.

Research output: Contribution to journalArticle

Stereochemistry
Ketones
Magnesium
Zinc
Substitution reactions
76 Citations (Scopus)

Chiral allene-containing phosphines in asymmetric catalysis

Cai, F., Pu, X., Qi, X., Lynch, V., Radha, A. & Ready, J. M., Nov 16 2011, In : Journal of the American Chemical Society. 133, 45, p. 18066-18069 4 p.

Research output: Contribution to journalArticle

Phosphines
Catalysis
Transition metals
Ligands
Enantioselectivity
82 Citations (Scopus)

Copper-promoted cycloaddition of diazocarbonyl compounds and acetylides

Qi, X. & Ready, J. M., 2007, In : Angewandte Chemie - International Edition. 46, 18, p. 3242-3244 3 p.

Research output: Contribution to journalArticle

Alkynes
Cycloaddition
Molecular orbitals
Copper
Pyrazoles
13 Citations (Scopus)

Cyclocondensation of amino-propargyl silanes

Wang, Y. & Ready, J. M., May 4 2012, In : Organic Letters. 14, 9, p. 2308-2311 4 p.

Research output: Contribution to journalArticle

Phosphoric Acids
Silanes
Carbonyl compounds
carbonyl compounds
Imines
28 Citations (Scopus)

Deconvolution of complex NMR spectra in small molecules by multi frequency homonuclear decoupling (MDEC)

Espindola, A. P. D. M., Crouch, R., DeBergh, J. R., Ready, J. M. & MacMillan, J. B., 2009, In : Journal of the American Chemical Society. 131, 44, p. 15994-15995 2 p.

Research output: Contribution to journalArticle

Deconvolution
Nuclear magnetic resonance
Menthol
Molecules
Fatty acids
15 Citations (Scopus)

Dehydrogenative coupling to enable the enantioselective total synthesis of (-)-simaomicin α

Wang, Y., Wang, C., Butler, J. R. & Ready, J. M., Oct 4 2013, In : Angewandte Chemie - International Edition. 52, 41, p. 10796-10799 4 p.

Research output: Contribution to journalArticle

Stereochemistry
Enantiomers
Cytotoxicity
Biological Products
Bacteria
10 Citations (Scopus)

Development of a scalable synthesis of P7C3-A20, a potent neuroprotective agent

Naidoo, J., Bemben, C. J., Allwein, S. R., Liang, J., Pieper, A. A. & Ready, J. M., Aug 14 2013, In : Tetrahedron Letters. 54, 33, p. 4429-4431 3 p.

Research output: Contribution to journalArticle

Neuroprotective Agents
Primates
Rodentia
Purification
112 Citations (Scopus)

Development of proneurogenic, neuroprotective small molecules

MacMillan, K. S., Naidoo, J., Liang, J., Melito, L., Williams, N. S., Morlock, L., Huntington, P. J., Estill, S. J., Longgood, J., Becker, G. L., McKnight, S. L., Pieper, A. A., De Brabander, J. K. & Ready, J. M., Feb 9 2011, In : Journal of the American Chemical Society. 133, 5, p. 1428-1437 10 p.

Research output: Contribution to journalArticle

Neurogenesis
Rats
Lead compounds
Affinity chromatography
Molecules
68 Citations (Scopus)

Direct and stereospecific synthesis of allenes via reduction of propargylic alcohols with Cp2Zr(H)Cl

Pu, X. & Ready, J. M., Aug 20 2008, In : Journal of the American Chemical Society. 130, 33, p. 10874-10875 2 p.

Research output: Contribution to journalArticle

Chirality
Alcohols
Hydrides
Magnesium
Zinc
14 Citations (Scopus)

Directed hydrozirconation of homopropargylic alcohols

Liu, X. & Ready, J. M., Jul 14 2008, In : Tetrahedron. 64, 29, p. 6955-6960 6 p.

