• 10832 Citations
  • 56 h-Index
1986 …2020

Research output per year

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Research Output

High-resolution cryo-EM structures of the E. Coli hemolysin ClyA oligomers

Peng, W., de Souza Santos, M., Li, Y., Tomchick, D. R. & Orth, K., May 2019, In : PloS one. 14, 5, e0213423.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Hijacking of host cell IKK signalosomes by the transforming parasite Theileria

Heussler, V. T., Rottenberg, S., Schwab, R., Küenzi, P., Fernandez, P. C., McKellar, S., Shiels, B., Chen, Z. J., Orth, K., Wallach, D. & Dobbelaere, D. A. E., Nov 1 2002, In : Science. 298, 5595, p. 1033-1036 4 p.

Research output: Contribution to journalArticle

106 Scopus citations

H-NS regulates the Vibrio parahaemolyticus type VI secretion system 1

Salomon, D., Klimko, J. A. & Orth, K., Sep 2014, In : Microbiology (United Kingdom). 160, PART 9, p. 1867-1873 7 p.

Research output: Contribution to journalArticle

26 Scopus citations

HTLV-1-Tax and ICAM-1 act on T-cell signal pathways to polarize the microtubule-organizing center at the virological synapse

Nejmeddine, M., Negi, V. S., Mukherjee, S., Tanaka, Y., Orth, K., Taylor, G. P. & Bangham, C. R. M., Nov 20 2009, In : Blood. 114, 5, p. 1016-1025 10 p.

Research output: Contribution to journalArticle

62 Scopus citations

Human pancreatic cancer cell exosomes, but not human normal cell exosomes, act as an initiator in cell transformation

Stefanius, K., Servage, K., de Souza Santos, M., Gray, H. F., Toombs, J. E., Chimalapati, S., Kim, M. S., Malladi, V. S., Brekken, R. & Orth, K., May 28 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B

Duan, H., Orth, K., Chinnaiyan, A. M., Poirier, G. G., Froelich, C. J., He, W. W. & Dixit, V. M., Jul 30 1996, In : Journal of Biological Chemistry. 271, 28, p. 16720-16724 5 p.

Research output: Contribution to journalArticle

294 Scopus citations

Identification of the human YVH1 protein-tyrosine phosphatase orthologue reveals a novel zinc binding domain essential for in vivo function

Muda, M., Manning, E. R., Orth, K. & Dixon, J. E., Aug 20 1999, In : Journal of Biological Chemistry. 274, 34, p. 23991-23995 5 p.

Research output: Contribution to journalArticle

38 Scopus citations

Inhibiting AMPylation: A novel screen to identify the first small molecule inhibitors of protein AMPylation

Lewallen, D. M., Sreelatha, A., Dharmarajan, V., Madoux, F., Chase, P., Griffin, P. R., Orth, K., Hodder, P. & Thompson, P. R., Feb 21 2014, In : ACS Chemical Biology. 9, 2, p. 433-442 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Inhibition of MAPK signaling pathways by VopA from Vibrio parahaemolyticus

Trosky, J. E., Mukherjee, S., Burdette, D. L., Roberts, M., McCarter, L., Siegel, R. M. & Orth, K., Dec 10 2004, In : Journal of Biological Chemistry. 279, 50, p. 51953-51957 5 p.

Research output: Contribution to journalArticle

82 Scopus citations

Inhibition of the mitogen-activated protein kinase kinase superfamily by a Yersinia effector

Orth, K., Palmer, L. E., Bao, Z. Q., Stewart, S., Rudolph, A. E., Bliska, J. B. & Dixon, J. E., Sep 17 1999, In : Science. 285, 5435, p. 1920-1923 4 p.

Research output: Contribution to journalArticle

308 Scopus citations

Intracellular Vibrio parahaemolyticus escapes the vacuole and establishes a replicative niche in the cytosol of epithelial cells

de Souza Santos, M. & Orth, K., Sep 9 2014, In : mBio. 5, 5, e01506-14.

