• 13259 Citations
  • 58 h-Index
19962019
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Research Output 1996 2019

  • 13259 Citations
  • 58 h-Index
  • 143 Article
  • 2 Comment/debate
  • 1 Chapter
  • 1 Conference contribution
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Article
2019
8 Citations (Scopus)

Inhibition of thioredoxin/thioredoxin reductase induces synthetic lethality in lung cancers with compromised glutathione homeostasis

Yan, X., Zhang, X., Wang, L., Zhang, R., Pu, X., Wu, S., Li, L., Tong, P., Wang, J., Meng, Q. H., Jensen, V. B., Girard, L., Minna, J. D., Roth, J. A., Swisher, S. G., Heymach, J. V. & Fang, B., Jan 1 2019, In : Cancer Research. 79, 1, p. 125-132 8 p.

Research output: Contribution to journalArticle

Thioredoxin-Disulfide Reductase
Thioredoxins
Glutathione
Lung Neoplasms
Oxidoreductases
1 Citation (Scopus)

Systematic analysis of gene expression in lung adenocarcinoma and squamous cell carcinoma with a case study of FAM83A and FAM83B

Cai, L., Luo, D., Yao, B., Yang, D. M., Lin, S., Girard, L., Deberardinis, R. J., Minna, J. D., Xie, Y. & Xiao, G., Jun 1 2019, In : Cancers. 11, 6, 886.

Research output: Contribution to journalArticle

Open Access
Squamous Cell Carcinoma
Lung Neoplasms
Gene Expression
Databases
Neoplasm Genes

Unbiased peptoid combinatorial cell screen identifies plectin protein as a potential biomarker for lung cancer stem cells

Raymond, A. C., Gao, B., Girard, L., Minna, J. D. & Gomika Udugamasooriya, D., Dec 1 2019, In : Scientific reports. 9, 1, 14954.

Research output: Contribution to journalArticle

Open Access
Plectin
Peptoids
Neoplastic Stem Cells
Lung Neoplasms
Biomarkers
2018
1 Citation (Scopus)

A quantitative method for assessing smoke associated molecular damage in lung cancers

Song, K., Bi, J. H., Qiu, Z. W., Felizardo, R., Girard, L., Minna, J. D. & Gazdar, A. F., Jan 1 2018, In : Translational Lung Cancer Research. 7, 4, p. 439-449 11 p.

Research output: Contribution to journalArticle

Smoke
Tobacco
Lung Neoplasms
Mutation
Small Cell Lung Carcinoma
17 Citations (Scopus)

Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer

McMillan, E. A., Ryu, M. J., Diep, C. H., Mendiratta, S., Clemenceau, J. R., Vaden, R. M., Kim, J. H., Motoyaji, T., Covington, K. R., Peyton, M., Huffman, K., Wu, X., Girard, L., Sung, Y., Chen, P. H., Mallipeddi, P. L., Lee, J. Y., Hanson, J., Voruganti, S., Yu, Y. & 20 others, Park, S., Sudderth, J., DeSevo, C., Muzny, D. M., Doddapaneni, H. V., Gazdar, A., Gibbs, R. A., Hwang, T. H., Heymach, J. V., Wistuba, I., Coombes, K. R., Williams, N. S., Wheeler, D. A., MacMillan, J. B., Deberardinis, R. J., Roth, M. G., Posner, B. A., Minna, J. D., Kim, H. S. & White, M. A., May 3 2018, In : Cell. 173, 4, p. 864-878.e29

Research output: Contribution to journalArticle

Lung Neoplasms
Neoplasms
Oncology
Biosynthesis
Small Molecule Libraries
2 Citations (Scopus)

Concomitant targeting of the mTOR/MAPK pathways: Novel therapeutic strategy in subsets of RICTOR/KRAS-altered non-small cell lung cancer

