• 21867 Citations
  • 48 h-Index
19982020

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Article
2020

Antisense-Mediated Transcript Knockdown Triggers Premature Transcription Termination

Lee, J. S. & Mendell, J. T., Mar 5 2020, In : Molecular cell. 77, 5, p. 1044-1054.e3

Research output: Contribution to journalArticle

9 Scopus citations

Loss of CHD1 Promotes Heterogeneous Mechanisms of Resistance to AR-Targeted Therapy via Chromatin Dysregulation

Zhang, Z., Zhou, C., Li, X., Barnes, S. D., Deng, S., Hoover, E., Chen, C. C., Lee, Y. S., Zhang, Y., Wang, C., Metang, L. A., Wu, C., Tirado, C. R., Johnson, N. A., Wongvipat, J., Navrazhina, K., Cao, Z., Choi, D., Huang, C. H., Linton, E. & 12 others, Chen, X., Liang, Y., Mason, C. E., de Stanchina, E., Abida, W., Lujambio, A., Li, S., Lowe, S. W., Mendell, J. T., Malladi, V. S., Sawyers, C. L. & Mu, P., Apr 13 2020, In : Cancer Cell. 37, 4, p. 584-598.e11

Research output: Contribution to journalArticle

Ribosome Recycling by ABCE1 Links Lysosomal Function and Iron Homeostasis to 3ʹ UTR-Directed Regulation and Nonsense-Mediated Decay

Zhu, X., Zhang, H. & Mendell, J. T., Jul 14 2020, In : Cell Reports. 32, 2, 107895.

Research output: Contribution to journalArticle

Open Access
2019

MIR205HG Is a Long Noncoding RNA that Regulates Growth Hormone and Prolactin Production in the Anterior Pituitary

Du, Q., Hoover, A. R., Dozmorov, I., Raj, P., Khan, S., Molina, E., Chang, T. C., de la Morena, M. T., Cleaver, O. B., Mendell, J. T. & van Oers, N. S. C., May 20 2019, In : Developmental cell. 49, 4, p. 618-631.e5

Research output: Contribution to journalArticle

6 Scopus citations

MiR-26 suppresses adipocyte progenitor differentiation and fat production by targeting Fbxl19

Acharya, A., Berry, D. C., Zhang, H., Jiang, Y., Jones, B. T., Hammer, R. E., Graff, J. M. & Mendell, J. T., Oct 1 2019, In : Genes and Development. 33, 19-20, p. 1367-1380 14 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

PUMILIO, but not RBMX, binding is required for regulation of genomic stability by noncoding RNA NORAD

Elguindy, M. M., Kopp, F., Goodarzi, M., Rehfeld, F., Thomas, A., Chang, T. C. & Mendell, J. T., Jul 1 2019, In : eLife. 8, e48625.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

PUMILIO hyperactivity drives premature aging of norad-deficient mice

Kopp, F., Elguindy, M. M., Yalvac, M. E., Zhang, H., Chen, B., Gillett, F. A., Lee, S., Sivakumar, S., Yu, H., Xie, Y., Mishra, P., Sahenk, Z. & Mendell, J. T., Feb 2019, In : eLife. 8, e42650.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Suppression of Ribosomal Pausing by eIF5A Is Necessary to Maintain the Fidelity of Start Codon Selection

Manjunath, H., Zhang, H., Rehfeld, F., Han, J., Chang, T. C. & Mendell, J. T., Dec 3 2019, In : Cell Reports. 29, 10, p. 3134-3146.e6

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2018

Loss of Dis3l2 partially phenocopies perlman syndrome in mice and results in upregulation of Igf2 in nephron progenitor cells

Hunter, R. W., Liu, Y., Manjunath, H., Acharya, A., Jones, B. T., Zhang, H., Chen, B., Ramalingam, H., Hammer, R. E., Xie, Y., Richardson, J. A., Rakheja, D., Carroll, T. J. & Mendell, J. T., Jul 1 2018, In : Genes and Development. 32, 13-14, p. 903-908 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Mutations in microRNA processing genes in wilms tumors derepress the IGF2 regulator PLAG1

