• 10121 Citations
  • 58 h-Index
1989 …2020

Research output per year

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Research Output

  • 10121 Citations
  • 58 h-Index
  • 119 Article
  • 5 Review article
  • 4 Comment/debate
  • 3 Short survey
2020

Mitochondrial substrate utilization regulates cardiomyocyte cell-cycle progression

Cardoso, A. C., Lam, N. T., Savla, J. J., Nakada, Y., Pereira, A. H. M., Elnwasany, A., Menendez-Montes, I., Ensley, E. L., Bezan Petric, U., Sharma, G., Sherry, A. D., Malloy, C. R., Khemtong, C., Kinter, M. T., Tan, W. L. W., Anene-Nzelu, C. G., Foo, R. S. Y., Nguyen, N. U. N., Li, S., Ahmed, M. S. & 14 others, Elhelaly, W. M., Abdisalaam, S., Asaithamby, A., Xing, C., Kanchwala, M., Vale, G., Eckert, K. M., Mitsche, M. A., McDonald, J. G., Hill, J. A., Huang, L., Shaul, P. W., Szweda, L. I. & Sadek, H. A., Feb 1 2020, In : Nature Metabolism. 2, 2, p. 167-178 12 p.

Research output: Contribution to journalArticle

1 Scopus citations
2019

Enhancing cardiac glycolysis causes an increase in PDK4 content in response to short-term high-fat diet

Newhardt, M. F., Batushansky, LA., Matsuzaki, S., Young, Z. T., West, M., Cer Chin, N., Szweda, L. I., Kinter, M. & Humphries, K. M., Nov 8 2019, In : Journal of Biological Chemistry. 294, 45, p. 16831-16845 15 p.

Research output: Contribution to journalArticle

Evidence for hormonal control of heart regenerative capacity during endothermy acquisition

Hirose, K., Payumo, A. Y., Cutie, S., Hoang, A., Zhang, H., Guyot, R., Lunn, D., Bigley, R. B., Yu, H., Wang, J., Smith, M., Gillett, E., Muroy, S. E., Schmid, T., Wilson, E., Field, K. A., Reeder, D. A. M., Maden, M., Yartsev, M. M., Wolfgang, M. J. & 8 others, Grützner, F., Scanlan, T. S., Szweda, L. I., Buffenstein, R., Hu, G., Flamant, F., Olgin, J. E. & Huang, G. N., Jan 1 2019, In : Science. 364, 6436, p. 184-188 5 p.

Research output: Contribution to journalArticle

49 Scopus citations

High-Phosphate Diet Induces Exercise Intolerance and Impairs Fatty Acid Metabolism in Mice

Peri-Okonny, P., Baskin, K. K., Iwamoto, G., Mitchell, J. H., Smith, S. A., Kim, H. K., Szweda, L. I., Bassel-Duby, R., Fujikawa, T., Castorena, C. M., Richardson, J., Shelton, J. M., Ayers, C., Berry, J. D., Malladi, V. S., Hu, M. C., Moe, O. W., Scherer, P. E. & Vongpatanasin, W., Mar 12 2019, In : Circulation. 139, 11, p. 1422-1434 13 p.

Research output: Contribution to journalArticle

5 Scopus citations
2018

Coenzyme A–mediated degradation of pyruvate dehydrogenase kinase 4 promotes cardiac metabolic flexibility after high-fat feeding in mice

Schafer, C., Young, Z. T., Makarewich, C. A., Elnwasany, A., Kinter, C., Kinter, M. & Szweda, L. I., May 4 2018, In : Journal of Biological Chemistry. 293, 18, p. 6915-6924 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Homozygous Expression of Mutant ELOVL4 Leads to Seizures and Death in a Novel Animal Model of Very Long-Chain Fatty Acid Deficiency

Hopiavuori, B. R., deák, F., Wilkerson, J. L., Brush, R. S., Rocha-Hopiavuori, N. A., Hopiavuori, A. R., Ozan, K. G., Sullivan, M. T., Wren, J. D., Georgescu, C., Szweda, L., Awasthi, V., Towner, R., Sherry, D. M., Anderson, R. E. & Agbaga, M. P., Feb 1 2018, In : Molecular Neurobiology. 55, 2, p. 1795-1813 19 p.

