• 10645 Citations
  • 55 h-Index
1986 …2019
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Research Output 1986 2019

  • 10645 Citations
  • 55 h-Index
  • 136 Article
  • 2 Review article
  • 1 Chapter
  • 1 Short survey
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Article
2019
1 Citation (Scopus)

Direct Detection of Tissue-Resident Bacteria and Chronic Inflammation in the Bladder Wall of Postmenopausal Women with Recurrent Urinary Tract Infection

De Nisco, N. J., Neugent, M., Mull, J. A., Chen, L., Kuprasertkul, A., de Souza Santos, M., Palmer, K. L., Zimmern, P. E. & Orth, K. A., Jan 1 2019, In : Journal of Molecular Biology.

Research output: Contribution to journalArticle

Urinary Tract Infections
Urinary Bladder
Urothelium
Inflammation
Bacteria

High-resolution cryo-EM structures of the E. Coli hemolysin ClyA oligomers

Peng, W., de Souza Santos, M., Li, Y., Tomchick, D. R. & Orth, K., May 1 2019, In : PloS one. 14, 5, e0213423.

Research output: Contribution to journalArticle

Open Access
hemolysins
Protein Subunits
protein subunits
Oligomers
Porins
2 Citations (Scopus)

Human pancreatic cancer cell exosomes, but not human normal cell exosomes, act as an initiator in cell transformation

Stefanius, K., Servage, K., de Souza Santos, M., Gray, H. F., Toombs, J. E., Chimalapati, S., Kim, M. S., Malladi, V. S., Brekken, R. & Orth, K., May 28 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
Exosomes
Pancreatic Neoplasms
Cells
Tumors
Neoplasms

The role of the type III secretion system in the intracellular lifestyle of enteric pathogens

Santos, M. D. S. & Orth, K. A., May 1 2019, In : Microbiology Spectrum. 7, 3, BAI-0008-2019.

Research output: Contribution to journalArticle

lifestyle
secretion
Life Style
pathogen
bacterium
2018
2 Citations (Scopus)

Adaptation to constant light requires Fic-mediated AMPylation of BiP to protect against reversible photoreceptor degeneration

Moehlman, A. T., Casey, A. K., Servage, K., Orth, K. & Krämer, H., Jul 17 2018, In : eLife. 7, e38752.

Research output: Contribution to journalArticle

Unfolded Protein Response
Light
Photoperiod
Diptera
Drosophila

My winding trail while fulfilling my love for science and family

Orth, K., Jan 1 2018, In : Journal of Biological Chemistry. 293, 27, p. 10435-10437 3 p.

Research output: Contribution to journalArticle

Love
Mentors
Spouses
4 Citations (Scopus)

Natural transformation in Vibrio parahaemolyticus: A rapid method to create genetic deletions

Chimalapati, S., Santos, M. D. S., Servage, K., De Nisco, N. J., Dalia, A. B. & Orth, K., Aug 1 2018, In : Journal of Bacteriology. 200, 15, e00032-18.

Research output: Contribution to journalArticle

Vibrio parahaemolyticus
Genome
Bacteria
Seafood
Vibrio
17 Citations (Scopus)

Protein AMPylation by an Evolutionarily Conserved Pseudokinase

Sreelatha, A., Yee, S. S., Lopez, V. A., Park, B. C., Kinch, L. N., Pilch, S., Servage, K. A., Zhang, J., Jiou, J., Karasiewicz-Urbańska, M., Łobocka, M., Grishin, N. V., Orth, K. A., Kucharczyk, R., Pawłowski, K., Tomchick, D. R. & Tagliabracci, V. S., Oct 18 2018, In : Cell. 175, 3, p. 809-821.e19

Research output: Contribution to journalArticle

Selenoproteins
Protein Kinases
Proteins
Adenosine Triphosphate
Catalysis
17 Citations (Scopus)

Rise of a Cereal Killer: The Biology of Magnaporthe oryzae Biotrophic Growth

Fernandez, J. & Orth, K., Jan 1 2018, (Accepted/In press) In : Trends in Microbiology.

Research output: Contribution to journalArticle

Magnaporthe
Growth
Fungi
Infection
Plant Cells
2017
23 Citations (Scopus)

Acute hepatopancreatic necrosis disease-causing Vibrio parahaemolyticus strains maintain an antibacterial type VI secretion system with versatile effector repertoires

Li, P., Kinch, L. N., Ray, A., Dalia, A. B., Cong, Q., Nunan, L. M., Camilli, A., Grishin, N. V., Salomon, D. & Orth, K., 2017, In : Applied and Environmental Microbiology. 83, 13, e00737-17.