Chen, K., Stroup, E. K., Budhipramono, A., Rakheja, D., Nichols-Vinueza, D., Xu, L., Stuart, S. H., Shukla, A. A., Fraire, C., Mendell, J. T. & Amatruda, J. F., Aug 1 2018, In : Genes and Development. 32, 15-16, p. 996-1007 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Safety and Efficacy of AAV Retrograde Pancreatic Ductal Gene Delivery in Normal and Pancreatic Cancer Mice

Quirin, K. A., Kwon, J. J., Alioufi, A., Factora, T., Temm, C. J., Jacobsen, M., Sandusky, G. E., Shontz, K., Chicoine, L. G., Clark, K. R., Mendell, J. T., Korc, M. & Kota, J., Mar 16 2018, In : Molecular Therapy - Methods and Clinical Development. 8, p. 8-20 13 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

An Argonaute phosphorylation cycle promotes microRNA-mediated silencing

Golden, R. J., Chen, B., Li, T., Braun, J., Manjunath, H., Chen, X., Wu, J., Schmid, V., Chang, T. C., Kopp, F., Ramirez-Martinez, A., Tagliabracci, V. S., Chen, Z. J., Xie, Y. & Mendell, J. T., Feb 9 2017, In : Nature. 542, 7640, p. 197-202 6 p.

Research output: Contribution to journalArticle

79 Scopus citations

MicroRNA-29 overexpression by adeno-associated virus suppresses fibrosis and restores muscle function in combination with micro-dystrophin

Heller, K. N., Mendell, J. T., Mendell, J. R. & Rodino-Klapac, L. R., May 4 2017, In : JCI insight. 2, 9

Research output: Contribution to journalArticle

Open Access
8 Scopus citations
2016

Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins

Lee, S., Kopp, F., Chang, T. C., Sataluri, A., Chen, B., Sivakumar, S., Yu, H., Xie, Y. & Mendell, J. T., Jan 14 2016, In : Cell. 164, 1-2, p. 69-80 12 p.

Research output: Contribution to journalArticle

262 Scopus citations

Targeting a long noncoding RNA in breast cancer

Mendell, J. T., Jun 9 2016, In : New England Journal of Medicine. 374, 23, p. 2287-2289 3 p.

Research output: Contribution to journalArticle

76 Scopus citations

Transcriptional regulation of miR-31 by oncogenic KRAS mediates metastatic phenotypes by repressing RASA1

Kent, O. A., Mendell, J. T. & Rottapel, R., Mar 2016, In : Molecular Cancer Research. 14, 3, p. 267-277 11 p.

Research output: Contribution to journalArticle

29 Scopus citations
2015

Genome-wide annotation of microRNA primary transcript structures reveals novel regulatory mechanisms

Chang, T. C., Pertea, M., Lee, S., Salzberg, S. L. & Mendell, J. T., Sep 1 2015, In : Genome Research. 25, 9, p. 1401-1409 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

Identification of miR-145 targets through an integrated omics analysis

Huang, T. C., Renuse, S., Pinto, S., Kumar, P., Yang, Y., Chaerkady, R., Godsey, B., Mendell, J. T., Halushka, M. K., Civin, C. I., Marchionni, L. & Pandey, A., Jan 1 2015, In : Molecular BioSystems. 11, 1, p. 197-207 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Precise let-7 expression levels balance organ regeneration against tumor suppression

Wu, L., Nguyen, L. H., Zhou, K., De Yvanka Soysa, T., Li, L., Miller, J. B., Tian, J., Locker, J., Zhang, S., Shinoda, G., Seligson, M. T., Zeitels, L. R., Acharya, A., Wang, S. C., Mendell, J. T., He, X., Nishino, J., Morrison, S. J., Siegwart, D. J., Daley, G. Q. & 2 others, Shyh-Chang, N. & Zhu, H., Oct 7 2015, In : eLife. 4, OCTOBER2015, e09431.

Research output: Contribution to journalArticle

33 Scopus citations

StringTie enables improved reconstruction of a transcriptome from RNA-seq reads

Pertea, M., Pertea, G. M., Antonescu, C. M., Chang, T. C., Mendell, J. T. & Salzberg, S. L., Feb 2015, In : Nature biotechnology. 33, 3, p. 290-295 6 p.

