• 487 Citations
  • 12 h-Index
20102019
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Research Output 2010 2019

  • 487 Citations
  • 12 h-Index
  • 20 Article
  • 3 Chapter
2019

CAPN5 genetic inactivation phenotype supports therapeutic inhibition trials

Wert, K. J., Koch, S. F., Velez, G., Hsu, C. W., Mahajan, M. A., Bassuk, A. G., Tsang, S. H. & Mahajan, V. B., Dec 1 2019, In : Human Mutation. 40, 12, p. 2377-2392 16 p.

Research output: Contribution to journalArticle

Knockout Mice
Phenotype
Exome
Electroretinography
Inborn Genetic Diseases

Insights into retinal development using live imaging in female carriers of choroideremia

Wert, K. J., Bakall, B., Bassuk, A. G., Tsang, S. H. & Mahajan, V. B., Jan 1 2019, In : Ophthalmic Surgery Lasers and Imaging Retina. 50, 5, p. E158-E162

Research output: Contribution to journalArticle

Choroideremia
Retina
X Chromosome Inactivation
Embryonic Development
Cell Movement

In vivo expression of mutant calpains in the eye using lentivirus

Wert, K. J. & Mahajan, V. B., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 233-247 15 p. (Methods in Molecular Biology; vol. 1915).

Research output: Chapter in Book/Report/Conference proceedingChapter

Lentivirus
Calpain
Exome
Mutation
Genes
2018
1 Citation (Scopus)

Cytotoxic Escherichia coli strains encoding colibactin isolated from immunocompromised mice with urosepsis and meningitis

Bakthavatchalu, V., Wert, K. J., Feng, Y., Mannion, A., Ge, Z., Garcia, A., Scott, K. E., Caron, T. J., Madden, C. M., Jacobsen, J. T., Victora, G., Jaenisch, R. & Fox, J. G., Mar 2018, In : PloS one. 13, 3, e0194443.

Research output: Contribution to journalArticle

Open Access
meningitis
Meningitis
Escherichia coli
Polyketide Synthases
polyketide synthases
6 Citations (Scopus)

Establishment of human pluripotent stem cell-derived pancreatic β-like cells in the mouse pancreas

Ma, H., Wert, K. J., Shvartsman, D., Melton, D. A. & Jaenisch, R., Jan 1 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 15, p. 3924-3929 6 p.

Research output: Contribution to journalArticle

Open Access
Pluripotent Stem Cells
Pancreas
Islets of Langerhans
Pancreas Transplantation
Endocrine Cells
3 Citations (Scopus)

Extracellular superoxide dismutase (SOD3) regulates oxidative stress at the vitreoretinal interface

Wert, K. J., Velez, G., Cross, M. R., Wagner, B. A., Teoh-Fitzgerald, M. L., Buettner, G. R., McAnany, J. J., Olivier, A., Tsang, S. H., Harper, M. M., Domann, F. E., Bassuk, A. G. & Mahajan, V. B., Aug 20 2018, In : Free Radical Biology and Medicine. 124, p. 408-419 12 p.

Research output: Contribution to journalArticle

Oxidative stress
Superoxide Dismutase
Oxidative Stress
Retina
Antioxidants
2016
25 Citations (Scopus)

Human neural crest cells contribute to coat pigmentation in interspecies chimeras after in utero injection into mouse embryos

Cohen, M. A., Wert, K. J., Goldmann, J., Markoulaki, S., Buganim, Y., Fu, D. & Jaenisch, R., Feb 9 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 6, p. 1570-1575 6 p.

Research output: Contribution to journalArticle

Open Access
Neural Crest
Pigmentation
Embryonic Structures
Injections
Ectoderm
148 Citations (Scopus)

Molecular Criteria for Defining the Naive Human Pluripotent State

Theunissen, T. W., Friedli, M., He, Y., Planet, E., O'Neil, R. C., Markoulaki, S., Pontis, J., Wang, H., Iouranova, A., Imbeault, M., Duc, J., Cohen, M. A., Wert, K. J., Castanon, R., Zhang, Z., Huang, Y., Nery, J. R., Drotar, J., Lungjangwa, T., Trono, D. & 2 others, Ecker, J. R. & Jaenisch, R., Oct 6 2016, In : Cell Stem Cell. 19, 4, p. 502-515 14 p.