Ruder, D., Papadimitrakopoulou, V., Shien, K., Behrens, C., Kalhor, N., Chen, H., Shen, L., Jack Lee, J., Hong, W. K., Tang, X., Girard, L., Minna, J. D., Diao, L., Wang, J., Mino, B., Villalobos, P., Rodriguez-Canales, J., Hanson, N. E., Sun, J., Miller, V. & 6 others, Greenbowe, J., Frampton, G., Herbst, R. S., Baladandayuthapani, V., Wistuba, I. I. & Izzo, J. G., Sep 1 2018, In : Oncotarget. 9, 74, p. 33995-34008 14 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Biodiversity
Therapeutics
Lung Neoplasms
Clinical Trials

eIF2β, a subunit of translation-initiation factor EIF2, is a potential therapeutic target for non-small cell lung cancer

Tanaka, I., Sato, M., Kato, T., Goto, D., Kakumu, T., Miyazawa, A., Yogo, N., Hase, T., Morise, M., Sekido, Y., Girard, L., Minna, J. D., Byers, L. A., Heymach, J. V., Coombes, K. R., Kondo, M. & Hasegawa, Y., Jan 1 2018, (Accepted/In press) In : Cancer Science.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-2
Peptide Initiation Factors
Non-Small Cell Lung Carcinoma
Lung Neoplasms
Small Interfering RNA

Kub5-HeraRPRD1B Deficiency Promotes "BRCAness" and Vulnerability to PARP Inhibition in BRCA-proficient Breast Cancers

Motea, E. A., Fattah, F. J., Xiao, L., Girard, L., Rommel, A., Morales, J. C., Patidar, P., Zhou, Y., Porter, A., Xie, Y., Minna, J. D. & Boothman, D. A., Dec 15 2018, In : Clinical Cancer Research. 24, 24, p. 6459-6470 12 p.

Research output: Contribution to journalArticle

Recombinational DNA Repair
Precision Medicine
Breast Neoplasms
DNA Damage
CDC2 Protein Kinase
3 Citations (Scopus)

LCE: an open web portal to explore gene expression and clinical associations in lung cancer

Cai, L., Lin, S. Y., Girard, L., Zhou, Y., Yang, L., Ci, B., Zhou, Q., Luo, D., Yao, B., Tang, H., Allen, J., Huffman, K., Gazdar, A. F., Heymach, J., Wistuba, I., Xiao, G., Minna, J. D. & Xie, Y., Jan 1 2018, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

Lung Neoplasms
Gene Expression
Databases
Survival Analysis
Meta-Analysis
14 Citations (Scopus)

Small cell lung cancer tumors and preclinical models display heterogeneity of neuroendocrine phenotypes

Zhang, W., Girard, L., Zhang, Y. A., Haruki, T., Papari-Zareei, M., Stastny, V., Ghayee, H. K., Pacak, K., Oliver, T. G., Minna, J. D. & Gazdar, A. F., Feb 1 2018, In : Translational Lung Cancer Research. 7, 1, p. 32-49 18 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Phenotype
Neoplasms
Tumor Cell Line
Cell Line
4 Citations (Scopus)

Telomerase-Mediated Strategy for Overcoming Non–Small Cell Lung Cancer Targeted Therapy and Chemotherapy Resistance

Mender, I., LaRanger, R., Luitel, K., Peyton, M., Girard, L., Lai, T. P., Batten, K., Cornelius, C., Dalvi, M. P., Ramirez, M., Du, W., Wu, L. F., Altschuler, S. J., Brekken, R., Martinez, E. D., Minna, J. D., Wright, W. E. & Shay, J. W., Aug 1 2018, In : Neoplasia (United States). 20, 8, p. 826-837 12 p.

Research output: Contribution to journalArticle

alpha-2'-deoxythioguanosine
Telomerase
Non-Small Cell Lung Carcinoma
Drug Therapy
Lung Neoplasms
5 Citations (Scopus)

The Epithelial Sodium Channel (αENaC) Is a Downstream Therapeutic Target of ASCL1 in Pulmonary Neuroendocrine Tumors

He, M., Liu, S., Gallolu Kankanamalage, S., Borromeo, M. D., Girard, L., Gazdar, A. F., Minna, J. D., Johnson, J. E. & Cobb, M. H., Apr 1 2018, In : Translational Oncology. 11, 2, p. 292-299 8 p.

