• 10832 Citations
  • 56 h-Index
1986 …2020

Research output per year

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Research Output

2020

Calcium-stimulated disassembly of focal adhesions mediated by an ORP3/IQSec1 complex

D'Souza, R. S., Lim, J. Y., Turgut, A., Servage, K., Zhang, J., Orth, K., Sosale, N. G., Lazzara, M. J., Allegood, J. & Casanova, J. E., Apr 1 2020, In : eLife. 9

Research output: Contribution to journalArticle

Open Access

GCNA Preserves Genome Integrity and Fertility Across Species

Bhargava, V., Goldstein, C. D., Russell, L., Xu, L., Ahmed, M., Li, W., Casey, A., Servage, K., Kollipara, R., Picciarelli, Z., Kittler, R., Yatsenko, A., Carmell, M., Orth, K., Amatruda, J. F., Yanowitz, J. L. & Buszczak, M., Jan 6 2020, In : Developmental cell. 52, 1, p. 38-52.e10

Research output: Contribution to journalArticle

3 Scopus citations
2019

Adhesins during infection

Krachler, A. M. & Orth, K., Jan 1 2019, Encyclopedia of Microbiology. Elsevier, p. 28-37 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

A novel mouse model of enteric vibrio parahaemolyticus infection reveals that the type iii secretion system 2 effector vopc plays a key role in tissue invasion and gastroenteritis

Yang, H., Santos, M. D. S., Lee, J., Law, H. T., Chimalapati, S., Verdu, E. F., Vallance, B. A. & Orth, K., Nov 1 2019, In : mBio. 10, 6, e02608-19.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Direct Detection of Tissue-Resident Bacteria and Chronic Inflammation in the Bladder Wall of Postmenopausal Women with Recurrent Urinary Tract Infection

De Nisco, N. J., Neugent, M., Mull, J. A., Chen, L., Kuprasertkul, A., de Souza Santos, M., Palmer, K. L., Zimmern, P. E. & Orth, K. A., Jan 1 2019, In : Journal of Molecular Biology.

Research output: Contribution to journalArticle

5 Scopus citations

High-resolution cryo-EM structures of the E. Coli hemolysin ClyA oligomers

Peng, W., de Souza Santos, M., Li, Y., Tomchick, D. R. & Orth, K., May 2019, In : PloS one. 14, 5, e0213423.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Human pancreatic cancer cell exosomes, but not human normal cell exosomes, act as an initiator in cell transformation

Stefanius, K., Servage, K., de Souza Santos, M., Gray, H. F., Toombs, J. E., Chimalapati, S., Kim, M. S., Malladi, V. S., Brekken, R. & Orth, K., May 28 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

The role of the type III secretion system in the intracellular lifestyle of enteric pathogens

Santos, M. D. S. & Orth, K. A., May 1 2019, In : Microbiology Spectrum. 7, 3, BAI-0008-2019.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Adaptation to constant light requires Fic-mediated AMPylation of BiP to protect against reversible photoreceptor degeneration

Moehlman, A. T., Casey, A. K., Servage, K., Orth, K. & Krämer, H., Jul 17 2018, In : eLife. 7, e38752.

Research output: Contribution to journalArticle

3 Scopus citations

Enzymes Involved in AMPylation and deAMPylation

Casey, A. K. & Orth, K., Feb 14 2018, In : Chemical Reviews. 118, 3, p. 1199-1215 17 p.

Research output: Contribution to journalReview article

12 Scopus citations

My winding trail while fulfilling my love for science and family

Orth, K., Jul 6 2018, In : Journal of Biological Chemistry. 293, 27, p. 10435-10437 3 p.

Research output: Contribution to journalArticle

Natural transformation in Vibrio parahaemolyticus: A rapid method to create genetic deletions

Chimalapati, S., Santos, M. D. S., Servage, K., De Nisco, N. J., Dalia, A. B. & Orth, K., Aug 1 2018, In : Journal of bacteriology. 200, 15, e00032-18.

