• 10832 Citations
  • 56 h-Index
1986 …2020

Research output per year

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Research Output

Structural analysis of Xanthomonas XopD provides insights into substrate specificity of ubiquitin-like protein proteases

Chosed, R., Tomchick, D. R., Brautigam, C. A., Mukherjee, S., Negi, V. S., Machius, M. & Orth, K. A., Mar 2 2007, In : Journal of Biological Chemistry. 282, 9, p. 6773-6782 10 p.

Research output: Contribution to journalArticle

54 Scopus citations

Structural and antigenic conservation of the P2 porin protein among strains of Haemophilus influenzae type b

Hansen, E. J., Pelzel, S. E., Orth, K., Moomaw, C. R., Radolf, J. D. & Slaughter, C. A., Jan 1 1989, In : Infection and immunity. 57, 11, p. 3270-3275 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Structural and regulatory mutations in Vibrio parahaemolyticus type III secretion systems display variable effects on virulence

Calder, T., de Souza Santos, M., Attah, V., Klimko, J., Fernandez, J., Salomon, D., Krachler, A. M. & Orth, K., Dec 1 2014, In : FEMS Microbiology Letters. 361, 2, p. 107-114 8 p.

Research output: Contribution to journalLetter

7 Scopus citations

Structural requirements for Yersinia YopJ inhibition of MAP kinase pathways

Hao, Y. H., Wang, Y., Burdette, D., Mukherjee, S., Keitany, G., Goldsmith, E. & Orth, K., Jan 2 2008, In : PloS one. 3, 1, e1375.

Research output: Contribution to journalArticle

28 Scopus citations

Subversion of cell signaling by pathogens

Alto, N. M. & Orth, K., Sep 1 2012, In : Cold Spring Harbor Perspectives in Biology. 4, 9

Research output: Contribution to journalArticle

56 Scopus citations

Subversion of the cytoskeleton by intracellular bacteria: Lessons from Listeria, Salmonella and Vibrio

de Souza Santos, M. & Orth, K., Feb 1 2015, In : Cellular Microbiology. 17, 2, p. 164-173 10 p.

Research output: Contribution to journalReview article

15 Scopus citations

T3SS effector VopL inhibits the host ROS response, promoting the intracellular survival of Vibrio parahaemolyticus

de Souza Santos, M., Salomon, D. & Orth, K., 2017, In : PLoS Pathogens. 13, 6, e1006438.

Research output: Contribution to journalArticle

12 Scopus citations

Targeting bacterial adherence inhibits multidrug-resistant Pseudomonas aeruginosa infection following burn injury

Huebinger, R. M., Stones, D. H., De Souza Santos, M., Carlson, D. L., Song, J., Vaz, D. P., Keen, E., Wolf, S. E., Orth, K. & Krachler, A. M., Dec 20 2016, In : Scientific reports. 6, 39341.

Research output: Contribution to journalArticle

13 Scopus citations

Targeting the bacteria-host interface strategies in anti-adhesion therapy

Krachler, A. M. & Orth, K., Jan 1 2013, In : Virulence. 4, 4, p. 284-294 11 p.

Research output: Contribution to journalReview article

97 Scopus citations

T-cell receptor ligation by peptide/MHC induces activation of a caspase in immature thymocytes: The molecular basis of negative selection

Clayton, L. K., Ghendler, Y., Mizoguchi, E., Patch, R. J., Ocain, T. D., Orth, K., Bhan, A. K., Dixit, V. M. & Reinherz, E. L., May 1 1997, In : EMBO Journal. 16, 9, p. 2282-2293 12 p.

Research output: Contribution to journalArticle

89 Scopus citations

The biochemistry of sensing: Enteric pathogens regulate type iii secretion in response to environmental and host cues

de Nisco, N. J., Rivera-Cancel, G. & Orth, K., Jan 1 2018, In : mBio. 9, 1, e02122-17.

Research output: Contribution to journalShort survey

7 Scopus citations

The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A

Orth, K., Chinnaiyan, A. M., Garg, M., Froelich, C. J. & Dixit, V. M., Jul 30 1996, In : Journal of Biological Chemistry. 271, 28, p. 16443-16446 4 p.

Research output: Contribution to journalArticle

364 Scopus citations

The cytotoxic type 3 secretion system 1 of Vibrio rewires host gene expression to subvert cell death and activate cell survival pathways

De Nisco, N. J., Kanchwala, M., Li, P., Fernandez, J., Xing, C. & Orth, K., May 16 2017, In : Science Signaling. 10, 479, l4501.

Research output: Contribution to journalArticle

3 Scopus citations

The elusive activity of the Yersinia protein kinase A kinase domain is revealed

Laskowski-Arce, M. A. & Orth, K., Oct 1 2007, In : Trends in Microbiology. 15, 10, p. 437-440 4 p.

