• 10704 Citations
  • 55 h-Index
1986 …2019

Research output per year

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Research Output

  • 10704 Citations
  • 55 h-Index
  • 135 Article
  • 2 Review article
  • 1 Chapter
  • 1 Short survey

20 Effector proteins of bacterial type III protein secretion systems: Elucidating their biochemical effects on eukaryotic signaling cascades

Orth, K., Dixon, J. E. & Bliska, J. B., 2002, In : Methods in Microbiology. 31, p. 361-376 16 p.

Research output: Contribution to journalArticle

Acanthamoeba castellanii promotes the survival of Vibrio parahaemolyticus

Laskowski-Arce, M. A. & Orth, K., Dec 2008, In : Applied and Environmental Microbiology. 74, 23, p. 7183-7188 6 p.

Research output: Contribution to journalArticle

23 Scopus citations

A chemical reporter for protein AMPylation

Grammel, M., Luong, P., Orth, K. & Hang, H. C., Nov 2 2011, In : Journal of the American Chemical Society. 133, 43, p. 17103-17105 3 p.

Research output: Contribution to journalArticle

43 Scopus citations

Acute hepatopancreatic necrosis disease-causing Vibrio parahaemolyticus strains maintain an antibacterial type VI secretion system with versatile effector repertoires

Li, P., Kinch, L. N., Ray, A., Dalia, A. B., Cong, Q., Nunan, L. M., Camilli, A., Grishin, N. V., Salomon, D. & Orth, K., 2017, In : Applied and Environmental Microbiology. 83, 13, e00737-17.

Research output: Contribution to journalArticle

23 Scopus citations

Adaptation to constant light requires Fic-mediated AMPylation of BiP to protect against reversible photoreceptor degeneration

Moehlman, A. T., Casey, A. K., Servage, K., Orth, K. & Krämer, H., Jul 17 2018, In : eLife. 7, e38752.

Research output: Contribution to journalArticle

2 Scopus citations

Adenylyl cyclase amino acid sequence: Possible channel- or transporter-like stucture

Krupinski, J., Coussen, F., Bakalyar, H. A., Tang, W. J., Feinstein, P. G., Orth, K., Slaughter, C., Reed, R. R. & Gilman, A. G., 1989, In : Science. 244, 4912, p. 1558-1564 7 p.

Research output: Contribution to journalArticle

483 Scopus citations

A distinctive role for the Yersinia protein kinase: Actin binding, kinase activation, and cytoskeleton disruption

Juris, S. J., Rudolph, A. E., Huddler, D., Orth, K. & Dixon, J. E., Aug 15 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 17, p. 9431-9436 6 p.

Research output: Contribution to journalArticle

139 Scopus citations

A MAM7 peptide-based inhibitor of staphylococcus aureus adhesion does not interfere with in vitro host cell function

Hawley, C. A., Watson, C. A., Orth, K. & Krachler, A. M., Nov 12 2013, In : PLoS One. 8, 11

Research output: Contribution to journalArticle

15 Scopus citations

Ampylation: Something old is new again

Woolery, A. R., Luong, P., Broberg, C. A. & Orth, K., 2010, In : Frontiers in Microbiology. 1, OCT, Article 113.

Research output: Contribution to journalArticle

43 Scopus citations

AMPylation is a new post-translational modiFICation

Yarbrough, M. L. & Orth, K., Jun 2009, In : Nature Chemical Biology. 5, 6, p. 378-379 2 p.

Research output: Contribution to journalArticle

24 Scopus citations

AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling

Yarbrough, M. L., Li, Y., Kinch, L. N., Grishin, N. V., Ball, H. L. & Orth, K., Jan 9 2009, In : Science. 323, 5911, p. 269-272 4 p.

Research output: Contribution to journalArticle

229 Scopus citations

AMPylation of rho GTPases subverts multiple host signaling processes

Woolery, A. R., Yu, X., LaBaer, J. & Orth, K., Nov 21 2014, In : Journal of Biological Chemistry. 289, 47, p. 32977-32988 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

A newly discovered post-translational modification - the acetylation of serine and threonine residues

Mukherjee, S., Hao, Y. H. & Orth, K., May 2007, In : Trends in Biochemical Sciences. 32, 5, p. 210-216 7 p.

