• 2004 Citations
  • 14 h-Index
19982019
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Research Output 1998 2019

  • 2004 Citations
  • 14 h-Index
  • 26 Article
  • 1 Chapter
  • 1 Comment/debate
  • 1 Editorial
2019

Author Correction: MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG (Nature Chemical Biology, (2018), 14, 11, (1032-1042), 10.1038/s41589-018-0136-y)

Fets, L., Driscoll, P. C., Grimm, F., Jain, A., Nunes, P. M., Gounis, M., Doglioni, G., Papageorgiou, G., Ragan, T. J., Campos, S., dos Santos, M. S., MacRae, J. I., O’Reilly, N., Wright, A. J., Benes, C. H., Courtney, K. D., House, D. & Anastasiou, D., Dec 1 2019, In : Nature chemical biology. 15, 12, 1 p.

Research output: Contribution to journalComment/debate

Glutamine
5 Citations (Scopus)

Blocking monocytic myeloid-derived suppressor cell function via anti-DC-HIL/GpNMB antibody restores the in vitro integrity of T cells from cancer patients

Kobayashi, M., Chung, J. S., Beg, M. S., Arriaga, Y. E., Verma, U., Courtney, K. D., Mansour, J. C., Haley, B. B., Khan, S., Horiuchi, Y., Ramani, V., Harker, D., Gopal, P., Araghizadeh, F., Cruz, P. D. & Ariizumi, K., Jan 15 2019, In : Clinical Cancer Research. 25, 2, p. 828-838 11 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Antibodies
Neoplasms
Colonic Neoplasms
Colorectal Neoplasms
1 Citation (Scopus)
Kidney Neoplasms
Neoplasm Metastasis
Survival
Brain
Renal Cell Carcinoma
Prostatic Neoplasms
Radiotherapy
Neoplasm Metastasis
Therapeutics
3 Citations (Scopus)
Renal Cell Carcinoma
radiation therapy
therapy
Radiotherapy
cancer
2018
30 Citations (Scopus)

Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo

Courtney, K. D., Bezwada, D., Mashimo, T., Pichumani, K., Vemireddy, V., Funk, A. M., Wimberly, J., McNeil, S. S., Kapur, P., Lotan, Y., Margulis, V., Cadeddu, J. A., Pedrosa, I., DeBerardinis, R. J., Malloy, C. R., Bachoo, R. & Maher, E. A., Nov 6 2018, In : Cell Metabolism. 28, 5, p. 793-800.e2

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Isotopes
Citric Acid Cycle
Glucose
Neoplasms
4 Citations (Scopus)

MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG

Fets, L., Driscoll, P. C., Grimm, F., Jain, A., Nunes, P. M., Gounis, M., Doglioni, G., Papageorgiou, G., Ragan, T. J., Campos, S., Silva dos Santos, M., MacRae, J. I., O’Reilly, N., Wright, A. J., Benes, C. H., Courtney, K. D., House, D. & Anastasiou, D., Nov 1 2018, In : Nature Chemical Biology. 14, 11, p. 1032-1042 11 p.

Research output: Contribution to journalArticle

Glutamine
Dioxygenases
Glutamate Dehydrogenase
Prodrugs
Metabolic Networks and Pathways
60 Citations (Scopus)

Phase I dose-escalation trial of PT2385, a first-in-class hypoxia-inducible factor-2a antagonist in patients with previously treated advanced clear cell renal cell carcinoma

Courtney, K. D., Infante, J. R., Lam, E. T., Figlin, R. A., Rini, B. I., Brugarolas, J., Zojwalla, N. J., Lowe, A. M., Wang, K., Wallace, E. M., Josey, J. A. & Choueiri, T. K., Jan 1 2018, In : Journal of Clinical Oncology. 36, 9, p. 867-874 8 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Safety
Pharmacokinetics
Hypoxia
Therapeutics
8 Citations (Scopus)

Safety and efficacy of concurrent immune checkpoint inhibitors and hypofractionated body radiotherapy

Mohamad, O., Diaz de Leon, A., Schroeder, S., Leiker, A., Christie, A., Zhang-Velten, E., Trivedi, L., Khan, S., Desai, N. B., Laine, A., Albuquerque, K., Iyengar, P., Arriaga, Y., Courtney, K., Gerber, D. E., Hammers, H., Choy, H., Timmerman, R., Brugarolas, J. & Hannan, R., Mar 10 2018, (Accepted/In press) In : OncoImmunology.