Research output: Contribution to journalArticle

Epithelial Sodium Channels
Neuroendocrine Tumors
Small Cell Lung Carcinoma
Lung
Lung Neoplasms
3 Citations (Scopus)

Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism

Updegraff, B. L., Zhou, X., Guo, Y., Padanad, M. S., Chen, P. H., Yang, C., Sudderth, J., Rodriguez-Tirado, C., Girard, L., Minna, J. D., Mishra, P., DeBerardinis, R. J. & O'Donnell-Mendell, K. A., Jan 1 2018, (Accepted/In press) In : Cell Reports.

Research output: Contribution to journalArticle

CD147 Antigens
Metabolism
Lactic Acid
Lung Neoplasms
Peptide Hydrolases
2017
54 Citations (Scopus)

CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells

Kim, J., Hu, Z., Cai, L., Li, K., Choi, E., Faubert, B., Bezwada, D., Rodriguez-Canales, J., Villalobos, P., Lin, Y. F., Ni, M., Huffman, K. E., Girard, L., Byers, L. A., Unsal-Kacmaz, K., Peña, C. G., Heymach, J. V., Wauters, E., Vansteenkiste, J., Castrillon, D. H. & 6 others, Chen, B. P. C., Wistuba, I., Lambrechts, D., Xu, J., Minna, J. D. & Deberardinis, R. J., Jun 1 2017, In : Nature. 546, 7656, p. 168-172 5 p.

Research output: Contribution to journalArticle

Carbamyl Phosphate
Ligases
Lung Neoplasms
DNA
Ammonia
6 Citations (Scopus)

GLI1 blockade potentiates the antitumor activity of PI3K antagonists in lung squamous cell carcinoma

Kasiri, S., Shao, C., Chen, B., Wilson, A. N., Yenerall, P., Timmons, B. C., Girard, L., Tian, H., Behrens, C., Wistuba, I. I., Gazdar, A. F. & Kim, J., Aug 15 2017, In : Cancer Research. 77, 16, p. 4448-4459 12 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinases
Squamous Cell Carcinoma
Lung
Gene Amplification
Tumor Cell Line
3 Citations (Scopus)

Identification of proteasomal catalytic subunit PSMA6 as a therapeutic target for lung cancer

Kakumu, T., Sato, M., Goto, D., Kato, T., Yogo, N., Hase, T., Morise, M., Fukui, T., Yokoi, K., Sekido, Y., Girard, L., Minna, J. D., Byers, L. A., Heymach, J. V., Coombes, K. R., Kondo, M. & Hasegawa, Y., Apr 1 2017, In : Cancer Science. 108, 4, p. 732-743 12 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Catalytic Domain
Proteasome Endopeptidase Complex
Cell Line
Small Interfering RNA
15 Citations (Scopus)

JAK1/STAT3 activation through a proinflammatory cytokine pathway leads to resistance to molecularly targeted therapy in non–small cell lung cancer

Shien, K., Papadimitrakopoulou, V. A., Ruder, D., Behrens, C., Shen, L., Kalhor, N., Song, J., Lee, J. J., Wang, J., Tang, X., Herbst, R. S., Toyooka, S., Girard, L., Minna, J. D., Kurie, J. M., Wistuba, I. I. & Izzo, J. G., Oct 1 2017, In : Molecular Cancer Therapeutics. 16, 10, p. 2234-2245 12 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Cytokines
Interleukin-6
Pharmaceutical Preparations
Oncostatin M
5 Citations (Scopus)

Non-malignant respiratory epithelial cells preferentially proliferate from resected non-small cell lung cancer specimens cultured under conditionally reprogrammed conditions