Research output: Contribution to journalArticle

Vibrio parahaemolyticus
secretion
necrosis
Necrosis
Poisons
2 Citations (Scopus)

Biochemical basis for activation of virulence genes by bile salts in Vibrio parahaemolyticus

Rivera-Cancel, G. & Orth, K., Feb 8 2017, (Accepted/In press) In : Gut Microbes. p. 1-8 8 p.

Research output: Contribution to journalArticle

Vibrio parahaemolyticus
Bile Acids and Salts
Transcriptional Activation
Virulence
Membrane Proteins
11 Citations (Scopus)

T3SS effector VopL inhibits the host ROS response, promoting the intracellular survival of Vibrio parahaemolyticus

de Souza Santos, M., Salomon, D. & Orth, K., 2017, In : PLoS Pathogens. 13, 6, e1006438.

Research output: Contribution to journalArticle

Vibrio parahaemolyticus
Reactive Oxygen Species
Niacinamide
Oxidoreductases
Phosphates
2 Citations (Scopus)

The cytotoxic type 3 secretion system 1 of Vibrio rewires host gene expression to subvert cell death and activate cell survival pathways

De Nisco, N. J., Kanchwala, M., Li, P., Fernandez, J., Xing, C. & Orth, K., May 16 2017, In : Science Signaling. 10, 479, l4501.

Research output: Contribution to journalArticle

Cell signaling
Vibrio parahaemolyticus
Vibrio
Cell death
Gene expression
8 Citations (Scopus)

Type VI secretion system MIX-effectors carry both antibacterial and anti-eukaryotic activities

Ray, A., Schwartz, N., de Souza Santos, M., Zhang, J., Orth, K. & Salomon, D., 2017, (Accepted/In press) In : EMBO Reports.

Research output: Contribution to journalArticle

Vibrio
Bacteria
Phagocytes
Actin Cytoskeleton
Proteomics
2016
15 Citations (Scopus)

Bile salt receptor complex activates a pathogenic type III secretion system

Li, P., Rivera-Cancel, G., Kinch, L. N., Salomon, D., Tomchick, D. R., Grishin, N. V. & Orth, K., Jul 5 2016, In : eLife. 5, 2016JULY, e15718.

Research output: Contribution to journalArticle

Bile Acids and Salts
Virulence
Bile
Crystal structure
Vibrio parahaemolyticus
4 Citations (Scopus)

Proteomics analysis reveals previously uncharacterized virulence factors in vibrio proteolyticus

Ray, A., Kinch, L. N., De Souza Santos, M., Grishin, N. V., Orth, K. & Salomon, D., Jul 1 2016, In : mBio. 7, 4, e01077-16.

Research output: Contribution to journalArticle

Vibrio
Virulence Factors
Proteomics
Leukocidins
Virulence
12 Citations (Scopus)

Targeting bacterial adherence inhibits multidrug-resistant Pseudomonas aeruginosa infection following burn injury

Huebinger, R. M., Stones, D. H., De Souza Santos, M., Carlson, D. L., Song, J., Vaz, D. P., Keen, E., Wolf, S. E., Orth, K. & Krachler, A. M., Dec 20 2016, In : Scientific Reports. 6, 39341.

Research output: Contribution to journalArticle

Pseudomonas Infections
Pseudomonas aeruginosa
Microspheres
Virulence
Wounds and Injuries
2015
14 Citations (Scopus)

Subversion of the cytoskeleton by intracellular bacteria: Lessons from Listeria, Salmonella and Vibrio

de Souza Santos, M. & Orth, K., Feb 1 2015, In : Cellular Microbiology. 17, 2, p. 164-173 10 p.

Research output: Contribution to journalArticle

Listeria
Vibrio
Cytoskeleton
Salmonella
Bacteria
4 Citations (Scopus)

Type VI secretion system

Salomon, D. & Orth, K., 2015, In : Current Biology. 25, 7, p. R265-R266

Research output: Contribution to journalArticle

bacterial toxins
Bacterial Toxins
Bacteria
bacteria
Type VI Secretion Systems
23 Citations (Scopus)

Type VI Secretion System Toxins Horizontally Shared between Marine Bacteria

Salomon, D., Klimko, J. A., Trudgian, D. C., Kinch, L. N., Grishin, N. V., Mirzaei, H. & Orth, K., Aug 1 2015, In : PLoS Pathogens. 11, 8, e1005128.