Research output: Contribution to journalArticle

5 Scopus citations

Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes

Logan, S., Pharaoh, G. A., Marlin, M. C., Masser, D. R., Matsuzaki, S., Wronowski, B., Yeganeh, A., Parks, E. E., Premkumar, P., Farley, J. A., Owen, D. B., Humphries, K. M., Kinter, M., Freeman, W. M., Szweda, L. I., Van Remmen, H. & Sonntag, W. E., Jan 1 2018, (Accepted/In press) In : Molecular Metabolism.

Research output: Contribution to journalArticle

29 Scopus citations

MOXI Is a Mitochondrial Micropeptide That Enhances Fatty Acid β-Oxidation

Makarewich, C. A., Baskin, K. K., Munir, A. Z., Bezprozvannaya, S., Sharma, G., Khemtong, C., Shah, A. M., McAnally, J. R., Malloy, C. R., Szweda, L. I., Bassel-Duby, R. & Olson, E. N., Jun 26 2018, In : Cell Reports. 23, 13, p. 3701-3709 9 p.

Research output: Contribution to journalArticle

27 Scopus citations

Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass

Ahn, B., Pharaoh, G., Premkumar, P., Huseman, K., Ranjit, R., Kinter, M., Szweda, L., Kiss, T., Fulop, G., Tarantini, S., Csiszar, A., Ungvari, Z. & Van Remmen, H., Jul 1 2018, In : Redox Biology. 17, p. 47-58 12 p.

Research output: Contribution to journalArticle

17 Scopus citations
2017

Consuming a Ketogenic Diet while Receiving Radiation and Chemotherapy for Locally Advanced Lung Cancer and Pancreatic Cancer: The University of Iowa Experience of Two Phase 1 Clinical Trials

Zahra, A., Fath, M. A., Opat, E., Mapuskar, K. A., Bhatia, S. K., Ma, D. C., Iii, S. N. R., Snyders, T. P., Chenard, C. A., Eichenberger-Gilmore, J. M., Bodeker, K. L., Ahmann, L., Smith, B. J., Vollstedt, S. A., Brown, H. A., Hejleh, T. A., Clamon, G. H., Berg, D. J., Szweda, L. I., Spitz, D. R. & 2 others, Buatti, J. M. & Allen, B. G., Jun 1 2017, In : Radiation research. 187, 6, p. 743-754 12 p.

Research output: Contribution to journalArticle

22 Scopus citations

Glucose availability controls adipogenesis in mouse 3T3-L1 adipocytes via up-regulation of nicotinamide metabolism

Jackson, R. M., Griesel, B. A., Gurley, J. M., Szweda, L. I. & Olson, A. L., Nov 10 2017, In : Journal of Biological Chemistry. 292, 45, p. 18556-18564 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Hypoxia induces heart regeneration in adult mice

Nakada, Y., Canseco, D. C., Thet, S., Abdisalaam, S., Aroumougame, A., Santos, C. X., Shah, A. M., Zhang, H., Faber, J. E., Kinter, M. T., Szweda, L. I., Xing, C., Hu, Z., DeBerardinis, R. J., Schiattarella, G., Hill, J. A., Oz, O. K., Lu, Z., Zhang, C., Kimura, W. & 1 others, Sadek, H. A., Jan 12 2017, In : Nature. 541, 7636, p. 222-227 6 p.

Research output: Contribution to journalArticle

204 Scopus citations

PPARα is essential for retinal lipid metabolism and neuronal survival

Pearsall, E. A., Cheng, R., Zhou, K., Takahashi, Y., Matlock, H. G., Vadvalkar, S. S., Shin, Y., Fredrick, T. W., Gantner, M. L., Meng, S., Fu, Z., Gong, Y., Kinter, M., Humphries, K. M., Szweda, L. I., Smith, L. E. H. & Ma, J. X., Nov 28 2017, In : BMC Biology. 15, 1, 113.

