• 43147 Citations
  • 98 h-Index
1978 …2020

Research output per year

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Research Output

2020

Circadian control of interferon-sensitive gene expression in murine skin

Greenberg, E. N., Marshall, M. E., Jin, S., Venkatesh, S., Dragan, M., Tsoi, L. C., Gudjonsson, J. E., Nie, Q., Takahashi, J. S. & Andersen, B., Mar 17 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 11, p. 5761-5771 11 p.

Research output: Contribution to journalArticle

Open Access

Noise-driven cellular heterogeneity in circadian periodicity

Li, Y., Shan, Y., Desai, R. V., Cox, K. H., Weinberger, L. S. & Takahashi, J. S., May 12 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 19, p. 10350-10356 7 p.

Research output: Contribution to journalArticle

Open Access
2019

A Hyperkinetic Redox Sensor Drives Flies to Sleep

Xu, P., Cox, K. H. & Takahashi, J. S., Jan 1 2019, In : Trends in Neurosciences.

Research output: Contribution to journalShort survey

1 Scopus citations

A novel mouse model overexpressing Nocturnin results in decreased fat mass in male mice

Le, P. T., Bornstein, S. A., Motyl, K. J., Tian, L., Stubblefield, J. J., Hong, H. K., Takahashi, J. S., Green, C. B., Rosen, C. J. & Guntur, A. R., Nov 1 2019, In : Journal of Cellular Physiology. 234, 11, p. 20228-20239 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

A novel mutation in Slc2a4 as a mouse model of fatigue

de Groot, M. H. M., Castorena, C. M., Cox, K. H., Kumar, V., Mohawk, J. A., Ahmed, N. I. & Takahashi, J. S., Jan 1 2019, In : Genes, Brain and Behavior. e12578.

Research output: Contribution to journalArticle

Chemical and structural analysis of a photoactive vertebrate cryptochrome from pigeon

Zoltowski, B. D., Chelliah, Y., Wickramaratne, A., Jarocha, L., Karki, N., Xu, W., Mouritsen, H., Hore, P. J., Hibbs, R. E., Green, C. B. & Takahashi, J. S., Sep 24 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 39, p. 19449-19457 9 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Circadian clock genes and the transcriptional architecture of the clock mechanism

Cox, K. H. & Takahashi, J. S., Nov 2019, In : Journal of Molecular Endocrinology. 63, 4, p. R93-R102

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Genetic analysis of activity, brain and behavioral associations in extended families with heavy genetic loading for bipolar disorder

Vreeker, A., Fears, S. C., Service, S. K., Pagani, L., Takahashi, J. S., Araya, C., Araya, X., Bejarano, J., Lopez, M. C., Montoya, G., Montoya, C. P., Teshiba, T. M., Escobar, J., Cantor, R. M., López-Jaramillo, C., MacAya, G., Molina, J., Reus, V. I., Sabatti, C., Ophoff, R. A. & 2 others, Freimer, N. B. & Bearden, C. E., Jan 1 2019, (Accepted/In press) In : Psychological Medicine.

Research output: Contribution to journalArticle

Genomics of circadian rhythms in health and disease

Rijo-Ferreira, F. & Takahashi, J. S., Dec 17 2019, In : Genome Medicine. 11, 1, 82.

Research output: Contribution to journalReview article

Open Access
2 Scopus citations

Medicine in the Fourth Dimension

Cederroth, C. R., Albrecht, U., Bass, J., Brown, S. A., Dyhrfjeld-Johnsen, J., Gachon, F., Green, C. B., Hastings, M. H., Helfrich-Förster, C., Hogenesch, J. B., Lévi, F., Loudon, A., Lundkvist, G. B., Meijer, J. H., Rosbash, M., Takahashi, J. S., Young, M. & Canlon, B., Aug 6 2019, In : Cell Metabolism. 30, 2, p. 238-250 13 p.