Research output: Contribution to journalArticle

5 Scopus citations

Protein AMPylation by an Evolutionarily Conserved Pseudokinase

Sreelatha, A., Yee, S. S., Lopez, V. A., Park, B. C., Kinch, L. N., Pilch, S., Servage, K. A., Zhang, J., Jiou, J., Karasiewicz-Urbańska, M., Łobocka, M., Grishin, N. V., Orth, K. A., Kucharczyk, R., Pawłowski, K., Tomchick, D. R. & Tagliabracci, V. S., Oct 18 2018, In : Cell. 175, 3, p. 809-821.e19

Research output: Contribution to journalArticle

21 Scopus citations

Rise of a Cereal Killer: The Biology of Magnaporthe oryzae Biotrophic Growth

Fernandez, J. & Orth, K., Jan 1 2018, (Accepted/In press) In : Trends in Microbiology.

Research output: Contribution to journalArticle

22 Scopus citations

The biochemistry of sensing: Enteric pathogens regulate type iii secretion in response to environmental and host cues

de Nisco, N. J., Rivera-Cancel, G. & Orth, K., Jan 1 2018, In : mBio. 9, 1, e02122-17.

Research output: Contribution to journalShort survey

7 Scopus citations
2017

Acute hepatopancreatic necrosis disease-causing Vibrio parahaemolyticus strains maintain an antibacterial type VI secretion system with versatile effector repertoires

Li, P., Kinch, L. N., Ray, A., Dalia, A. B., Cong, Q., Nunan, L. M., Camilli, A., Grishin, N. V., Salomon, D. & Orth, K., 2017, In : Applied and Environmental Microbiology. 83, 13, e00737-17.

Research output: Contribution to journalArticle

27 Scopus citations

Biochemical basis for activation of virulence genes by bile salts in Vibrio parahaemolyticus

Rivera-Cancel, G. & Orth, K., Feb 8 2017, (Accepted/In press) In : Gut Microbes. p. 1-8 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Science signaling podcast for 16 may 2017: Vibrio rewires host cells

De Nisco, N. J., Orth, K. & VanHook, A. M., May 16 2017, In : Science Signaling. 10, 479, 5621.

Research output: Contribution to journalReview article

T3SS effector VopL inhibits the host ROS response, promoting the intracellular survival of Vibrio parahaemolyticus

de Souza Santos, M., Salomon, D. & Orth, K., 2017, In : PLoS Pathogens. 13, 6, e1006438.

Research output: Contribution to journalArticle

12 Scopus citations

The cytotoxic type 3 secretion system 1 of Vibrio rewires host gene expression to subvert cell death and activate cell survival pathways

De Nisco, N. J., Kanchwala, M., Li, P., Fernandez, J., Xing, C. & Orth, K., May 16 2017, In : Science Signaling. 10, 479, l4501.

Research output: Contribution to journalArticle

3 Scopus citations

Type VI secretion system MIX-effectors carry both antibacterial and anti-eukaryotic activities

Ray, A., Schwartz, N., de Souza Santos, M., Zhang, J., Orth, K. & Salomon, D., Nov 2017, In : EMBO Reports. 18, 11, p. 1978-1990 13 p.

Research output: Contribution to journalArticle

10 Scopus citations
2016

Bile salt receptor complex activates a pathogenic type III secretion system

Li, P., Rivera-Cancel, G., Kinch, L. N., Salomon, D., Tomchick, D. R., Grishin, N. V. & Orth, K., Jul 5 2016, In : eLife. 5, 2016JULY, e15718.

Research output: Contribution to journalArticle

18 Scopus citations

Proteomics analysis reveals previously uncharacterized virulence factors in vibrio proteolyticus

Ray, A., Kinch, L. N., De Souza Santos, M., Grishin, N. V., Orth, K. & Salomon, D., Jul 1 2016, In : mBio. 7, 4, e01077-16.

Research output: Contribution to journalArticle

5 Scopus citations

Targeting bacterial adherence inhibits multidrug-resistant Pseudomonas aeruginosa infection following burn injury

Huebinger, R. M., Stones, D. H., De Souza Santos, M., Carlson, D. L., Song, J., Vaz, D. P., Keen, E., Wolf, S. E., Orth, K. & Krachler, A. M., Dec 20 2016, In : Scientific reports. 6, 39341.