Research output: Contribution to journalArticle

94 Scopus citations

An interview with Kim Orth.

Orth, K., Jul 2013, In : Trends in Biochemical Sciences. 38, 7, p. 331-332 2 p.

Research output: Contribution to journalArticle

AopP, a type III effector protein of Aeromonas salmonicida, inhibits the NF-κB signalling pathway

Fehr, D., Casanova, C., Liverman, A., Blazkova, H., Orth, K., Dobbelaere, D., Frey, J. & Burr, S. E., Sep 2006, In : Microbiology. 152, 9, p. 2809-2818 10 p.

Research output: Contribution to journalArticle

64 Scopus citations

Arp2/3-independent assembly of actin by Vibrio type III effector VopL

Liverman, A. D. B., Cheng, H. C., Trosky, J. E., Leung, D. W., Yarbrough, M. L., Burdette, D. L., Rosen, M. K. & Orth, K., Oct 23 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 43, p. 17117-17122 6 p.

Research output: Contribution to journalArticle

111 Scopus citations

A transforming growth factor β receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability

Myeroff, L. L., Parsons, R., Kim, S. J., Hedrick, L., Cho, K. R., Orth, K., Mathis, M., Kinzler, K. W., Lutterbaugh, J., Park, K., Bang, Y. J., Hwa Young Lee, Y. L., Park -, J. G., Lynch, H. T., Roberts, A. B., Vogelstein, B. & Markowitz, S. D., 1995, In : Cancer Research. 55, 23, p. 5545-5547 3 p.

Research output: Contribution to journalArticle

447 Scopus citations

A Vibrio effector protein is an inositol phosphatase and disrupts host cell membrane integrity

Broberg, C. A., Zhang, L., Gonzalez, H., Laskowski-Arce, M. A. & Orth, K., Sep 24 2010, In : Science. 329, 5999, p. 1660-1662 3 p.

Research output: Contribution to journalArticle

63 Scopus citations

Bik and Bak induce apoptosis downstream of CrmA but upstream of inhibitor of apoptosis

Orth, K. & Dixit, V. M., Apr 4 1997, In : Journal of Biological Chemistry. 272, 14, p. 8841-8844 4 p.

Research output: Contribution to journalArticle

57 Scopus citations

Bile salt receptor complex activates a pathogenic type III secretion system

Li, P., Rivera-Cancel, G., Kinch, L. N., Salomon, D., Tomchick, D. R., Grishin, N. V. & Orth, K., Jul 5 2016, In : eLife. 5, 2016JULY, e15718.

Research output: Contribution to journalArticle

17 Scopus citations

Binding in vitro of multiple cellular proteins to immunoglobulin heavy-chain enhancer DNA

Peterson, C. L., Orth, K. & Calame, K. L., 1986, In : Molecular and Cellular Biology. 6, 12, p. 4168-4178 11 p.

Research output: Contribution to journalArticle

37 Scopus citations

Biochemical basis for activation of virulence genes by bile salts in Vibrio parahaemolyticus

Rivera-Cancel, G. & Orth, K., Feb 8 2017, (Accepted/In press) In : Gut Microbes. p. 1-8 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Characterization of AMPylation on threonine, serine, and tyrosine using mass spectrometry

Li, Y., Al-Eryani, R., Yarbrough, M. L., Orth, K. & Ball, H. L., Apr 2011, In : Journal of the American Society for Mass Spectrometry. 22, 4, p. 752-761 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Characterization of a rabbit polyclonal antibody against threonine-AMPylation

Hao, Y. H., Chuang, T., Ball, H. L., Luong, P., Li, Y., Flores-Saaib, R. D. & Orth, K., Feb 10 2011, In : Journal of Biotechnology. 151, 3, p. 251-254 4 p.

Research output: Contribution to journalArticle

23 Scopus citations

Cleavage of focal adhesion kinase by caspases during apoptosis

Wen, L. P., Fahrni, J. A., Troie, S., Guan, J. L., Orth, K. & Rosen, G. D., Oct 10 1997, In : Journal of Biological Chemistry. 272, 41, p. 26056-26061 6 p.