Research output: Contribution to journalArticle

Metals
Alcohols
Stereochemistry
Alkenes
Hydroxyl Radical
25 Citations (Scopus)

Directed hydrozirconation of propargylic alcohols

Zhang, D. & Ready, J. M., Oct 10 2007, In : Journal of the American Chemical Society. 129, 40, p. 12088-12089 2 p.

Research output: Contribution to journalArticle

Alkynes
Alcohols
Vinyl Chloride
Zinc chloride
Regioselectivity
35 Citations (Scopus)

Discovery of a neuroprotective chemical, (S)- N -(3-(3,6-Dibromo-9 H -carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(-)-P7C3-S243], with improved druglike properties

Naidoo, J., De Jesus-Cortes, H., Huntington, P., Estill, S., Morlock, L. K., Starwalt, R., Mangano, T. J., Williams, N. S., Pieper, A. A. & Ready, J. M., May 8 2014, In : Journal of Medicinal Chemistry. 57, 9, p. 3746-3754 9 p.

Research output: Contribution to journalArticle

Amines
Neurons
Neurogenesis
Neuroprotective Agents
Substantia Nigra
214 Citations (Scopus)

Discovery of a Proneurogenic, Neuroprotective Chemical

Pieper, A. A., Xie, S., Capota, E., Estill, S. J., Zhong, J., Long, J. M., Becker, G. L., Huntington, P., Goldman, S. E., Shen, C. H., Capota, M., Britt, J. K., Kotti, T., Ure, K., Brat, D. J., Williams, N. S., MacMillan, K. S., Naidoo, J., Melito, L., Hsieh, J. & 3 others, De Brabander, J. K., Ready, J. M. & McKnight, S. L., Jul 2010, In : Cell. 142, 1, p. 39-51 13 p.

Research output: Contribution to journalArticle

Neurons
Dentate Gyrus
Neurogenesis
Apoptosis
Gene encoding
1 Citation (Scopus)

Discovery of Cytochrome P450 4F11-Activated Inhibitors of Stearoyl Coenzyme A Desaturase

Winterton, S. E., Capota, E., Wang, X., Chen, H., Mallipeddi, P. L., Williams, N. S., Posner, B. A., Nijhawan, D. & Ready, J. M., Jan 12 2018, (Accepted/In press) In : Journal of Medicinal Chemistry.

Research output: Contribution to journalArticle

Stearoyl-CoA Desaturase
Cytochrome P-450 Enzyme System
Unsaturated Fatty Acids
Structure-Activity Relationship
Urea
43 Citations (Scopus)

Discovery of small-molecule inhibitors of tyrosinase

Germanas, J. P., Wang, S., Miner, A., Hao, W. & Ready, J. M., Dec 15 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 24, p. 6871-6875 5 p.

Research output: Contribution to journalArticle

Monophenol Monooxygenase
Molecules
Assays
Hyperpigmentation
Agaricales
20 Citations (Scopus)

Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase

Theodoropoulos, P. C., Gonzales, S. S., Winterton, S. E., Rodriguez-Navas, C., McKnight, J. S., Morlock, L. K., Hanson, J. M., Cross, B., Owen, A. E., Duan, Y., Moreno, J. R., Lemoff, A., Mirzaei, H., Posner, B. A., Williams, N. S., Ready, J. M. & Nijhawan, D., Apr 1 2016, In : Nature Chemical Biology. 12, 4, p. 218-225 8 p.

Research output: Contribution to journalArticle

Stearoyl-CoA Desaturase
Benzothiazoles
Neoplasms
Cell Line
Cytochrome P-450 Enzyme System
47 Citations (Scopus)

Enantioselective total synthesis of ( - )-kibdelone C

Butler, J. R., Wang, C., Bian, J. & Ready, J. M., Jul 6 2011, In : Journal of the American Chemical Society. 133, 26, p. 9956-9959 4 p.

Research output: Contribution to journalArticle

Polyketides
Stereochemistry
Epoxidation
Cyclization
Cytotoxicity
59 Citations (Scopus)

Enantioselective total synthesis of (+)- and (-)-nigellamine A2

Bian, J., Van Wingerden, M. & Ready, J. M., Jun 14 2006, In : Journal of the American Chemical Society. 128, 23, p. 7428-7429 2 p.