Research output: Contribution to journalArticle

Vibrio alginolyticus
Bacteria
Horizontal Gene Transfer
Vibrio
Poisons
14 Citations (Scopus)

Vibrio effector protein VopQ inhibits fusion of V-ATPase-containing membranes

Sreelatha, A., Bennett, T. L., Carpinone, E. M., O'Brien, K. M., Jordan, K. D., Burdette, D. L., Orth, K. & Starai, V. J., Jan 6 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 1, p. 100-105 6 p.

Research output: Contribution to journalArticle

Vacuolar Proton-Translocating ATPases
Membrane Fusion
Proton-Translocating ATPases
Vibrio
Vacuoles
2014
20 Citations (Scopus)

AMPylation of rho GTPases subverts multiple host signaling processes

Woolery, A. R., Yu, X., LaBaer, J. & Orth, K., Nov 21 2014, In : Journal of Biological Chemistry. 289, 47, p. 32977-32988 12 p.

Research output: Contribution to journalArticle

rho GTP-Binding Proteins
Switches
25 Citations (Scopus)

Copper-catalyzed azide-alkyne cycloaddition (click chemistry)-based Detection of Global Pathogen-host AMPylation on Self-assembled Human Protein Microarrays

Yu, X., Woolery, A. R., Luong, P., Hao, Y. H., Grammel, M., Westcott, N., Park, J., Wang, J., Bian, X., Demirkan, G., Hang, H. C., Orth, K. & LaBaer, J., Nov 1 2014, In : Molecular and Cellular Proteomics. 13, 11, p. 3164-3176 13 p.

Research output: Contribution to journalArticle

Click Chemistry
Protein Array Analysis
Alkynes
Azides
Cycloaddition
24 Citations (Scopus)

H-NS regulates the Vibrio parahaemolyticus type VI secretion system 1

Salomon, D., Klimko, J. A. & Orth, K., Sep 1 2014, In : Microbiology (Reading, England). 160, p. 1867-1873 7 p.

Research output: Contribution to journalArticle

Vibrio parahaemolyticus
Multigene Family
Bacteria
Quorum Sensing
Salinity
12 Citations (Scopus)

Inhibiting AMPylation: A novel screen to identify the first small molecule inhibitors of protein AMPylation

Lewallen, D. M., Sreelatha, A., Dharmarajan, V., Madoux, F., Chase, P., Griffin, P. R., Orth, K., Hodder, P. & Thompson, P. R., Feb 21 2014, In : ACS Chemical Biology. 9, 2, p. 433-442 10 p.

Research output: Contribution to journalArticle

Adenosine Monophosphate
Molecules
calmidazolium
High-Throughput Screening Assays
Vibrio parahaemolyticus
19 Citations (Scopus)

Intracellular Vibrio parahaemolyticus escapes the vacuole and establishes a replicative niche in the cytosol of epithelial cells

de Souza Santos, M. & Orth, K., Sep 9 2014, In : mBio. 5, 5, e01506-14.

Research output: Contribution to journalArticle

Vibrio parahaemolyticus
Vacuoles
Cytosol
Epithelial Cells
Bacteria
54 Citations (Scopus)

Marker for type VI secretion system effectors

Salomon, D., Kinch, L. N., Trudgian, D. C., Guo, X., Klimko, J. A., Grishin, N. V., Mirzaei, H. & Orth, K., Jun 24 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 25, p. 9271-9276 6 p.

Research output: Contribution to journalArticle

Proteins
Bacterial Proteins
Computational Biology
Proteomics
Virulence
7 Citations (Scopus)

Structural and regulatory mutations in Vibrio parahaemolyticus type III secretion systems display variable effects on virulence

Calder, T., de Souza Santos, M., Attah, V., Klimko, J., Fernandez, J., Salomon, D., Krachler, A. M. & Orth, K., Dec 1 2014, In : FEMS Microbiology Letters. 361, 2, p. 107-114 8 p.

Research output: Contribution to journalArticle

Vibrio parahaemolyticus
Virulence
Mutation
Seafood
Foodborne Diseases
39 Citations (Scopus)

Unfolded protein response-regulated Drosophila Fic (dFic) protein reversibly AMPylates BiP chaperone during endoplasmic reticulum homeostasis

Ham, H., Woolery, A. R., Tracy, C., Stenesen, D., Krämer, H. & Orth, K., 2014, In : Journal of Biological Chemistry. 289, 52, p. 36059-36069 11 p.