Gao, B., Huang, C., Kernstine, K., Pelekanou, V., Kluger, Y., Jiang, T., Peters-Hall, J. R., Coquelin, M., Girard, L., Zhang, W., Huffman, K., Oliver, D., Kinose, F., Haura, E., Teer, J. K., Rix, U., Le, A. T., Aisner, D. L., Varella-Garcia, M., Doebele, R. C. & 10 others, Covington, K. R., Hampton, O. A., Doddapaneni, H. V., Jayaseelan, J. C., Hu, J., Wheeler, D. A., Shay, J. W., Rimm, D. L., Gazdar, A. & Minna, J. D., 2017, In : Oncotarget. 8, 7, p. 11114-11126 13 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Epithelial Cells
Cell Culture Techniques
Neoplasms
Lung
15 Citations (Scopus)

PROTOCADHERIN 7 acts through SET and PP2A to potentiate MAPK signaling by EGFR and KRAS during lung tumorigenesis

Zhou, X., Updegraff, B. L., Guo, Y., Peyton, M., Girard, L., Larsen, J. E., Xie, X-J., Zhou, Y., Hwang, T. H., Xie, Y., Rodriguez-Canales, J., Villalobos, P., Behrens, C., Wistuba, I. I., Minna, J. D. & O'Donnell-Mendell, K. A., Jan 1 2017, In : Cancer Research. 77, 1, p. 187-197 11 p.

Research output: Contribution to journalArticle

Carcinogenesis
Non-Small Cell Lung Carcinoma
Lung
Neoplasms
Phosphoprotein Phosphatases
6 Citations (Scopus)

Quantitative Proteomic Analysis of Optimal Cutting Temperature (OCT) Embedded Core-Needle Biopsy of Lung Cancer

Zhao, X., Huffman, K. E., Fujimoto, J., Canales, J. R., Girard, L., Nie, G., Heymach, J. V., Wistuba, I. I., Minna, J. D. & Yu, Y., Oct 1 2017, In : Journal of the American Society for Mass Spectrometry. 28, 10, p. 2078-2089 12 p.

Research output: Contribution to journalArticle

Large-Core Needle Biopsy
Biopsy
Needles
Proteomics
Lung Neoplasms
23 Citations (Scopus)

SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers

Tagal, V., Wei, S., Zhang, W., Brekken, R. A., Posner, B. A., Peyton, M., Girard, L., Hwang, T., Wheeler, D. A., Minna, J. D., White, M. A., Gazdar, A. F. & Roth, M. G., Jan 19 2017, In : Nature Communications. 8, 14098.

Research output: Contribution to journalArticle

Aurora Kinase A
mutations
Non-Small Cell Lung Carcinoma
lungs
inhibitors
28 Citations (Scopus)

Taxane-Platin-Resistant Lung Cancers Co-develop Hypersensitivity to JumonjiC Demethylase Inhibitors

Dalvi, M. P., Wang, L., Zhong, R., Kollipara, R. K., Park, H., Bayo, J., Yenerall, P., Zhou, Y., Timmons, B. C., Rodriguez-Canales, J., Behrens, C., Mino, B., Villalobos, P., Parra, E. R., Suraokar, M., Pataer, A., Swisher, S. G., Kalhor, N., Bhanu, N. V., Garcia, B. A. & 9 others, Heymach, J. V., Coombes, K., Xie, Y., Girard, L., Gazdar, A. F., Kittler, R., Wistuba, I. I., Minna, J. D. & Martinez, E. D., May 23 2017, In : Cell Reports. 19, 8, p. 1669-1684 16 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Hypersensitivity
Chemotherapy
Cells
Non-Small Cell Lung Carcinoma
2016
41 Citations (Scopus)

An expression signature as an aid to the histologic classification of non-small cell lung cancer

Girard, L., Rodriguez-Canales, J., Behrens, C., Thompson, D. M., Botros, I. W., Tang, H., Xie, Y., Rekhtman, N., Travis, W. D., Wistuba, I. I., Minna, J. D. & Gazdar, A. F., Oct 1 2016, In : Clinical Cancer Research. 22, 19, p. 4880-4889 10 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Squamous Cell Carcinoma
Adenocarcinoma
Atlases
Lung
77 Citations (Scopus)

ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs

Borromeo, M. D., Savage, T. K., Kollipara, R. K., He, M., Augustyn, A., Osborne, J. K., Girard, L., Minna, J. D., Gazdar, A. F., Cobb, M. H. & Johnson, J. E., Aug 2 2016, In : Cell Reports. 16, 5, p. 1259-1272 14 p.

