• 2943 Citations
  • 32 h-Index
1980 …2020

Research output per year

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Research Output

  • 2943 Citations
  • 32 h-Index
  • 74 Article
  • 2 Review article
  • 1 Letter
2020

DC-HIL/GpNMB is a negative regulator of tumor response to immune checkpoint inhibitors

Chung, J. S., Ramani, V., Kobayashi, M., Fattah, F., Popat, V., Zhang, S., Cruz, P. D., Gerber, D. E. & Ariizumi, K., Mar 15 2020, In : Clinical Cancer Research. 26, 6, p. 1449-1459 11 p.

Research output: Contribution to journalArticle

2019

Blocking monocytic myeloid-derived suppressor cell function via anti-DC-HIL/GpNMB antibody restores the in vitro integrity of T cells from cancer patients

Kobayashi, M., Chung, J-S., Beg, M., Arriaga, Y., Verma, U., Courtney, K., Mansour, J., Haley, B., Khan, S., Horiuchi, Y., Ramani, V., Harker, D., Gopal, P., Araghizadeh, F., Cruz, P. D. & Ariizumi, K., Jan 15 2019, In : Clinical Cancer Research. 25, 2, p. 828-838 11 p.

Research output: Contribution to journalArticle

11 Scopus citations
2018

Expansion of Myeloid-Derived Suppressor Cells in the Peripheral Blood and Lesional Skin of Cutaneous Lupus Patients

Florez-Pollack, S., Tseng, L. C., Kobayashi, M., Hosler, G. A., Ariizumi, K. & Chong, B., Jan 1 2018, (Accepted/In press) In : Journal of Investigative Dermatology.

Research output: Contribution to journalArticle

2 Scopus citations

Melanoma-Derived Soluble DC-HIL/GPNMB Promotes Metastasis by Excluding T-Lymphocytes from the Pre-Metastatic Niches

Ramani, V., Teshima, T., Tamura, K., Chung, J. S., Kobayashi, M., Cruz, P. D. & Ariizumi, K., Jan 1 2018, (Accepted/In press) In : Journal of Investigative Dermatology.

Research output: Contribution to journalArticle

2 Scopus citations

NF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation

Brosseau, J. P., Liao Ph.D., C. P., Wang, Y., Ramani, V., Vandergriff, T. W., Lee, M., Patel, A., Ariizumi, K. & Le, L. Q., Dec 1 2018, In : Nature communications. 9, 1, 5014.

Research output: Contribution to journalArticle

8 Scopus citations
2016

Myeloid-Derived Suppressor Cells in Psoriasis Are an Expanded Population Exhibiting Diverse T-Cell–Suppressor Mechanisms

Cao, L. Y., Chung, J. S., Teshima, T., Feigenbaum, L., Cruz, P. D., Jacobe, H., Chong, B. & Ariizumi, K., Sep 1 2016, In : Journal of Investigative Dermatology. 136, 9, p. 1801-1810 10 p.

Research output: Contribution to journalArticle

17 Scopus citations
2014

DC-HIL+CD14+HLA-DRno/lowcells are a potential blood marker and therapeutic target for melanoma

Turrentine, J., Chung, J. S., Nezafati, K., Tamura, K., Harker-Murray, A., Huth, J. F., Sharma, R., Harker, D. B., Ariizumi, K. & Cruz, P. D., Nov 5 2014, In : Journal of Investigative Dermatology. 134, 11, p. 2839-2842 4 p.

Research output: Contribution to journalLetter

7 Scopus citations

DC-HIL-expressing myelomonocytic cells are critical promoters of melanoma growth

Chung, J. S., Tamura, K., Cruz, P. D. & Ariizumi, K., Nov 5 2014, In : Journal of Investigative Dermatology. 134, 11, p. 2784-2794 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

The DC-HIL/Syndecan-4 Pathway Regulates Autoimmune Responses through Myeloid-Derived Suppressor Cells

Chung, J. S., Tamura, K., Akiyoshi, H., Cruz, P. D. & Ariizumi, K., Mar 15 2014, In : Journal of Immunology. 192, 6, p. 2576-2584 9 p.

Research output: Contribution to journalArticle

17 Scopus citations
2013

T-cell-specific deletion of Mof blocks their differentiation and results in genomic instability in mice

Gupta, A., Hunt, C. R., Pandita, R. K., Pae, J., Komal, K., Singh, M., Shay, J. W., Kumar, R., Ariizumi, K., Horikoshi, N., Hittelman, W. N., Guha, C., Ludwig, T. & Pandita, T. K., May 2013, In : Mutagenesis. 28, 3, p. 263-270 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

The DC-HIL ligand syndecan-4 is a negative regulator of T-cell allo-reactivity responsible for graft-versus-host disease

Chung, J. S., Tomihari, M., Tamura, K., Kojima, T., Cruz, P. D. & Ariizumi, K., Feb 1 2013, In : Immunology. 138, 2, p. 173-182 10 p.

