• 11710 Citations
  • 26 h-Index
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Fingerprint Dive into the research topics where Lijun Sun is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 3 Similar Profiles
Antiviral Agents Medicine & Life Sciences
Innate Immunity Medicine & Life Sciences
Ubiquitin Medicine & Life Sciences
Ubiquitination Medicine & Life Sciences
GMP synthase (glutamine-hydrolyzing) Medicine & Life Sciences
Polyubiquitin Medicine & Life Sciences
Interferon Type I Medicine & Life Sciences
DNA Medicine & Life Sciences

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Research Output 2004 2019

  • 11710 Citations
  • 26 h-Index
  • 29 Article
  • 2 Review article
2 Citations (Scopus)

cGAS activation causes lupus-like autoimmune disorders in a TREX1 mutant mouse model

Xiao, N., Wei, J., Xu, S., Du, H., Huang, M., Zhang, S., Ye, W., Sun, L. & Chen, Q., Jun 1 2019, In : Journal of Autoimmunity. 100, p. 84-94 11 p.

Research output: Contribution to journalArticle

Systemic Lupus Erythematosus
Autoimmune Diseases
19 Citations (Scopus)

Detection of Microbial Infections Through Innate Immune Sensing of Nucleic Acids

Tan, X., Sun, L., Chen, J. & Chen, Z. J., Sep 8 2018, In : Annual Review of Microbiology. 72, p. 447-478 32 p.

Research output: Contribution to journalReview article

Pattern Recognition Receptors
Nucleic Acids
Interferon Type I
81 Citations (Scopus)

cGAS is essential for the antitumor effect of immune checkpoint blockade

Wang, H., Hu, S., Chen, X., Shi, H., Chen, C., Sun, L. & Chen, Z. J., Feb 14 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 7, p. 1637-1642 6 p.

Research output: Contribution to journalArticle

Adenosine Monophosphate
Interferon Type I
Experimental Melanomas
318 Citations (Scopus)

Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing

Chen, Q., Sun, L. & Chen, Z. J., Sep 20 2016, In : Nature Immunology. 17, 10, p. 1142-1149 8 p.

Research output: Contribution to journalReview article

GMP synthase (glutamine-hydrolyzing)
Second Messenger Systems
Innate Immunity
Nucleic Acids
106 Citations (Scopus)

The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop

Zhang, X., Wu, J., Du, F., Xu, H., Sun, L., Chen, Z., Brautigam, C. A., Zhang, X. & Chen, Z., Feb 13 2014, In : Cell Reports. 6, 3, p. 421-430 10 p.

Research output: Contribution to journalArticle

Chemical activation
GMP synthase (glutamine-hydrolyzing)