Research output: Contribution to journalArticle

Radiotherapy
Safety
Disease-Free Survival
Fatigue
Melanoma
2017
31 Citations (Scopus)

Aberrant corticosteroid metabolism in tumor cells enables GR takeover in enzalutamide resistant prostate cancer

Li, J., Alyamani, M., Zhang, A., Chang, K. H., Berk, M., Li, Z., Zhu, Z., Petro, M., Magi-Galluzzi, C., Taplin, M. E., Garcia, J. A., Courtney, K., Klein, E. A. & Sharifi, N., Feb 13 2017, In : eLife. 6, e20183.

Research output: Contribution to journalArticle

Glucocorticoid Receptors
Metabolism
Tumors
Prostatic Neoplasms
Adrenal Cortex Hormones
7 Citations (Scopus)

Natural history of 'second' biochemical failure after salvage radiation therapy for prostate cancer: A multi-institution study

Tumati, V., Jackson, W. C., Abugharib, A. E., Raj, G., Roehrborn, C., Lotan, Y., Courtney, K. D., Bagrodia, A., Gahan, J., Zumsteg, Z. S., Folkert, M. R., Laine, A. M., Hannan, R., Spratt, D. E. & Desai, N. B., 2017, (Accepted/In press) In : BJU International.

Research output: Contribution to journalArticle

Salvage Therapy
Natural History
Prostatic Neoplasms
Radiotherapy
Recurrence
2016
189 Citations (Scopus)

Targeting renal cell carcinoma with a HIF-2 antagonist

Chen, W., Hill, H., Christie, A., Kim, M. S., Holloman, E., Pavia-Jimenez, A., Homayoun, F., Ma, Y., Patel, N., Yell, P., Hao, G., Yousuf, Q., Joyce, A., Pedrosa, I., Geiger, H., Zhang, H., Chang, J., Gardner, K. H., Bruick, R. K., Reeves, C. & 14 others, Hwang, T. H., Courtney, K., Frenkel, E., Sun, X., Zojwalla, N., Wong, T., Rizzi, J. P., Wallace, E. M., Josey, J. A., Xie, Y., Xie, X. J., Kapur, P., McKay, R. M. & Brugarolas, J., 2016, In : Nature. 539, 7627, p. 112-117 6 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Neoplasms
Carcinogenesis
Genetic Suppression
Mutation
2015
22 Citations (Scopus)

A phase i study of everolimus and docetaxel in patients with castration-resistant prostate cancer

Courtney, K. D., Manola, J. B., Elfiky, A. A., Ross, R., Oh, W. K., Yap, J. T., Van Den Abbeele, A. D., Ryan, C. W., Beer, T. M., Loda, M., Priolo, C., Kantoff, P. & Taplin, M. E., Apr 1 2015, In : Clinical Genitourinary Cancer. 13, 2, p. 113-123 11 p.

Research output: Contribution to journalArticle

docetaxel
Castration
Prostatic Neoplasms
Prostate-Specific Antigen
Metabolic Diseases
12 Citations (Scopus)

Changing trends in utilization of neoadjuvant chemotherapy in muscle-invasive bladder cancer

Krabbe, L. M., Westerman, M. E., Margulis, V., Raj, G., Sagalowsky, A. I., Courtney, K. D., Arriaga, Y. E. & Lotan, Y., 2015, In : Canadian Journal of Urology. 22, 4, p. 7865-7875 11 p.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Drug Therapy
Muscles
Cystectomy
Adjuvant Chemotherapy