Research output: Contribution to journalShort survey

2 Scopus citations

The first engagement of partners in the Euprymna scolopes-Vibrio fischeri symbiosis is a two-step process initiated by a few environmental symbiont cells

Altura, M. A., Heath-Heckman, E. A. C., Gillette, A., Kremer, N., Krachler, A. M., Brennan, C., Ruby, E. G., Orth, K. & Mcfall-Ngai, M. J., Nov 1 2013, In : Environmental Microbiology. 15, 11, p. 2937-2950 14 p.

Research output: Contribution to journalArticle

30 Scopus citations

The pore-forming bacterial effector, VopQ, halts autophagic turnover

Sreelatha, A., Orth, K. & Starai, V. J., Dec 1 2013, In : Autophagy. 9, 12, p. 2169-2170 2 p.

Research output: Contribution to journalArticle

6 Scopus citations

The primary structures of four subunits of the human, high-molecular-weight proteinase, macropain (proteasome), are distinct but homologous

DeMartino, G. N., Orth, K., McCullough, M. L., Lee, L. W., Munn, T. Z., Moomaw, C. R., Dawson, P. A. & Slaughter, C. A., Aug 9 1991, In : Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular. 1079, 1, p. 29-38 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

The role of the type III secretion system in the intracellular lifestyle of enteric pathogens

Santos, M. D. S. & Orth, K. A., May 1 2019, In : Microbiology Spectrum. 7, 3, BAI-0008-2019.

Research output: Contribution to journalArticle

1 Scopus citations

The role of type III secretion System 2 in Vibrio parahaemolyticus pathogenicity

Ham, H. & Orth, K., Nov 12 2012, In : Journal of Microbiology. 50, 5, p. 719-725 7 p.

Research output: Contribution to journalReview article

27 Scopus citations

Tipping the balance by manipulating post-translational modifications

Broberg, C. A. & Orth, K., Feb 1 2010, In : Current Opinion in Microbiology. 13, 1, p. 34-40 7 p.

Research output: Contribution to journalReview article

25 Scopus citations

Turnabout is fair play: Use of the bacterial multivalent adhesion molecule 7 as an antimicrobial agent

Krachler, A. M., Ham, H. & Orth, K., Jan 1 2012, In : Virulence. 3, 1, p. 68-71 4 p.

Research output: Contribution to journalArticle

22 Scopus citations

Type III Effector VopC Mediates Invasion for Vibrio Species

Zhang, L., Krachler, A. M., Broberg, C. A., Li, Y., Mirzael, H., Gilpin, C. J. & Orth, K., May 31 2012, In : Cell Reports. 1, 5, p. 453-460 8 p.

Research output: Contribution to journalArticle

66 Scopus citations

Type VI secretion system

Salomon, D. & Orth, K., 2015, In : Current Biology. 25, 7, p. R265-R266

Research output: Contribution to journalArticle

4 Scopus citations

Type VI secretion system MIX-effectors carry both antibacterial and anti-eukaryotic activities

Ray, A., Schwartz, N., de Souza Santos, M., Zhang, J., Orth, K. & Salomon, D., Nov 2017, In : EMBO Reports. 18, 11, p. 1978-1990 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

Type VI Secretion System Toxins Horizontally Shared between Marine Bacteria

Salomon, D., Klimko, J. A., Trudgian, D. C., Kinch, L. N., Grishin, N. V., Mirzaei, H. & Orth, K., Aug 1 2015, In : PLoS Pathogens. 11, 8, e1005128.

Research output: Contribution to journalArticle

27 Scopus citations

Tyrosine 67 in the epidermal growth factor-like domain of tissue-type plasminogen activator is important for clearance by a specific hepatic receptor

Bassel-Duby, R., Jiang, N. Y., Bittick, T., Madison, E., McGookey, D., Orth, K., Shohet, R., Sambrook, J. & Gething, M. J., Jan 1 1992, In : Journal of Biological Chemistry. 267, 14, p. 9668-9677 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

Unfolded protein response-regulated Drosophila Fic (dFic) protein reversibly AMPylates BiP chaperone during endoplasmic reticulum homeostasis

Ham, H., Woolery, A. R., Tracy, C., Stenesen, D., Krämer, H. & Orth, K., 2014, In : Journal of Biological Chemistry. 289, 52, p. 36059-36069 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

Versatile type III effector mechanisms can disrupt target-cell functions

Orth, K., Apr 2007, In : Microbe. 2, 4, p. 183-186 4 p.

