• 10832 Citations
  • 56 h-Index
1986 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2020

Calcium-stimulated disassembly of focal adhesions mediated by an orp3/iqsec1 complex

D’souza, R. S., Lim, J. Y., Turgut, A., Servage, K., Zhang, J., Orth, K., Sosale, N. G., Lazzara, M. J., Allegood, J. & Casanova, J. E., Apr 2020, In : eLife. 9, e54113.

Research output: Contribution to journalArticle

Open Access

GCNA Preserves Genome Integrity and Fertility Across Species

Bhargava, V., Goldstein, C. D., Russell, L., Xu, L., Ahmed, M., Li, W., Casey, A., Servage, K., Kollipara, R., Picciarelli, Z., Kittler, R., Yatsenko, A., Carmell, M., Orth, K., Amatruda, J. F., Yanowitz, J. L. & Buszczak, M., Jan 6 2020, In : Developmental cell. 52, 1, p. 38-52.e10

Research output: Contribution to journalArticle

3 Scopus citations

Proteomic Profiling of Small Extracellular Vesicles Secreted by Human Pancreatic Cancer Cells Implicated in Cellular Transformation

Servage, K. A., Stefanius, K., Gray, H. F. & Orth, K., Dec 1 2020, In : Scientific reports. 10, 1, 7713.

Research output: Contribution to journalArticle

Open Access
2019

A novel mouse model of enteric vibrio parahaemolyticus infection reveals that the type iii secretion system 2 effector vopc plays a key role in tissue invasion and gastroenteritis

Yang, H., Santos, M. D. S., Lee, J., Law, H. T., Chimalapati, S., Verdu, E. F., Vallance, B. A. & Orth, K., Nov 1 2019, In : mBio. 10, 6, e02608-19.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Direct Detection of Tissue-Resident Bacteria and Chronic Inflammation in the Bladder Wall of Postmenopausal Women with Recurrent Urinary Tract Infection

De Nisco, N. J., Neugent, M., Mull, J. A., Chen, L., Kuprasertkul, A., de Souza Santos, M., Palmer, K. L., Zimmern, P. E. & Orth, K. A., Jan 1 2019, In : Journal of Molecular Biology.

Research output: Contribution to journalArticle

5 Scopus citations

High-resolution cryo-EM structures of the E. Coli hemolysin ClyA oligomers

Peng, W., de Souza Santos, M., Li, Y., Tomchick, D. R. & Orth, K., May 2019, In : PloS one. 14, 5, e0213423.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Human pancreatic cancer cell exosomes, but not human normal cell exosomes, act as an initiator in cell transformation

Stefanius, K., Servage, K., de Souza Santos, M., Gray, H. F., Toombs, J. E., Chimalapati, S., Kim, M. S., Malladi, V. S., Brekken, R. & Orth, K., May 28 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

The role of the type III secretion system in the intracellular lifestyle of enteric pathogens

Santos, M. D. S. & Orth, K. A., May 1 2019, In : Microbiology Spectrum. 7, 3, BAI-0008-2019.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Adaptation to constant light requires Fic-mediated AMPylation of BiP to protect against reversible photoreceptor degeneration

Moehlman, A. T., Casey, A. K., Servage, K., Orth, K. & Krämer, H., Jul 17 2018, In : eLife. 7, e38752.

Research output: Contribution to journalArticle

3 Scopus citations

My winding trail while fulfilling my love for science and family

Orth, K., Jul 6 2018, In : Journal of Biological Chemistry. 293, 27, p. 10435-10437 3 p.

Research output: Contribution to journalArticle

Natural transformation in Vibrio parahaemolyticus: A rapid method to create genetic deletions

Chimalapati, S., Santos, M. D. S., Servage, K., De Nisco, N. J., Dalia, A. B. & Orth, K., Aug 1 2018, In : Journal of bacteriology. 200, 15, e00032-18.

