• 10767 Citations
  • 56 h-Index
1986 …2019

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

1999

Identification of the human YVH1 protein-tyrosine phosphatase orthologue reveals a novel zinc binding domain essential for in vivo function

Muda, M., Manning, E. R., Orth, K. & Dixon, J. E., Aug 20 1999, In : Journal of Biological Chemistry. 274, 34, p. 23991-23995 5 p.

Research output: Contribution to journalArticle

38 Scopus citations

Inhibition of the mitogen-activated protein kinase kinase superfamily by a Yersinia effector

Orth, K., Palmer, L. E., Bao, Z. Q., Stewart, S., Rudolph, A. E., Bliska, J. B. & Dixon, J. E., Sep 17 1999, In : Science. 285, 5435, p. 1920-1923 4 p.

Research output: Contribution to journalArticle

307 Scopus citations

Signaling network of paclitaxel-induced apoptosis in the LNCaP prostate cancer cell line

Panvichian, R., Orth, K., Pilat, M. J., Day, M. L., Day, K. C., Yee, C., Kamradt, J. M. & Pienta, K. J., Oct 1 1999, In : Urology. 54, 4, p. 746-752 7 p.

Research output: Contribution to journalArticle

16 Scopus citations
1998

Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of cdk2: Role of a caspase cascade

Levkau, B., Koyama, H., Raines, E. W., Clurman, B. E., Herren, B., Orth, K., Roberts, J. M. & Ross, R., Mar 1998, In : Molecular cell. 1, 4, p. 553-563 11 p.

Research output: Contribution to journalArticle

Open Access
403 Scopus citations

Paclitaxel-associated multimininucleation is permitted by the inhibition of caspase activation: A potential early step in drug resistance

Panvichian, R., Orth, K., Day, M. L., Day, K. C., Pilat, M. J. & Pienta, K. J., Oct 15 1998, In : Cancer Research. 58, 20, p. 4667-4672 6 p.

Research output: Contribution to journalArticle

73 Scopus citations

Proteolysis of poly(ADP-ribose) polymerase by caspase 3: Kinetics of cleavage of mono(ADP-ribosyl)ated and DNA-bound substrates

D'Amours, D., Germain, M., Orth, K., Dixit, V. M. & Poirier, G. G., Jul 1 1998, In : Radiation research. 150, 1, p. 3-10 8 p.

Research output: Contribution to journalArticle

55 Scopus citations
1997

Bik and Bak induce apoptosis downstream of CrmA but upstream of inhibitor of apoptosis

Orth, K. & Dixit, V. M., Apr 4 1997, In : Journal of Biological Chemistry. 272, 14, p. 8841-8844 4 p.

Research output: Contribution to journalArticle

57 Scopus citations

Cleavage of focal adhesion kinase by caspases during apoptosis

Wen, L. P., Fahrni, J. A., Troie, S., Guan, J. L., Orth, K. & Rosen, G. D., Oct 10 1997, In : Journal of Biological Chemistry. 272, 41, p. 26056-26061 6 p.

Research output: Contribution to journalArticle

300 Scopus citations

Granule-mediated killing: Pathways for granzyme B-initiated apoptosis

Talanian, R. V., Yang, X. H., Turbov, J., Seth, P., Ghayur, T., Casiano, C. A., Orth, K. & Froelich, C. J., Oct 20 1997, In : Journal of Experimental Medicine. 186, 8, p. 1323-1331 9 p.

Research output: Contribution to journalArticle

153 Scopus citations

Purification of the death substrate poly(ADP-ribose) polymerase.

D'Amours, D., Duriez, P. J., Orth, K., Shah, R. G., Dixit, V. M., Earnshaw, W. C., Alnemri, E. S. & Poirier, G. G., Jun 15 1997, In : Analytical biochemistry. 249, 1, p. 106-108 3 p.

Research output: Contribution to journalArticle

8 Scopus citations

T-cell receptor ligation by peptide/MHC induces activation of a caspase in immature thymocytes: The molecular basis of negative selection

Clayton, L. K., Ghendler, Y., Mizoguchi, E., Patch, R. J., Ocain, T. D., Orth, K., Bhan, A. K., Dixit, V. M. & Reinherz, E. L., May 1 1997, In : EMBO Journal. 16, 9, p. 2282-2293 12 p.

Research output: Contribution to journalArticle

89 Scopus citations
1996

Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3

Chinnaiyan, A. M., Hanna, W. L., Orth, K., Duan, H., Poirier, G. G., Froelich, C. J. & Dixit, V. M., Jan 1 1996, In : Current Biology. 6, 7, p. 897-899 3 p.