Research output: Contribution to journalArticle

1345 Scopus citations

Systemic delivery of scAAV8-encoded MiR-29a ameliorates hepatic fibrosis in carbon tetrachloride-treated mice

Knabel, M. K., Ramachandran, K., Karhadkar, S., Hwang, H. W., Creamer, T. J., Chivukula, R. R., Sheikh, F., Clark, K. R., Torbenson, M., Montgomery, R. A., Cameron, A. M., Mendell, J. T. & Warren, D. S., Apr 29 2015, In : PLoS One. 10, 4, e0124411.

Research output: Contribution to journalArticle

24 Scopus citations
2014

An essential mesenchymal function for miR-143/145 in intestinal epithelial regeneration

Chivukula, R. R., Shi, G., Acharya, A., Mills, E. W., Zeitels, L. R., Anandam, J. L., Abdelnaby, A. A., Balch, G. C., Mansour, J. C., Yopp, A. C., Maitra, A. & Mendell, J. T., May 22 2014, In : Cell. 157, 5, p. 1104-1116 13 p.

Research output: Contribution to journalArticle

118 Scopus citations

MiR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2

Krzeszinski, J. Y., Wei, W., Huynh, H., Jin, Z., Wang, X., Chang, T. C., Xie, X. J., He, L., Mangala, L. S., Lopez-Berestein, G., Sood, A. K., Mendell, J. T. & Wan, Y., Aug 28 2014, In : Nature. 512, 7515, p. 431-435 5 p.

Research output: Contribution to journalArticle

222 Scopus citations

PIPE-CLIP: A comprehensive online tool for CLIP-seq data analysis

Chen, B., Yun, J., Kim, M. S., Mendell, J. T. & Xie, Y., Jan 1 2014, In : Genome biology. 15, 1, R18.

Research output: Contribution to journalArticle

60 Scopus citations

Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours

Rakheja, D., Chen, K., Liu, Y., Shukla, A. A., Schmid, V., Chang, T-C., Khokhar, S., Wickiser, J. E., Karandikar, N. J., Malter, J. S., Mendell, J. T. & Amatruda, J. F., Sep 5 2014, In : Nature communications. 2, 4802.

Research output: Contribution to journalArticle

113 Scopus citations

Tumor suppression by miR-26 overrides potential oncogenic activity in intestinal tumorigenesis

Zeitels, L. R., Acharya, A., Shi, G., Chivukula, D., Chivukula, R. R., Anandam, J. L., Abdelnaby, A. A., Balch, G. C., Mansour, J. C., Yopp, A. C., Richardson, J. A. & Mendell, J. T., Dec 1 2014, In : Genes and Development. 28, 23, p. 2585-2590 6 p.

Research output: Contribution to journalArticle

42 Scopus citations
2012

A novel source for miR-21 expression through the alternative polyadenylation of VMP1 gene transcripts

Ribas, J., Ni, X., Castanares, M., Liu, M. M., Esopi, D., Yegnasubramanian, S., Rodriguez, R., Mendell, J. T. & Lupold, S. E., Aug 2012, In : Nucleic acids research. 40, 14, p. 6821-6833 13 p.

Research output: Contribution to journalArticle

58 Scopus citations

Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver

Hsu, S. H., Wang, B., Kota, J., Yu, J., Costinean, S., Kutay, H., Yu, L., Bai, S., Perle, K. L., Chivukula, R. R., Mao, H., Wei, M., Clark, K. R., Mendell, J. R., Caligiuri, M. A., Jacob, S. T., Mendell, J. T. & Ghoshal, K., Aug 1 2012, In : Journal of Clinical Investigation. 122, 8, p. 2871-2883 13 p.

Research output: Contribution to journalArticle

482 Scopus citations
2011

KIT signaling regulates MITF expression through miRNAs in normal and malignant mast cell proliferation

Lee, Y. N., Brandal, S., Noel, P., Wentzel, E., Mendell, J. T., McDevitt, M. A., Kapur, R., Carter, M., Metcalfe, D. D. & Takemoto, C. M., Mar 31 2011, In : Blood. 117, 13, p. 3629-3640 12 p.