Research output: Contribution to journalArticle

Alkaloids
Stereochemistry
Epoxidation
Diterpenes
Cyclization
120 Citations (Scopus)

Evolution of a synthetic strategy: Total synthesis of (±)- welwitindolinone A isonitrile

Reisman, S. E., Ready, J. M., Weiss, M. M., Hasuoka, A., Hirata, M., Tamaki, K., Ovaska, T. V., Smith, C. J. & Wood, J. L., Feb 13 2008, In : Journal of the American Chemical Society. 130, 6, p. 2087-2100 14 p.

Research output: Contribution to journalArticle

Cyclization
Cycloaddition
Chlorine
Cycloaddition Reaction
Biological Products
306 Citations (Scopus)

Highly active oligomeric (salen)Co catalysts for asymmetric epoxide ring-opening reactions

Ready, J. M. & Jacobsen, E. N., 2001, In : Journal of the American Chemical Society. 123, 11, p. 2687-2688 2 p.

Research output: Contribution to journalArticle

Epoxy Compounds
Catalysts
disalicylaldehyde ethylenediamine
25 Citations (Scopus)

Identification of DNMT1 selective antagonists using a novel scintillation proximity assay

Kilgore, J. A., Du, X., Melito, L., Wei, S., Wang, C., Chin, H. G., Posner, B., Pradhan, S., Ready, J. M. & Williams, N. S., Jul 5 2013, In : Journal of Biological Chemistry. 288, 27, p. 19673-19684 12 p.

Research output: Contribution to journalArticle

Methyltransferases
Scintillation
Assays
Catalase
DNA
10 Citations (Scopus)

Inhibiting pyrimidine biosynthesis impairs Ebola virus replication through depletion of nucleoside pools and activation of innate immune responses

Luthra, P., Naidoo, J., Pietzsch, C. A., De, S., Khadka, S., Anantpadma, M., Williams, C. G., Edwards, M. R., Davey, R. A., Bukreyev, A., Ready, J. M. & Basler, C. F., Oct 1 2018, In : Antiviral Research. 158, p. 288-302 15 p.

Research output: Contribution to journalArticle

Ebolavirus
Virus Replication
Nucleosides
Innate Immunity
brequinar
85 Citations (Scopus)

Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration

Zhang, Y., Desai, A., Yang, S. Y., Bae, K. B., Antczak, M. I., Fink, S. P., Tiwari, S., Willis, J. E., Williams, N. S., Dawson, D. M., Wald, D., Chen, W. D., Wang, Z., Kasturi, L., Larusch, G. A., He, L., Cominelli, F., Di Martino, L., Djuric, Z., Milne, G. L. & 12 others, Chance, M., Sanabria, J., Dealwis, C., Mikkola, D., Naidoo, J., Wei, S., Tai, H. H., Gerson, S. L., Ready, J. M., Posner, B., Willson, J. K. V. & Markowitz, S. D., Jun 12 2015, In : Science. 348, 6240, 2340.

Research output: Contribution to journalArticle

15-hydroxyprostaglandin dehydrogenase
Prostaglandins
Regeneration
Enzymes
Dinoprostone
6 Citations (Scopus)

Inhibitors of 15-Prostaglandin Dehydrogenase To Potentiate Tissue Repair

Antczak, M. I., Zhang, Y., Wang, C., Doran, J., Naidoo, J., Voruganti, S., Williams, N. S., Markowitz, S. D. & Ready, J. M., May 11 2017, In : Journal of Medicinal Chemistry. 60, 9, p. 3979-4001 23 p.