Research output: Contribution to journalArticle

Neuroendocrine Tumors
Small Cell Lung Carcinoma
Tumors
Genes
Lung
25 Citations (Scopus)

Epithelial-mesenchymal transition predicts polo-like kinase 1 inhibitor-mediated apoptosis in non-small cell lung cancer

Ferrarotto, R., Goonatilake, R., Yoo, S. Y., Tong, P., Giri, U., Peng, S., Minna, J., Girard, L., Wang, Y., Wang, L., Li, L., Diao, L., Peng, D. H., Gibbons, D. L., Glisson, B. S., Heymach, J. V., Wang, J., Byers, L. A. & Johnson, F. M., Apr 1 2016, In : Clinical Cancer Research. 22, 7, p. 1674-1686 13 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Non-Small Cell Lung Carcinoma
Apoptosis
Cell Line
polo-like kinase 1
7 Citations (Scopus)

Identification of gene expression differences between lymphangiogenic and non-lymphangiogenic non-small cell lung cancer cell lines

Regan, E., Sibley, R. C., Cenik, B. K., Silva, A., Girard, L., Minna, J. D. & Dellinger, M. T., Mar 1 2016, In : PLoS One. 11, 3, e150963.

Research output: Contribution to journalArticle

Lymphangiogenesis
lung neoplasms
Gene expression
Non-Small Cell Lung Carcinoma
Tumors
15 Citations (Scopus)

ITPKA gene body methylation regulates gene expression and serves as an early diagnostic marker in lung and other cancers

Wang, Y. W., Ma, X., Zhang, Y. A., Wang, M. J., Yatabe, Y., Lam, S., Girard, L., Chen, J. Y. & Gazdar, A. F., 2016, In : Journal of Thoracic Oncology. 11, 9, p. 1469-1481 13 p.

Research output: Contribution to journalArticle

Inositol
Methylation
Lung Neoplasms
Phosphotransferases
Gene Expression
1 Citation (Scopus)

Selecting reliable mRNA expression measurements across platforms improves downstream analysis

Tong, P., Diao, L., Shen, L., Li, L., Heymach, J. V., Girard, L., Minna, J. D., Coombes, K. R., Byers, L. A. & Wang, J., 2016, In : Cancer Informatics. 15, p. 81-89 9 p.

Research output: Contribution to journalArticle

RNA Sequence Analysis
Messenger RNA
Genes
Gene Expression
Technology
6 Citations (Scopus)

SHOX2 is a Potent Independent Biomarker to Predict Survival of WHO Grade II–III Diffuse Gliomas

Zhang, Y. A., Zhou, Y., Luo, X., Song, K., Ma, X., Sathe, A., Girard, L., Xiao, G. & Gazdar, A. F., Nov 1 2016, In : EBioMedicine. 13, p. 80-89 10 p.

Research output: Contribution to journalArticle

Methylation
Biomarkers
Glioma
Survival
Genes
9 Citations (Scopus)

Validation of SCT methylation as a hallmark biomarker for lung cancers

Zhang, Y. A., Ma, X., Sathe, A., Fujimoto, J., Wistuba, I. I., Lam, S., Yatabe, Y., Wang, Y. W., Stastny, V., Gao, B., Larsen, J. E., Girard, L., Liu, X., Song, K., Behrens, C., Kalhor, N., Xie, Y., Zhang, M. Q., Minna, J. D. & Gazdar, A. F., Mar 23 2016, In : Journal of Thoracic Oncology. 11, 3, p. 346-360 15 p.

