• 1664 Citations
  • 15 h-Index
19982019
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Research Output 1998 2019

  • 1664 Citations
  • 15 h-Index
  • 25 Article
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Article
2019

Long-Term Effects of Bevacizumab on Vestibular Schwannoma Volume in Neurofibromatosis Type 2 Patients

Killeen, D. E., Klesse, L. J., Tolisano, A. M., Hunter, J. B. & Kutz, J. W., Jan 1 2019, In : Journal of Neurological Surgery, Part B: Skull Base. 80, 5, p. 540-546 7 p.

Research output: Contribution to journalArticle

Neurofibromatosis 2
Acoustic Neuroma
Hearing
Therapeutics
Tumor Burden
1 Citation (Scopus)

Rate and frequency of bullying victimization in school-age children with neurofibromatosis type 1 (NF1)

Holland, A. A., Stavinoha, P. L., Swearer, S. M., Solesbee, C., Patel, S. & Klesse, L. J., Nov 2019, In : School Psychology. 34, 6, p. 687-694 8 p.

Research output: Contribution to journalArticle

Bullying
Neurofibromatosis 1
Crime Victims
victimization
Christianity
2018
1 Citation (Scopus)

Metabolic syndrome is a sequela of radiation exposure in hypothalamic obesity among survivors of childhood brain tumors

Cooksey, R., Wu, S. Y., Klesse, L. J., Oden, J. D., Bland, R. E., Hodges, J. C., Gargan, L., Vega, G. L. & Bowers, D. C., Jan 1 2018, (Accepted/In press) In : Journal of Investigative Medicine.

Research output: Contribution to journalArticle

Brain Neoplasms
Survivors
Tumors
Brain
Obesity
2017
6 Citations (Scopus)

Targeted MAPK pathway inhibitors in patients with disseminated pilocytic astrocytomas

Drobysheva, A., Klesse, L. J., Bowers, D. C., Rajaram, V., Rakheja, D., Timmons, C. F., Wang, J., Koral, K., Gargan, L., Ramos, E. & Park, J. Y., Aug 1 2017, In : JNCCN Journal of the National Comprehensive Cancer Network. 15, 8, p. 978-982 5 p.

Research output: Contribution to journalArticle

Astrocytoma
Neoplasms
Mutation
Pediatrics
2016
4 Citations (Scopus)

Postoperative surveillance of pediatric cerebellar pilocytic astrocytoma

Alford, R., Gargan, L., Bowers, D. C., Klesse, L. J., Weprin, B. & Koral, K., Oct 1 2016, In : Journal of Neuro-Oncology. 130, 1, p. 149-154 6 p.

Research output: Contribution to journalArticle

Astrocytoma
Pediatrics
Recurrence
Tumor Burden
Neoplasms
26 Citations (Scopus)

Randomized placebo-controlled study of lovastatin in children with neurofibromatosis type 1

Payne, J. M., Barton, B., Ullrich, N. J., Cantor, A., Hearps, S. J. C., Cutter, G., Rosser, T., Walsh, K. S., Gioia, G. A., Wolters, P. L., Tonsgard, J., Schorry, E., Viskochil, D., Klesse, L., Fisher, M., Gutmann, D. H., Silva, A. J., Hunter, S. J., Rey-Casserly, C., Cantor, N. L. & 10 others, Byars, A. W., Stavinoha, P. L., Ackerson, J. D., Armstrong, C. L., Isenberg, J., O'Neil, S. H., Packer, R. J., Korf, B., Acosta, M. T. & North, K. N., Dec 13 2016, In : Neurology. 87, 24, p. 2575-2584 10 p.

Research output: Contribution to journalArticle

Lovastatin
Neurofibromatosis 1
Placebos
Learning
Paired-Associate Learning
2014
20 Citations (Scopus)

Pleomorphic xanthoastrocytoma of childhood: MR imaging and diffusion MR imaging features

Moore, W., Mathis, D., Gargan, L., Bowers, D. C., Klesse, L. J., Margraf, L. & Koral, K., Nov 1 2014, In : American Journal of Neuroradiology. 35, 11, p. 2192-2196 5 p.

