• 2867 Citations
  • 32 h-Index
1980 …2019
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Research Output 1980 2019

  • 2867 Citations
  • 32 h-Index
  • 76 Article
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Article
2019
5 Citations (Scopus)

Blocking monocytic myeloid-derived suppressor cell function via anti-DC-HIL/GpNMB antibody restores the in vitro integrity of T cells from cancer patients

Kobayashi, M., Chung, J. S., Beg, M. S., Arriaga, Y. E., Verma, U., Courtney, K. D., Mansour, J. C., Haley, B. B., Khan, S., Horiuchi, Y., Ramani, V., Harker, D., Gopal, P., Araghizadeh, F., Cruz, P. D. & Ariizumi, K., Jan 15 2019, In : Clinical Cancer Research. 25, 2, p. 828-838 11 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Antibodies
Neoplasms
Colonic Neoplasms
Colorectal Neoplasms
2018
2 Citations (Scopus)

Expansion of Myeloid-Derived Suppressor Cells in the Peripheral Blood and Lesional Skin of Cutaneous Lupus Patients

Florez-Pollack, S., Tseng, L. C., Kobayashi, M., Hosler, G. A., Ariizumi, K. & Chong, B., Jan 1 2018, (Accepted/In press) In : Journal of Investigative Dermatology.

Research output: Contribution to journalArticle

Skin
Blood
Myeloid-Derived Suppressor Cells

Melanoma-Derived Soluble DC-HIL/GPNMB Promotes Metastasis by Excluding T-Lymphocytes from the Pre-Metastatic Niches

Ramani, V., Teshima, T., Tamura, K., Chung, J. S., Kobayashi, M., Cruz, P. D. & Ariizumi, K., Jan 1 2018, (Accepted/In press) In : Journal of Investigative Dermatology.

Research output: Contribution to journalArticle

T-cells
Tumors
Melanoma
Neoplasm Metastasis
T-Lymphocytes
2 Citations (Scopus)

NF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation

Brosseau, J. P., Liao Ph.D., C. P., Wang, Y., Ramani, V., Vandergriff, T. W., Lee, M., Patel, A., Ariizumi, K. & Le, L. Q., Dec 1 2018, In : Nature Communications. 9, 1, 5014.

Research output: Contribution to journalArticle

Neurofibromatosis 1
Tumors
Carcinogenesis
tumors
genes
2016
15 Citations (Scopus)

Myeloid-Derived Suppressor Cells in Psoriasis Are an Expanded Population Exhibiting Diverse T-Cell–Suppressor Mechanisms

Cao, L. Y., Chung, J. S., Teshima, T., Feigenbaum, L., Cruz, P. D., Jacobe, H., Chong, B. & Ariizumi, K., Sep 1 2016, In : Journal of Investigative Dermatology. 136, 9, p. 1801-1810 10 p.

Research output: Contribution to journalArticle

T-cells
Psoriasis
Interleukin-17
Population
Skin
2014
6 Citations (Scopus)

DC-HIL+CD14+HLA-DRno/lowcells are a potential blood marker and therapeutic target for melanoma

Turrentine, J., Chung, J. S., Nezafati, K., Tamura, K., Harker-Murray, A., Huth, J. F., Sharma, R., Harker, D. B., Ariizumi, K. & Cruz, P. D., Nov 5 2014, In : Journal of Investigative Dermatology. 134, 11, p. 2839-2842 4 p.

Research output: Contribution to journalArticle

Dysplastic Nevus Syndrome
CD14 Antigens
Membrane Glycoproteins
HLA-DR Antigens
Skin Neoplasms
11 Citations (Scopus)

DC-HIL-expressing myelomonocytic cells are critical promoters of melanoma growth

Chung, J. S., Tamura, K., Cruz, P. D. & Ariizumi, K., Nov 5 2014, In : Journal of Investigative Dermatology. 134, 11, p. 2784-2794 11 p.