Research output: Contribution to journalArticle

10 Scopus citations

Regulation of pyruvate dehydrogenase kinase 4 in the heart through degradation by the lon protease in response to mitochondrial substrate availability

Crewe, C., Schafer, C., Lee, I., Kinter, M. & Szweda, L. I., Jan 6 2017, In : Journal of Biological Chemistry. 292, 1, p. 305-312 8 p.

Research output: Contribution to journalArticle

15 Scopus citations
2016

Catalase-dependent H2O2 consumption by cardiac mitochondria and redox-mediated loss in insulin signaling

Rindler, P. M., Cacciola, A., Kinter, M. & Szweda, L. I., Jan 1 2016, In : American Journal of Physiology - Heart and Circulatory Physiology. 311, 5, p. H1091-H1096

Research output: Contribution to journalArticle

11 Scopus citations

Nutrient sensing and utilization: Getting to the heart of metabolic flexibility

Griffin, T. M., Humphries, K. M., Kinter, M., Lim, H. Y. & Szweda, L. I., May 1 2016, In : Biochimie. 124, p. 74-83 10 p.

Research output: Contribution to journalReview article

21 Scopus citations

Pyrophosphate-dependent ATP formation from acetyl coenzyme a in Syntrophus aciditrophicus, a new twist on ATP formation

James, K. L., Ríos-Hernández, L. A., Wofford, N. Q., Mouttaki, H., Sieber, J. R., Sheik, C. S., Nguyen, H. H., Yang, Y., Xie, Y., Erde, J., Rohlin, L., Karr, E. A., Loo, J. A., Loo, R. R. O., Hurst, G. B., Gunsalus, R. P., Szweda, L. I. & McInerney, M. J., Jul 1 2016, In : mBio. 7, 4, e01208-16.

Research output: Contribution to journalArticle

6 Scopus citations
2015

Lysine Acetylation Activates Mitochondrial Aconitase in the Heart

Fernandes, J., Weddle, A., Kinter, C. S., Humphries, K. M., Mather, T., Szweda, L. I. & Kinter, M., Jun 30 2015, In : Biochemistry. 54, 25, p. 4008-4018 11 p.

Research output: Contribution to journalArticle

33 Scopus citations

Metabolic Damage and Premature Thymus Aging Caused by Stromal Catalase Deficiency

Griffith, A. V., Venables, T., Shi, J., Farr, A., van Remmen, H., Szweda, L., Fallahi, M., Rabinovitch, P. & Petrie, H. T., Aug 18 2015, In : Cell Reports. 12, 7, p. 1071-1079 9 p.

Research output: Contribution to journalArticle

21 Scopus citations
2014

Deficiency in adipocyte chemokine receptor CXCR4 exacerbates obesity and compromises thermoregulatory responses of brown adipose tissue in a mouse model of diet-induced obesity

Yao, L., Heuser-Baker, J., Herlea-Pana, O., Zhang, N., Szweda, L. I., Griffin, T. M. & Barlic-Dicen, J., Oct 1 2014, In : FASEB Journal. 28, 10, p. 4534-4550 17 p.

Research output: Contribution to journalArticle

17 Scopus citations

Erratum: The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response (Cell (2014) 157 (741-743))

Puente, B. N., Kimura, W., Muralidhar, S. A., Moon, J., Amatruda, J. F., Phelps, K. L., Grinsfelder, D., Rothermel, B. A., Chen, R., Garcia, J. A., Santos, C. X., Thet, S., Mori, E., Kinter, M. T., Rindler, P. M., Zacchigna, S., Mukherjee, S., Chen, D. J., Mahmoud, A. I., Giacca, M. & 5 others, Rabinovitch, P. S., Asaithamby, A., Shah, A. M., Szweda, L. I. & Sadek, H. A., May 22 2014, In : Cell. 157, 5, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Targeted metabolomics connects thioredoxin-interacting protein (TXNIP) to mitochondrial fuel selection and regulation of specific oxidoreductase enzymes in skeletal muscle

DeBalsi, K. L., Wong, K. E., Koves, T. R., Slentz, D. H., Seiler, S. E., Wittmann, A. H., Ilkayeva, O. R., Stevens, R. D., Perry, C. G. R., Lark, D. S., Hui, S. T., Szweda, L., Neufer, P. D. & Muoio, D. M., Mar 21 2014, In : Journal of Biological Chemistry. 289, 12, p. 8106-8120 15 p.