Research output: Contribution to journalArticle

22 Scopus citations

In vitro activation of the IκB kinase complex by human T-cell leukemia virus type-1 tax

Mukherjee, S., Negi, V. S., Keitany, G., Tanaka, Y. & Orth, K., May 30 2008, In : Journal of Biological Chemistry. 283, 22, p. 15127-15133 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

In vitro characterization of multivalent adhesion molecule 7-based inhibition of multidrug-resistant bacteria isolated from wounded military personnel

Krachler, A. M., Mende, K., Murray, C. & Orth, K., Jan 1 2012, In : Virulence. 3, 4, p. 389-399 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

In Vitro Signaling by MAPK and NFκB Pathways Inhibited by Yersinia YopJ

Mukherjee, S. & Orth, K., 2008, In : Methods in Enzymology. 438, p. 343-353 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Kinetic and structural insights into the mechanism of AMPylation by VopS Fic domain

Luong, P., Kinch, L. N., Brautigam, C. A., Grishin, N. V., Tomchick, D. R. & Orth, K. A., Jun 25 2010, In : Journal of Biological Chemistry. 285, 26, p. 20155-20163 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

Lost after translation: Post-translational modifications by bacterial type III effectors

Salomon, D. & Orth, K., Apr 1 2013, In : Current Opinion in Microbiology. 16, 2, p. 213-220 8 p.

Research output: Contribution to journalReview article

6 Scopus citations
366 Scopus citations
49 Scopus citations

Made to stick: Anti-adhesion therapy for bacterial infections

Krachler, A. M. & Orth, K., Jul 1 2013, In : Microbe. 8, 7, p. 286-290 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Manipulation of host membranes by bacterial effectors

Ham, H., Sreelatha, A. & Orth, K., Sep 1 2011, In : Nature Reviews Microbiology. 9, 9, p. 635-646 12 p.

Research output: Contribution to journalReview article

86 Scopus citations

Manipulation of kinase signaling by bacterial pathogens

Krachler, A. M., Woolery, A. R. & Orth, K., Dec 1 2011, In : Journal of Cell Biology. 195, 7, p. 1083-1092 10 p.

Research output: Contribution to journalArticle

77 Scopus citations

Marker for type VI secretion system effectors

Salomon, D., Kinch, L. N., Trudgian, D. C., Guo, X., Klimko, J. A., Grishin, N. V., Mirzaei, H. & Orth, K., Jun 24 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 25, p. 9271-9276 6 p.

Research output: Contribution to journalArticle

58 Scopus citations

Microbiology: A protein pupylation paradigm

Mukherjee, S. & Orth, K., Nov 14 2008, In : Science. 322, 5904, p. 1062-1063 2 p.

Research output: Contribution to journalShort survey

1 Scopus citations

Molecular characterization of Vibrio parahaemolyticus vSGLT. A model for sodium-coupled sugar cotransporters

Turk, E., Kim, O., Le Coutre, J., Whitelegge, J. P., Eskandari, S., Lam, J. T., Kreman, M., Zampighi, G., Faull, K. F. & Wright, E. M., Aug 18 2000, In : Journal of Biological Chemistry. 275, 33, p. 25711-25716 6 p.

Research output: Contribution to journalArticle

70 Scopus citations
70 Scopus citations

Molecular dissection of ligand binding sites on the low density lipoprotein receptor-related protein

Willnow, T. E., Orth, K. & Herz, J., Jun 3 1994, In : Journal of Biological Chemistry. 269, 22, p. 15827-15832 6 p.

Research output: Contribution to journalArticle

108 Scopus citations

Molecular ordering of apoptotic mammalian CED-3/ICE-like proteases

Orth, K., O'Rourke, K., Salvesen, G. S. & Dixit, V. M., Sep 16 1996, In : Journal of Biological Chemistry. 271, 35, p. 20977-20980 4 p.

