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20042019

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2019

Dissecting primate early post-implantation development using long-term in vitro embryo culture

Niu, Y., Sun, N., Li, C., Lei, Y., Huang, Z., Wu, J., Si, C., Dai, X., Liu, C., Wei, J., Liu, L., Feng, S., Kang, Y., Si, W., Wang, H., Zhang, E., Zhao, L., Li, Z., Luo, X., Cui, G. & 4 others, Peng, G., Belmonte, J. C. I., Ji, W. & Tan, T., Nov 15 2019, In : Science. 366, 6467, eaaw5754.

Research output: Contribution to journalArticle

3 Scopus citations

Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures

Li, R., Zhong, C., Yu, Y., Liu, H., Sakurai, M., Yu, L., Min, Z., Shi, L., Wei, Y., Takahashi, Y., Liao, H. K., Qiao, J., Deng, H., Nuñez-Delicado, E., Rodriguez Esteban, C., Wu, J. & Izpisua Belmonte, J. C., Oct 17 2019, In : Cell. 179, 3, p. 687-702.e18

Research output: Contribution to journalArticle

4 Scopus citations

Generation of pig induced pluripotent stem cells using an extended pluripotent stem cell culture system

Xu, J., Yu, L., Guo, J., Xiang, J., Zheng, Z., Gao, D., Shi, B., Hao, H., Jiao, D., Zhong, L., Wang, Y., Wu, J., Wei, H. & Han, J., Jun 27 2019, In : Stem Cell Research and Therapy. 10, 1, 193.

Research output: Contribution to journalArticle

Open Access

Mutations in foregut SOX2+ cells induce efficient proliferation via CXCR2 pathway

Hishida, T., Vazquez-Ferrer, E., Hishida-Nozaki, Y., Sancho-Martinez, I., Takahashi, Y., Hatanaka, F., Wu, J., Ocampo, A., Reddy, P., Wu, M. Z., Gerken, L., Shaw, R. J., Rodriguez Esteban, C., Benner, C., Nakagawa, H., Guillen Garcia, P., Nuñez Delicado, E., Castells, A., Campistol, J. M., Liu, G. H. & 1 others, Izpisua Belmonte, J. C., Jul 1 2019, In : Protein and Cell. 10, 7, p. 485-495 11 p.

Research output: Contribution to journalArticle

Open Access

Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction

Suzuki, K., Yamamoto, M., Hernandez-Benitez, R., Li, Z., Wei, C., Soligalla, R. D., Aizawa, E., Hatanaka, F., Kurita, M., Reddy, P., Ocampo, A., Hishida, T., Sakurai, M., Nemeth, A. N., Nuñez Delicado, E., Campistol, J. M., Magistretti, P., Guillen, P., Rodriguez Esteban, C., Gong, J. & 7 others, Yuan, Y., Gu, Y., Liu, G. H., López-Otín, C., Wu, J., Zhang, K. & Izpisua Belmonte, J. C., Oct 1 2019, In : Cell Research. 29, 10, p. 804-819 16 p.

Research output: Contribution to journalArticle

1 Scopus citations

Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells

Zhang, Y., Li, T., Preissl, S., Amaral, M. L., Grinstein, J. D., Farah, E. N., Destici, E., Qiu, Y., Hu, R., Lee, A. Y., Chee, S., Ma, K., Ye, Z., Zhu, Q., Huang, H., Fang, R., Yu, L., Izpisua Belmonte, J. C., Wu, J., Evans, S. M. & 2 others, Chi, N. C. & Ren, B., Sep 1 2019, In : Nature genetics. 51, 9, p. 1380-1388 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Up-regulation of FOXD1 by yap alleviates senescence and osteoarthritis

Fu, L., Hu, Y., Song, M., Liu, Z., Zhang, W., Yu, F. X., Wu, J., Wang, S., Belmonte, J. C. I., Chan, P., Qu, J., Tang, F. & Liu, G. H., Apr 2019, In : PLoS biology. 17, 4, e3000201.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2018

ATF6 safeguards organelle homeostasis and cellular aging in human mesenchymal stem cells

Wang, S., Hu, B., Ding, Z., Dang, Y., Wu, J., Li, D., Liu, X., Xiao, B., Zhang, W., Ren, R., Lei, J., Hu, H., Chen, C., Chan, P., Li, D., Qu, J., Tang, F. & Liu, G. H., Dec 1 2018, In : Cell Discovery. 4, 1, 2.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations

Efficient derivation of stable primed pluripotent embryonic stem cells from bovine blastocysts

Bogliotti, Y. S., Wu, J., Vilarino, M., Okamura, D., Soto, D. A., Zhong, C., Sakurai, M., Sampaio, R. V., Suzuki, K., Izpisua Belmonte, J. C. & Ross, P. J., Feb 27 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 9, p. 2090-2095 6 p.