Research output: Contribution to journalArticle

82 Scopus citations

ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B

Duan, H., Orth, K., Chinnaiyan, A. M., Poirier, G. G., Froelich, C. J., He, W. W. & Dixit, V. M., Jul 30 1996, In : Journal of Biological Chemistry. 271, 28, p. 16720-16724 5 p.

Research output: Contribution to journalArticle

294 Scopus citations

Molecular ordering of apoptotic mammalian CED-3/ICE-like proteases

Orth, K., O'Rourke, K., Salvesen, G. S. & Dixit, V. M., Sep 16 1996, In : Journal of Biological Chemistry. 271, 35, p. 20977-20980 4 p.

Research output: Contribution to journalArticle

184 Scopus citations

Molecular ordering of the cell death pathway: Bcl-2 and Bcl-xL function upstream of the ced-3-like apoptotic proteases

Chinnaiyan, A. M., Orth, K., O'Rourke, K., Duan, H., Poirier, G. G. & Dixit, V. M., Mar 1 1996, In : Journal of Biological Chemistry. 271, 9, p. 4573-4576 4 p.

Research output: Contribution to journalArticle

592 Scopus citations

New paradigm for lymphocyte granule-mediated cytotoxicity: Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis

Froelich, C. J., Orth, K., Turbov, J., Seth, P., Gottlieb, R., Babior, B., Shah, G. M., Bleackley, R. C., Dixit, V. M. & Hanna, W., Nov 26 1996, In : Journal of Biological Chemistry. 271, 46, p. 29073-29079 7 p.

Research output: Contribution to journalArticle

296 Scopus citations

The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A

Orth, K., Chinnaiyan, A. M., Garg, M., Froelich, C. J. & Dixit, V. M., Jul 30 1996, In : Journal of Biological Chemistry. 271, 28, p. 16443-16446 4 p.

Research output: Contribution to journalArticle

364 Scopus citations
1995

A Transforming Growth Factor β Receptor Type II Gene Mutation Common in Colon and Gastric but Rare in Endometrial Cancers with Microsatellite Instability

Myeroff, L. L., Parsons, R., Kim, S. J., Hedrick, L., Cho, K. R., Orth, K., Mathis, M., Kinzler, K. W., Lutterbaugh, J., Park, K., Bang, Y. J., Hwa Young Lee, Y. L., Park -, J. G., Lynch, H. T., Roberts, A. B., Vogelstein, B. & Markowitz, S. D., Dec 1 1995, In : Cancer research. 55, 23, p. 5545-5547 3 p.

Research output: Contribution to journalArticle

447 Scopus citations
1994

Genetic instability in human ovarian cancer cell lines

Orth, K., Hung, J., Gazdar, A., Bowcock, A., Mathis, J. M. & Sambrook, J., Sep 27 1994, In : Proceedings of the National Academy of Sciences of the United States of America. 91, 20, p. 9495-9499 5 p.

Research output: Contribution to journalArticle

Open Access
130 Scopus citations
49 Scopus citations

Molecular dissection of ligand binding sites on the low density lipoprotein receptor-related protein

Willnow, T. E., Orth, K. & Herz, J., Jun 3 1994, In : Journal of Biological Chemistry. 269, 22, p. 15827-15832 6 p.

Research output: Contribution to journalArticle

108 Scopus citations

Ovarian tumors display persistent microsatellite instability caused by mutation in the mismatch repair gene hMSH-2

Orth, K., Hung, J., Gazdar, A., Mathis, M., Bowcock, A. & Sambrook, J., Jan 1 1994, In : Cold Spring Harbor symposia on quantitative biology. 59, p. 349-356 8 p.

Research output: Contribution to journalArticle

4 Scopus citations
1992
Open Access
209 Scopus citations
366 Scopus citations

Tyrosine 67 in the epidermal growth factor-like domain of tissue-type plasminogen activator is important for clearance by a specific hepatic receptor

Bassel-Duby, R., Jiang, N. Y., Bittick, T., Madison, E., McGookey, D., Orth, K., Shohet, R., Sambrook, J. & Gething, M. J., Jan 1 1992, In : Journal of Biological Chemistry. 267, 14, p. 9668-9677 10 p.

Research output: Contribution to journalArticle

30 Scopus citations
1991

Expression and Characterization of Recombinant Human Acyloxyacyl Hydrolase, a Leukocyte Enzyme That Deacylates Bacterial Lipopolysaccharides

Hagen, F. S., Grant, F. J., Kuijper, J. L., Slaughter, C. A., Moomaw, C. R., Orth, K., O'Hara, P. J. & Munford, R. S., Aug 1 1991, In : Biochemistry. 30, 34, p. 8415-8423 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

Genetic and molecular characterization of tube, a Drosophila gene maternally required for embryonic dorsoventral polarity

Letsou, A., Alexander, S., Orth, K. & Wasserman, S. A., Jan 1 1991, In : Proceedings of the National Academy of Sciences of the United States of America. 88, 3, p. 810-814 5 p.