Research output: Contribution to journalArticle

15 Scopus citations
2012

T-cell inhibitors: A bench-to-bedside review

Das, S., Ariizumi, K. & Cruz, P. D., Sep 1 2012, In : Dermatitis. 23, 5, p. 195-202 8 p.

Research output: Contribution to journalReview article

3 Scopus citations
2011

Inhibition of T-cell activation by syndecan-4 is mediated by CD148 through protein tyrosine phosphatase activity

Chung, J. S., Cruz, P. D. & Ariizumi, K., Jun 1 2011, In : European Journal of Immunology. 41, 6, p. 1794-1799 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

Sézary syndrome cells overexpress syndecan-4 bearing distinct heparan sulfate moieties that suppress T-cell activation by binding DC-HIL and trapping TGF-β on the cell surface

Chung, J. S., Shiue, L. H., Duvic, M., Pandya, A. G., Cruz, P. D. & Ariizumi, K., Mar 24 2011, In : Blood. 117, 12, p. 3382-3390 9 p.

Research output: Contribution to journalArticle

22 Scopus citations
2010

CARD9 mediates dectin-2-induced IκBα kinase ubiquitination leading to activation of NF-κB in response to stimulation by the hyphal form of Candida albicans

Bi, L., Gojestani, S., Wu, W., Hsu, Y. M. S., Zhu, J., Ariizumi, K. & Lin, X., Aug 20 2010, In : Journal of Biological Chemistry. 285, 34, p. 25969-25977 9 p.

Research output: Contribution to journalArticle

80 Scopus citations

DC-HIL/glycoprotein Nmb promotes growth of melanoma in mice by inhibiting the activation of tumor-reactive T cells

Tomihari, M., Chung, J. S., Akiyoshi, H., Cruz, P. D. & Ariizumi, K., Jul 15 2010, In : Cancer research. 70, 14, p. 5778-5787 10 p.

Research output: Contribution to journalArticle

41 Scopus citations
10 Scopus citations
2009

Binding of DC-HIL to dermatophytic fungi induces tyrosine phosphorylation and potentiates antigen presenting cell function

Chung, J. S., Yudate, T., Tomihari, M., Akiyoshi, H., Cruz, P. D. & Ariizumi, K., Oct 15 2009, In : Journal of Immunology. 183, 8, p. 5190-5198 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Gpnmb is a melanosome-associated glycoprotein that contributes to melanocyte/keratinocyte adhesion in a RGD-dependent fashion

Tomihari, M., Hwang, S. H., Chung, J. S., Cruz, P. D. & Ariizumi, K., Jun 17 2009, In : Experimental Dermatology. 18, 7, p. 586-595 10 p.

Research output: Contribution to journalArticle

51 Scopus citations

Recognition of non-self-polysaccharides by C-type lectin receptors dectin-1 and dectin-2

Hollmig, S. T., Ariizumi, K. & Cruz, P. D., 2009, In : Glycobiology. 19, 6, p. 568-575 8 p.

Research output: Contribution to journalReview article

35 Scopus citations

The DC-HIL/syndecan-4 pathway inhibits human allogeneic T-cell responses

Chung, J. S., Bonkobara, M., Tomihari, M., Cruz, P. D. & Ariizumi, K., Jun 26 2009, In : European Journal of Immunology. 39, 4, p. 965-974 10 p.

Research output: Contribution to journalArticle

49 Scopus citations
2008

Immunization with a lentivector that targets tumor antigen expression to dendritic cells induces potent CD8+ and CD4+ T-cell responses

Lopes, L., Dewannieux, M., Gileadi, U., Bailey, R., Ikeda, Y., Whittaker, C., Collin, M. P., Cerundolo, V., Tomihari, M., Ariizumi, K. & Collins, M. K., Jan 2008, In : Journal of virology. 82, 1, p. 86-95 10 p.

Research output: Contribution to journalArticle

56 Scopus citations
2007

DC-HIL is a negative regulator of T lymphocyte activation

Chung, J. S., Sato, K., Dougherty, I. I., Cruz, P. D. & Ariizumi, K., May 15 2007, In : Blood. 109, 10, p. 4320-4327 8 p.

Research output: Contribution to journalArticle

76 Scopus citations

Syndecan-4 mediates the coinhibitory function of DC-HIL on T cell activation

Chung, J. S., Dougherty, I., Cruz, P. D. & Ariizumi, K., Nov 1 2007, In : Journal of Immunology. 179, 9, p. 5778-5784 7 p.