Research output: Contribution to journalArticle

26 Scopus citations

The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response

Puente, B. N., Kimura, W., Muralidhar, S. A., Moon, J., Amatruda, J. F., Phelps, K. L., Grinsfelder, D., Rothermel, B. A., Chen, R., Garcia, J. A., Santos, C. X., Thet, S., Mori, E., Kinter, M. T., Rindler, P. M., Zacchigna, S., Mukherjee, S., Chen, D. J., Mahmoud, A. I., Giacca, M. & 5 others, Rabinovitch, P. S., Aroumougame, A., Shah, A. M., Szweda, L. I. & Sadek, H. A., Apr 24 2014, In : Cell. 157, 3, p. 565-579 15 p.

Research output: Contribution to journalArticle

285 Scopus citations

Glutathionylation of α-ketoglutarate dehydrogenase: The chemical nature and relative susceptibility of the cofactor lipoic acid to modification

McLain, A. L., Cormier, P. J., Kinter, M. & Szweda, L. I., May 9 2013, In : Free Radical Biology and Medicine. 61, p. 161-169 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

High dietary fat selectively increases catalase expression within cardiac mitochondria

Rindler, P. M., Plafker, S. M., Szweda, L. I. & Kinter, M., Jan 18 2013, In : Journal of Biological Chemistry. 288, 3, p. 1979-1990 12 p.

Research output: Contribution to journalArticle

80 Scopus citations

Identification of ATP synthase as a lipid peroxide protein adduct in pancreatic islets from humans with and without type 2 diabetes mellitus

MacDonald, M. J., Langberg, E. C., Tibell, A., Sabat, G., Kendrick, M. A., Szweda, L. I. & Ostenson, C. G., Apr 2013, In : Journal of Clinical Endocrinology and Metabolism. 98, 4, p. E727-E731

Research output: Contribution to journalArticle

9 Scopus citations

Ketogenic diets enhance oxidative stress and radio-chemo-therapy responses in lung cancer xenografts

Allen, B. G., Bhatia, S. K., Buatti, J. M., Brandt, K. E., Lindholm, K. E., Button, A. M., Szweda, L. I., Smith, B. J., Spitz, D. R. & Fath, M. A., Jul 15 2013, In : Clinical Cancer Research. 19, 14, p. 3905-3913 9 p.

Research output: Contribution to journalArticle

82 Scopus citations

Neurofilaments are the major neuronal target of hydroxynonenal-mediated protein cross-links

Perry, E. A., Castellani, R. J., Moreira, P. I., Nunomura, A., Lui, Q., Harris, P. L. R., Sayre, L. M., Szweda, P. A., Szweda, L. I., Zhu, X., Smith, M. A. & Perry, G., Jul 1 2013, In : Free Radical Research. 47, 6-7, p. 507-510 4 p.

Research output: Contribution to journalArticle

11 Scopus citations

Oxidative modification of lipoic acid by HNE in alzheimer disease brain

Hardas, S. S., Sultana, R., Clark, A. M., Beckett, T. L., Szweda, L. I., Paul Murphy, M. & Butterfield, D. A., Jan 1 2013, In : Redox Biology. 1, 1, p. 80-85 6 p.

Research output: Contribution to journalArticle

70 Scopus citations

Rapid Inhibition of Pyruvate Dehydrogenase: An Initiating Event in High Dietary Fat-Induced Loss of Metabolic Flexibility in the Heart

Crewe, C., Kinter, M. & Szweda, L. I., Oct 7 2013, In : PloS one. 8, 10, e77280.