Research output: Contribution to journalReview article

Open Access
5 Scopus citations

Vibrio effector protein, VopQ, forms a lysosomal gated channel that disrupts host ion homeostasis and autophagic flux

Sreelatha, A., Bennett, T. L., Zheng, H., Jiang, Q. X., Orth, K. & Starai, V. J., Jul 9 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 28, p. 11559-11564 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

Vibrio effector protein VopQ inhibits fusion of V-ATPase-containing membranes

Sreelatha, A., Bennett, T. L., Carpinone, E. M., O'Brien, K. M., Jordan, K. D., Burdette, D. L., Orth, K. & Starai, V. J., Jan 6 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 1, p. 100-105 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

Vibrio parahaemolyticus cell biology and pathogenicity determinants

Broberg, C. A., Calder, T. J. & Orth, K., Nov 1 2011, In : Microbes and Infection. 13, 12-13, p. 992-1001 10 p.

Research output: Contribution to journalShort survey

168 Scopus citations

Vibrio parahaemolyticus orchestrates a multifaceted host cell infection by induction of autophagy, cell rounding, and then cell lysis

Burdette, D. L., Yarbrough, M. L., Orvedahl, A., Gilpin, C. J. & Orth, K., Aug 26 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 34, p. 12497-12502 6 p.

Research output: Contribution to journalArticle

78 Scopus citations

Vibrio parahaemolyticus Type VI Secretion System 1 Is Activated in Marine Conditions to Target Bacteria, and Is Differentially Regulated from System 2

Salomon, D., Gonzalez, H., Updegraff, B. L. & Orth, K., Apr 16 2013, In : PloS one. 8, 4, e61086.

Research output: Contribution to journalArticle

81 Scopus citations

Vibrio parahaemolyticus virulence determinants

De Souza Santos, M., Salomon, D., Li, P., Krachler, A. M. & Orth, K., Jun 5 2015, The Comprehensive Sourcebook of Bacterial Protein Toxins. Elsevier Inc., p. 230-260 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

Vibrio type III effector VPA1380 is related to the cysteine protease domain of large bacterial toxins

Calder, T., Kinch, L. N., Fernandez, J., Salomon, D., Grishin, N. V. & Orth, K., Aug 6 2014, In : PloS one. 9, 8, e104387.

Research output: Contribution to journalArticle

11 Scopus citations

Viorio VopQ induces Pu-kmase-independent autophagy and antagonizes phagocytosis

Burdette, D. L., Seemann, J. & Orth, K., Aug 1 2009, In : Molecular Microbiology. 73, 4, p. 639-649 11 p.

Research output: Contribution to journalArticle

63 Scopus citations

Virulence determinants for Vibrio parahaemolyticus infection

Zhang, L. & Orth, K., Feb 1 2013, In : Current Opinion in Microbiology. 16, 1, p. 70-77 8 p.

Research output: Contribution to journalReview article

85 Scopus citations

Visual neurotransmission in Drosophila requires expression of Fic in glial capitate projections

Rahman, M., Ham, H., Liu, X., Sugiura, Y., Orth, K. & Krämer, H., Jun 1 2012, In : Nature neuroscience. 15, 6, p. 871-875 5 p.

Research output: Contribution to journalArticle

41 Scopus citations

VopA inhibits ATP binding by acetylating the catalytic loop of MAPK kinases

Trosky, J. E., Li, Y., Mukherjee, S., Keitany, G., Ball, H. & Orth, K., Nov 23 2007, In : Journal of Biological Chemistry. 282, 47, p. 34299-34305 7 p.

Research output: Contribution to journalArticle

76 Scopus citations

What Pathogens Have Taught Us about Posttranslational Modifications

Salomon, D. & Orth, K., Sep 11 2013, In : Cell Host and Microbe. 14, 3, p. 269-279 11 p.

Research output: Contribution to journalReview article

27 Scopus citations

Xanthomonas type III effector XopD targets SUMO-conjugated proteins in planta

Hotson, A., Chosed, R., Shu, H., Orth, K. & Mudgett, M. B., Oct 1 2003, In : Molecular Microbiology. 50, 2, p. 377-389 13 p.

Research output: Contribution to journalArticle

197 Scopus citations

Yersinia effector YopJ inhibits yeast MAPK signaling pathways by an evolutionarily conserved mechanism

Yoon, S., Liu, Z., Eyobo, Y. & Orth, K., Jan 24 2003, In : Journal of Biological Chemistry. 278, 4, p. 2131-2135 5 p.

Research output: Contribution to journalArticle

39 Scopus citations

Yersinia outer proteins: Yops

Trosky, J. E., Liverman, A. D. B. & Orth, K., Mar 1 2008, In : Cellular Microbiology. 10, 3, p. 557-565 9 p.

Research output: Contribution to journalShort survey

81 Scopus citations

Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation

Mukherjee, S., Keitany, G., Li, Y., Wang, Y., Ball, H. L., Goldsmith, E. J. & Orth, K., May 26 2006, In : Science. 312, 5777, p. 1211-1214 4 p.

Research output: Contribution to journalArticle

407 Scopus citations