Research output: Contribution to journalArticle

5 Scopus citations

Protein AMPylation by an Evolutionarily Conserved Pseudokinase

Sreelatha, A., Yee, S. S., Lopez, V. A., Park, B. C., Kinch, L. N., Pilch, S., Servage, K. A., Zhang, J., Jiou, J., Karasiewicz-Urbańska, M., Łobocka, M., Grishin, N. V., Orth, K. A., Kucharczyk, R., Pawłowski, K., Tomchick, D. R. & Tagliabracci, V. S., Oct 18 2018, In : Cell. 175, 3, p. 809-821.e19

Research output: Contribution to journalArticle

21 Scopus citations

Rise of a Cereal Killer: The Biology of Magnaporthe oryzae Biotrophic Growth

Fernandez, J. & Orth, K., Jan 1 2018, (Accepted/In press) In : Trends in Microbiology.

Research output: Contribution to journalArticle

22 Scopus citations
2017

Acute hepatopancreatic necrosis disease-causing Vibrio parahaemolyticus strains maintain an antibacterial type VI secretion system with versatile effector repertoires

Li, P., Kinch, L. N., Ray, A., Dalia, A. B., Cong, Q., Nunan, L. M., Camilli, A., Grishin, N. V., Salomon, D. & Orth, K., 2017, In : Applied and Environmental Microbiology. 83, 13, e00737-17.

Research output: Contribution to journalArticle

27 Scopus citations

Biochemical basis for activation of virulence genes by bile salts in Vibrio parahaemolyticus

Rivera-Cancel, G. & Orth, K., Feb 8 2017, (Accepted/In press) In : Gut Microbes. p. 1-8 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

T3SS effector VopL inhibits the host ROS response, promoting the intracellular survival of Vibrio parahaemolyticus

de Souza Santos, M., Salomon, D. & Orth, K., 2017, In : PLoS Pathogens. 13, 6, e1006438.

Research output: Contribution to journalArticle

12 Scopus citations

The cytotoxic type 3 secretion system 1 of Vibrio rewires host gene expression to subvert cell death and activate cell survival pathways

De Nisco, N. J., Kanchwala, M., Li, P., Fernandez, J., Xing, C. & Orth, K., May 16 2017, In : Science Signaling. 10, 479, l4501.

Research output: Contribution to journalArticle

3 Scopus citations

Type VI secretion system MIX-effectors carry both antibacterial and anti-eukaryotic activities

Ray, A., Schwartz, N., de Souza Santos, M., Zhang, J., Orth, K. & Salomon, D., Nov 2017, In : EMBO Reports. 18, 11, p. 1978-1990 13 p.

Research output: Contribution to journalArticle

10 Scopus citations
2016

Bile salt receptor complex activates a pathogenic type III secretion system

Li, P., Rivera-Cancel, G., Kinch, L. N., Salomon, D., Tomchick, D. R., Grishin, N. V. & Orth, K., Jul 5 2016, In : eLife. 5, 2016JULY, e15718.

Research output: Contribution to journalArticle

18 Scopus citations

Proteomics analysis reveals previously uncharacterized virulence factors in vibrio proteolyticus

Ray, A., Kinch, L. N., De Souza Santos, M., Grishin, N. V., Orth, K. & Salomon, D., Jul 1 2016, In : mBio. 7, 4, e01077-16.

Research output: Contribution to journalArticle

5 Scopus citations

Targeting bacterial adherence inhibits multidrug-resistant Pseudomonas aeruginosa infection following burn injury

Huebinger, R. M., Stones, D. H., De Souza Santos, M., Carlson, D. L., Song, J., Vaz, D. P., Keen, E., Wolf, S. E., Orth, K. & Krachler, A. M., Dec 20 2016, In : Scientific reports. 6, 39341.

Research output: Contribution to journalArticle

13 Scopus citations
2015

Type VI secretion system

Salomon, D. & Orth, K., 2015, In : Current Biology. 25, 7, p. R265-R266

Research output: Contribution to journalArticle

4 Scopus citations

Type VI Secretion System Toxins Horizontally Shared between Marine Bacteria

Salomon, D., Klimko, J. A., Trudgian, D. C., Kinch, L. N., Grishin, N. V., Mirzaei, H. & Orth, K., Aug 1 2015, In : PLoS Pathogens. 11, 8, e1005128.