Research output: Contribution to journalArticle

Open Access
Embryonic Structures
X-Linked Genes
Pluripotent Stem Cells
DNA Transposable Elements
Human Development
14 Citations (Scopus)

Neuroretinal hypoxic signaling in a new preclinical murine model for proliferative diabetic retinopathy

Wert, K. J., Mahajan, V. B., Zhang, L., Yan, Y., Li, Y., Tosi, J., Hsu, C. W., Nagasaki, T., Janisch, K. M., Grant, M. B., Mahajan, M., Bassuk, A. G. & Tsang, S. H., Jan 1 2016, In : Signal Transduction and Targeted Therapy. 1, 16005.

Research output: Contribution to journalArticle

Open Access
Hypoxia-Inducible Factor 1
Diabetic Retinopathy
Von Hippel-Lindau Tumor Suppressor Protein
Vitreous Hemorrhage
Ubiquitination

Pathology and mechanism of eye diseases

Wert, K. J., Kroeger, H., Wu, F., Tsang, S. H. & Lin, J. H., Oct 1 2016, Ophthalmic disease mechanisms and drug discovery. World Scientific Publishing Co. Pte Ltd, p. 3-32 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Eye Diseases
Pathology
2015
50 Citations (Scopus)

A systematic approach to identify candidate transcription factors that control cell identity

D'Alessio, A. C., Fan, Z. P., Wert, K. J., Baranov, P., Cohen, M. A., Saini, J. S., Cohick, E., Charniga, C., Dadon, D., Hannett, N. M., Young, M. J., Temple, S., Jaenisch, R., Lee, T. I. & Young, R. A., Nov 10 2015, In : Stem Cell Reports. 5, 5, p. 763-775 13 p.

Research output: Contribution to journalArticle

Open Access
Transcription Factors
Atlases
Cells
Retinal Pigments
Fibroblasts
17 Citations (Scopus)

CAPN5 mutation in hereditary uveitis: The R243L mutation increases calpain catalytic activity and triggers intraocular inflammation in a mouse model

Wert, K. J., Bassuk, A. G., Wu, W. H., Gakhar, L., Coglan, D., Mahajan, M. A., Wu, S., Yang, J., Lin, C. S., Tsang, S. H. & Mahajan, V. B., Apr 28 2015, In : Human molecular genetics. 24, 16, p. 4584-4598 15 p.

Research output: Contribution to journalArticle

Calpain
Uveitis
Inflammation
Mutation
Retina
2014
18 Citations (Scopus)

Functional validation of a human CAPN5 exome variant by lentiviral transduction into mouse retina

Wert, K. J., Skeie, J. M., Bassuk, A. G., Olivier, A. K., Tsang, S. H. & Mahajan, V. B., May 2014, In : Human molecular genetics. 23, 10, p. 2665-2677 13 p., ddt661.

Research output: Contribution to journalArticle

Open Access
Exome
Retina
Calpain
Alleles
Retinal Degeneration
4 Citations (Scopus)

General pathophysiology in retinal degeneration

Wert, K. J., Lin, J. H. & Tsang, S. H., Apr 22 2014, Cell-Based Therapy for Retinal Degenerative Disease. S. Karger AG, Vol. 53. p. 33-43 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Retinal Degeneration
Light Signal Transduction
Retinitis Pigmentosa
Chemical activation
Type 6 Cyclic Nucleotide Phosphodiesterases
27 Citations (Scopus)

General pathophysiology in retinal degeneration

Wert, K. J., Lin, J. H. & Tsang, S. H., Jan 1 2014, In : Developments in Ophthalmology. 53, p. 33-43 11 p.

Research output: Contribution to journalArticle

Retinal Degeneration
Light Signal Transduction
Retinitis Pigmentosa
Type 6 Cyclic Nucleotide Phosphodiesterases
Cell Death
22 Citations (Scopus)

Mid-stage intervention achieves similar efficacy as conventional early-stage treatment using gene therapy in a pre-clinical model of retinitis pigmentosa

Wert, K. J., Sancho-Pelluz, J. & Tsang, S. H., Jan 2014, In : Human molecular genetics. 23, 2, p. 514-523 10 p.