Research output: Contribution to journalArticle

Prostaglandin Antagonists
Dinoprostone
Prostaglandins
Oxidoreductases
Regeneration
41 Citations (Scopus)

In silico derived small molecules bind the filovirus VP35 protein and inhibit its polymerase cofactor activity

Brown, C. S., Lee, M. S., Leung, D. W., Wang, T., Xu, W., Luthra, P., Anantpadma, M., Shabman, R. S., Melito, L. M., Macmillan, K. S., Borek, D. M., Otwinowski, Z., Ramanan, P., Stubbs, A. J., Peterson, D. S., Binning, J. M., Tonelli, M., Olson, M. A., Davey, R. A., Ready, J. M. & 2 others, Basler, C. F. & Amarasinghe, G. K., May 15 2014, In : Journal of Molecular Biology. 426, 10, p. 2045-2058 14 p.

Research output: Contribution to journalArticle

Viral Proteins
Computer Simulation
Ebolavirus
Nucleoproteins
Proteins
90 Citations (Scopus)

Iron-catalyzed carbometalation of propargylic and homopropargylic alcohols

Zhang, D. & Ready, J. M., Nov 29 2006, In : Journal of the American Chemical Society. 128, 47, p. 15050-15051 2 p.

Research output: Contribution to journalArticle

Alkynes
Alcohols
Iron
Bromosuccinimide
Regioselectivity
74 Citations (Scopus)

Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis

Tesla, R., Wolf, H., Xu, P., Drawbridge, J., Estill, S., Huntington, P., McDaniel, L., Knobbe, W., Burket, A., Tran, S., Starwalt, R., Morlock, L., Naidoo, J., Williams, N. S., Ready, J. M., McKnight, S. L. & Pieper, A. A., Oct 16 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 42, p. 17016-17021 6 p.

Research output: Contribution to journalArticle

Carbazoles
Amyotrophic Lateral Sclerosis
Cell Death
Rotarod Performance Test
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
76 Citations (Scopus)

Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease

De Jesús-Cort́es, H., Xu, P., Drawbridge, J., Estill, S. J., Huntington, P., Tran, S., Britt, J., Tesla, R., Morlock, L., Naidoo, J., Melito, L. M., Wang, G., Williams, N. S., Ready, J. M., McKnight, S. L. & Pieper, A. A., Oct 16 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 42, p. 17010-17015 6 p.

Research output: Contribution to journalArticle

Carbazoles
Dentate Gyrus
Parkinson Disease
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Dopaminergic Neurons
3 Citations (Scopus)

On the rapid oxidation of allene-containing phosphines

Cai, F., Thangada, N. D., Pan, E. & Ready, J. M., Oct 14 2013, In : Organometallics. 32, 19, p. 5619-5622 4 p.

Research output: Contribution to journalArticle

Phosphines
phosphines
Oxidation
oxidation
zwitterions
2 Citations (Scopus)

Optically active allenes from an allylic substitution/isomerization sequence

Zhang, W. & Ready, J. M., Dec 2013, In : ChemCatChem. 5, 12, p. 3497-3498 2 p.

Research output: Contribution to journalArticle

alkylation
Alkylation
Isomerization
isomerization
Hydrogen
38 Citations (Scopus)

P7C3 and an unbiased approach to drug discovery for neurodegenerative diseases

Pieper, A. A., McKnight, S. L. & Ready, J. M., 2014, In : Chemical Society Reviews. 43, 19, p. 6716-6726 11 p.

Research output: Contribution to journalArticle

Neurodegenerative diseases
Brain
Derivatives
Molecules
Pharmaceutical Preparations
57 Citations (Scopus)

P7C3 neuroprotective chemicals block axonal degeneration and preserve function after traumatic brain injury

Yin, T. C., Britt, J. K., De Jesús-Cortés, H., Lu, Y., Genova, R. M., Khan, M. Z., Voorhees, J. R., Shao, J., Katzman, A. C., Huntington, P. J., Wassink, C., McDaniel, L., Newell, E. A., Dutca, L. M., Naidoo, J., Cui, H., Bassuk, A. G., Harper, M. M., McKnight, S. L., Ready, J. M. & 1 others, Pieper, A. A., Sep 25 2014, In : Cell Reports. 8, 6, p. 1731-1740 10 p.