Research output: Contribution to journalArticle

Supratentorial Neoplasms
Edema
Neoplasms
Pediatrics
Brain
2013
4 Citations (Scopus)

Intracerebral schwannomas: A rare disease with varying natural history Report of 3 cases

Scott, W. W., Koral, K., Margraf, L. R., Klesse, L., Sacco, D. J. & Weprin, B. E., Jul 2013, In : Journal of Neurosurgery: Pediatrics. 12, 1, p. 6-12 7 p.

Research output: Contribution to journalArticle

Neurilemmoma
Rare Diseases
Natural History
Neoplasms
Recurrence
2011
3 Citations (Scopus)
Wilms Tumor
Lymphoproliferative Disorders
Nephrectomy
Transplants
Kidney
2010
14 Citations (Scopus)

Acute myeloid leukemia with inv(16) with CBFB-MYH11, 3'CBFB deletion, variant t(9;22) with BCR-ABL1, and del(7)(q22q32) in a pediatric patient: case report and literature review

Tirado, C. A., Valdez, F., Klesse, L., Karandikar, N. J., Uddin, N., Arbini, A., Fustino, N., Collins, R., Patel, S., Smart, R. L., Garcia, R., Doolittle, J. & Chen, W., Jul 2010, In : Cancer Genetics and Cytogenetics. 200, 1, p. 54-59 6 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Pediatrics
Clone Cells
Interphase
Fluorescence In Situ Hybridization
21 Citations (Scopus)

Childhood medulloblastoma: Current status of biology and treatment

Klesse, L. J. & Bowers, D. C., 2010, In : CNS Drugs. 24, 4, p. 285-301 17 p.

Research output: Contribution to journalArticle

Medulloblastoma
Therapeutics
Poisons
Brain Neoplasms
Neoplasms
2 Citations (Scopus)

Cutaneous features predict paraspinal neurofibromas in neurofibromatosis type 1

Brown, R. M., Klesse, L. J. & Le, L. Q., Sep 2010, In : Journal of Investigative Dermatology. 130, 9, p. 2167-2169 3 p.

Research output: Contribution to journalArticle

Plexiform Neurofibroma
Neurofibroma
Neurofibromatosis 1
Screening
Skin
16 Citations (Scopus)

Wilms tumor in a child with L-2-hydroxyglutaric aciduria

Rogers, R. E., DeBerardinis, R. J., Klesse, L. J., Boriack, R. L., Margraf, L. R. & Rakheja, D., Sep 2010, In : Pediatric and Developmental Pathology. 13, 5, p. 408-411 4 p.

Research output: Contribution to journalArticle

Wilms Tumor
Inborn Errors Metabolism
Central Nervous System Neoplasms
Brain Diseases
Neoplasms
2005
52 Citations (Scopus)

The zinc finger transcription factor Klf7 is required for TrkA gene expression and development of nociceptive sensory neurons

Lei, L., Laub, F., Lush, M., Romero, M., Zhou, J., Luikart, B., Klesse, L., Ramirez, F. & Parada, L. F., Jun 1 2005, In : Genes and Development. 19, 11, p. 1354-1364 11 p.

Research output: Contribution to journalArticle

Nociceptors
Zinc Fingers
Sensory Receptor Cells
Transcription Factors
Gene Expression
2003
87 Citations (Scopus)

Activation of Ras is necessary and sufficient for upregulation of vanilloid receptor type 1 in sensory neurons by neurotrophic factors

Bron, R., Klesse, L. J., Shah, K., Parada, L. F. & Winter, J., Jan 1 2003, In : Molecular and Cellular Neuroscience. 22, 1, p. 118-132 15 p.

Research output: Contribution to journalArticle

Nerve Growth Factors
Sensory Receptor Cells
Up-Regulation
Spinal Ganglia
Phosphatidylinositol 3-Kinase
2002
18 Citations (Scopus)

BDNF activated TrkB/IRR receptor chimera promotes survival of sympathetic neurons through ras and PI-3 kinase signaling

Kelly-Spratt, K. S., Klesse, L. J. & Parada, L. F., Jul 15 2002, In : Journal of Neuroscience Research. 69, 2, p. 151-159 9 p.