Research output: Contribution to journalArticle

28 Scopus citations

Redox regulation of insulin sensitivity due to enhanced fatty acid utilization in the mitochondria

Rindler, P. M., Crewe, C. L., Fernandes, J., Kinter, M. & Szweda, L. I., Sep 1 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 305, 5, p. H634-H643

Research output: Contribution to journalReview article

31 Scopus citations
2012

A Quantitative Proteomic Profile of the Nrf2-Mediated Antioxidant Response of Macrophages to Oxidized LDL Determined by Multiplexed Selected Reaction Monitoring

Kinter, C. S., Lundie, J. M., Patel, H., Rindler, P. M., Szweda, L. I. & Kinter, M., Nov 16 2012, In : PloS one. 7, 11, e50016.

Research output: Contribution to journalArticle

19 Scopus citations

Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover

Zhu, X., Castellani, R. J., Moreira, P. I., Aliev, G., Shenk, J. C., Siedlak, S. L., Harris, P. L. R., Fujioka, H., Sayre, L. M., Szweda, P. A., Szweda, L. I., Smith, M. A. & Perry, G., Feb 1 2012, In : Free Radical Biology and Medicine. 52, 3, p. 699-704 6 p.

Research output: Contribution to journalArticle

19 Scopus citations

Mechanisms for Countering Oxidative Stress and Damage in Retinal Pigment Epithelium

Plafker, S. M., O'Mealey, G. B. & Szweda, L. I., Aug 14 2012, In : International Review of Cell and Molecular Biology. 298, p. 135-177 43 p.

Research output: Contribution to journalArticle

57 Scopus citations
2011

Proteasome alterations during adipose differentiation and aging: Links to impaired adipocyte differentiation and development of oxidative stress

Dasuri, K., Zhang, L., Ebenezer, P., Fernandez-Kim, S. O., Bruce-Keller, A. J., Szweda, L. I. & Keller, J. N., Nov 1 2011, In : Free Radical Biology and Medicine. 51, 9, p. 1727-1735 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

α-Ketoglutarate dehydrogenase: A mitochondrial redox sensor

McLain, A. L., Szweda, P. A. & Szweda, L. I., Jan 1 2011, In : Free Radical Research. 45, 1, p. 29-36 8 p.

Research output: Contribution to journalReview article

78 Scopus citations
2010

Ischaemic preconditioning improves proteasomal activity and increases the degradation of PKC during reperfusion

Churchill, E. N., Ferreira, J. C., Brum, P. C., Szweda, L. I. & Mochly-Rosen, D., Jan 1 2010, In : Cardiovascular Research. 85, 2, p. 385-394 10 p.

Research output: Contribution to journalArticle

68 Scopus citations

Ohr (organic hydroperoxide resistance protein) possesses a previously undescribed activity, lipoyl-dependent peroxidase

Cussiol, J. R. R., Alegria, T. G. P., Szweda, L. I. & Netto, L. E. S., Jul 16 2010, In : Journal of Biological Chemistry. 285, 29, p. 21943-21950 8 p.

Research output: Contribution to journalArticle

43 Scopus citations
2009

Mitochondrial superoxide production and respiratory activity: Biphasic response to ischemic duration

Matsuzaki, S., Szweda, L. I. & Humphries, K. M., Apr 1 2009, In : Archives of Biochemistry and Biophysics. 484, 1, p. 87-93 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Regulated production of free radicals by the mitochondrial electron transport chain: Cardiac ischemic preconditioning

Matsuzaki, S., Szweda, P. A., Szweda, L. I. & Humphries, K. M., Nov 30 2009, In : Advanced Drug Delivery Reviews. 61, 14, p. 1324-1331 8 p.

Research output: Contribution to journalReview article

20 Scopus citations
2008

Hypoxia-inducible factor-2α transactivates Abcg2 and promotes cytoprotection in cardiac side population cells

Martin, C. M., Ferdous, A., Gallardo, T., Humphries, C., Sadek, H., Caprioli, A., Garcia, J. A., Szweda, L. I., Garry, M. G. & Garry, D. J., May 1 2008, In : Circulation research. 102, 9, p. 1075-1081 7 p.