Research output: Contribution to journalArticle

46 Scopus citations

Restitution of tumor suppressor microRNAs using a systemic nanovector inhibits pancreatic cancer growth in mice

Pramanik, D., Campbell, N. R., Karikari, C., Chivukula, R., Kent, O. A., Mendell, J. T. & Maitra, A., Aug 2011, In : Molecular Cancer Therapeutics. 10, 8, p. 1470-1480 11 p.

Research output: Contribution to journalArticle

219 Scopus citations

Role of pri-miRNA tertiary structure in miR-17∼92 miRNA biogenesis

Chaulk, S. G., Thede, G. L., Kent, O. A., Xu, Z., Gesner, E. M., Veldhoen, R. A., Khanna, S. K., Goping, I. S., MacMillan, A. M., Mendell, J. T., Young, H. S., Fahlman, R. P. & Glover, J. N. M., Jan 1 2011, In : RNA Biology. 8, 6

Research output: Contribution to journalArticle

59 Scopus citations
2010

Identifying targets of miR-143 using a SILAC-based proteomic approach

Yang, Y., Chaerkady, R., Kandasamy, K., Huang, T. C., Selvan, L. D. N., Dwivedi, S. B., Kent, O. A., Mendell, J. T. & Pandey, A., Oct 1 2010, In : Molecular BioSystems. 6, 10, p. 1873-1882 10 p.

Research output: Contribution to journalArticle

49 Scopus citations

P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis

Yamakuchi, M., Lotterman, C. D., Bao, C., Hruban, R. H., Karim, B., Mendell, J. T., Huso, D. & Lowenstein, C. J., Apr 6 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 14, p. 6334-6339 6 p.

Research output: Contribution to journalArticle

305 Scopus citations

Quantification of global microRNA abundance by selective isotachophoresis

Persat, A., Chivukula, R. R., Mendell, J. T. & Santiago, J. G., Dec 1 2010, In : Analytical chemistry. 82, 23, p. 9631-9635 5 p.

Research output: Contribution to journalArticle

33 Scopus citations

Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathway

Kent, O. A., Chivukula, R. R., Mullendore, M., Wentzel, E. A., Feldmann, G., Lee, K. H., Liu, S., Leach, S. D., Maitra, A. & Mendell, J. T., Dec 15 2010, In : Genes and Development. 24, 24, p. 2754-2759 6 p.

Research output: Contribution to journalArticle

224 Scopus citations
2009

A resource for analysis of microRNA expression and function in pancreatic ductal adenocarcinoma cells

Kent, O. A., Mullendore, M., Wentzel, E. A., López-Romero, P., Tan, A. C., Alvarez, H., West, K., Ochs, M. F., Hidalgo, M., Arking, D. E., Maitra, A. & Mendell, J. T., Nov 1 2009, In : Cancer Biology and Therapy. 8, 21, p. 2013-2024 12 p.

Research output: Contribution to journalArticle

97 Scopus citations

Cell- cell contact globally activates microRNA biogenesis

Hwang, H. W., Wentzel, E. A. & Mendell, J. T., Apr 28 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 17, p. 7016-7021 6 p.

Research output: Contribution to journalArticle

107 Scopus citations

C-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

Gao, P., Tchernyshyov, I., Chang, T. C., Lee, Y. S., Kita, K., Ochi, T., Zeller, K. I., De Marzo, A. M., Van Eyk, J. E., Mendell, J. T. & Dang, C. V., Apr 9 2009, In : Nature. 458, 7239, p. 762-765 4 p.

Research output: Contribution to journalArticle

1241 Scopus citations

Epigenetic silencing of microRNA miR-107 regulates cyclin-dependent kinase 6 expression in pancreatic cancer

Lee, K. H., Lotterman, C., Karikari, C., Omura, N., Feldmann, G., Habbe, N., Goggins, M. G., Mendell, J. T. & Maitra, A., May 2009, In : Pancreatology. 9, 3, p. 293-301 9 p.

Research output: Contribution to journalArticle

172 Scopus citations

Identification of miR-21 targets in breast cancer cells using a quantitative proteomic approach

Yang, Y., Chaerkady, R., Beer, M. A., Mendell, J. T. & Pandey, A., Mar 1 2009, In : Proteomics. 9, 5, p. 1374-1384 11 p.