Research output: Contribution to journalArticle

T-cells
Melanoma
Bearings (structural)
Syndecan-4
T-Lymphocytes
16 Citations (Scopus)

The DC-HIL/Syndecan-4 Pathway Regulates Autoimmune Responses through Myeloid-Derived Suppressor Cells

Chung, J. S., Tamura, K., Akiyoshi, H., Cruz, P. D. & Ariizumi, K., Mar 15 2014, In : Journal of Immunology. 192, 6, p. 2576-2584 9 p.

Research output: Contribution to journalArticle

Syndecan-4
Autoimmunity
Dendritic Cells
Autoimmune Experimental Encephalomyelitis
T-Lymphocytes
2013
21 Citations (Scopus)

T-cell-specific deletion of Mof blocks their differentiation and results in genomic instability in mice

Gupta, A., Hunt, C. R., Pandita, R. K., Pae, J., Komal, K., Singh, M., Shay, J. W., Kumar, R., Ariizumi, K., Horikoshi, N., Hittelman, W. N., Guha, C., Ludwig, T. & Pandita, T. K., May 2013, In : Mutagenesis. 28, 3, p. 263-270 8 p.

Research output: Contribution to journalArticle

T-cells
Genomic Instability
T-Lymphocytes
Thymus
B-Lymphocytes
13 Citations (Scopus)

The DC-HIL ligand syndecan-4 is a negative regulator of T-cell allo-reactivity responsible for graft-versus-host disease

Chung, J. S., Tomihari, M., Tamura, K., Kojima, T., Cruz, P. D. & Ariizumi, K., Feb 2013, In : Immunology. 138, 2, p. 173-182 10 p.

Research output: Contribution to journalArticle

Syndecan-4
Graft vs Host Disease
Ligands
T-Lymphocytes
Antigen-Presenting Cells
2012
3 Citations (Scopus)

T-cell inhibitors: A bench-to-bedside review

Das, S., Ariizumi, K. & Cruz, P. D., Sep 2012, In : Dermatitis. 23, 5, p. 195-202 8 p.

Research output: Contribution to journalArticle

Allergic Contact Dermatitis
Textbooks
Adaptive Immunity
Ligands
T-Lymphocytes
2011
14 Citations (Scopus)

Inhibition of T-cell activation by syndecan-4 is mediated by CD148 through protein tyrosine phosphatase activity

Chung, J. S., Cruz, P. D. & Ariizumi, K., Jun 2011, In : European Journal of Immunology. 41, 6, p. 1794-1799 6 p.

Research output: Contribution to journalArticle

Syndecan-4
Protein Tyrosine Phosphatases
T-Lymphocytes
Syntenins
Heparan Sulfate Proteoglycans
21 Citations (Scopus)

Sézary syndrome cells overexpress syndecan-4 bearing distinct heparan sulfate moieties that suppress T-cell activation by binding DC-HIL and trapping TGF-β on the cell surface

Chung, J. S., Shiue, L. H., Duvic, M., Pandya, A. G., Cruz, P. D. & Ariizumi, K., Mar 24 2011, In : Blood. 117, 12, p. 3382-3390 9 p.

Research output: Contribution to journalArticle

Bearings (structural)
Syndecan-4
Heparan Sulfate Proteoglycans
Heparitin Sulfate
T-cells
2010
78 Citations (Scopus)

CARD9 mediates dectin-2-induced IκBα kinase ubiquitination leading to activation of NF-κB in response to stimulation by the hyphal form of Candida albicans

Bi, L., Gojestani, S., Wu, W., Hsu, Y. M. S., Zhu, J., Ariizumi, K. & Lin, X., Aug 20 2010, In : Journal of Biological Chemistry. 285, 34, p. 25969-25977 9 p.

Research output: Contribution to journalArticle

Forms (concrete)
Hyphae
Candida
Ubiquitination
Candida albicans
39 Citations (Scopus)

DC-HIL/glycoprotein Nmb promotes growth of melanoma in mice by inhibiting the activation of tumor-reactive T cells

Tomihari, M., Chung, J. S., Akiyoshi, H., Cruz, P. D. & Ariizumi, K., Jul 15 2010, In : Cancer Research. 70, 14, p. 5778-5787 10 p.