Research output: Contribution to journalArticle

Open Access
36 Scopus citations

First stem cell transplantation to regenerate human lung

Wang, S., Wu, J. & Liu, G. H., Mar 1 2018, In : Protein and Cell. 9, 3, p. 244-245 2 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Ma et al. reply

Ma, H., Marti-Gutierrez, N., Park, S. W., Wu, J., Hayama, T., Darby, H., Van Dyken, C., Li, Y., Koski, A., Liang, D., Suzuki, K., Gu, Y., Gong, J., Xu, X., Ahmed, R., Lee, Y., Kang, E., Ji, D., Park, A. R., Kim, D. & 12 others, Kim, S. T., Heitner, S. B., Battaglia, D., Krieg, S. A., Lee, D. M., Wu, D. H., Wolf, D. P., Amato, P., Kaul, S., Belmonte, J. C. I., Kim, J. S. & Mitalipov, S., Aug 9 2018, In : Nature. 560, 7717, p. E10-E23

Research output: Contribution to journalArticle

11 Scopus citations
2017

Correction of a pathogenic gene mutation in human embryos

Ma, H., Marti-Gutierrez, N., Park, S. W., Wu, J., Lee, Y., Suzuki, K., Koski, A., Ji, D., Hayama, T., Ahmed, R., Darby, H., Van Dyken, C., Li, Y., Kang, E., Park, A. R., Kim, D., Kim, S. T., Gong, J., Gu, Y., Xu, X. & 11 others, Battaglia, D., Krieg, S. A., Lee, D. M., Wu, D. H., Wolf, D. P., Heitner, S. B., Belmonte, J. C. I., Amato, P., Kim, J. S., Kaul, S. & Mitalipov, S., Aug 24 2017, In : Nature. 548, 7668, p. 413-419 7 p.

Research output: Contribution to journalArticle

358 Scopus citations

CRISPR-Cas9 mediated one-step disabling of pancreatogenesis in pigs

Wu, J., Vilarino, M., Suzuki, K., Okamura, D., Bogliotti, Y. S., Park, I., Rowe, J., McNabb, B., Ross, P. J. & Belmonte, J. C. I., Dec 1 2017, In : Scientific reports. 7, 1, 10487.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency

Yang, Y., Liu, B., Xu, J., Wang, J., Wu, J., Shi, C., Xu, Y., Dong, J., Wang, C., Lai, W., Zhu, J., Xiong, L., Zhu, D., Li, X., Yang, W., Yamauchi, T., Sugawara, A., Li, Z., Sun, F., Li, X. & 15 others, Li, C., He, A., Du, Y., Wang, T., Zhao, C., Li, H., Chi, X., Zhang, H., Liu, Y., Li, C., Duo, S., Yin, M., Shen, H., Belmonte, J. C. I. & Deng, H., Apr 6 2017, In : Cell. 169, 2, p. 243-257.e25

Research output: Contribution to journalArticle

Open Access
92 Scopus citations

Integration of CpG-free DNA induces de novo methylation of CpG islands in pluripotent stem cells

Takahashi, Y., Wu, J., Suzuki, K., Martinez-Redondo, P., Li, M., Liao, H. K., Wu, M. Z., Hernández-Benítez, R., Hishida, T., Shokhirev, M. N., Rodriguez Esteban, C., Sancho-Martinez, I. & Izpisua Belmonte, J. C., May 5 2017, In : Science. 356, 6337, p. 503-508 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Interspecies Chimerism with Mammalian Pluripotent Stem Cells

Wu, J., Platero-Luengo, A., Sakurai, M., Sugawara, A., Gil, M. A., Yamauchi, T., Suzuki, K., Bogliotti, Y. S., Cuello, C., Morales Valencia, M., Okumura, D., Luo, J., Vilariño, M., Parrilla, I., Soto, D. A., Martinez, C. A., Hishida, T., Sánchez-Bautista, S., Martinez-Martinez, M. L., Wang, H. & 17 others, Nohalez, A., Aizawa, E., Martinez-Redondo, P., Ocampo, A., Reddy, P., Roca, J., Maga, E. A., Esteban, C. R., Berggren, W. T., Nuñez Delicado, E., Lajara, J., Guillen, I., Guillen, P., Campistol, J. M., Martinez, E. A., Ross, P. J. & Izpisua Belmonte, J. C., Jan 26 2017, In : Cell. 168, 3, p. 473-486.e15

Research output: Contribution to journalArticle

Open Access
159 Scopus citations

Visualization of aging-associated chromatin alterations with an engineered TALE system

Ren, R., Deng, L., Xue, Y., Suzuki, K., Zhang, W., Yu, Y., Wu, J., Sun, L., Gong, X., Luan, H., Yang, F., Ju, Z., Ren, X., Wang, S., Tang, H., Geng, L., Zhang, W., Li, J., Qiao, J., Xu, T. & 2 others, Qu, J. & Liu, G. H., Apr 1 2017, In : Cell Research. 27, 4, p. 483-504 22 p.