Research output: Contribution to journalArticle

13 Scopus citations
2015

Subversion of the cytoskeleton by intracellular bacteria: Lessons from Listeria, Salmonella and Vibrio

de Souza Santos, M. & Orth, K., Feb 1 2015, In : Cellular Microbiology. 17, 2, p. 164-173 10 p.

Research output: Contribution to journalReview article

15 Scopus citations

Type VI secretion system

Salomon, D. & Orth, K., 2015, In : Current Biology. 25, 7, p. R265-R266

Research output: Contribution to journalArticle

4 Scopus citations

Type VI Secretion System Toxins Horizontally Shared between Marine Bacteria

Salomon, D., Klimko, J. A., Trudgian, D. C., Kinch, L. N., Grishin, N. V., Mirzaei, H. & Orth, K., Aug 1 2015, In : PLoS Pathogens. 11, 8, e1005128.

Research output: Contribution to journalArticle

27 Scopus citations

Vibrio effector protein VopQ inhibits fusion of V-ATPase-containing membranes

Sreelatha, A., Bennett, T. L., Carpinone, E. M., O'Brien, K. M., Jordan, K. D., Burdette, D. L., Orth, K. & Starai, V. J., Jan 6 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 1, p. 100-105 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

Vibrio parahaemolyticus virulence determinants

De Souza Santos, M., Salomon, D., Li, P., Krachler, A. M. & Orth, K., Jun 5 2015, The Comprehensive Sourcebook of Bacterial Protein Toxins. Elsevier Inc., p. 230-260 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations
2014

AMPylation of rho GTPases subverts multiple host signaling processes

Woolery, A. R., Yu, X., LaBaer, J. & Orth, K., Nov 21 2014, In : Journal of Biological Chemistry. 289, 47, p. 32977-32988 12 p.

Research output: Contribution to journalArticle

21 Scopus citations

Copper-catalyzed azide-alkyne cycloaddition (click chemistry)-based Detection of Global Pathogen-host AMPylation on Self-assembled Human Protein Microarrays

Yu, X., Woolery, A. R., Luong, P., Hao, Y. H., Grammel, M., Westcott, N., Park, J., Wang, J., Bian, X., Demirkan, G., Hang, H. C., Orth, K. & LaBaer, J., Nov 1 2014, In : Molecular and Cellular Proteomics. 13, 11, p. 3164-3176 13 p.

Research output: Contribution to journalArticle

26 Scopus citations

H-NS regulates the Vibrio parahaemolyticus type VI secretion system 1

Salomon, D., Klimko, J. A. & Orth, K., Sep 2014, In : Microbiology (United Kingdom). 160, PART 9, p. 1867-1873 7 p.

Research output: Contribution to journalArticle

26 Scopus citations

Inhibiting AMPylation: A novel screen to identify the first small molecule inhibitors of protein AMPylation

Lewallen, D. M., Sreelatha, A., Dharmarajan, V., Madoux, F., Chase, P., Griffin, P. R., Orth, K., Hodder, P. & Thompson, P. R., Feb 21 2014, In : ACS Chemical Biology. 9, 2, p. 433-442 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Intracellular Vibrio parahaemolyticus escapes the vacuole and establishes a replicative niche in the cytosol of epithelial cells

de Souza Santos, M. & Orth, K., Sep 9 2014, In : mBio. 5, 5, e01506-14.

Research output: Contribution to journalArticle

22 Scopus citations

Marker for type VI secretion system effectors

Salomon, D., Kinch, L. N., Trudgian, D. C., Guo, X., Klimko, J. A., Grishin, N. V., Mirzaei, H. & Orth, K., Jun 24 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 25, p. 9271-9276 6 p.

Research output: Contribution to journalArticle

58 Scopus citations

Structural and regulatory mutations in Vibrio parahaemolyticus type III secretion systems display variable effects on virulence

Calder, T., de Souza Santos, M., Attah, V., Klimko, J., Fernandez, J., Salomon, D., Krachler, A. M. & Orth, K., Dec 1 2014, In : FEMS Microbiology Letters. 361, 2, p. 107-114 8 p.