Research output: Contribution to journalArticle

300 Scopus citations

Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of cdk2: Role of a caspase cascade

Levkau, B., Koyama, H., Raines, E. W., Clurman, B. E., Herren, B., Orth, K., Roberts, J. M. & Ross, R., Mar 1998, In : Molecular Cell. 1, 4, p. 553-563 11 p.

Research output: Contribution to journalArticle

403 Scopus citations

Comparison of the soluble and membrane-bound forms of the puromycin-sensitive enkephalin-degrading aminopeptidases from rat

Dyer, S. H., Slaughter, C. A., Orth, K., Moomaw, C. R. & Hersh, L. B., 1990, In : Journal of Neurochemistry. 54, 2, p. 547-554 8 p.

Research output: Contribution to journalArticle

58 Scopus citations
209 Scopus citations

Copper-catalyzed azide-alkyne cycloaddition (click chemistry)-based Detection of Global Pathogen-host AMPylation on Self-assembled Human Protein Microarrays

Yu, X., Woolery, A. R., Luong, P., Hao, Y. H., Grammel, M., Westcott, N., Park, J., Wang, J., Bian, X., Demirkan, G., Hang, H. C., Orth, K. & LaBaer, J., Nov 1 2014, In : Molecular and Cellular Proteomics. 13, 11, p. 3164-3176 13 p.

Research output: Contribution to journalArticle

25 Scopus citations

Cutting edge: Salmonella AvrA effector inhibits the key proinflammatory, anti-apoptotic NF-κB pathway

Collier-Hyams, L. S., Zeng, H., Sun, J., Tomlinson, A. D., Bao, Z. Q., Chen, H., Madara, J. L., Orth, K. & Neish, A. S., Sep 15 2002, In : Journal of Immunology. 169, 6, p. 2846-2850 5 p.

Research output: Contribution to journalArticle

205 Scopus citations

Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3

Chinnaiyan, A. M., Hanna, W. L., Orth, K., Duan, H., Poirier, G. G., Froelich, C. J. & Dixit, V. M., Jul 1 1996, In : Current Biology. 6, 7, p. 897-899 3 p.

Research output: Contribution to journalArticle

82 Scopus citations

De-AMPylation unmasked: Modulation of host membrane trafficking

Ham, H. & Orth, K., Oct 11 2011, In : Science Signaling. 4, 194, pe42.

Research output: Contribution to journalArticle

5 Scopus citations

Direct Detection of Tissue-Resident Bacteria and Chronic Inflammation in the Bladder Wall of Postmenopausal Women with Recurrent Urinary Tract Infection

De Nisco, N. J., Neugent, M., Mull, J. A., Chen, L., Kuprasertkul, A., de Souza Santos, M., Palmer, K. L., Zimmern, P. E. & Orth, K. A., Jan 1 2019, In : Journal of Molecular Biology.

Research output: Contribution to journalArticle

3 Scopus citations

Disruption of signaling by yersinia effector YopJ, a ubiquitin-like protein protease

Orth, K., Xu, Z., Mudgett, M. B., Bao, Z. Q., Palmer, L. E., Bliska, J. B., Mangel, W. F., Staskawicz, B. & Dixon, J. E., Nov 24 2000, In : Science. 290, 5496, p. 1594-1597 4 p.

Research output: Contribution to journalArticle

405 Scopus citations

Effectors of animal and plant pathogens use a common domain to bind host phosphoinositides.

Salomon, D., Guo, Y., Kinch, L. N., Grishin, N. V., Gardner, K. H. & Orth, K., 2013, In : Nature Communications. 4, 2973.

Research output: Contribution to journalArticle

31 Scopus citations

Enzymes Involved in AMPylation and deAMPylation

Casey, A. K. & Orth, K., Feb 14 2018, In : Chemical Reviews. 118, 3, p. 1199-1215 17 p.

