• 5473 Citations
  • 33 h-Index
19942019
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Fingerprint Dive into the research topics where Lawrence Lum is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 5 Similar Profiles
Porcupines Medicine & Life Sciences
RNA Interference Medicine & Life Sciences
Catenins Medicine & Life Sciences
Hedgehogs Medicine & Life Sciences
Wnt Signaling Pathway Medicine & Life Sciences
Signal Transduction Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Wnt Proteins Medicine & Life Sciences

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Research Output 1994 2019

  • 5473 Citations
  • 33 h-Index
  • 58 Article
  • 3 Chapter

CRISPR-Cas9-based mutagenesis frequently provokes on-target mRNA misregulation

Tuladhar, R., Yeu, Y., Tyler Piazza, J., Tan, Z., Rene Clemenceau, J., Wu, X., Barrett, Q., Herbert, J., Mathews, D. H., Kim, J., Hyun Hwang, T. & Lum, L., Dec 1 2019, In : Nature communications. 10, 1, 4056.

Research output: Contribution to journalArticle

Open Access
Clustered Regularly Interspaced Short Palindromic Repeats
mutagenesis
deletion
Mutagenesis
insertion

Stereoselective fatty acylation is essential for the release of lipidated WNT proteins from the acyltransferase Porcupine (PORCN)

Tuladhar, R., Yarravarapu, N., Ma, Y., Zhang, C., Herbert, J., Kim, J., Chen, C. & Lum, L., Jan 1 2019, In : Journal of Biological Chemistry. 294, 16, p. 6273-6282 10 p.

Research output: Contribution to journalArticle

Porcupines
Acylation
Animals
Acyltransferases
Proteins

A synthetic combinatorial approach to disabling deviant Hedgehog signaling

Fan, C. W., Yarravarapu, N., Shi, H., Kulak, O., Kim, J., Chen, C. & Lum, L., Dec 1 2018, In : Scientific Reports. 8, 1, 1133.

Research output: Contribution to journalArticle

Histone Deacetylases
Medulloblastoma
Critical Pathways
Basal Cell Carcinoma
DNA-Binding Proteins
4 Citations (Scopus)

Chemical Modulation of WNT Signaling in Cancer

Zhang, L. S. & Lum, L., Jan 1 2018, WNT Signaling in Health and Disease. Elsevier B.V., p. 245-269 25 p. (Progress in Molecular Biology and Translational Science; vol. 153).

Research output: Chapter in Book/Report/Conference proceedingChapter

Porcupines
Acyltransferases
Antineoplastic Agents
Regeneration
Melanoma
1 Citation (Scopus)

EGF receptor and mTORC1 are novel therapeutic targets in nonseminomatous germ cell tumors

Chen, K., Fustino, N. J., Shukla, A. A., Stroup, E. K., Budhipramono, A., Ateek, C., Stuart, S. H., Yamaguchi, K., Kapur, P., Frazier, A. L., Lum, L., Looijenga, L. H. J., Laetsch, T. W., Rakheja, D. & Amatruda, J. F., May 1 2018, In : Molecular Cancer Therapeutics. 17, 5, p. 1079-1089 11 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Germ Cell and Embryonal Neoplasms
Seminoma
Therapeutics
Embryonal Carcinoma