Research output: Contribution to journalArticle

27 Scopus citations

Vibrio effector protein VopQ inhibits fusion of V-ATPase-containing membranes

Sreelatha, A., Bennett, T. L., Carpinone, E. M., O'Brien, K. M., Jordan, K. D., Burdette, D. L., Orth, K. & Starai, V. J., Jan 6 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 1, p. 100-105 6 p.

Research output: Contribution to journalArticle

15 Scopus citations
2014

AMPylation of rho GTPases subverts multiple host signaling processes

Woolery, A. R., Yu, X., LaBaer, J. & Orth, K., Nov 21 2014, In : Journal of Biological Chemistry. 289, 47, p. 32977-32988 12 p.

Research output: Contribution to journalArticle

21 Scopus citations

Copper-catalyzed azide-alkyne cycloaddition (click chemistry)-based Detection of Global Pathogen-host AMPylation on Self-assembled Human Protein Microarrays

Yu, X., Woolery, A. R., Luong, P., Hao, Y. H., Grammel, M., Westcott, N., Park, J., Wang, J., Bian, X., Demirkan, G., Hang, H. C., Orth, K. & LaBaer, J., Nov 1 2014, In : Molecular and Cellular Proteomics. 13, 11, p. 3164-3176 13 p.

Research output: Contribution to journalArticle

26 Scopus citations

H-NS regulates the Vibrio parahaemolyticus type VI secretion system 1

Salomon, D., Klimko, J. A. & Orth, K., Sep 2014, In : Microbiology (United Kingdom). 160, PART 9, p. 1867-1873 7 p.

Research output: Contribution to journalArticle

26 Scopus citations

Inhibiting AMPylation: A novel screen to identify the first small molecule inhibitors of protein AMPylation

Lewallen, D. M., Sreelatha, A., Dharmarajan, V., Madoux, F., Chase, P., Griffin, P. R., Orth, K., Hodder, P. & Thompson, P. R., Feb 21 2014, In : ACS Chemical Biology. 9, 2, p. 433-442 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Intracellular Vibrio parahaemolyticus escapes the vacuole and establishes a replicative niche in the cytosol of epithelial cells

de Souza Santos, M. & Orth, K., Sep 9 2014, In : mBio. 5, 5, e01506-14.

Research output: Contribution to journalArticle

22 Scopus citations

Marker for type VI secretion system effectors

Salomon, D., Kinch, L. N., Trudgian, D. C., Guo, X., Klimko, J. A., Grishin, N. V., Mirzaei, H. & Orth, K., Jun 24 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 25, p. 9271-9276 6 p.

Research output: Contribution to journalArticle

58 Scopus citations

Unfolded protein response-regulated Drosophila Fic (dFic) protein reversibly AMPylates BiP chaperone during endoplasmic reticulum homeostasis

Ham, H., Woolery, A. R., Tracy, C., Stenesen, D., Krämer, H. & Orth, K., 2014, In : Journal of Biological Chemistry. 289, 52, p. 36059-36069 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

Vibrio type III effector VPA1380 is related to the cysteine protease domain of large bacterial toxins

Calder, T., Kinch, L. N., Fernandez, J., Salomon, D., Grishin, N. V. & Orth, K., Aug 6 2014, In : PloS one. 9, 8, e104387.

Research output: Contribution to journalArticle

11 Scopus citations
2013

A MAM7 peptide-based inhibitor of staphylococcus aureus adhesion does not interfere with in vitro host cell function

Hawley, C. A., Watson, C. A., Orth, K. & Krachler, A. M., Nov 12 2013, In : PloS one. 8, 11

Research output: Contribution to journalArticle

15 Scopus citations

Effectors of animal and plant pathogens use a common domain to bind host phosphoinositides

Salomon, D., Guo, Y., Kinch, L. N., Grishin, N. V., Gardner, K. H. & Orth, K., Dec 18 2013, In : Nature communications. 4, 2973.

Research output: Contribution to journalArticle

Open Access
31 Scopus citations

Made to stick: Anti-adhesion therapy for bacterial infections

Krachler, A. M. & Orth, K., Jul 1 2013, In : Microbe. 8, 7, p. 286-290 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

The first engagement of partners in the Euprymna scolopes-Vibrio fischeri symbiosis is a two-step process initiated by a few environmental symbiont cells

Altura, M. A., Heath-Heckman, E. A. C., Gillette, A., Kremer, N., Krachler, A. M., Brennan, C., Ruby, E. G., Orth, K. & Mcfall-Ngai, M. J., Nov 1 2013, In : Environmental Microbiology. 15, 11, p. 2937-2950 14 p.