Research output: Contribution to journalArticle

trkB Receptor
Brain-Derived Neurotrophic Factor
Phosphatidylinositol 3-Kinases
Neurons
Superior Cervical Ganglion
2 Citations (Scopus)

Erratum: Neurotrophins use the Erk5 pathway to mediate a retrograde survival response (Nature Neuroscience (2001) 4 (981-988))

Watson, F. L., Heerssen, H. M., Bhattacharyya, A., Klesse, L., Lin, M. Z. & Segal, R. A., Oct 2002, In : Nature Neuroscience. 5, 10, p. 1017 1 p.

Research output: Contribution to journalArticle

2001
359 Citations (Scopus)

Neurotrophins use the Erk5 pathway to mediate a retrograde survival response

Watson, F. L., Heerssen, H. M., Bhattacharyya, A., Klesse, L., Lin, M. Z. & Segal, R. A., 2001, In : Nature Neuroscience. 4, 10, p. 981-988 8 p.

Research output: Contribution to journalArticle

Nerve Growth Factors
Protein Kinases
Endocytosis
Mitogen-Activated Protein Kinases
Intercellular Signaling Peptides and Proteins
2000
53 Citations (Scopus)

Loss of brain-derived neurotrophic factor-dependent neural crest-derived sensory neurons in neurotrophin-4 mutant mice

Liebl, D. J., Klesse, L. J., Tessarollo, L., Wohlman, T. & Parada, L. F., Feb 29 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 5, p. 2297-2302 6 p.

Research output: Contribution to journalArticle

Neural Crest
Brain-Derived Neurotrophic Factor
Sensory Receptor Cells
Neurons
Proprioception
293 Citations (Scopus)

Requirement for nitric oxide activation of p21(ras)/extracellular regulated kinase in neuronal ischemic preconditioning

Gonzalez-Zulueta, M., Feldman, A. B., Klesse, L. J., Kalb, R. G., Dillman, J. F., Parada, L. F., Dawson, T. M. & Dawson, V. L., Jan 4 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 1, p. 436-441 6 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins p21(ras)
Ischemic Preconditioning
Nitric Oxide
Phosphotransferases
Oxygen
1999
20 Citations (Scopus)

A TrkB/insulin receptor-related receptor chimeric receptor induces PC12 cell differentiation and exhibits prolonged activation of mitogen-activated protein kinase

Kelly-Spratt, K. S., Klesse, L. J., Merenmies, J. & Parada, L. F., Dec 1999, In : Cell Growth and Differentiation. 10, 12, p. 805-812 8 p.

Research output: Contribution to journalArticle

trkB Receptor
PC12 Cells
Mitogen-Activated Protein Kinases
Cell Differentiation
Insulin Receptor
250 Citations (Scopus)

Mouse tumor model for neurofibromatosis type 1

Vogel, K. S., Klesse, L. J., Velasco-Miguel, S., Meyers, K., Rushing, E. J. & Parada, L. F., Dec 10 1999, In : Science. 286, 5447, p. 2176-2179 4 p.

Research output: Contribution to journalArticle

Neurofibromatosis 1
Sarcoma
Mutation
Neural Crest
Loss of Heterozygosity
175 Citations (Scopus)

Nerve growth factor induces survival and differentiation through two distinct signaling cascades in PC12 cells

Klesse, L., Meyers, K., Marshall, C. & Parada, L., Mar 25 1999, In : Oncogene. 18, 12, p. 2055-2068 14 p.

Research output: Contribution to journalArticle

PC12 Cells
Nerve Growth Factor
Phosphatidylinositol 3-Kinases
Serum-Free Culture Media
Pheochromocytoma
130 Citations (Scopus)

Trks: Signal transduction and intracellular pathways

Klesse, L. J. & Parada, L. F., May 15 1999, In : Microscopy Research and Technique. 45, 4-5, p. 210-216 7 p.

Research output: Contribution to journalArticle

Signal transduction
neurotrophins
Nerve Growth Factors
signal transduction
Signal Transduction
1998
107 Citations (Scopus)

p21 Ras and phosphatidylinositol-3 kinase are required for survival of wild-type and NF1 mutant sensory neurons

Klesse, L. J. & Parada, L. F., Dec 15 1998, In : Journal of Neuroscience. 18, 24, p. 10420-10428 9 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Proto-Oncogene Proteins p21(ras)
Sensory Receptor Cells
Nerve Growth Factor
Neurofibromin 1