Research output: Contribution to journalArticle

23 Scopus citations
2016

3D Culture Supports Long-Term Expansion of Mouse and Human Nephrogenic Progenitors

Li, Z., Araoka, T., Wu, J., Liao, H. K., Li, M., Lazo, M., Zhou, B., Sui, Y., Wu, M. Z., Tamura, I., Xia, Y., Beyret, E., Matsusaka, T., Pastan, I., Rodriguez Esteban, C., Guillen, I., Guillen, P., Campistol, J. M. & Izpisua Belmonte, J. C., Oct 6 2016, In : Cell Stem Cell. 19, 4, p. 516-529 14 p.

Research output: Contribution to journalArticle

Open Access
64 Scopus citations

An overview of mammalian pluripotency

Wu, J., Yamauchi, T. & Belmonte, J. C. I., May 15 2016, In : Development (Cambridge). 143, 10, p. 1644-1648 5 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Generation of human organs in pigs via interspecies blastocyst complementation

Wu, J., Platero Luengo, A., Gil, M. A., Suzuki, K., Cuello, C., Morales Valencia, M., Parrilla, I., Martinez, C. A., Nohalez, A., Roca, J., Martinez, E. A. & Izpisua Belmonte, J. C., Oct 1 2016, In : Reproduction in Domestic Animals. 51, p. 18-24 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration

Suzuki, K., Tsunekawa, Y., Hernandez-Benitez, R., Wu, J., Zhu, J., Kim, E. J., Hatanaka, F., Yamamoto, M., Araoka, T., Li, Z., Kurita, M., Hishida, T., Li, M., Aizawa, E., Guo, S., Chen, S., Goebl, A., Soligalla, R. D., Qu, J., Jiang, T. & 15 others, Fu, X., Jafari, M., Esteban, C. R., Berggren, W. T., Lajara, J., Nuñez-Delicado, E., Guillen, P., Campistol, J. M., Matsuzaki, F., Liu, G. H., Magistretti, P., Zhang, K., Callaway, E. M., Zhang, K. & Belmonte, J. C. I., Dec 1 2016, In : Nature. 540, 7631, p. 144-149 6 p.

Research output: Contribution to journalArticle

328 Scopus citations

Loss of MAX results in meiotic entry in mouse embryonic and germline stem cells

Suzuki, A., Hirasaki, M., Hishida, T., Wu, J., Okamura, D., Ueda, A., Nishimoto, M., Nakachi, Y., Mizuno, Y., Okazaki, Y., Matsui, Y., Belmonte, J. C. I. & Okuda, A., Mar 30 2016, In : Nature communications. 7, 11056.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations

Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations

Kang, E., Wu, J., Gutierrez, N. M., Koski, A., Tippner-Hedges, R., Agaronyan, K., Platero-Luengo, A., Martinez-Redondo, P., Ma, H., Lee, Y., Hayama, T., Van Dyken, C., Wang, X., Luo, S., Ahmed, R., Li, Y., Ji, D., Kayali, R., Cinnioglu, C., Olson, S. & 10 others, Jensen, J., Battaglia, D., Lee, D., Wu, D., Huang, T., Wolf, D. P., Temiakov, D., Belmonte, J. C. I., Amato, P. & Mitalipov, S., Dec 8 2016, In : Nature. 540, 7632, p. 270-275 6 p.

Research output: Contribution to journalArticle

79 Scopus citations

Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCs

Fu, L., Xu, X., Ren, R., Wu, J., Zhang, W., Yang, J., Ren, X., Wang, S., Zhao, Y., Sun, L., Yu, Y., Wang, Z., Yang, Z., Yuan, Y., Qiao, J., Belmonte, J. C. I., Qu, J. & Liu, G. H., Mar 1 2016, In : Protein and Cell. 7, 3, p. 210-221 12 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2

Pan, H., Guan, D., Liu, X., Li, J., Wang, L., Wu, J., Zhou, J., Zhang, W., Ren, R., Zhang, W., Li, Y., Yang, J., Hao, Y., Yuan, T., Yuan, G., Wang, H., Ju, Z., Mao, Z., Li, J., Qu, J. & 2 others, Tang, F. & Liu, G. H., Feb 1 2016, In : Cell Research. 26, 2, p. 190-205 16 p.