Research output: Contribution to journalReview article

19 Scopus citations

Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge

Nohara, K., Mallampalli, V., Nemkov, T., Wirianto, M., Yang, J., Ye, Y., Sun, Y., Han, L., Esser, K. A., Mileykovskaya, E., D’Alessandro, A., Green, C. B., Takahashi, J. S., Dowhan, W., Yoo, S. H. & Chen, Z., Dec 1 2019, In : Nature communications. 10, 1, 3923.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Tissue-specific BMAL1 cistromes reveal that rhythmic transcription is associated with rhythmic enhancer–enhancer interactions

Beytebiere, J. R., Trott, A. J., Greenwell, B. J., Osborne, C. A., Vitet, H., Spence, J., Yoo, S. H., Chen, Z., Takahashi, J. S., Ghaffari, N. & Menet, J. S., Mar 1 2019, In : Genes and Development. 33, 5-6, p. 294-309 16 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

Tissue-specific FAH deficiency alters sleep-wake patterns and results in chronic tyrosinemia in mice

Yang, S., Siepka, S. M., Cox, K. H., Kumar, V., De Groot, M., Chelliah, Y., Chen, J., Tu, B. & Takahashi, J. S., Oct 29 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 44, p. 22229-22236 8 p.

Research output: Contribution to journalArticle

Open Access

Transcriptional Basis for Rhythmic Control of Hunger and Metabolism within the AgRP Neuron

Cedernaes, J., Huang, W., Ramsey, K. M., Waldeck, N., Cheng, L., Marcheva, B., Omura, C., Kobayashi, Y., Peek, C. B., Levine, D. C., Dhir, R., Awatramani, R., Bradfield, C. A., Wang, X. A., Takahashi, J. S., Mokadem, M., Ahima, R. S. & Bass, J., May 7 2019, In : Cell Metabolism. 29, 5, p. 1078-1091.e5

Research output: Contribution to journalArticle

12 Scopus citations
2018

An evolutionary hotspot defines functional differences between CRYPTOCHROMES

Rosensweig, C., Reynolds, K. A., Gao, P., Laothamatas, I., Shan, Y., Ranganathan, R., Takahashi, J. S. & Green, C. B., Dec 1 2018, In : Nature Communications. 9, 1, 1138.

Research output: Contribution to journalArticle

17 Scopus citations

Cell-Autonomous Regulation of Astrocyte Activation by the Circadian Clock Protein BMAL1

Lananna, B. V., Nadarajah, C. J., Izumo, M., Cedeño, M. R., Xiong, D. D., Dimitry, J., Tso, C. F., McKee, C. A., Griffin, P., Sheehan, P. W., Haspel, J. A., Barres, B. A., Liddelow, S. A., Takahashi, J. S., Karatsoreos, I. N. & Musiek, E. S., Oct 2 2018, In : Cell Reports. 25, 1, p. 1-9.e5

Research output: Contribution to journalArticle

15 Scopus citations

Development and Therapeutic Potential of Small-Molecule Modulators of Circadian Systems

Chen, Z., Yoo, S. H. & Takahashi, J. S., Jan 6 2018, In : Annual Review of Pharmacology and Toxicology. 58, p. 231-252 22 p.

Research output: Contribution to journalReview article

31 Scopus citations

Mean-variance QTL mapping identifies novel QTL for circadian activity and exploratory behavior in mice

Corty, R. W., Kumar, V., Tarantino, L. M., Takahashi, J. S. & Valdar, W., Dec 1 2018, In : G3: Genes, Genomes, Genetics. 8, 12, p. 3783-3790 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Sleeping sickness is a circadian disorder

Rijo-Ferreira, F., Carvalho, T., Afonso, C., Sanches-Vaz, M., Costa, R. M., Figueiredo, L. M. & Takahashi, J. S., Dec 1 2018, In : Nature Communications. 9, 1, 02484.

Research output: Contribution to journalArticle

24 Scopus citations

The Genomic Landscape and Pharmacogenomic Interactions of Clock Genes in Cancer Chronotherapy

Ye, Y., Xiang, Y., Ozguc, F. M., Kim, Y., Liu, C. J., Park, P. K., Hu, Q., Diao, L., Lou, Y., Lin, C., Guo, A. Y., Zhou, B., Wang, L., Chen, Z., Takahashi, J. S., Mills, G. B., Yoo, S. H. & Han, L., Jan 1 2018, (Accepted/In press) In : Cell Systems.

Research output: Contribution to journalArticle

28 Scopus citations
2017

An actigraphy study investigating sleep in bipolar I patients, unaffected siblings and controls

Verkooijen, S., van Bergen, A. H., Knapen, S. E., Vreeker, A., Abramovic, L., Pagani, L., Jung, Y., Riemersma-van der Lek, R., Schoevers, R. A., Takahashi, J. S., Kahn, R. S., Boks, M. P. M. & Ophoff, R. A., Jan 15 2017, In : Journal of affective disorders. 208, p. 248-254 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Bmal1 function in skeletal muscle regulates sleep

Ehlen, J. C., Brager, A. J., Baggs, J., Pinckney, L., Gray, C. L., DeBruyne, J. P., Esser, K. A., Takahashi, J. S. & Paul, K. N., Jul 20 2017, In : eLife. 6, e26557.