Research output: Contribution to journalArticle

Open Access
Type 6 Cyclic Nucleotide Phosphodiesterases
Retinitis Pigmentosa
Genetic Therapy
Photoreceptor Cells
Viruses
8 Citations (Scopus)

Silencing of tuberin enhances photoreceptor survival and function in a preclinical model of retinitis pigmentosa (an American ophthalmological society thesis)

Tsang, S. H., Chan, L., Tsai, Y. T., Wu, W. H., Hsu, C. W., Yang, J., Tosi, J., Wert, K. J., Davis, R. J. & Mahajan, V. B., Jan 1 2014, In : Transactions of the American Ophthalmological Society. 112, p. 103-115 13 p.

Research output: Contribution to journalArticle

Retinitis Pigmentosa
Proto-Oncogene Proteins c-akt
Phosphotransferases
Ribosomal Protein S6
Peptides
2013
41 Citations (Scopus)

Gene therapy provides long-term visual function in a pre-clinical model of retinitis pigmentosa

Wert, K. J., Davis, R. J., Sancho-pelluz, J., Nishina, P. M. & Tsang, S. H., Feb 1 2013, In : Human molecular genetics. 22, 3, p. 558-567 10 p., dds466.

Research output: Contribution to journalArticle

Open Access
Retinitis Pigmentosa
Genetic Therapy
Vertebrate Photoreceptor Cells
Retina
Type 6 Cyclic Nucleotide Phosphodiesterases
15 Citations (Scopus)

Therapeutic margins in a novel preclinical model of retinitis pigmentosa

Davis, R. J., Hsu, C. W., Tsai, Y. T., Wert, K. J., Sancho-Pelluz, J., Lin, C. S. & Tsang, S. H., Aug 20 2013, In : Journal of Neuroscience. 33, 33, p. 13475-13483 9 p.

Research output: Contribution to journalArticle

Open Access
Type 6 Cyclic Nucleotide Phosphodiesterases
Retinitis Pigmentosa
Genetic Therapy
Vertebrate Photoreceptor Cells
Viral Genes
2012
19 Citations (Scopus)

Subretinal injection of gene therapy vectors and stem cells in the perinatal mouse eye.

Wert, K. J., Skeie, J. M., Davis, R. J., Tsang, S. H. & Mahajan, V. B., 2012, In : Journal of visualized experiments : JoVE. 69

Research output: Contribution to journalArticle

Gene therapy
Stem cells
Genetic Therapy
Stem Cells
Injections
2011
8 Citations (Scopus)

Deoxygenation of aromatic ketones using transfer hydrogenolysis with Raney nickel in 2-propanol

Zuidema, D. R., Williams, S. L., Wert, K. J., Bosma, K. J., Smith, A. L. & Mebane, R. C., Jul 11 2011, In : Synthetic Communications. 41, 19, p. 2927-2931 5 p.

Research output: Contribution to journalArticle

Hydrogenolysis
Alkanes
2-Propanol
Nickel
Ketones
2010
3 Citations (Scopus)

Novel method of reducing ketones using sodium hydroxide in isopropanol

Zuidema, D. R., Wert, K. J., Williams, S. L., Chill, S. T., Holte, K. L., Kokes, N. K. & Mebane, R. C., Jan 1 2010, In : Synthetic Communications. 40, 8, p. 1187-1191 5 p.

Research output: Contribution to journalArticle

Sodium Hydroxide
2-Propanol
Ketones
Alcohols
58 Citations (Scopus)

Transplantation of reprogrammed embryonic stem cells improves visual function in a mouse model for retinitis pigmentosa

Wang, N. K., Tosi, J., Kasanuki, J. M., Chou, C. L., Kong, J., Parmalee, N., Wert, K. J., Allikmets, R., Lai, C. C., Chien, C. L., Nagasaki, T., Lin, C. S. & Tsang, S. H., Apr 1 2010, In : Transplantation. 89, 8, p. 911-919 9 p.

Research output: Contribution to journalArticle

Retinitis Pigmentosa
Retinal Pigments
Embryonic Stem Cells
Transplantation
Epithelial Cells