• 1197 Citations
  • 13 h-Index
20042019
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Research Output 2004 2019

  • 1197 Citations
  • 13 h-Index
  • 16 Article
  • 1 Review article
2019
2 Citations (Scopus)

Tau local structure shields an amyloid-forming motif and controls aggregation propensity

Chen, D., Drombosky, K. W., Hou, Z., Sari, L., Kashmer, O. M., Ryder, B. D., Perez, V. A., Woodard, D. N. R., Lin, M. M., Diamond, M. I. & Joachimiak, L. A., Dec 1 2019, In : Nature communications. 10, 1, 2493.

Research output: Contribution to journalArticle

Open Access
Tauopathies
mutations
Agglomeration
tau Proteins
Mutation
3 Citations (Scopus)

The ATP-powered gymnastics of TRiC/CCT: an asymmetric protein folding machine with a symmetric origin story

Gestaut, D., Limatola, A., Joachimiak, L. & Frydman, J., Apr 2019, In : Current Opinion in Structural Biology. 55, p. 50-58 9 p.

Research output: Contribution to journalReview article

Gymnastics
Protein Folding
Chaperonin Containing TCP-1
Adenosine Triphosphate
Cryoelectron Microscopy
5 Citations (Scopus)

The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis

Gestaut, D., Roh, S. H., Ma, B., Pintilie, G., Joachimiak, L. A., Leitner, A., Walzthoeni, T., Aebersold, R., Chiu, W. & Frydman, J., Apr 18 2019, In : Cell. 177, 3, p. 751-765.e15

Research output: Contribution to journalArticle

Chaperonin Containing TCP-1
Chaperonins
Static Electricity
Electrostatics
Conformations
2017
26 Citations (Scopus)

Structure and dynamics of the Huntingtin Exon-1 N-Terminus: A solution NMR perspective

Baias, M., Smith, P. E. S., Shen, K., Joachimiak, L. A., Zerko, S., Koźmiński, W., Frydman, J. & Frydman, L., Jan 25 2017, In : Journal of the American Chemical Society. 139, 3, p. 1168-1176 9 p.

Research output: Contribution to journalArticle

Exons
Nuclear magnetic resonance
Proteins
Agglomeration
Toxicity
2015
44 Citations (Scopus)

XTract: Software for characterizing conformational changes of protein complexes by quantitative cross-linking mass spectrometry

Walzthoeni, T., Joachimiak, L. A., Rosenberger, G., Röst, H. L., Malmström, L., Leitner, A., Frydman, J. & Aebersold, R., Dec 1 2015, In : Nature methods. 12, 12, p. 1185-1190 6 p.

Research output: Contribution to journalArticle

Mass spectrometry
Mass Spectrometry
Software
Firefly Luciferases
Proteins
2014
97 Citations (Scopus)

Chemical cross-linking/mass spectrometry targeting acidic residues in proteins and protein complexes

Leitner, A., Joachimiak, L. A., Unverdorben, P., Walzthoeni, T., Frydman, J., Förster, F. & Aebersold, R., Jul 1 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 26, p. 9455-9460 6 p.

Research output: Contribution to journalArticle

Open Access
Cross-Linking Reagents
Mass Spectrometry
Chaperonin Containing TCP-1
Peptides
Proteins
69 Citations (Scopus)

The structural basis of substrate recognition by the eukaryotic chaperonin TRiC/CCT

Joachimiak, L. A., Walzthoeni, T., Liu, C. W., Aebersold, R. & Frydman, J., Nov 20 2014, In : Cell. 159, 5, p. 1042-1055 14 p.

Research output: Contribution to journalArticle

Open Access
Chaperonin Containing TCP-1
Chaperonins
Substrates
Binding Sites
Peptides
2013
37 Citations (Scopus)

Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes

Sontag, E. M., Joachimiak, L. A., Tan, Z., Tomlinson, A., Housman, D. E., Glabe, C. G., Potkinj, S. G., Frydman, J. & Thompson, L. M., Feb 19 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 8, p. 3077-3082 6 p.

Research output: Contribution to journalArticle

Open Access
Chaperonins
Huntington Disease
Phenotype
Chaperonin Containing TCP-1
Human Immunodeficiency Virus tat Gene Products
2012
47 Citations (Scopus)

A Gradient of ATP Affinities Generates an Asymmetric Power Stroke Driving the Chaperonin TRIC/CCT Folding Cycle

Reissmann, S., Joachimiak, L. A., Chen, B., Meyer, A. S., Nguyen, A. & Frydman, J., Oct 25 2012, In : Cell Reports. 2, 4, p. 866-877 12 p.