Research output: Contribution to journalArticle

Unfolded Protein Response
Endoplasmic Reticulum
Drosophila
Homeostasis
Substrates
10 Citations (Scopus)

Vibrio type III effector VPA1380 is related to the cysteine protease domain of large bacterial toxins

Calder, T., Kinch, L. N., Fernandez, J., Salomon, D., Grishin, N. V. & Orth, K., Aug 6 2014, In : PLoS One. 9, 8, e104387.

Research output: Contribution to journalArticle

bacterial toxins
Bacterial Toxins
Vibrio
Cysteine Proteases
cysteine proteinases
2013
15 Citations (Scopus)

A MAM7 peptide-based inhibitor of staphylococcus aureus adhesion does not interfere with in vitro host cell function

Hawley, C. A., Watson, C. A., Orth, K. & Krachler, A. M., Nov 12 2013, In : PLoS One. 8, 11

Research output: Contribution to journalArticle

Methicillin-Resistant Staphylococcus aureus
Bacterial Adhesins
adhesion
Staphylococcus aureus
Adhesion

An interview with Kim Orth.

Orth, K., Jul 2013, In : Trends in Biochemical Sciences. 38, 7, p. 331-332 2 p.

Research output: Contribution to journalArticle

Biochemistry
Molecular biology
Bacterial Proteins
Virulence Factors
29 Citations (Scopus)

Effectors of animal and plant pathogens use a common domain to bind host phosphoinositides.

Salomon, D., Guo, Y., Kinch, L. N., Grishin, N. V., Gardner, K. H. & Orth, K., 2013, In : Nature Communications. 4, 2973.

Research output: Contribution to journalArticle

effectors
pathogens
Pathogens
Phosphatidylinositols
animals
5 Citations (Scopus)

Lost after translation: Post-translational modifications by bacterial type III effectors

Salomon, D. & Orth, K., Apr 2013, In : Current Opinion in Microbiology. 16, 2, p. 213-220 8 p.

Research output: Contribution to journalArticle

Post Translational Protein Processing
Proteins
Type III Secretion Systems
5 Citations (Scopus)

Made to stick: Anti-adhesion therapy for bacterial infections

Krachler, A. M. & Orth, K., Jul 2013, In : Microbe. 8, 7, p. 286-290 5 p.

Research output: Contribution to journalArticle

Bacterial Infections
Adhesives
Biological Availability
Anti-Bacterial Agents
Bacteria
92 Citations (Scopus)

Targeting the bacteria-host interface strategies in anti-adhesion therapy

Krachler, A. M. & Orth, K., 2013, In : Virulence. 4, 4, p. 284-294 11 p.

Research output: Contribution to journalArticle

Bacterial Infections
Bacteria
Therapeutics
Anti-Bacterial Agents
Morbidity
28 Citations (Scopus)

The first engagement of partners in the Euprymna scolopes-Vibrio fischeri symbiosis is a two-step process initiated by a few environmental symbiont cells

Altura, M. A., Heath-Heckman, E. A. C., Gillette, A., Kremer, N., Krachler, A. M., Brennan, C., Ruby, E. G., Orth, K. & Mcfall-Ngai, M. J., Nov 2013, In : Environmental Microbiology. 15, 11, p. 2937-2950 14 p.

Research output: Contribution to journalArticle

Aliivibrio fischeri
Vibrio fischeri
Symbiosis
symbiont
symbiosis
6 Citations (Scopus)

The pore-forming bacterial effector, VopQ, halts autophagic turnover

Sreelatha, A., Orth, K. & Starai, V. J., Dec 2013, In : Autophagy. 9, 12, p. 2169-2170 2 p.

Research output: Contribution to journalArticle

Autophagy
Vacuolar Proton-Translocating ATPases
Vibrio parahaemolyticus
Membranes
Protons
26 Citations (Scopus)

Vibrio effector protein, VopQ, forms a lysosomal gated channel that disrupts host ion homeostasis and autophagic flux

Sreelatha, A., Bennett, T. L., Zheng, H., Jiang, Q. X., Orth, K. & Starai, V. J., Jul 9 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 28, p. 11559-11564 6 p.