Research output: Contribution to journalArticle

184 Scopus citations

Molecular ordering of the cell death pathway: Bcl-2 and Bcl-xL function upstream of the ced-3-like apoptotic proteases

Chinnaiyan, A. M., Orth, K., O'Rourke, K., Duan, H., Poirier, G. G. & Dixit, V. M., Mar 1 1996, In : Journal of Biological Chemistry. 271, 9, p. 4573-4576 4 p.

Research output: Contribution to journalArticle

593 Scopus citations
Open Access
135 Scopus citations

My winding trail while fulfilling my love for science and family

Orth, K., Jul 6 2018, In : Journal of Biological Chemistry. 293, 27, p. 10435-10437 3 p.

Research output: Contribution to journalArticle

Natural transformation in Vibrio parahaemolyticus: A rapid method to create genetic deletions

Chimalapati, S., Santos, M. D. S., Servage, K., De Nisco, N. J., Dalia, A. B. & Orth, K., Aug 1 2018, In : Journal of bacteriology. 200, 15, e00032-18.

Research output: Contribution to journalArticle

5 Scopus citations

New paradigm for lymphocyte granule-mediated cytotoxicity: Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis

Froelich, C. J., Orth, K., Turbov, J., Seth, P., Gottlieb, R., Babior, B., Shah, G. M., Bleackley, R. C., Dixit, V. M. & Hanna, W., Nov 26 1996, In : Journal of Biological Chemistry. 271, 46, p. 29073-29079 7 p.

Research output: Contribution to journalArticle

297 Scopus citations

Not without cause: Vibrio parahaemolyticus induces acute autophagy and cell death

Burdette, D. L., Yarbrough, M. L. & Orth, K., Jan 1 2009, In : Autophagy. 5, 1, p. 100-102 3 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations
63 Scopus citations

Ovarian tumors display persistent microsatellite instability caused by mutation in the mismatch repair gene hMSH-2

Orth, K., Hung, J., Gazdar, A., Mathis, M., Bowcock, A. & Sambrook, J., Jan 1 1994, In : Cold Spring Harbor symposia on quantitative biology. 59, p. 349-356 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Paclitaxel-associated multimininucleation is permitted by the inhibition of caspase activation: A potential early step in drug resistance

Panvichian, R., Orth, K., Day, M. L., Day, K. C., Pilat, M. J. & Pienta, K. J., Oct 15 1998, In : Cancer Research. 58, 20, p. 4667-4672 6 p.

Research output: Contribution to journalArticle

73 Scopus citations

Peroxisome proliferation and induction of peroxisomal enzymes in mouse and rat liver by dehydroepiandrosterone feeding

Frenkel, R. A., Slaughter, C. A., Orth, K., Moomaw, C. R., Hicks, S. H., Snyder, J. M., Bennett, M., Prough, R. A., Putnam, R. S. & Milewich, L., Feb 1990, In : Journal of Steroid Biochemistry. 35, 2, p. 333-342 10 p.

Research output: Contribution to journalArticle

91 Scopus citations

Primary structure of the porin protein of Haemophilus influenzae type b determined by nucleotide sequence analysis

Hansen, E. J., Hasemann, C., Clausell, A., Capra, J. D., Orth, K., Moomaw, C. R., Slaughter, C. A., Latimer, J. L. & Miller, E. E., Jan 1 1989, In : Infection and immunity. 57, 4, p. 1100-1107 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Protein AMPylation by an Evolutionarily Conserved Pseudokinase

Sreelatha, A., Yee, S. S., Lopez, V. A., Park, B. C., Kinch, L. N., Pilch, S., Servage, K. A., Zhang, J., Jiou, J., Karasiewicz-Urbańska, M., Łobocka, M., Grishin, N. V., Orth, K. A., Kucharczyk, R., Pawłowski, K., Tomchick, D. R. & Tagliabracci, V. S., Oct 18 2018, In : Cell. 175, 3, p. 809-821.e19

Research output: Contribution to journalArticle

21 Scopus citations

Proteolysis of poly(ADP-ribose) polymerase by caspase 3: Kinetics of cleavage of mono(ADP-ribosyl)ated and DNA-bound substrates

D'Amours, D., Germain, M., Orth, K., Dixit, V. M. & Poirier, G. G., Jul 1 1998, In : Radiation research. 150, 1, p. 3-10 8 p.