Research output: Contribution to journalArticle

32 Scopus citations

Circadian rhythms in parasites

Rijo-Ferreira, F., Takahashi, J. S. & Figueiredo, L. M., Oct 1 2017, In : PLoS Pathogens. 13, 10, e1006590.

Research output: Contribution to journalReview article

6 Scopus citations

Enriching the Circadian Proteome

Takahashi, J. S., Jan 10 2017, In : Cell Metabolism. 25, 1, p. 1-2 2 p.

Research output: Contribution to journalShort survey

1 Scopus citations

Foreword

Takahashi, J. S., Jan 1 2017, Biological Timekeeping: Clocks, Rhythms and Behaviour. Springer (India) Private Ltd., p. vii-viii

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

Formation of a repressive complex in the mammalian circadian clock is mediated by the secondary pocket of CRY1

Michael, A. K., Fribourgh, J. L., Chelliah, Y., Sandate, C. R., Hura, G. L., Schneidman-Duhovny, D., Tripathi, S. M., Takahashi, J. S. & Partch, C. L., Feb 14 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 7, p. 1560-1565 6 p.

Research output: Contribution to journalArticle

26 Scopus citations

Guidelines for Genome-Scale Analysis of Biological Rhythms

Hughes, M. E., Abruzzi, K. C., Allada, R., Anafi, R., Arpat, A. B., Asher, G., Baldi, P., de Bekker, C., Bell-Pedersen, D., Blau, J., Brown, S., Ceriani, M. F., Chen, Z., Chiu, J. C., Cox, J., Crowell, A. M., DeBruyne, J. P., Dijk, D. J., DiTacchio, L., Doyle, F. J. & 73 others, Duffield, G. E., Dunlap, J. C., Eckel-Mahan, K., Esser, K. A., FitzGerald, G. A., Forger, D. B., Francey, L. J., Fu, Y. H., Gachon, F., Gatfield, D., de Goede, P., Golden, S. S., Green, C., Harer, J., Harmer, S., Haspel, J., Hastings, M. H., Herzel, H., Herzog, E. D., Hoffmann, C., Hong, C., Hughey, J. J., Hurley, J. M., de la Iglesia, H. O., Johnson, C., Kay, S. A., Koike, N., Kornacker, K., Kramer, A., Lamia, K., Leise, T., Lewis, S. A., Li, J., Li, X., Liu, A. C., Loros, J. J., Martino, T. A., Menet, J. S., Merrow, M., Millar, A. J., Mockler, T., Naef, F., Nagoshi, E., Nitabach, M. N., Olmedo, M., Nusinow, D. A., Ptáček, L. J., Rand, D., Reddy, A. B., Robles, M. S., Roenneberg, T., Rosbash, M., Ruben, M. D., Rund, S. S. C., Sancar, A., Sassone-Corsi, P., Sehgal, A., Sherrill-Mix, S., Skene, D. J., Storch, K. F., Takahashi, J. S., Ueda, H. R., Wang, H., Weitz, C., Westermark, P. O., Wijnen, H., Xu, Y., Wu, G., Yoo, S. H., Young, M., Zhang, E. E., Zielinski, T. & Hogenesch, J. B., Oct 1 2017, In : Journal of Biological Rhythms. 32, 5, p. 380-393 14 p.

Research output: Contribution to journalArticle

44 Scopus citations

HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections

Sun, L., Jiang, Z., Acosta-Rodriguez, V. A., Berger, M., Du, X., Choi, J. H., Wang, J., Wang, K. W., Kilaru, G. K., Mohawk, J. A., Quan, J., Scott, L., Hildebrand, S., Li, X., Tang, M., Zhan, X., Murray, A. R., Vine, D. L., Moresco, E. M. Y., Takahashi, J. S. & 1 others, Beutler, B., Nov 1 2017, In : Journal of Experimental Medicine. 214, 11, p. 3263-3277 15 p.

Research output: Contribution to journalArticle

8 Scopus citations

HDAC5 and Its Target Gene, Npas4, Function in the Nucleus Accumbens to Regulate Cocaine-Conditioned Behaviors

Taniguchi, M., Carreira, M. B., Cooper, Y. A., Bobadilla, A. C., Heinsbroek, J. A., Koike, N., Larson, E. B., Balmuth, E. A., Hughes, B. W., Penrod, R. D., Kumar, J., Smith, L. N., Guzman, D., Takahashi, J. S., Kim, T. K., Kalivas, P. W., Self, D. W., Lin, Y. & Cowan, C. W., Sep 27 2017, In : Neuron. 96, 1, p. 130-144 15 p.