Research output: Contribution to journalArticle

Melanoma
Glycoproteins
T-Lymphocytes
Syndecan-4
Growth
9 Citations (Scopus)
Syndecan-4
Heparan Sulfate Proteoglycans
Integrins
Dendritic Cells
Haptens
2009
22 Citations (Scopus)

Binding of DC-HIL to dermatophytic fungi induces tyrosine phosphorylation and potentiates antigen presenting cell function

Chung, J. S., Yudate, T., Tomihari, M., Akiyoshi, H., Cruz, P. D. & Ariizumi, K., Oct 15 2009, In : Journal of Immunology. 183, 8, p. 5190-5198 9 p.

Research output: Contribution to journalArticle

Antigen-Presenting Cells
Dendritic Cells
Tyrosine
Fungi
Phosphorylation
48 Citations (Scopus)

Gpnmb is a melanosome-associated glycoprotein that contributes to melanocyte/keratinocyte adhesion in a RGD-dependent fashion

Tomihari, M., Hwang, S. H., Chung, J. S., Cruz, P. D. & Ariizumi, K., 2009, In : Experimental Dermatology. 18, 7, p. 586-595 10 p.

Research output: Contribution to journalArticle

Melanocyte-Stimulating Hormones
Melanosomes
Melanocytes
Keratinocytes
Glycoproteins
33 Citations (Scopus)

Recognition of non-self-polysaccharides by C-type lectin receptors dectin-1 and dectin-2

Hollmig, S. T., Ariizumi, K. & Cruz, P. D., 2009, In : Glycobiology. 19, 6, p. 568-575 8 p.

Research output: Contribution to journalArticle

C-Type Lectins
Sugars
Polysaccharides
Immunity
Antigen-Presenting Cells
47 Citations (Scopus)

The DC-HIL/syndecan-4 pathway inhibits human allogeneic T-cell responses

Chung, J. S., Bonkobara, M., Tomihari, M., Cruz, P. D. & Ariizumi, K., 2009, In : European Journal of Immunology. 39, 4, p. 965-974 10 p.

Research output: Contribution to journalArticle

Syndecan-4
T-Lymphocytes
Monocytes
Heparin Lyase
Langerhans Cells
2008
56 Citations (Scopus)

Immunization with a lentivector that targets tumor antigen expression to dendritic cells induces potent CD8+ and CD4+ T-cell responses

Lopes, L., Dewannieux, M., Gileadi, U., Bailey, R., Ikeda, Y., Whittaker, C., Collin, M. P., Cerundolo, V., Tomihari, M., Ariizumi, K. & Collins, M. K., Jan 2008, In : Journal of Virology. 82, 1, p. 86-95 10 p.

Research output: Contribution to journalArticle

Neoplasm Antigens
dendritic cells
Dendritic Cells
Immunization
immunization
2007
73 Citations (Scopus)

DC-HIL is a negative regulator of T lymphocyte activation

Chung, J. S., Sato, K., Dougherty, I. I., Cruz, P. D. & Ariizumi, K., May 15 2007, In : Blood. 109, 10, p. 4320-4327 8 p.

Research output: Contribution to journalArticle

T-cells
Lymphocyte Activation
Chemical activation
T-Lymphocytes
Antigen-Presenting Cells
68 Citations (Scopus)

Syndecan-4 mediates the coinhibitory function of DC-HIL on T cell activation

Chung, J. S., Dougherty, I., Cruz, P. D. & Ariizumi, K., Nov 1 2007, In : Journal of Immunology. 179, 9, p. 5778-5784 7 p.

Research output: Contribution to journalArticle

Syndecan-4
T-Lymphocytes
Ligands
Heparan Sulfate Proteoglycans
Heparin
2006
293 Citations (Scopus)

Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor γ chain to induce innate immune responses

Sato, K., Yang, X. L., Yudate, T., Chung, J. S., Wu, J., Phelps, K. J., Kimberly, R. P., Underhill, D., Cruz, P. D. & Ariizumi, K., Dec 15 2006, In : Journal of Biological Chemistry. 281, 50, p. 38854-38866 13 p.