PI3K

Courtney, K. D. & Cantley, L. C., Jan 1 2015, Molecular Oncology: Causes of Cancer and Targets for Treatment. Cambridge University Press, p. 218-230 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Phosphatidylinositol 3-Kinase
Phosphatidylinositols
Phosphatidylinositol 3-Kinases
Class III Phosphatidylinositol 3-Kinases
Protein Isoforms
2013
35 Citations (Scopus)

Identification of CDCP1 as a hypoxia-inducible factor 2α (HIF-2α) target gene that is associated with survival in clear cell renal cell carcinoma patients

Emerling, B. M., Benes, C. H., Poulogiannis, G., Bell, E. L., Courtney, K., Liu, H., Choo-Wing, R., Bellinger, G., Tsukazawa, K. S., Brown, V., Signoretti, S., Soltoff, S. P. & Cantley, L. C., Feb 26 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 9, p. 3483-3488 6 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Survival
Genes
Neoplasms
Tyrosine
2012
3 Citations (Scopus)

Erratum: Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis (Nature Chemical Biology (2012) 8 (839-847))

Anastasiou, D., Yu, Y., Israelsen, W. J., Jiang, J. K., Boxer, M. B., Hong, B. S., Tempel, W., Dimov, S., Shen, M., Jha, A., Yang, H., Mattaini, K. R., Metallo, C. M., Fiske, B. P., Courtney, K. D., Malstrom, S., Khan, T. M., Kung, C., Skoumbourdis, A. P., Veith, H. & 23 others, Southall, N., Walsh, M. J., Brimacombe, K. R., Leister, W., Lunt, S. Y., Johnson, Z. R., Yen, K. E., Kunii, K., Davidson, S. M., Christofk, H. R., Austin, C. P., Inglese, J., Harris, M. H., Asara, J. M., Stephanopoulos, G., Salituro, F. G., Jin, S., Dang, L., Auld, D. S., Park, H. W., Cantley, L. C., Thomas, C. J. & Vander Heiden, M. G., Dec 2012, In : Nature Chemical Biology. 8, 12, p. 1008 1 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Phase II trial of RAD001 and bicalutamide for castration-resistant prostate cancer

Nakabayashi, M., Werner, L., Courtney, K. D., Buckle, G., Oh, W. K., Bubley, G. J., Hayes, J. H., Weckstein, D., Elfiky, A., Sims, D. M., Kantoff, P. W. & Taplin, M. E., Dec 2012, In : BJU International. 110, 11, p. 1729-1735 7 p.

Research output: Contribution to journalArticle

Castration
Prostatic Neoplasms
Phosphatidylinositol 3-Kinases
Androgen Receptors
Prostate-Specific Antigen
329 Citations (Scopus)

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

Anastasiou, D., Yu, Y., Israelsen, W. J., Jiang, J. K., Boxer, M. B., Hong, B. S., Tempel, W., Dimov, S., Shen, M., Jha, A., Yang, H., Mattaini, K. R., Metallo, C. M., Fiske, B. P., Courtney, K. D., Malstrom, S., Khan, T. M., Kung, C., Skoumbourdis, A. P., Veith, H. & 23 others, Southall, N., Walsh, M. J., Brimacombe, K. R., Leister, W., Lunt, S. Y., Johnson, Z. R., Yen, K. E., Kunii, K., Davidson, S. M., Christofk, H. R., Austin, C. P., Inglese, J., Harris, M. H., Asara, J. M., Stephanopoulos, G., Salituro, F. G., Jin, S., Dang, L., Auld, D. S., Park, H. W., Cantley, L. C., Thomas, C. J. & Vander Heiden, M. G., 2012, In : Nature Chemical Biology. 8, 10, p. 839-847 9 p.

Research output: Contribution to journalArticle

Pyruvate Kinase
Carcinogenesis
Neoplasms
Cell Proliferation
Phosphotyrosine
19 Citations (Scopus)

The evolving paradigm of second-line hormonal therapy options for castration-resistant prostate cancer

Courtney, K. D. & Taplin, M. E., May 2012, In : Current Opinion in Oncology. 24, 3, p. 272-277 6 p.