Research output: Contribution to journalArticle

Open Access
93 Scopus citations
2015

An alternative pluripotent state confers interspecies chimaeric competency

Wu, J., Okamura, D., Li, M., Suzuki, K., Luo, C., Ma, L., He, Y., Li, Z., Benner, C., Tamura, I., Krause, M. N., Nery, J. R., Du, T., Zhang, Z., Hishida, T., Takahashi, Y., Aizawa, E., Kim, N. Y., Lajara, J., Guillen, P. & 7 others, Campistol, J. M., Esteban, C. R., Ross, P. J., Saghatelian, A., Ren, B., Ecker, J. R. & Belmonte, J. C. I., May 21 2015, In : Nature. 521, 7552, p. 316-321 6 p.

Research output: Contribution to journalArticle

119 Scopus citations

Creating Patient-Specific Neural Cells for the in Vitro Study of Brain Disorders

Brennand, K. J., Marchetto, M. C., Benvenisty, N., Brüstle, O., Ebert, A., Izpisua Belmonte, J. C., Kaykas, A., Lancaster, M. A., Livesey, F. J., McConnell, M. J., McKay, R. D., Morrow, E. M., Muotri, A. R., Panchision, D. M., Rubin, L. L., Sawa, A., Soldner, F., Song, H., Studer, L., Temple, S. & 5 others, Vaccarino, F. M., Wu, J., Vanderhaeghen, P., Gage, F. H. & Jaenisch, R., Dec 8 2015, In : Stem Cell Reports. 5, 6, p. 933-945 13 p.

Research output: Contribution to journalArticle

Open Access
53 Scopus citations

CRISPR/Cas9 and TALE: beyond cut and paste

Deng, L., Ren, R., Wu, J., Suzuki, K., Izpisua Belmote, J. C. & Liu, G. H., Jan 1 2015, In : Protein and Cell. 6, 3, p. 157-159 3 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Metabolic exit from naive pluripotency

Wu, J. & Belmonte, J. C. I., Nov 27 2015, In : Nature Cell Biology. 17, 12, p. 1519-1521 3 p.

Research output: Contribution to journalArticle

15 Scopus citations

Metabolic rescue in pluripotent cells from patients with mtDNA disease

Ma, H., Folmes, C. D. L., Wu, J., Morey, R., Mora-Castilla, S., Ocampo, A., Ma, L., Poulton, J., Wang, X., Ahmed, R., Kang, E., Lee, Y., Hayama, T., Li, Y., Van Dyken, C., Gutierrez, N. M., Tippner-Hedges, R., Koski, A., Mitalipov, N., Amato, P. & 6 others, Wolf, D. P., Huang, T., Terzic, A., Laurent, L. C., Belmonte, J. C. I. & Mitalipov, S., Aug 13 2015, In : Nature. 524, 7564, p. 234-238 5 p.

Research output: Contribution to journalArticle

87 Scopus citations

PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype

Duan, S., Yuan, G., Liu, X., Ren, R., Li, J., Zhang, W., Wu, J., Xu, X., Fu, L., Li, Y., Yang, J., Zhang, W., Bai, R., Yi, F., Suzuki, K., Gao, H., Esteban, C. R., Zhang, C., Belmonte, J. C. I., Chen, Z. & 5 others, Wang, X., Jiang, T., Qu, J., Tang, F. & Liu, G. H., Dec 3 2015, In : Nature communications. 6, 10068.

Research output: Contribution to journalArticle

Open Access
55 Scopus citations

Regenerative medicine: Targeted genome editing in vivo

Wang, L., Wu, J., Fang, W., Liu, G. H. & Belmonte, J. C. I., Mar 5 2015, In : Cell Research. 25, 3, p. 271-272 2 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Selective elimination of mitochondrial mutations in the germline by genome editing

Reddy, P., Ocampo, A., Suzuki, K., Luo, J., Bacman, S. R., Williams, S. L., Sugawara, A., Okamura, D., Tsunekawa, Y., Wu, J., Lam, D., Xiong, X., Montserrat, N., Esteban, C. R., Liu, G. H., Sancho-Martinez, I., Manau, D., Civico, S., Cardellach, F., Del Mar O'Callaghan, M. & 5 others, Campistol, J., Zhao, H., Campistol, J. M., Moraes, C. T. & Izpisua Belmonte, J. C., Apr 23 2015, In : Cell. 161, 3, p. 459-469 11 p.