Research output: Contribution to journalArticle

94 Scopus citations

Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation

Chang, T. C., Zeitels, L. R., Hwang, H. W., Chivukula, R. R., Wentzel, E. A., Dews, M., Jung, J., Gao, P., Dang, C. V., Beer, M. A., Thomas-Tikhonenko, A. & Mendella, J. T., Mar 3 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 9, p. 3384-3389 6 p.

Research output: Contribution to journalArticle

291 Scopus citations

MicroRNA miR-155 is a biomarker of early pancreatic neoplasia

Habbe, N., Koorstra, J. B. M., Mendell, J. T., Offerhaus, G. J., Ji, K. R., Feldmann, G., Mullendore, M. E., Goggins, M. G., Hong, S. M. & Maitra, A., Feb 15 2009, In : Cancer Biology and Therapy. 8, 4, p. 340-346 7 p.

Research output: Contribution to journalArticle

Open Access
242 Scopus citations

miR-21: An androgen receptor-regulated microRNA that promotes hormone-dependent and hormone-independent prostate cancer growth

Ribas, J., Ni, X., Haffner, M., Wentzel, E. A., Salmasi, A. H., Chowdhury, W. H., Kudrolli, T. A., Yegnasubramanian, S., Luo, J., Rodriguez, R., Mendell, J. T. & Lupold, S. E., Oct 13 2009, In : Cancer research. 69, 18, p. 7165-7169 5 p.

Research output: Contribution to journalArticle

315 Scopus citations

Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model

Kota, J., Chivukula, R. R., O'Donnell-Mendell, K. A., Wentzel, E. A., Montgomery, C. L., Hwang, H. W., Chang, T-C., Vivekanandan, P., Torbenson, M., Clark, K. R., Mendell, J. R. & Mendell, J. T., Jun 12 2009, In : Cell. 137, 6, p. 1005-1017 13 p.

Research output: Contribution to journalArticle

1344 Scopus citations
2008

Analysis of regulatory network topology reveals functionally distinct classes of microRNAs

Yu, X., Lin, J., Zack, D. J., Mendell, J. T. & Qian, J., 2008, In : Nucleic acids research. 36, 20, p. 6494-6503 10 p.

Research output: Contribution to journalArticle

65 Scopus citations

c-Myb oncoprotein is an essential target of the dleu2 tumor suppressor microRNA cluster

Chung, E. Y., Dews, M., Cozma, D., Yu, D., Wentzel, E. A., Chang, T. C., Schelter, J. M., Cleary, M. A., Mendell, J. T. & Thomas-Tikhonenko, A., Nov 2008, In : Cancer Biology and Therapy. 7, 11, p. 1758-1764 7 p.

Research output: Contribution to journalArticle

Open Access
47 Scopus citations

MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1

Harris, T. A., Yamakuchi, M., Ferlito, M., Mendell, J. T. & Lowenstein, C. J., Feb 5 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 5, p. 1516-1521 6 p.

Research output: Contribution to journalArticle

702 Scopus citations

Widespread microRNA repression by Myc contributes to tumorigenesis

Chang, T. C., Yu, D., Lee, Y. S., Wentzel, E. A., Arking, D. E., West, K. M., Dang, C. V., Thomas-Tikhonenko, A. & Mendell, J. T., Jan 1 2008, In : Nature genetics. 40, 1, p. 43-50 8 p.

Research output: Contribution to journalArticle

991 Scopus citations
2007

A hexanucleotide element directs microRNA nuclear import

Hwang, H. W., Wentzel, E. A. & Mendell, J. T., Jan 5 2007, In : Science. 315, 5808, p. 97-100 4 p.

Research output: Contribution to journalArticle

477 Scopus citations

Regulated expression of microRNAs in normal and polycythemia vera erythropoiesis

Bruchova, H., Yoon, D., Agarwal, A. M., Mendell, J. & Prchal, J. T., Nov 1 2007, In : Experimental Hematology. 35, 11, p. 1657-1667 11 p.

Research output: Contribution to journalArticle

154 Scopus citations