Research output: Contribution to journalArticle

Secretin
Methylation
Lung Neoplasms
Biomarkers
Genes
88 Citations (Scopus)

ZEB1 drives epithelial-to-mesenchymal transition in lung cancer

Larsen, J. E., Nathan, V., Osborne, J. K., Farrow, R. K., Deb, D., Sullivan, J. P., Dospoy, P. D., Augustyn, A., Hight, S. K., Sato, M., Girard, L., Behrens, C., Wistuba, I. I., Gazdar, A. F., Hayward, N. K. & Minna, J. D., Sep 1 2016, In : Journal of Clinical Investigation. 126, 9, p. 3219-3235 17 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Lung Neoplasms
Epithelial Cells
Non-Small Cell Lung Carcinoma
Protein Splicing
2015
238 Citations (Scopus)

Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities

Skoulidis, F., Byers, L. A., Diao, L., Papadimitrakopoulou, V. A., Tong, P., Izzo, J., Behrens, C., Kadara, H., Parra, E. R., Canales, J. R., Zhang, J., Giri, U., Gudikote, J., Cortez, M. A., Yang, C., Fan, Y., Peyton, M., Girard, L., Coombes, K. R., Toniatti, C. & 17 others, Heffernan, T. P., Choi, M., Frampton, G. M., Miller, V., Weinstein, J. N., Herbst, R. S., Wong, K. K., Zhang, J., Sharma, P., Mills, G. B., Hong, W. K., Minna, J. D., Allison, J. P., Futrea, A., Wang, J., Wistuba, I. I. & Heymach, J. V., Aug 1 2015, In : Cancer Discovery. 5, 8, p. 861-878 18 p.

Research output: Contribution to journalArticle

Biomarkers
Therapeutics
Neoplasms
Proteomics
Immune System
5 Citations (Scopus)
Linear Energy Transfer
Epithelial Cells
Radiation
Agar
Lung Neoplasms
9 Citations (Scopus)

On comparing heterogeneity across biomarkers

Steininger, R. J., Rajaram, S., Girard, L., Minna, J. D., Wu, L. F. & Altschuler, S. J., Jun 1 2015, In : Cytometry Part A. 87, 6, p. 558-567 10 p.

Research output: Contribution to journalArticle

Biomarkers
Microscopy
Cell Line
Lung Neoplasms
Staining and Labeling
12 Citations (Scopus)

Systematic siRNA screen unmasks NSCLC growth dependence by palmitoyltransferase DHHC5

Tian, H., Lu, J. Y., Shao, C., Huffman, K. E., Carstens, R. M., Larsen, J. E., Girard, L., Liu, H., Rodriguez-Canales, J., Frenkel, E. P., Wistuba, I. I., Minna, J. D. & Hofmann, S. L., Apr 1 2015, In : Molecular Cancer Research. 13, 4, p. 784-794 11 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Small Interfering RNA
Lipoylation
Growth
Neoplasms
2014
37 Citations (Scopus)

Aiolos promotes anchorage independence by silencing p66Shc transcription in cancer cells

Li, X., Xu, Z., Du, W., Zhang, Z., Wei, Y., Wang, H., Zhu, Z., Qin, L., Wang, L., Niu, Q., Zhao, X., Girard, L., Gong, Y., Ma, Z., Sun, B., Yao, Z., Minna, J. D., Terada, L. S. & Liu, Z., May 12 2014, In : Cancer Cell. 25, 5, p. 575-589 15 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Neoplasms
Anoikis
Lymphocytes
Survival
58 Citations (Scopus)

Analysis of TP53 mutation status in human cancer cell lines: A reassessment

Leroy, B., Girard, L., Hollestelle, A., Minna, J. D., Gazdar, A. F. & Soussi, T., 2014, In : Human Mutation. 35, 6, p. 756-765 10 p.