Research output: Contribution to journalArticle

Cell death
Brain
Cell Death
Hope
Carbazoles
97 Citations (Scopus)

P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage

Wang, G., Han, T., Nijhawan, D., Theodoropoulos, P., Naidoo, J., Yadavalli, S., Mirzaei, H., Pieper, A. A., Ready, J. M. & McKnight, S. L., Sep 11 2014, In : Cell. 158, 6, p. 1324-1334 11 p.

Research output: Contribution to journalArticle

Salvaging
Nicotinamide Phosphoribosyltransferase
NAD
Enzymes
Doxorubicin
32 Citations (Scopus)

Palladium Catalyzed Asymmetric Three-Component Coupling of Boronic Esters, Indoles, and Allylic Acetates

Panda, S. & Ready, J. M., May 3 2017, In : Journal of the American Chemical Society. 139, 17, p. 6038-6041 4 p.

Research output: Contribution to journalArticle

Indoles
Regioselectivity
Palladium
Esters
Acetates
29 Citations (Scopus)

Pharmacologic rescue of motor and sensory function by the neuroprotective compound P7C3 following neonatal nerve injury

Kemp, S. W. P., Szynkaruk, M., Stanoulis, K. N., Wood, M. D., Liu, E. H., Willand, M. P., Morlock, L., Naidoo, J., Williams, N. S., Ready, J. M., Mangano, T. J., Beggs, S., Salter, M. W., Gordon, T., Pieper, A. A. & Borschel, G. H., Jan 2 2015, In : Neuroscience. 284, p. 202-216 15 p.

Research output: Contribution to journalArticle

Wounds and Injuries
Neuroprotective Agents
Nerve Crush
Peripheral Nerve Injuries
Hypesthesia
39 Citations (Scopus)

Preparation of substituted enol derivatives from terminal alkynes and their synthetic utility

DeBergh, J. R., Spivey, K. M. & Ready, J. M., Jun 25 2008, In : Journal of the American Chemical Society. 130, 25, p. 7828-7829 2 p.

Research output: Contribution to journalArticle

Alkynes
Aldehydes
Amination
Alkenes
Derivatives
6 Citations (Scopus)

Prostaglandin dehydrogenase is a target for successful induction of cervical ripening

Kishore, A. H., Liang, H., Kanchwala, M., Xing, C., Ganesh, T., Akgul, Y., Posner, B., Ready, J. M., Markowitz, S. D. & Word, R. A., Aug 1 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 31, p. E6427-E6436

Research output: Contribution to journalArticle

Cervical Ripening
Dinoprostone
Prostaglandins
Oxidoreductases
Cervix Uteri
20 Citations (Scopus)

Rhodium-Catalyzed Enantioselective Radical Addition of CX4 Reagents to Olefins

Chen, B., Fang, C., Liu, P. & Ready, J. M., Jul 17 2017, In : Angewandte Chemie - International Edition. 56, 30, p. 8780-8784 5 p.

Research output: Contribution to journalArticle

Bromine
Rhodium
Alkenes
Bromides
Catalysis
1 Citation (Scopus)

Science at the interface of chemistry and biology at the University of Texas Southwestern Medical Center

Ready, J. M. & Lynch, K. W., Aug 2007, In : ACS Chemical Biology. 2, 8, p. 512-514 3 p.

Research output: Contribution to journalArticle

Graduate Education
Research

Selective Synthesis of (+)-Dysoline

Coffin, A. & Ready, J. M., Feb 1 2019, In : Organic Letters. 21, 3, p. 648-651 4 p.

Research output: Contribution to journalArticle

Chromones
alkaloids
piperidine
nucleophiles
stereochemistry
8 Citations (Scopus)

Structure elucidation of nigricanoside A through enantioselective total synthesis

Chen, J., Koswatta, P., DeBergh, J. R., Fu, P., Pan, E., MacMillan, J. B. & Ready, J. M., May 1 2015, In : Chemical Science. 6, 5, p. 2932-2937 6 p.

Research output: Contribution to journalArticle

Stereochemistry
Cytotoxicity
Algae
Bioactivity
Biological Products