Research output: Contribution to journalArticle

Open Access
90 Scopus citations

The primary structures of four subunits of the human, high-molecular-weight proteinase, macropain (proteasome), are distinct but homologous

DeMartino, G. N., Orth, K., McCullough, M. L., Lee, L. W., Munn, T. Z., Moomaw, C. R., Dawson, P. A. & Slaughter, C. A., Aug 9 1991, In : Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular. 1079, 1, p. 29-38 10 p.

Research output: Contribution to journalArticle

40 Scopus citations
1990

Comparison of the Soluble and Membrane‐Bound Forms of the Puromycin‐Sensitive Enkephalin‐Degrading Aminopeptidases from Rat

Dyer, S. H., Slaughter, C. A., Orth, K., Moomaw, C. R. & Hersh, L. B., Feb 1990, In : Journal of Neurochemistry. 54, 2, p. 547-554 8 p.

Research output: Contribution to journalArticle

58 Scopus citations

Peroxisome proliferation and induction of peroxisomal enzymes in mouse and rat liver by dehydroepiandrosterone feeding

Frenkel, R. A., Slaughter, C. A., Orth, K., Moomaw, C. R., Hicks, S. H., Snyder, J. M., Bennett, M., Prough, R. A., Putnam, R. S. & Milewich, L., Feb 1990, In : Journal of Steroid Biochemistry. 35, 2, p. 333-342 10 p.

Research output: Contribution to journalArticle

91 Scopus citations

Relationships among the subunits of the high molecular weight proteinase, macropain (proteasome)

Lee, L. W., Moomaw, C. R., Orth, K., McGuire, M. J., DeMartino, G. N. & Slaughter, C. A., Feb 9 1990, In : Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular. 1037, 2, p. 178-185 8 p.

Research output: Contribution to journalArticle

56 Scopus citations

Sorting of peroxisomal membrane protein PMP47 from Candida boidinii into peroxisomal membranes of Saccharomyces cerevisiae

McCammon, M. T., Dowds, C. A., Orth, K., Moomaw, C. R., Slaughter, C. A. & Goodman, J. M., Dec 18 1990, In : Journal of Biological Chemistry. 265, 33, p. 20099-20105 7 p.

Research output: Contribution to journalArticle

44 Scopus citations
1989

Adenylyl cyclase amino acid sequence: Possible channel- or transporter-like stucture

Krupinski, J., Coussen, F., Bakalyar, H. A., Tang, W. J., Feinstein, P. G., Orth, K., Slaughter, C., Reed, R. R. & Gilman, A. G., Jan 1 1989, In : Science. 244, 4912, p. 1558-1564 7 p.

Research output: Contribution to journalArticle

484 Scopus citations
70 Scopus citations

Primary structure of the porin protein of Haemophilus influenzae type b determined by nucleotide sequence analysis

Hansen, E. J., Hasemann, C., Clausell, A., Capra, J. D., Orth, K., Moomaw, C. R., Slaughter, C. A., Latimer, J. L. & Miller, E. E., Jan 1 1989, In : Infection and immunity. 57, 4, p. 1100-1107 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Sequence analysis of the 47-kilodalton major integral membrane immunogen of Treponema pallidum

Hus, P. L., Chamberlain, N. R., Orth, K., Moomaw, C. R., Zhang, L. Q., Slaughter, C. A., Radolf, J. D., Sell, S. & Norgard, M. V., Jan 1 1989, In : Infection and immunity. 57, 1, p. 196-203 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Structural and antigenic conservation of the P2 porin protein among strains of Haemophilus influenzae type b

Hansen, E. J., Pelzel, S. E., Orth, K., Moomaw, C. R., Radolf, J. D. & Slaughter, C. A., Jan 1 1989, In : Infection and immunity. 57, 11, p. 3270-3275 6 p.

Research output: Contribution to journalArticle

10 Scopus citations
1988
Open Access
135 Scopus citations
1986

Binding in vitro of multiple cellular proteins to immunoglobulin heavy-chain enhancer DNA

Peterson, C. L., Orth, K. & Calame, K. L., Jan 1 1986, In : Molecular and cellular biology. 6, 12, p. 4168-4178 11 p.

Research output: Contribution to journalArticle

Open Access
37 Scopus citations