Research output: Contribution to journalReview article

11 Scopus citations

ERK7 Is an Autoactivated Member of the MAPK Family

Abe, M. K., Kahle, K. T., Saelzler, M. P., Orth, K., Dixon, J. E. & Rosner, M. R., Jun 15 2001, In : Journal of Biological Chemistry. 276, 24, p. 21272-21279 8 p.

Research output: Contribution to journalArticle

53 Scopus citations

Evolution of a signalling system that incorporates both redundancy and diversity: Arabidopsis SUMOylation

Chosed, R., Mukherjee, S., Lois, L. M. & Orth, K., Sep 15 2006, In : Biochemical Journal. 398, 3, p. 521-529 9 p.

Research output: Contribution to journalArticle

45 Scopus citations

Expression and characterization of recombinant human acyloxyacyl hydrolase, a leukocyte enzyme that deacylates bacterial lipopolysaccharides

Hagen, F. S., Grant, F. J., Kuijper, J. L., Slaughter, C. A., Moomaw, C. R., Orth, K., O'Hara, P. J. & Munford, R. S., 1991, In : Biochemistry. 30, 34, p. 8415-8423 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

Fido, a novel ampylation domain common to fic, doc, and AvrB

Kinch, L. N., Yarbrough, M. L., Orth, K. & Grishin, N. V., Jun 5 2009, In : PLoS One. 4, 6, e5818.

Research output: Contribution to journalArticle

94 Scopus citations
41 Scopus citations

Functional expression of the Vibrio parahaemolyticus Na+/galactose (vSGLT) cotransporter in Xenopus laevis oocytes

Leung, D. W., Turk, E., Kim, O. & Wright, E. M., May 1 2002, In : Journal of Membrane Biology. 187, 1, p. 65-70 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Function of the Yersinia effector YopJ

Orth, K., 2002, In : Current Opinion in Microbiology. 5, 1, p. 38-43 6 p.

Research output: Contribution to journalArticle

150 Scopus citations
90 Scopus citations

Genetic instability in human ovarian cancer cell lines

Orth, K., Hung, J., Gazdar, A., Bowcock, A., Mathis, J. M. & Sambrook, J., Sep 27 1994, In : Proceedings of the National Academy of Sciences of the United States of America. 91, 20, p. 9495-9499 5 p.

Research output: Contribution to journalArticle

130 Scopus citations

Granule-mediated killing: Pathways for granzyme B-initiated apoptosis

Talanian, R. V., Yang, X. H., Turbov, J., Seth, P., Ghayur, T., Casiano, C. A., Orth, K. & Froelich, C. J., Oct 20 1997, In : Journal of Experimental Medicine. 186, 8, p. 1323-1331 9 p.

Research output: Contribution to journalArticle

153 Scopus citations

High-resolution cryo-EM structures of the E. Coli hemolysin ClyA oligomers

Peng, W., de Souza Santos, M., Li, Y., Tomchick, D. R. & Orth, K., May 1 2019, In : PloS one. 14, 5, e0213423.

Research output: Contribution to journalArticle

Open Access

Hijacking of host cell IKK signalosomes by the transforming parasite Theileria

Heussler, V. T., Rottenberg, S., Schwab, R., Küenzi, P., Fernandez, P. C., McKellar, S., Shiels, B., Chen, Z. J., Orth, K., Wallach, D. & Dobbelaere, D. A. E., Nov 1 2002, In : Science. 298, 5595, p. 1033-1036 4 p.

Research output: Contribution to journalArticle

102 Scopus citations

H-NS regulates the Vibrio parahaemolyticus type VI secretion system 1

Salomon, D., Klimko, J. A. & Orth, K., Sep 1 2014, In : Microbiology (Reading, England). 160, p. 1867-1873 7 p.

Research output: Contribution to journalArticle

24 Scopus citations

HTLV-1-Tax and ICAM-1 act on T-cell signal pathways to polarize the microtubule-organizing center at the virological synapse

Nejmeddine, M., Negi, V. S., Mukherjee, S., Tanaka, Y., Orth, K., Taylor, G. P. & Bangham, C. R. M., 2009, In : Blood. 114, 5, p. 1016-1025 10 p.

Research output: Contribution to journalArticle

62 Scopus citations