Research output: Contribution to journalArticle

Cell Line
Mutation
Neoplasms
Tumor Cell Line
Databases
6 Citations (Scopus)

A reevaluation of CD22 expression in human lung cancer

Pop, L. M., Barman, S., Shao, C., Poe, J. C., Venturi, G. M., Shelton, J. M., Pop, I. V., Gerber, D. E., Girard, L., Liu, X. Y., Behrens, C., Rodriguez-Canales, J., Liu, H., Wistuba, I. I., Richardson, J. A., Minna, J. D., Tedder, T. F. & Vitetta, E. S., Jan 1 2014, In : Cancer Research. 74, 1, p. 263-271 9 p.

Research output: Contribution to journalArticle

Immunotoxins
Lung Neoplasms
Cell Line
B-Lymphocytes
Proteins

ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers

Augustyn, A., Borromeo, M., Wang, T., Fujimoto, J., Shao, C., Dospoy, P. D., Lee, V., Tan, C., Sullivan, J. P., Larsen, J. E., Girard, L., Behrens, C., Wistuba, I. I., Xie, Y., Cobb, M. H., Gazdar, A. F., Johnson, J. E. & Minna, J. D., Oct 14 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 41, p. 14788-14793 6 p.

Research output: Contribution to journalArticle

Oncogenes
Lung Neoplasms
Non-Small Cell Lung Carcinoma
Small Cell Lung Carcinoma
Therapeutics
85 Citations (Scopus)

ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers

Augustyn, A., Borromeo, M., Wang, T., Fujimoto, J., Shao, C., Dospoy, P. D., Lee, V., Tan, C., Sullivan, J. P., Larsen, J. E., Girard, L., Behrens, C., Wistuba, I. I., Xie, Y., Cobb, M. H., Gazdar, A. F., Johnson, J. E., Minna, J. D. & Vogt, P. K., Oct 14 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 41, p. 14788-14793 6 p.

Research output: Contribution to journalArticle

Oncogenes
Lung Neoplasms
Non-Small Cell Lung Carcinoma
Small Cell Lung Carcinoma
Therapeutics
19 Citations (Scopus)

A search for novel cancer/testis antigens in lung cancer identifies VCX/Y genes, expanding the repertoire of potential immunotherapeutic targets

Taguchi, A., Taylor, A. D., Rodriguez, J., Çeliktaş, M., Liu, H., Ma, X., Zhang, Q., Wong, C. H., Chin, A., Girard, L., Behrens, C., Lam, W. L., Lam, S., Minna, J. D., Wistuba, I. I., Gazdar, A. F. & Hanash, S. M., Sep 1 2014, In : Cancer Research. 74, 17, p. 4694-4705 12 p.

Research output: Contribution to journalArticle

Testicular Neoplasms
Lung Neoplasms
Antigens
Genes
Neoplasms
79 Citations (Scopus)

Essential role of aldehyde dehydrogenase 1A3 for the maintenance of non-small cell lung cancer stem cells is associated with the STAT3 pathway

Shao, C., Sullivan, J. P., Girard, L., Augustyn, A., Yenerall, P., Rodriguez-Canales, J., Liu, H., Behrens, C., Shay, J. W., Wistuba, I. I. & Minna, J. D., Aug 1 2014, In : Clinical Cancer Research. 20, 15, p. 4154-4166 13 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Neoplastic Stem Cells
Non-Small Cell Lung Carcinoma
Maintenance
Genes

Genes suppressed by DNA methylation in non-small cell lung cancer reveal the epigenetics of epithelial-mesenchymal transition

Lin, S. H., Wang, J., Saintigny, P., Wu, C. C., Giri, U., Zhang, J., Menju, T., Diao, L., Byers, L., Weinstein, J. N., Coombes, K. R., Girard, L., Komaki, R., Wistuba, I. I., Date, H., Minna, J. D. & Heymach, J. V., 2014, In : BMC Genomics. 15, p. 1079 1 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
DNA Methylation
Epigenomics
Non-Small Cell Lung Carcinoma
Genes

Genes suppressed by DNA methylation in non-small cell lung cancer reveal the epigenetics of epithelial-mesenchymal transition

