• 1209 Citations
  • 13 h-Index
20042019

Research output per year

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Research Output

  • 1209 Citations
  • 13 h-Index
  • 16 Article
  • 1 Review article
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Article
2019

Tau local structure shields an amyloid-forming motif and controls aggregation propensity

Chen, D., Drombosky, K. W., Hou, Z., Sari, L., Kashmer, O. M., Ryder, B. D., Perez, V. A., Woodard, D. N. R., Lin, M. M., Diamond, M. I. & Joachimiak, L. A., Dec 1 2019, In : Nature communications. 10, 1, 2493.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis

Gestaut, D., Roh, S. H., Ma, B., Pintilie, G., Joachimiak, L. A., Leitner, A., Walzthoeni, T., Aebersold, R., Chiu, W. & Frydman, J., Apr 18 2019, In : Cell. 177, 3, p. 751-765.e15

Research output: Contribution to journalArticle

5 Scopus citations
2017

Structure and dynamics of the Huntingtin Exon-1 N-Terminus: A solution NMR perspective

Baias, M., Smith, P. E. S., Shen, K., Joachimiak, L. A., Zerko, S., Koźmiński, W., Frydman, J. & Frydman, L., Jan 25 2017, In : Journal of the American Chemical Society. 139, 3, p. 1168-1176 9 p.

Research output: Contribution to journalArticle

26 Scopus citations
2015

XTract: Software for characterizing conformational changes of protein complexes by quantitative cross-linking mass spectrometry

Walzthoeni, T., Joachimiak, L. A., Rosenberger, G., Röst, H. L., Malmström, L., Leitner, A., Frydman, J. & Aebersold, R., Dec 1 2015, In : Nature methods. 12, 12, p. 1185-1190 6 p.

Research output: Contribution to journalArticle

44 Scopus citations
2014

Chemical cross-linking/mass spectrometry targeting acidic residues in proteins and protein complexes

Leitner, A., Joachimiak, L. A., Unverdorben, P., Walzthoeni, T., Frydman, J., Förster, F. & Aebersold, R., Jul 1 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 26, p. 9455-9460 6 p.

Research output: Contribution to journalArticle

Open Access
100 Scopus citations

The structural basis of substrate recognition by the eukaryotic chaperonin TRiC/CCT

Joachimiak, L. A., Walzthoeni, T., Liu, C. W., Aebersold, R. & Frydman, J., Nov 20 2014, In : Cell. 159, 5, p. 1042-1055 14 p.

Research output: Contribution to journalArticle

Open Access
69 Scopus citations
2013

Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes

Sontag, E. M., Joachimiak, L. A., Tan, Z., Tomlinson, A., Housman, D. E., Glabe, C. G., Potkinj, S. G., Frydman, J. & Thompson, L. M., Feb 19 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 8, p. 3077-3082 6 p.

Research output: Contribution to journalArticle

Open Access
37 Scopus citations
2012

A Gradient of ATP Affinities Generates an Asymmetric Power Stroke Driving the Chaperonin TRIC/CCT Folding Cycle

Reissmann, S., Joachimiak, L. A., Chen, B., Meyer, A. S., Nguyen, A. & Frydman, J., Oct 25 2012, In : Cell Reports. 2, 4, p. 866-877 12 p.

Research output: Contribution to journalArticle

Open Access
48 Scopus citations

The molecular architecture of the eukaryotic chaperonin TRiC/CCT

Leitner, A., Joachimiak, L. A., Bracher, A., Mönkemeyer, L., Walzthoeni, T., Chen, B., Pechmann, S., Holmes, S., Cong, Y., Ma, B., Ludtke, S., Chiu, W., Hartl, F. U., Aebersold, R. & Frydman, J., May 9 2012, In : Structure. 20, 5, p. 814-825 12 p.

Research output: Contribution to journalArticle

Open Access
165 Scopus citations
2011

A De Novo Protein Binding Pair By Computational Design and Directed Evolution

Karanicolas, J., Corn, J. E., Chen, I., Joachimiak, L. A., Dym, O., Peck, S. H., Albeck, S., Unger, T., Hu, W., Liu, G., Delbecq, S., T. Montelione, G., P. Spiegel, C., Liu, D. R. & Baker, D., Apr 22 2011, In : Molecular cell. 42, 2, p. 250-260 11 p.

Research output: Contribution to journalArticle

Open Access
123 Scopus citations

Cryo-EM structure of a group II chaperonin in the prehydrolysis ATP-bound state leading to lid closure

Zhang, J., Ma, B., Dimaio, F., Douglas, N. R., Joachimiak, L. A., Baker, D., Frydman, J., Levitt, M. & Chiu, W., May 11 2011, In : Structure. 19, 5, p. 633-639 7 p.

Research output: Contribution to journalArticle

Open Access
36 Scopus citations
2009

The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation

Tam, S., Spiess, C., Auyeung, W., Joachimiak, L., Chen, B., Poirier, M. A. & Frydman, J., Dec 1 2009, In : Nature Structural and Molecular Biology. 16, 12, p. 1279-1285 7 p.

Research output: Contribution to journalArticle

155 Scopus citations
2008

Experimental and Computational Analyses of the Energetic Basis for Dual Recognition of Immunity Proteins by Colicin Endonucleases

Keeble, A. H., Joachimiak, L. A., Maté, M. J., Meenan, N., Kirkpatrick, N., Baker, D. & Kleanthous, C., Jun 13 2008, In : Journal of Molecular Biology. 379, 4, p. 745-759 15 p.

Research output: Contribution to journalArticle

29 Scopus citations
2006

Computational Design of a New Hydrogen Bond Network and at Least a 300-fold Specificity Switch at a Protein-Protein Interface

Joachimiak, L. A., Kortemme, T., Stoddard, B. L. & Baker, D., Aug 4 2006, In : Journal of Molecular Biology. 361, 1, p. 195-208 14 p.

Research output: Contribution to journalArticle

117 Scopus citations
2005

Conservation of a novel protein associated with an antibiotic efflux operon in Burkholderia cenocepacia

Nair, B. M., Joachimiak, L. A., Chattopadhyay, S., Montano, I. & Burns, J. L., Apr 15 2005, In : FEMS Microbiology Letters. 245, 2, p. 337-344 8 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations
2004

Computational redesign of protein-protein interaction specificity

Kortemme, T., Joachimiak, L. A., Bullock, A. N., Schuler, A. D., Stoddard, B. L. & Baker, D., Apr 1 2004, In : Nature Structural and Molecular Biology. 11, 4, p. 371-379 9 p.

Research output: Contribution to journalArticle

237 Scopus citations