Research output: Contribution to journalArticle

Pattern Recognition Receptors
Fc Receptors
Fungi
Innate Immunity
Ligation
1 Citation (Scopus)

Identification and cornification-related gene expression of canine keratinocyte differentiation-associated protein, Kdap

Yagihara, H., Terada, Y., Sugimoto, S., Hidaka, F., Yamada, O., Ono, K., Washizu, T., Ariizumi, K. & Bonkobara, M., Jul 2006, In : Veterinary Journal. 172, 1, p. 141-146 6 p.

Research output: Contribution to journalArticle

keratinocytes
Keratinocytes
Canidae
Gene Expression
gene expression
7 Citations (Scopus)

Identification and gene expression of bovine C-type lectin dectin-2

Bonkobara, M., Hoshino, M., Yagihara, H., Tamura, K., Isotani, M., Tanaka, Y., Washizu, T. & Ariizumi, K., Mar 15 2006, In : Veterinary Immunology and Immunopathology. 110, 1-2, p. 179-186 8 p.

Research output: Contribution to journalArticle

C-Type Lectins
lectins
Gene Expression
gene expression
cattle
14 Citations (Scopus)

Selective expression of vacuolar H+-ATPase subunit d2 by particular subsets of dendritic cells among leukocytes

Sato, K., Shikano, S., Xia, G., Takao, J., Chung, J. S., Cruz, P. D., Xie, X-S. & Ariizumi, K., Mar 2006, In : Molecular Immunology. 43, 9, p. 1443-1453 11 p.

Research output: Contribution to journalArticle

Vacuolar Proton-Translocating ATPases
Dendritic Cells
Leukocytes
Protein Isoforms
Macrophages
2005
5 Citations (Scopus)

Canine epidermal langerhans cells express α and γ but not β chains of high-affinity IgE receptor

Bonkobara, M., Miyake, F., Yagihara, H., Yamada, O., Azakami, D., Washizu, T., Cruz, P. D. & Ariizumi, K., Aug 2005, In : Veterinary Research Communications. 29, 6, p. 499-505 7 p.

Research output: Contribution to journalArticle

Langerhans cells
IgE Receptors
Langerhans Cells
Canidae
receptors
34 Citations (Scopus)

Identification and expression profiling of a human C-type lectin, structurally homologous to mouse dectin-2

Gavino, A. C. P., Chung, J. S., Sato, K., Ariizumi, K. & Cruz, P. D., Apr 2005, In : Experimental Dermatology. 14, 4, p. 281-288 8 p.

Research output: Contribution to journalArticle

C-Type Lectins
T-cells
Gene expression
Langerhans Cells
T-Lymphocytes
7 Citations (Scopus)

Ultraviolet-B radiation upregulates expression of dectin-2 on epidermal Langerhans cells by activating the gene promoter

Bonkobara, M., Yagihara, H., Yudate, T., Chung, J. S., Washizu, T., Ariizumi, K. & Cruz, P. D., Jul 2005, In : Photochemistry and Photobiology. 81, 4, p. 944-948 5 p.

Research output: Contribution to journalArticle

Langerhans Cells
genes
Up-Regulation
Genes
Radiation
2004
18 Citations (Scopus)

Characterization of Kdap, a protein secreted by keratinocytes

Tsuchida, S., Bonkobara, M., McMillan, J. R., Akiyama, M., Yudate, T., Aragane, Y., Tezuka, T., Shimizu, H., Cruz, P. D. & Ariizumi, K., May 2004, In : Journal of Investigative Dermatology. 122, 5, p. 1225-1234 10 p.

Research output: Contribution to journalArticle

Keratinocytes
Proteins
Messenger RNA
Protein Sorting Signals
Skin
4 Citations (Scopus)

Transcriptional regulation of dectin-2 promoter in transgenic mouse

Bonkobara, M., Yudate, T., Yagihara, H., Washizu, T., Cruz, P. D. & Ariizumi, K., Dec 2004, In : Journal of Veterinary Medical Science. 66, 12, p. 1483-1489 7 p.

Research output: Contribution to journalArticle

Langerhans cells
Langerhans Cells
Transgenic Mice
promoter regions
genetically modified organisms
2003
57 Citations (Scopus)

Expression of NF-κB in epidermis and the relationship between NF-κB activation and inhibition of keratinocyte growth

Takao, J., Yudate, T., Das, A., Shikano, S., Bonkobara, M., Ariizumi, K. & Cruz, P. D., Apr 1 2003, In : British Journal of Dermatology. 148, 4, p. 680-688 9 p.