Lin, S. H., Wang, J., Saintigny, P., Wu, C. C., Giri, U., Zhang, J., Menju, T., Diao, L., Byers, L., Weinstein, J. N., Coombes, K. R., Girard, L., Komaki, R., Wistuba, I. I., Date, H., Minna, J. D. & Heymach, J. V., Dec 8 2014, (Accepted/In press) In : BMC Genomics. p. 1-15 15 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
DNA Methylation
Epigenomics
Non-Small Cell Lung Carcinoma
Genes
29 Citations (Scopus)

Genes suppressed by DNA methylation in non-small cell lung cancer reveal the epigenetics of epithelial-mesenchymal transition

Lin, S. H., Wang, J., Saintigny, P., Wu, C. C., Giri, U., Zhang, J., Menju, T., Diao, L., Byers, L., Weinstein, J. N., Coombes, K. R., Girard, L., Komaki, R., Wistuba, I. I., Date, H., Minna, J. D. & Heymach, J. V., Dec 8 2014, In : BMC Genomics. 15, 1, 1079.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
DNA Methylation
Epigenomics
Non-Small Cell Lung Carcinoma
Genes
2 Citations (Scopus)

Nonlinear quantitative radiation sensitivity prediction model based on NCI-60 cancer cell lines

Zhang, C., Girard, L., Das, A., Chen, S., Zheng, G. & Song, K., 2014, In : Scientific World Journal. 2014, 903602.

Research output: Contribution to journalArticle

Radiation Tolerance
cancer
Genes
Cells
Radiation
15 Citations (Scopus)

Nullifying the CDKN2AB locus promotes mutant K-ras lung tumorigenesis

Schuster, K., Venkateswaran, N., Rabellino, A., Girard, L., Penã-Llopis, S. & Scaglioni, P. P., 2014, In : Molecular Cancer Research. 12, 6, p. 912-923 12 p.

Research output: Contribution to journalArticle

Tumor Suppressor Protein p14ARF
Lung Neoplasms
Carcinogenesis
Lung
Cyclin-Dependent Kinase Inhibitor p16
17 Citations (Scopus)

Radiation-enhanced lung cancer progression in a transgenic mouse model of lung cancer is predictive of outcomes in human lung and breast cancer

Delgado, O., Batten, K. G., Richardson, J. A., Xie, X. J., Gazdar, A. F., Kaisani, A. A., Girard, L., Behrens, C., Suraokar, M., Fasciani, G., Wright, W. E., Story, M. D., Wistuba, I. I., Minna, J. D. & Shay, J. W., 2014, In : Clinical Cancer Research. 20, 6, p. 1610-1622 13 p.

Research output: Contribution to journalArticle

Transgenic Mice
Lung Neoplasms
Carcinogenesis
Radiation
Breast Neoplasms
14 Citations (Scopus)

Ras regulates kinesin 13 family members to control cell migration pathways in transformed human bronchial epithelial cells

Zaganjor, E., Osborne, J. K., Weil, L. M., Diaz-Martinez, L. A., Gonzales, J. X., Singel, S. M., Larsen, J. E., Girard, L., Minna, J. D. & Cobb, M. H., Nov 20 2014, In : Oncogene. 33, 47, p. 5457-5466 10 p.

Research output: Contribution to journalArticle

Kinesin
Cell Movement
Epithelial Cells
Microtubules
Aptitude
27 Citations (Scopus)

VEGF/VEGFR-2 upregulates EZH2 expression in lung adenocarcinoma cells and EZH2 depletion enhances the response to platinum-based and VEGFR-2-targeted therapy

Riquelme, E., Suraokar, M., Behrens, C., Lin, H. Y., Girard, L., Nilsson, M. B., Simon, G., Wang, J., Coombes, K. R., Lee, J. J., Hong, W. K., Heymach, J., Minna, J. D. & Wistuba, I. I., Jul 15 2014, In : Clinical Cancer Research. 20, 14, p. 3849-3861 13 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor Receptor-2
Platinum
Vascular Endothelial Growth Factor A
Up-Regulation
Therapeutics