Research output: Contribution to journalArticle

102 Scopus citations

Intraretinal leakage and oxidation of LDL in diabetic retinopathy

Wu, M., Chen, Y., Wilson, K., Chirindel, A., Ihnat, M. A., Yu, Y., Boulton, M. E., Szweda, L. I., Ma, J. X. & Lyons, T. J., Jun 1 2008, In : Investigative Ophthalmology and Visual Science. 49, 6, p. 2679-2685 7 p.

Research output: Contribution to journalArticle

66 Scopus citations

Pigment epithelium-derived factor mitigates inflammation and oxidative stress in retinal pericytes exposed to oxidized low-density lipoprotein

Zhang, S. X., Wang, J. J., Dashti, A., Wilson, K., Zou, M. H., Szweda, L., Ma, J. X. & Lyons, T. J., Sep 1 2008, In : Journal of molecular endocrinology. 41, 3-4, p. 135-143 9 p.

Research output: Contribution to journalArticle

58 Scopus citations

Reversible inhibition of α-ketoglutarate dehydrogenase by hydrogen peroxide: Glutathionylation and protection of lipoic acid

Applegate, M. A. B., Humphries, K. M. & Szweda, L. I., Jan 8 2008, In : Biochemistry. 47, 1, p. 473-478 6 p.

Research output: Contribution to journalArticle

90 Scopus citations
2007

Autophagocytosis of mitochondria is prominent in Alzheimer disease

Moreira, P. I., Siedlak, S. L., Wang, X., Santos, M. S., Oliveira, C. R., Tabaton, M., Nunomura, A., Szweda, L. I., Aliev, G., Smith, M. A., Zhu, X. & Perry, G., Jun 1 2007, In : Journal of Neuropathology and Experimental Neurology. 66, 6, p. 525-532 8 p.

Research output: Contribution to journalArticle

120 Scopus citations

Early myocardial dysfunction in streptozotocin-induced diabetic mice: A study using in vivo magnetic resonance imaging (MRI)

Yu, X., Tesiram, Y. A., Towner, R. A., Abbott, A., Patterson, E., Huang, S., Garrett, M. W., Chandrasekaran, S., Matsuzaki, S., Szweda, L. I., Gordon, B. E. & Kem, D. C., Mar 9 2007, In : Cardiovascular Diabetology. 6, 6.

Research output: Contribution to journalArticle

46 Scopus citations

Erratum: Autophagocytosis of mitochondria is prominent in Alzheimer disease (Journal of Neuropathology and Experimental Neurology (2007) 66, (525-532))

Moreira, P. I., Siedlak, S. L., Wang, X., Santos, M. S., Oliveira, C. R., Tabaton, M., Nunomura, A., Szweda, L. I., Aliev, G., Smith, M. A., Zhu, X. & Perry, G., Jul 1 2007, In : Journal of neuropathology and experimental neurology. 66, 7, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Erratum: Increased autophagic degradation of mitochondria in Alzheimer disease (Autophagy)

Moreira, P. I., Siedlak, S. L., Wang, X., Santos, M. S., Oliveira, C. R., Tabaton, M., Nunomura, A., Szweda, L. I., Aliev, G., Smith, M. A., Zhu, X. & Perry, G., Jan 1 2007, In : Autophagy. 3, 6, p. 614-615 2 p.

Research output: Contribution to journalComment/debate

Open Access
112 Scopus citations

Hypoxia-inducible factor 2α regulates expression of the mitochondrial aconitase chaperone protein frataxin

Oktay, Y., Dioum, E., Matsuzaki, S., Ding, K., Yan, L. J., Haller, R. G., Szweda, L. I. & Garcia, J. A., Apr 20 2007, In : Journal of Biological Chemistry. 282, 16, p. 11750-11756 7 p.

Research output: Contribution to journalArticle

63 Scopus citations