Research output: Contribution to journalArticle

Keratinocytes
Epidermis
Growth
Tetradecanoylphorbol Acetate
Sodium Salicylate
14 Citations (Scopus)

Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes

Bonkobara, M., Das, A., Takao, J., Cruz, P. D. & Ariizumi, K., Apr 1 2003, In : British Journal of Dermatology. 148, 4, p. 654-664 11 p.

Research output: Contribution to journalArticle

Keratinocytes
Membrane Proteins
Genes
Peptides
Expressed Sequence Tags
66 Citations (Scopus)

Involvement of dectin-2 in ultraviolet radiation-induced tolerance

Aragane, Y., Maeda, A., Schwarz, A., Tezuka, T., Ariizumi, K. & Schwarz, T., Oct 1 2003, In : Journal of Immunology. 171, 7, p. 3801-3807 7 p.

Research output: Contribution to journalArticle

Radiation Tolerance
Haptens
T-Lymphocytes
Contact Dermatitis
Regulatory T-Lymphocytes
2002
50 Citations (Scopus)

Genomic scale analysis of the human keratinocyte response to broad-band ultraviolet-B irradiation

Takao, J., Ariizumi, K., Dougherty, I. I. & Cruz, P. D., 2002, In : Photodermatology Photoimmunology and Photomedicine. 18, 1, p. 5-13 9 p.

Research output: Contribution to journalArticle

Keratinocytes
Genes
Complementary RNA
Ribosomal Proteins
Cytochromes c
2001
24 Citations (Scopus)

Activation of HIV in human skin by ultraviolet B radiation and its inhibition by NFκB blocking agents

Breuer-McHam, J., Simpson, E., Dougherty, I., Bonkobara, M., Ariizumi, K., Lewis, D. E., Dawson, D. B., Duvic, M. & Cruz, P. D., Dec 1 2001, In : Photochemistry and Photobiology. 74, 6, p. 805-810 6 p.

Research output: Contribution to journalArticle

human immunodeficiency virus
NF-kappa B
Skin
Chemical activation
HIV
32 Citations (Scopus)

Development of a Langerhans cell-targeted gene therapy format using a dendritic cell-specific promoter

Morita, A., Ariizumi, K., Ritter, R., Jester, J. V., Kumamoto, T., Johnston, S. A. & Takashima, A., 2001, In : Gene Therapy. 8, 22, p. 1729-1737 9 p.

Research output: Contribution to journalArticle

Langerhans Cells
Genetic Therapy
Dendritic Cells
Firearms
Genes
39 Citations (Scopus)

Epidermal Langerhans cell-targeted gene expression by a dectin-2 promoter

Bonkobara, M., Zukas, P. K., Shikano, S., Nakamura, S., Cruz, P. D. & Ariizumi, K., Dec 15 2001, In : Journal of Immunology. 167, 12, p. 6893-6900 8 p.

Research output: Contribution to journalArticle

Langerhans Cells
Gene Expression
Luciferases
Dendritic Cells
Epidermis
75 Citations (Scopus)

Identification of a human homologue of the dendritic cell-associated C-type lectin-1, dectin-1

Yokota, K., Takashima, A., Bergstresser, P. R. & Ariizumi, K., Jul 11 2001, In : Gene. 272, 1-2, p. 51-60 10 p.

Research output: Contribution to journalArticle

Mitogen Receptors
C-Type Lectins
Forensic Anthropology
Dendritic Cells
Langerhans Cells
130 Citations (Scopus)
Heparan Sulfate Proteoglycans
Cloning
Endothelial cells
Molecular Cloning
Dendritic Cells
2000
128 Citations (Scopus)

Cloning of a second dendritic cell-associated C-type lectin (dectin-2) and its alternatively spliced isoforms

Ariizumi, K., Shen, G. L., Shikano, S., Ritter, R., Zukas, P., Edelbaum, D., Morita, A. & Takashima, A., Apr 21 2000, In : Journal of Biological Chemistry. 275, 16, p. 11957-11963 7 p.