Research output: Contribution to journalArticle

30 Scopus citations

The pore-forming bacterial effector, VopQ, halts autophagic turnover

Sreelatha, A., Orth, K. & Starai, V. J., Dec 1 2013, In : Autophagy. 9, 12, p. 2169-2170 2 p.

Research output: Contribution to journalArticle

6 Scopus citations

Vibrio effector protein, VopQ, forms a lysosomal gated channel that disrupts host ion homeostasis and autophagic flux

Sreelatha, A., Bennett, T. L., Zheng, H., Jiang, Q. X., Orth, K. & Starai, V. J., Jul 9 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 28, p. 11559-11564 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

Vibrio parahaemolyticus Type VI Secretion System 1 Is Activated in Marine Conditions to Target Bacteria, and Is Differentially Regulated from System 2

Salomon, D., Gonzalez, H., Updegraff, B. L. & Orth, K., Apr 16 2013, In : PloS one. 8, 4, e61086.

Research output: Contribution to journalArticle

81 Scopus citations
2012

In vitro characterization of multivalent adhesion molecule 7-based inhibition of multidrug-resistant bacteria isolated from wounded military personnel

Krachler, A. M., Mende, K., Murray, C. & Orth, K., Jan 1 2012, In : Virulence. 3, 4, p. 389-399 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Subversion of cell signaling by pathogens

Alto, N. M. & Orth, K., Sep 1 2012, In : Cold Spring Harbor Perspectives in Biology. 4, 9

Research output: Contribution to journalArticle

56 Scopus citations

Turnabout is fair play: Use of the bacterial multivalent adhesion molecule 7 as an antimicrobial agent

Krachler, A. M., Ham, H. & Orth, K., Jan 1 2012, In : Virulence. 3, 1, p. 68-71 4 p.

Research output: Contribution to journalArticle

22 Scopus citations

Type III Effector VopC Mediates Invasion for Vibrio Species

Zhang, L., Krachler, A. M., Broberg, C. A., Li, Y., Mirzael, H., Gilpin, C. J. & Orth, K., May 31 2012, In : Cell Reports. 1, 5, p. 453-460 8 p.

Research output: Contribution to journalArticle

66 Scopus citations

Visual neurotransmission in Drosophila requires expression of Fic in glial capitate projections

Rahman, M., Ham, H., Liu, X., Sugiura, Y., Orth, K. & Krämer, H., Jun 1 2012, In : Nature neuroscience. 15, 6, p. 871-875 5 p.

Research output: Contribution to journalArticle

41 Scopus citations
2011

A chemical reporter for protein AMPylation

Grammel, M., Luong, P., Orth, K. & Hang, H. C., Nov 2 2011, In : Journal of the American Chemical Society. 133, 43, p. 17103-17105 3 p.

Research output: Contribution to journalArticle

43 Scopus citations

Characterization of AMPylation on threonine, serine, and tyrosine using mass spectrometry

Li, Y., Al-Eryani, R., Yarbrough, M. L., Orth, K. & Ball, H. L., Apr 1 2011, In : Journal of the American Society for Mass Spectrometry. 22, 4, p. 752-761 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Characterization of a rabbit polyclonal antibody against threonine-AMPylation

Hao, Y. H., Chuang, T., Ball, H. L., Luong, P., Li, Y., Flores-Saaib, R. D. & Orth, K., Feb 10 2011, In : Journal of Biotechnology. 151, 3, p. 251-254 4 p.

Research output: Contribution to journalArticle

23 Scopus citations
42 Scopus citations

Manipulation of kinase signaling by bacterial pathogens

Krachler, A. M., Woolery, A. R. & Orth, K., Dec 1 2011, In : Journal of Cell Biology. 195, 7, p. 1083-1092 10 p.

Research output: Contribution to journalArticle

77 Scopus citations
63 Scopus citations