Research output: Contribution to journalArticle

55 Scopus citations

Proteomics analysis reveals previously uncharacterized virulence factors in vibrio proteolyticus

Ray, A., Kinch, L. N., De Souza Santos, M., Grishin, N. V., Orth, K. & Salomon, D., Jul 1 2016, In : mBio. 7, 4, e01077-16.

Research output: Contribution to journalArticle

5 Scopus citations

Purification of the death substrate poly(ADP-ribose) polymerase.

D'Amours, D., Duriez, P. J., Orth, K., Shah, R. G., Dixit, V. M., Earnshaw, W. C., Alnemri, E. S. & Poirier, G. G., Jun 15 1997, In : Analytical biochemistry. 249, 1, p. 106-108 3 p.

Research output: Contribution to journalArticle

8 Scopus citations

Relationships among the subunits of the high molecular weight proteinase, macropain (proteasome)

Lee, L. W., Moomaw, C. R., Orth, K., McGuire, M. J., DeMartino, G. N. & Slaughter, C. A., Feb 9 1990, In : Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular. 1037, 2, p. 178-185 8 p.

Research output: Contribution to journalArticle

56 Scopus citations

Rise of a Cereal Killer: The Biology of Magnaporthe oryzae Biotrophic Growth

Fernandez, J. & Orth, K., Jan 1 2018, (Accepted/In press) In : Trends in Microbiology.

Research output: Contribution to journalArticle

22 Scopus citations

Salmonella secreted factor l deubiquitinase of Salmonella typhimurium inhibits NF-κB, Suppresses IkBαUbiquitination and modulates innate immune responses

Negrate, G. L., Faustin, B., Welsh, K., Loeffler, M., Krajewska, M., Hasegawa, P., Mukherjee, S., Orth, K., Krajewski, S., Godzik, A., Guiney, D. G. & Reed, J. C., Apr 1 2008, In : Journal of Immunology. 180, 7, p. 5045-5056 12 p.

Research output: Contribution to journalArticle

101 Scopus citations

Science signaling podcast for 16 may 2017: Vibrio rewires host cells

De Nisco, N. J., Orth, K. & VanHook, A. M., May 16 2017, In : Science Signaling. 10, 479, 5621.

Research output: Contribution to journalReview article

Sequence analysis of the 47-kilodalton major integral membrane immunogen of Treponema pallidum

Hus, P. L., Chamberlain, N. R., Orth, K., Moomaw, C. R., Zhang, L. Q., Slaughter, C. A., Radolf, J. D., Sell, S. & Norgard, M. V., Jan 1 1989, In : Infection and immunity. 57, 1, p. 196-203 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Signaling network of paclitaxel-induced apoptosis in the LNCaP prostate cancer cell line

Panvichian, R., Orth, K., Pilat, M. J., Day, M. L., Day, K. C., Yee, C., Kamradt, J. M. & Pienta, K. J., Oct 1 1999, In : Urology. 54, 4, p. 746-752 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Sorting of peroxisomal membrane protein PMP47 from Candida boidinii into peroxisomal membranes of Saccharomyces cerevisiae

McCammon, M. T., Dowds, C. A., Orth, K., Moomaw, C. R., Slaughter, C. A. & Goodman, J. M., Dec 18 1990, In : Journal of Biological Chemistry. 265, 33, p. 20099-20105 7 p.

Research output: Contribution to journalArticle

44 Scopus citations

Structural analysis of Xanthomonas XopD provides insights into substrate specificity of ubiquitin-like protein proteases

Chosed, R., Tomchick, D. R., Brautigam, C. A., Mukherjee, S., Negi, V. S., Machius, M. & Orth, K. A., Mar 2 2007, In : Journal of Biological Chemistry. 282, 9, p. 6773-6782 10 p.

Research output: Contribution to journalArticle

54 Scopus citations