Research output: Contribution to journalArticle

Open Access
71 Scopus citations
2006

Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor γ chain to induce innate immune responses

Sato, K., Yang, X. L., Yudate, T., Chung, J. S., Wu, J., Phelps, K. J., Kimberly, R. P., Underhill, D., Cruz, P. D. & Ariizumi, K., Dec 15 2006, In : Journal of Biological Chemistry. 281, 50, p. 38854-38866 13 p.

Research output: Contribution to journalArticle

301 Scopus citations

Identification and cornification-related gene expression of canine keratinocyte differentiation-associated protein, Kdap

Yagihara, H., Terada, Y., Sugimoto, S., Hidaka, F., Yamada, O., Ono, K., Washizu, T., Ariizumi, K. & Bonkobara, M., Jul 1 2006, In : Veterinary Journal. 172, 1, p. 141-146 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Identification and gene expression of bovine C-type lectin dectin-2

Bonkobara, M., Hoshino, M., Yagihara, H., Tamura, K., Isotani, M., Tanaka, Y., Washizu, T. & Ariizumi, K., Mar 15 2006, In : Veterinary Immunology and Immunopathology. 110, 1-2, p. 179-186 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Selective expression of vacuolar H+-ATPase subunit d2 by particular subsets of dendritic cells among leukocytes

Sato, K., Shikano, S., Xia, G., Takao, J., Chung, J. S., Cruz, P. D., Xie, X-S. & Ariizumi, K., Mar 1 2006, In : Molecular Immunology. 43, 9, p. 1443-1453 11 p.

Research output: Contribution to journalArticle

14 Scopus citations
2005

Canine epidermal langerhans cells express α and γ but not β chains of high-affinity IgE receptor

Bonkobara, M., Miyake, F., Yagihara, H., Yamada, O., Azakami, D., Washizu, T., Cruz, P. D. & Ariizumi, K., Aug 1 2005, In : Veterinary Research Communications. 29, 6, p. 499-505 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Identification and expression profiling of a human C-type lectin, structurally homologous to mouse dectin-2

Gavino, A. C. P., Chung, J. S., Sato, K., Ariizumi, K. & Cruz, P. D., Apr 1 2005, In : Experimental Dermatology. 14, 4, p. 281-288 8 p.

Research output: Contribution to journalArticle

34 Scopus citations

Ultraviolet-B radiation upregulates expression of dectin-2 on epidermal Langerhans cells by activating the gene promoter

Bonkobara, M., Yagihara, H., Yudate, T., Chung, J. S., Washizu, T., Ariizumi, K. & Cruz, P. D., Jul 1 2005, In : Photochemistry and Photobiology. 81, 4, p. 944-948 5 p.

Research output: Contribution to journalArticle

7 Scopus citations
2004

Characterization of Kdap, a protein secreted by keratinocytes

Tsuchida, S., Bonkobara, M., McMillan, J. R., Akiyama, M., Yudate, T., Aragane, Y., Tezuka, T., Shimizu, H., Cruz, P. D. & Ariizumi, K., May 2004, In : Journal of Investigative Dermatology. 122, 5, p. 1225-1234 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Transcriptional regulation of dectin-2 promoter in transgenic mouse

Bonkobara, M., Yudate, T., Yagihara, H., Washizu, T., Cruz, P. D. & Ariizumi, K., Dec 1 2004, In : Journal of Veterinary Medical Science. 66, 12, p. 1483-1489 7 p.

Research output: Contribution to journalArticle

4 Scopus citations
2003

Expression of NF-κB in epidermis and the relationship between NF-κB activation and inhibition of keratinocyte growth

Takao, J., Yudate, T., Das, A., Shikano, S., Bonkobara, M., Ariizumi, K. & Cruz, P. D., Apr 1 2003, In : British Journal of Dermatology. 148, 4, p. 680-688 9 p.

Research output: Contribution to journalArticle

57 Scopus citations

Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes

Bonkobara, M., Das, A., Takao, J., Cruz, P. D. & Ariizumi, K., Apr 1 2003, In : British Journal of Dermatology. 148, 4, p. 654-664 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Involvement of dectin-2 in ultraviolet radiation-induced tolerance

Aragane, Y., Maeda, A., Schwarz, A., Tezuka, T., Ariizumi, K. & Schwarz, T., Oct 1 2003, In : Journal of Immunology. 171, 7, p. 3801-3807 7 p.

Research output: Contribution to journalArticle

Open Access
66 Scopus citations
2002

Genomic scale analysis of the human keratinocyte response to broad-band ultraviolet-B irradiation

Takao, J., Ariizumi, K., Dougherty, I. I. & Cruz, P. D., Jun 5 2002, In : Photodermatology Photoimmunology and Photomedicine. 18, 1, p. 5-13 9 p.