Research output: Contribution to journalArticle

Castration
Androgens
Prostatic Neoplasms
Steroid 17-alpha-Hydroxylase
docetaxel
2010
864 Citations (Scopus)

The PI3K pathway as drug target in human cancer

Courtney, K. D., Corcoran, R. B. & Engelman, J. A., Feb 20 2010, In : Journal of Clinical Oncology. 28, 6, p. 1075-1083 9 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Pharmaceutical Preparations
Neoplasms
Cell Survival
Tumor Microenvironment
13 Citations (Scopus)

Updates on novel therapies for metastatic renal cell carcinoma

Courtney, K. D. & Choueiri, T. K., May 2010, In : Therapeutic Advances in Medical Oncology. 2, 3, p. 209-219 11 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Therapeutics
Angiogenesis Inhibitors
Sirolimus
Palliative Care
2009
8 Citations (Scopus)

Optimizing recent advances in metastatic renal cell carcinoma

Courtney, K. D. & Choueiri, T. K., 2009, In : Current Oncology Reports. 11, 3, p. 218-226 9 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Therapeutics
Receptor Protein-Tyrosine Kinases
Sirolimus
Vascular Endothelial Growth Factor A
2008
6 Citations (Scopus)

PI3K Enters Beta-Testing

Shaywitz, A. J., Courtney, K. D., Patnaik, A. & Cantley, L. C., Sep 3 2008, In : Cell Metabolism. 8, 3, p. 179-181 3 p.

Research output: Contribution to journalArticle

Phosphatidylinositols
Phosphotransferases
Protein Isoforms
Carcinogenesis
Cell Proliferation
2007
1 Citation (Scopus)

Pulmonary thrombectomy in a patient with hemoglobin Nottingham

Memtsoudis, S. G., Lekowski, R. W., Rosenberger, P., Khalpey, Z., FitzGerald, D. J., Claypoole, V., Courtney, K. D., Landzberg, M. J., Bunn, H. F. & Shekar, P. S., 2007, In : Perfusion. 22, 4, p. 299-301 3 p.

Research output: Contribution to journalArticle

Thrombectomy
Hemoglobin
hypertension
Deep Hypothermia Induced Circulatory Arrest
Disease
2001
109 Citations (Scopus)

The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia

Stradal, T., Courtney, K. D., Rottner, K., Hahne, P., Small, J. V. & Pendergast, A. M., Jun 5 2001, In : Current Biology. 11, 11, p. 891-895 5 p.

Research output: Contribution to journalArticle

pseudopodia
Pseudopodia
Polymerization
polymerization
actin
2000
46 Citations (Scopus)

Analysis of the biologic properties of p230 Bcr-Abl reveals unique and overlapping properties with the oncogenic p185 and p210 Bcr-Abl tyrosine kinases

Quackenbush, R. C., Reuther, G. W., Miller, J. P., Courtney, K. D., Pear, W. S. & Pendergast, A. M., May 1 2000, In : Blood. 95, 9, p. 2913-2921 9 p.

Research output: Contribution to journalArticle

bcr-abl Fusion Proteins
Bone
Bone Marrow Cells
Cells
Intercellular Signaling Peptides and Proteins
48 Citations (Scopus)

Localization and phosphorylation of AbI-interactor proteins, Abi-1 and Abi-2, in the developing nervous system

Courtney, K. D., Grove, M., Vandongen, H., Vandongen, A., LaMantia, A. S. & Pendergast, A. M., 2000, In : Molecular and Cellular Neurosciences. 16, 3, p. 244-257 14 p.

Research output: Contribution to journalArticle

Nervous System
Phosphorylation
Proteins
Neurons
Growth Cones
1998
95 Citations (Scopus)

Oncogenic ABl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway

Dai, Z., Quackenbush, R. C., Courtney, K. D., Grove, M., Cortez, D., Reuther, G. W. & Pendergast, A. M., May 15 1998, In : Genes and Development. 12, 10, p. 1415-1424 10 p.

Research output: Contribution to journalArticle

src-Family Kinases
Ubiquitin
Proteolysis
Proteins
Protein-Tyrosine Kinases