Research output: Contribution to journalArticle

C-Type Lectins
Cloning
Dendritic Cells
Organism Cloning
Protein Isoforms
338 Citations (Scopus)

Identification of a novel, dendritic cell-associated molecule, dectin-1, by subtractive cDNA cloning

Ariizumi, K., Shen, G. L., Shikano, S., Xu, S., Ritter, R., Kumamoto, T., Edelbaum, D., Morita, A., Bergstresser, P. R. & Takashima, A., Jun 30 2000, In : Journal of Biological Chemistry. 275, 26, p. 20157-20167 11 p.

Research output: Contribution to journalArticle

Cloning
Dendritic Cells
Organism Cloning
Complementary DNA
Molecules
1997
3 Citations (Scopus)

Subtractive cDNA cloning: A new approach to understanding dendritic cell biology

Ariizumi, K., Bergstresser, P. R. & Takashima, A., 1997, In : Advances in Experimental Medicine and Biology. 417, p. 449-454 6 p.

Research output: Contribution to journalArticle

Cytology
Langerhans Cells
Cloning
Antigen Presentation
Molecular Cloning
1 Citation (Scopus)

T cell-mediated terminal maturation of dendritic cells

Bergstresser, P. R., Kitajima, T., Xu, S., Ariizumi, K. & Takashima, A., 1997, In : Advances in Experimental Medicine and Biology. 417, p. 65-69 5 p.

Research output: Contribution to journalArticle

T-cells
Langerhans Cells
Immunosuppressive Agents
Cell Communication
Dendritic Cells
33 Citations (Scopus)

Ultraviolet light suppresses IFN-γ-induced IL-7 gene expression in murine keratinocytes by interfering with IFN regulatory factors

Aragane, Y., Schwarz, A., Luger, T. A., Ariizumi, K., Takashima, A. & Schwarz, T., 1997, In : Journal of Immunology. 158, 11, p. 5394-5399 6 p.

Research output: Contribution to journalArticle

Interleukin-7
Ultraviolet Rays
Keratinocytes
Gene Expression
Response Elements
1996
78 Citations (Scopus)

A novel mechanism of glucocorticoid-induced immune suppression: The inhibition of T cell-mediated terminal maturation of a murine dendritic cell line

Kitajima, T., Ariizumi, K., Bergstresser, P. R. & Takashima, A., Jul 1 1996, In : Journal of Clinical Investigation. 98, 1, p. 142-147 6 p.

Research output: Contribution to journalArticle

Dendritic Cells
Dexamethasone
Glucocorticoids
T-Lymphocytes
Cell Line
23 Citations (Scopus)

Cytokine-Mediated Communication between Dendritic Epidermal T Cells and Langerhans Cells: In Vitro Studies Using Cell Lines

Yokota, K., Ariizumi, K., Kitajima, T., Bergstresser, P. R., Street, N. E. & Takashima, A., Aug 15 1996, In : Journal of Immunology. 157, 4, p. 1529-1537 9 p.

Research output: Contribution to journalArticle

Langerhans Cells
Communication
Cytokines
T-Lymphocytes
Cell Line
26 Citations (Scopus)

Expression of the common cytokine receptor γ chain by murine dendritic cells including epidermal Langerhans cells

Mohamadzadeh, M., Ariizumi, K., Sugamura, K., Bergstresser, P. R. & Takashima, A., Jan 1996, In : European Journal of Immunology. 26, 1, p. 156-160 5 p.

Research output: Contribution to journalArticle

Cytokine Receptors
Langerhans Cells
Dendritic Cells
Interleukin-4
Interleukin-15 Receptors
6 Citations (Scopus)

IL-7 upregulates T cell receptor/CD3 expression by cultured dendritic epidermal T cells

Ono, M., Ariizumi, K., Bergstresser, P. R. & Takashima, A., Feb 1996, In : Journal of Dermatological Science. 11, 2, p. 89-96 8 p.

Research output: Contribution to journalArticle

Interleukin-7
T-cells
T-Cell Antigen Receptor
Up-Regulation
T-Lymphocytes