Research output: Contribution to journalArticle

29 Scopus citations

Mice under Caloric Restriction Self-Impose a Temporal Restriction of Food Intake as Revealed by an Automated Feeder System

Acosta-Rodríguez, V. A., de Groot, M. H. M., Rijo-Ferreira, F., Green, C. B. & Takahashi, J. S., Jul 5 2017, In : Cell Metabolism. 26, 1, p. 267-277.e2

Research output: Contribution to journalArticle

45 Scopus citations

Novel transcriptional networks regulated by clock in human neurons

Fontenot, M. R., Berto, S., Liu, Y., Werthmann, G., Douglas, C., Usu, N., Gleason, K., Tamminga, C. A., Takahashi, J. S. & Konopka, G., Nov 1 2017, In : Genes and Development. 31, 21, p. 2121-2135 15 p.

Research output: Contribution to journalArticle

8 Scopus citations

Period2 3′-UTR and microRNA-24 regulate circadian rhythms by repressing PERIOD2 protein accumulation

Yoo, S. H., Kojima, S., Shimomura, K., Koike, N., Buhr, E. D., Furukawa, T., Ko, C. H., Gloston, G., Ayoub, C., Nohara, K., Reyes, B. A., Tsuchiya, Y., Yoo, O. J., Yagita, K., Lee, C., Chen, Z., Yamazaki, S., Green, C. B. & Takahashi, J. S., Oct 17 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 42, p. E8855-E8864

Research output: Contribution to journalArticle

17 Scopus citations

Time-Restricted Feeding Shifts the Skin Circadian Clock and Alters UVB-Induced DNA Damage

Wang, H., van Spyk, E., Liu, Q., Geyfman, M., Salmans, M. L., Kumar, V., Ihler, A., Li, N., Takahashi, J. S. & Andersen, B., Aug 1 2017, In : Cell Reports. 20, 5, p. 1061-1072 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Transcriptional architecture of the mammalian circadian clock

Takahashi, J. S., Mar 1 2017, In : Nature Reviews Genetics. 18, 3, p. 164-179 16 p.

Research output: Contribution to journalReview article

403 Scopus citations

Trypanosoma brucei metabolism is under circadian control

Rijo-Ferreira, F., Pinto-Neves, D., Barbosa-Morais, N. L., Takahashi, J. S. & Figueiredo, L. M., Mar 13 2017, In : Nature Microbiology. 2, 17032.

Research output: Contribution to journalArticle

22 Scopus citations
2016

Circadian oscillations of NADH redox state using a heterologous metabolic sensor in mammalian cells

Huang, G., Zhang, Y., Shan, Y., Yang, S., Chelliah, Y., Wang, H. & Takahashi, J. S., Nov 11 2016, In : Journal of Biological Chemistry. 291, 46, p. 23906-23914 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Forward-genetics analysis of sleep in randomly mutagenized mice

Funato, H., Miyoshi, C., Fujiyama, T., Kanda, T., Sato, M., Wang, Z., Ma, J., Nakane, S., Tomita, J., Ikkyu, A., Kakizaki, M., Hotta-Hirashima, N., Kanno, S., Komiya, H., Asano, F., Honda, T., Kim, S. J., Harano, K., Muramoto, H., Yonezawa, T. & 17 others, Mizuno, S., Miyazaki, S., Connor, L., Kumar, V., Miura, I., Suzuki, T., Watanabe, A., Abe, M., Sugiyama, F., Takahashi, S., Sakimura, K., Hayashi, Y., Liu, Q., Kume, K., Wakana, S., Takahashi, J. S. & Yanagisawa, M., 2016, In : Nature. 539, 7629, p. 378-383 6 p.