Research output: Contribution to journalLetter

7 Scopus citations

Unfolded protein response-regulated Drosophila Fic (dFic) protein reversibly AMPylates BiP chaperone during endoplasmic reticulum homeostasis

Ham, H., Woolery, A. R., Tracy, C., Stenesen, D., Krämer, H. & Orth, K., 2014, In : Journal of Biological Chemistry. 289, 52, p. 36059-36069 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

Vibrio type III effector VPA1380 is related to the cysteine protease domain of large bacterial toxins

Calder, T., Kinch, L. N., Fernandez, J., Salomon, D., Grishin, N. V. & Orth, K., Aug 6 2014, In : PloS one. 9, 8, e104387.

Research output: Contribution to journalArticle

11 Scopus citations
2013

A MAM7 peptide-based inhibitor of staphylococcus aureus adhesion does not interfere with in vitro host cell function

Hawley, C. A., Watson, C. A., Orth, K. & Krachler, A. M., Nov 12 2013, In : PloS one. 8, 11

Research output: Contribution to journalArticle

15 Scopus citations

An interview with Kim Orth.

Orth, K., Jul 2013, In : Trends in biochemical sciences. 38, 7, p. 331-332 2 p.

Research output: Contribution to journalComment/debate

Effectors of animal and plant pathogens use a common domain to bind host phosphoinositides

Salomon, D., Guo, Y., Kinch, L. N., Grishin, N. V., Gardner, K. H. & Orth, K., Dec 18 2013, In : Nature communications. 4, 2973.

Research output: Contribution to journalArticle

Open Access
31 Scopus citations

Lost after translation: Post-translational modifications by bacterial type III effectors

Salomon, D. & Orth, K., Apr 1 2013, In : Current Opinion in Microbiology. 16, 2, p. 213-220 8 p.

Research output: Contribution to journalReview article

6 Scopus citations

Made to stick: Anti-adhesion therapy for bacterial infections

Krachler, A. M. & Orth, K., Jul 1 2013, In : Microbe. 8, 7, p. 286-290 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Targeting the bacteria-host interface strategies in anti-adhesion therapy

Krachler, A. M. & Orth, K., Jan 1 2013, In : Virulence. 4, 4, p. 284-294 11 p.

Research output: Contribution to journalReview article

97 Scopus citations

The first engagement of partners in the Euprymna scolopes-Vibrio fischeri symbiosis is a two-step process initiated by a few environmental symbiont cells

Altura, M. A., Heath-Heckman, E. A. C., Gillette, A., Kremer, N., Krachler, A. M., Brennan, C., Ruby, E. G., Orth, K. & Mcfall-Ngai, M. J., Nov 1 2013, In : Environmental Microbiology. 15, 11, p. 2937-2950 14 p.

Research output: Contribution to journalArticle

30 Scopus citations

The pore-forming bacterial effector, VopQ, halts autophagic turnover

Sreelatha, A., Orth, K. & Starai, V. J., Dec 1 2013, In : Autophagy. 9, 12, p. 2169-2170 2 p.

Research output: Contribution to journalArticle

6 Scopus citations

Vibrio effector protein, VopQ, forms a lysosomal gated channel that disrupts host ion homeostasis and autophagic flux

Sreelatha, A., Bennett, T. L., Zheng, H., Jiang, Q. X., Orth, K. & Starai, V. J., Jul 9 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 28, p. 11559-11564 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

Vibrio parahaemolyticus Type VI Secretion System 1 Is Activated in Marine Conditions to Target Bacteria, and Is Differentially Regulated from System 2

Salomon, D., Gonzalez, H., Updegraff, B. L. & Orth, K., Apr 16 2013, In : PloS one. 8, 4, e61086.

Research output: Contribution to journalArticle

81 Scopus citations

Virulence determinants for Vibrio parahaemolyticus infection

Zhang, L. & Orth, K., Feb 1 2013, In : Current Opinion in Microbiology. 16, 1, p. 70-77 8 p.

Research output: Contribution to journalReview article

85 Scopus citations

What Pathogens Have Taught Us about Posttranslational Modifications

Salomon, D. & Orth, K., Sep 11 2013, In : Cell Host and Microbe. 14, 3, p. 269-279 11 p.

Research output: Contribution to journalReview article

27 Scopus citations