Research output: Contribution to journalArticle

52 Scopus citations
2001

Activation of HIV in human skin by ultraviolet B radiation and its inhibition by NFκB blocking agents

Breuer-McHam, J., Simpson, E., Dougherty, I., Bonkobara, M., Ariizumi, K., Lewis, D. E., Dawson, D. B., Duvic, M. & Cruz, P. D., Dec 1 2001, In : Photochemistry and Photobiology. 74, 6, p. 805-810 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Development of a Langerhans cell-targeted gene therapy format using a dendritic cell-specific promoter

Morita, A., Ariizumi, K., Ritter, R., Jester, J. V., Kumamoto, T., Johnston, S. A. & Takashima, A., Dec 1 2001, In : Gene Therapy. 8, 22, p. 1729-1737 9 p.

Research output: Contribution to journalArticle

32 Scopus citations

Epidermal Langerhans cell-targeted gene expression by a dectin-2 promoter

Bonkobara, M., Zukas, P. K., Shikano, S., Nakamura, S., Cruz, P. D. & Ariizumi, K., Dec 15 2001, In : Journal of Immunology. 167, 12, p. 6893-6900 8 p.

Research output: Contribution to journalArticle

Open Access
39 Scopus citations

Identification of a human homologue of the dendritic cell-associated C-type lectin-1, dectin-1

Yokota, K., Takashima, A., Bergstresser, P. R. & Ariizumi, K., Jul 11 2001, In : Gene. 272, 1-2, p. 51-60 10 p.

Research output: Contribution to journalArticle

76 Scopus citations
133 Scopus citations
2000

Cloning of a second dendritic cell-associated C-type lectin (dectin-2) and its alternatively spliced isoforms

Ariizumi, K., Shen, G. L., Shikano, S., Ritter, R., Zukas, P., Edelbaum, D., Morita, A. & Takashima, A., Apr 21 2000, In : Journal of Biological Chemistry. 275, 16, p. 11957-11963 7 p.

Research output: Contribution to journalArticle

129 Scopus citations

Identification of a novel, dendritic cell-associated molecule, dectin-1, by subtractive cDNA cloning

Ariizumi, K., Shen, G. L., Shikano, S., Xu, S., Ritter, R., Kumamoto, T., Edelbaum, D., Morita, A., Bergstresser, P. R. & Takashima, A., Jun 30 2000, In : Journal of Biological Chemistry. 275, 26, p. 20157-20167 11 p.

Research output: Contribution to journalArticle

341 Scopus citations
1997

Subtractive cDNA cloning: A new approach to understanding dendritic cell biology

Ariizumi, K., Bergstresser, P. R. & Takashima, A., Jan 1 1997, In : Advances in experimental medicine and biology. 417, p. 449-454 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

T cell-mediated terminal maturation of dendritic cells

Bergstresser, P. R., Kitajima, T., Xu, S., Ariizumi, K. & Takashima, A., Jan 1 1997, In : Advances in experimental medicine and biology. 417, p. 65-69 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Ultraviolet light suppresses IFN-γ-induced IL-7 gene expression in murine keratinocytes by interfering with IFN regulatory factors

Aragane, Y., Schwarz, A., Luger, T. A., Ariizumi, K., Takashima, A. & Schwarz, T., Dec 1 1997, In : Journal of Immunology. 158, 11, p. 5394-5399 6 p.

Research output: Contribution to journalArticle

33 Scopus citations
1996

A novel mechanism of glucocorticoid-induced immune suppression: The inhibition of T cell-mediated terminal maturation of a murine dendritic cell line

Kitajima, T., Ariizumi, K., Bergstresser, P. R. & Takashima, A., Jul 1 1996, In : Journal of Clinical Investigation. 98, 1, p. 142-147 6 p.

Research output: Contribution to journalArticle

Open Access
78 Scopus citations

Cytokine-Mediated Communication between Dendritic Epidermal T Cells and Langerhans Cells: In Vitro Studies Using Cell Lines

Yokota, K., Ariizumi, K., Kitajima, T., Bergstresser, P. R., Street, N. E. & Takashima, A., Aug 15 1996, In : Journal of Immunology. 157, 4, p. 1529-1537 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Expression of the common cytokine receptor γ chain by murine dendritic cells including epidermal Langerhans cells

Mohamadzadeh, M., Ariizumi, K., Sugamura, K., Bergstresser, P. R. & Takashima, A., Jan 1 1996, In : European Journal of Immunology. 26, 1, p. 156-160 5 p.

Research output: Contribution to journalArticle

27 Scopus citations