Research output: Contribution to journalArticle

75 Scopus citations

Genetic contributions to circadian activity rhythm and sleep pattern phenotypes in pedigrees segregating for severe bipolar disorder

Pagani, L., Clair, P. A. S., Teshiba, T. M., Service, S. K., Fears, S. C., Araya, C., Araya, X., Bejarano, J., Ramirez, M., Castrillón, G., Gomez-Makhinson, J., Lopez, M. C., Montoya, G., Montoya, C. P., Aldana, I., Navarro, L., Freimer, D. G., Safaie, B., Keung, L. W., Greenspan, K. & 14 others, Chou, K., Escobar, J. I., Ospina-Duque, J., Kremeyer, B., Ruiz-Linares, A., Cantor, R. M., Lopez-Jaramillo, C., Macaya, G., Molina, J., Reus, V. I., Sabatti, C., Bearden, C. E., Takahashi, J. S. & Freimer, N. B., Feb 9 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 6, p. E754-E761

Research output: Contribution to journalArticle

34 Scopus citations

Identification of mutations through dominant screening for obesity using C57BL/6 substrains

Hossain, M. S., Asano, F., Fujiyama, T., Miyoshi, C., Sato, M., Ikkyu, A., Kanno, S., Hotta, N., Kakizaki, M., Honda, T., Kim, S. J., Komiya, H., Miura, I., Suzuki, T., Kobayashi, K., Kaneda, H., Kumar, V., Takahashi, J. S., Wakana, S., Funato, H. & 1 others, Yanagisawa, M., Sep 2 2016, In : Scientific Reports. 6, 32453.

Research output: Contribution to journalArticle

5 Scopus citations

Loss of ZBTB20 impairs circadian output and leads to unimodal behavioral rhythms

Qu, Z., Zhang, H., Huang, M., Shi, G., Liu, Z., Xie, P., Li, H., Wang, W., Xu, G., Zhang, Y., Yang, L., Huang, G., Takahashi, J. S., Zhang, W. J. & Xu, Y., Sep 22 2016, In : eLife. 5, September, e17171.

Research output: Contribution to journalArticle

10 Scopus citations
9 Scopus citations

Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies

Lee, W. H., Higuchi, H., Ikeda, S., Macke, E. L., Takimoto, T., Pattnaik, B. R., Liu, C., Chu, L. F., Siepka, S. M., Krentz, K. J., Rubinstein, C. D., Kalejta, R. F., Thomson, J. A., Mullins, R. F., Takahashi, J. S., Pinto, L. H. & Ikeda, A., Nov 15 2016, In : eLife. 5, November 2016, e19264.

Research output: Contribution to journalArticle

17 Scopus citations

The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome

He, B., Nohara, K., Park, N., Park, Y. S., Guillory, B., Zhao, Z., Garcia, J. M., Koike, N., Lee, C. C., Takahashi, J. S., Yoo, S. H. & Chen, Z., Apr 12 2016, In : Cell Metabolism. 23, 4, p. 610-621 12 p.

Research output: Contribution to journalArticle

125 Scopus citations
2015

A tunable artificial circadian clock in clock-defective mice

D'Alessandro, M., Beesley, S., Kim, J. K., Chen, R., Abich, E., Cheng, W., Yi, P., Takahashi, J. S. & Lee, C., Nov 30 2015, In : Nature communications. 6, 8587.

Research output: Contribution to journalArticle

24 Scopus citations

In Vivo Single-Cell Detection of Metabolic Oscillations in Stem Cells

Stringari, C., Wang, H., Geyfman, M., Crosignani, V., Kumar, V., Takahashi, J. S., Andersen, B. & Gratton, E., Jan 6 2015, In : Cell Reports. 10, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

57 Scopus citations

Molecular components of the circadian clock in mammals

Takahashi, J. S., Sep 1 2015, In : Diabetes, Obesity and Metabolism. 17, S1, p. 6-11 6 p.

Research output: Contribution to journalArticle

88 Scopus citations

Neuromedin s-producing neurons act as essential pacemakers in the suprachiasmatic nucleus to couple clock neurons and dictate circadian rhythms

Lee, I. T., Chang, A. S., Manandhar, M., Shan, Y., Fan, J., Izumo, M., Ikeda, Y., Motoike, T., Dixon, S., Seinfeld, J. E., Takahashi, J. S. & Yanagisawa, M., Mar 4 2015, In : Neuron. 85, 5, p. 1086-1102 17 p.

Research output: Contribution to journalArticle

70 Scopus citations

The circadian clock in skin: Implications for adult stem cells, tissue regeneration, cancer, aging, and immunity

Plikus, M. V., Van Spyk, E. N., Pham, K., Geyfman, M., Kumar, V., Takahashi, J. S. & Andersen, B., Jun 4 2015, In : Journal of Biological Rhythms. 30, 3, p. 163-182 20 p.

Research output: Contribution to journalArticle

61 Scopus citations
26 Scopus citations