Research output: Contribution to journalArticle

Vibrio
Vacuolar Proton-Translocating ATPases
Homeostasis
Ions
Lysosomes
74 Citations (Scopus)

Vibrio parahaemolyticus Type VI Secretion System 1 Is Activated in Marine Conditions to Target Bacteria, and Is Differentially Regulated from System 2

Salomon, D., Gonzalez, H., Updegraff, B. L. & Orth, K., Apr 16 2013, In : PLoS One. 8, 4, e61086.

Research output: Contribution to journalArticle

Vibrio parahaemolyticus
Bacteria
bacteria
Shellfish
Cues
72 Citations (Scopus)

Virulence determinants for Vibrio parahaemolyticus infection

Zhang, L. & Orth, K., Feb 2013, In : Current Opinion in Microbiology. 16, 1, p. 70-77 8 p.

Research output: Contribution to journalArticle

Vibrio Infections
Vibrio parahaemolyticus
Virulence Factors
Virulence
Host-Pathogen Interactions
25 Citations (Scopus)

What Pathogens Have Taught Us about Posttranslational Modifications

Salomon, D. & Orth, K., Sep 11 2013, In : Cell Host and Microbe. 14, 3, p. 269-279 11 p.

Research output: Contribution to journalArticle

Post Translational Protein Processing
Ubiquitination
Infection
Proteins
Research Design
2012
18 Citations (Scopus)

In vitro characterization of multivalent adhesion molecule 7-based inhibition of multidrug-resistant bacteria isolated from wounded military personnel

Krachler, A. M., Mende, K., Murray, C. & Orth, K., Jul 1 2012, In : Virulence. 3, 4, p. 389-399 11 p.

Research output: Contribution to journalArticle

Military Personnel
Biofilms
Bacteria
Virulence
Acinetobacter calcoaceticus
56 Citations (Scopus)

Subversion of cell signaling by pathogens

Alto, N. M. & Orth, K., Sep 2012, In : Cold Spring Harbor perspectives in biology. 4, 9

Research output: Contribution to journalArticle

Cell signaling
Cell Shape
Pathogens
GTP-Binding Proteins
Innate Immunity

Subversion of cell signaling by pathogens.

Alto, N. M. & Orth, K., Sep 2012, In : Cold Spring Harbor perspectives in biology. 4, 9

Research output: Contribution to journalArticle

Cell signaling
Cell Shape
Pathogens
GTP-Binding Proteins
Innate Immunity
26 Citations (Scopus)

The role of type III secretion System 2 in Vibrio parahaemolyticus pathogenicity

Ham, H. & Orth, K., 2012, In : Journal of Microbiology. 50, 5, p. 719-725 7 p.

Research output: Contribution to journalArticle

Vibrio parahaemolyticus
Virulence
Bacteria
Seafood
Foodborne Diseases
22 Citations (Scopus)

Turnabout is fair play: Use of the bacterial multivalent adhesion molecule 7 as an antimicrobial agent

Krachler, A. M., Ham, H. & Orth, K., Jan 2012, In : Virulence. 3, 1, p. 68-71 4 p.

Research output: Contribution to journalArticle

Bacterial Adhesion
Anti-Infective Agents
Gram-Negative Bacterial Infections
Infection
Bacterial Infections
61 Citations (Scopus)

Type III Effector VopC Mediates Invasion for Vibrio Species

Zhang, L., Krachler, A. M., Broberg, C. A., Li, Y., Mirzael, H., Gilpin, C. J. & Orth, K., May 31 2012, In : Cell Reports. 1, 5, p. 453-460 8 p.

Research output: Contribution to journalArticle

Vibrio
Bacteria
Pathogens
Virulence
Cholera
41 Citations (Scopus)

Visual neurotransmission in Drosophila requires expression of Fic in glial capitate projections

Rahman, M., Ham, H., Liu, X., Sugiura, Y., Orth, K. & Krämer, H., Jun 2012, In : Nature Neuroscience. 15, 6, p. 871-875 5 p.

Research output: Contribution to journalArticle

Synaptic Transmission
Neuroglia
Histamine
Drosophila
Recycling
2011
43 Citations (Scopus)

A chemical reporter for protein AMPylation

Grammel, M., Luong, P., Orth, K. & Hang, H. C., Nov 2 2011, In : Journal of the American Chemical Society. 133, 43, p. 17103-17105 3 p.

Research output: Contribution to journalArticle

Proteins
Substrates
Azides
Cytology
Post Translational Protein Processing