Research output: Contribution to journalArticle

Open Access
Chaperonin Containing TCP-1
Chaperonins
Adenosine Triphosphate
Stroke
Nucleosides
163 Citations (Scopus)

The molecular architecture of the eukaryotic chaperonin TRiC/CCT

Leitner, A., Joachimiak, L. A., Bracher, A., Mönkemeyer, L., Walzthoeni, T., Chen, B., Pechmann, S., Holmes, S., Cong, Y., Ma, B., Ludtke, S., Chiu, W., Hartl, F. U., Aebersold, R. & Frydman, J., May 9 2012, In : Structure. 20, 5, p. 814-825 12 p.

Research output: Contribution to journalArticle

Open Access
Chaperonin Containing TCP-1
Chaperonins
Structural Models
Proteome
X-Ray Diffraction
2011
122 Citations (Scopus)

A De Novo Protein Binding Pair By Computational Design and Directed Evolution

Karanicolas, J., Corn, J. E., Chen, I., Joachimiak, L. A., Dym, O., Peck, S. H., Albeck, S., Unger, T., Hu, W., Liu, G., Delbecq, S., T. Montelione, G., P. Spiegel, C., Liu, D. R. & Baker, D., Apr 22 2011, In : Molecular cell. 42, 2, p. 250-260 11 p.

Research output: Contribution to journalArticle

Open Access
Protein Binding
Proteins
Point Mutation
36 Citations (Scopus)

Cryo-EM structure of a group II chaperonin in the prehydrolysis ATP-bound state leading to lid closure

Zhang, J., Ma, B., Dimaio, F., Douglas, N. R., Joachimiak, L. A., Baker, D., Frydman, J., Levitt, M. & Chiu, W., May 11 2011, In : Structure. 19, 5, p. 633-639 7 p.

Research output: Contribution to journalArticle

Open Access
Group II Chaperonins
Adenosine Triphosphate
Chaperonins
Group I Chaperonins
Hydrolysis
2009
154 Citations (Scopus)

The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation

Tam, S., Spiess, C., Auyeung, W., Joachimiak, L., Chen, B., Poirier, M. A. & Frydman, J., Dec 1 2009, In : Nature Structural and Molecular Biology. 16, 12, p. 1279-1285 7 p.

Research output: Contribution to journalArticle

Chaperonins
Molecular Chaperones
Neurodegenerative Diseases
Huntington Disease
polyglutamine
2008
28 Citations (Scopus)

Experimental and Computational Analyses of the Energetic Basis for Dual Recognition of Immunity Proteins by Colicin Endonucleases

Keeble, A. H., Joachimiak, L. A., Maté, M. J., Meenan, N., Kirkpatrick, N., Baker, D. & Kleanthous, C., Jun 13 2008, In : Journal of Molecular Biology. 379, 4, p. 745-759 15 p.

Research output: Contribution to journalArticle

Deoxyribonucleases
Endonucleases
Immunity
Alanine
Colicins
2006
116 Citations (Scopus)

Computational Design of a New Hydrogen Bond Network and at Least a 300-fold Specificity Switch at a Protein-Protein Interface

Joachimiak, L. A., Kortemme, T., Stoddard, B. L. & Baker, D., Aug 4 2006, In : Journal of Molecular Biology. 361, 1, p. 195-208 14 p.

Research output: Contribution to journalArticle

Hydrogen
Proteins
Deoxyribonucleases
Immunity
Colicins
2005
12 Citations (Scopus)

Conservation of a novel protein associated with an antibiotic efflux operon in Burkholderia cenocepacia

Nair, B. M., Joachimiak, L. A., Chattopadhyay, S., Montano, I. & Burns, J. L., Apr 15 2005, In : FEMS Microbiology Letters. 245, 2, p. 337-344 8 p.

Research output: Contribution to journalArticle

Open Access
Burkholderia cenocepacia
Operon
Anti-Bacterial Agents
Hydrolases
Proteins
2004
236 Citations (Scopus)

Computational redesign of protein-protein interaction specificity

Kortemme, T., Joachimiak, L. A., Bullock, A. N., Schuler, A. D., Stoddard, B. L. & Baker, D., Apr 1 2004, In : Nature Structural and Molecular Biology. 11, 4, p. 371-379 9 p.

Research output: Contribution to journalArticle

Proteins
Protein Interaction Maps
Deoxyribonucleases
X-Rays
In Vitro Techniques