Research output: Contribution to journalArticle

Open Access
126 Scopus citations
2013

Chemically induced pluripotent stem cells (CiPSCs): A transgene-free approach

Masuda, S., Wu, J., Hishida, T., Pandian, G. N., Sugiyama, H. & Izpisua Belmonte, J. C., Oct 1 2013, In : Journal of molecular cell biology. 5, 5, p. 354-355 2 p.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations

DNA damage-induced sustained p53 activation contributes to inflammation-associated hepatocarcinogenesis in rats

Yan, H. X., Wu, H. P., Zhang, H. L., Ashton, C., Tong, C., Wu, J., Qian, Q. J., Wang, H. Y. & Ying, Q. L., Sep 19 2013, In : Oncogene. 32, 38, p. 4565-4571 7 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Modulation of β-catenin function maintains mouse epiblast stem cell and human embryonic stem cell self-renewal

Kim, H., Wu, J., Ye, S., Tai, C. I., Zhou, X., Yan, H., Li, P., Pera, M. & Ying, Q. L., Aug 29 2013, In : Nature communications. 4, 3403.

Research output: Contribution to journalArticle

85 Scopus citations
2012

The GCTM-5 epitope associated with the mucin-like glycoprotein FCGBP marks progenitor cells in tissues of endodermal origin

Stamp, L. A., Braxton, D. R., Wu, J., Akopian, V., Hasegawa, K., Chandrasoma, P. T., Hawes, S. M., McLean, C., Petrovic, L. M., Wang, K. & Pera, M. F., Sep 1 2012, In : Stem Cells. 30, 9, p. 1999-2009 11 p.

Research output: Contribution to journalArticle

14 Scopus citations
2008

Cdc14B depletion leads to centriole amplification, and its overexpression prevents unscheduled centriole duplication

Wu, J., Cho, H. P., Rhee, D. B., Johnson, D. K., Dunlap, J., Liu, Y. & Wang, Y., May 5 2008, In : Journal of Cell Biology. 181, 3, p. 475-483 9 p.

Research output: Contribution to journalArticle

Open Access
38 Scopus citations

Nucleophosmin/B23 negatively regulates GCN5-dependent histone acetylation and transactivation

Zou, Y., Wu, J., Giannone, R. J., Boucher, L., Du, H., Huang, Y., Johnson, D. K., Liu, Y. & Wang, Y., Feb 29 2008, In : Journal of Biological Chemistry. 283, 9, p. 5728-5737 10 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations
2007

A preference for edgewise interactions between aromatic rings and carboxylate anions: The biological relevance of anion-quadrupole interactions

Jackson, M. R., Beahm, R., Duvvuru, S., Narasimhan, C., Wu, J., Wang, H. N., Philip, V. M., Hinde, R. J. & Howell, E. E., Jul 19 2007, In : Journal of Physical Chemistry B. 111, 28, p. 8242-8249 8 p.

Research output: Contribution to journalArticle

50 Scopus citations

Dual-tagging system for the affinity purification of mammalian protein complexes

Giannone, R. J., McDonald, W. H., Hurst, G. B., Huang, Y., Wu, J., Liu, Y. & Wang, Y., Sep 1 2007, In : BioTechniques. 43, 3, p. 296-302 7 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations
2006

PARP1 is a TRF2-associated poly(ADP-ribose)polymerase and protects eroded telomeres

Gomez, M., Wu, J., Schreiber, V., Dunlap, J., Dantzer, F., Wang, Y. & Liu, Y., Apr 1 2006, In : Molecular biology of the cell. 17, 4, p. 1686-1696 11 p.

Research output: Contribution to journalArticle

76 Scopus citations
2005

An increase in telomere sister chromatid exchange in murine embryonic stem cells possessing critically shortened telomeres

Wang, Y., Erdmann, N., Giannone, R. J., Wu, J., Gomez, M. & Liu, Y., Jul 19 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 29, p. 10256-10260 5 p.

Research output: Contribution to journalArticle

42 Scopus citations
2004

Defining the binding site of homotetrameric R67 dihydrofolate reductase and correlating binding enthalpy with catalysis

Strader, M. B., Chopra, S., Jackson, M., Smiley, R. D., Stinnett, L., Wu, J. & Howell, E. E., Jun 15 2004, In : Biochemistry. 43, 23, p. 7403-7412 10 p.

Research output: Contribution to journalArticle

18 Scopus citations