• 5089 Citations
  • 39 h-Index
1987 …2018
If you made any changes in Pure, your changes will be visible here soon.

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 7 Similar Profiles
Trypanosoma brucei brucei Medicine & Life Sciences
Ornithine Decarboxylase Medicine & Life Sciences
Adenosylmethionine Decarboxylase Medicine & Life Sciences
Enzymes Medicine & Life Sciences
Plasmodium falciparum Medicine & Life Sciences
Polyamines Medicine & Life Sciences
Parasites Medicine & Life Sciences
African Trypanosomiasis Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1987 2018

  • 5089 Citations
  • 39 h-Index
  • 120 Article
  • 2 Chapter
  • 1 Short survey
  • 1 Review article
Adenosylmethionine Decarboxylase
Trypanosoma brucei brucei
S-Adenosylmethionine
Polyamines
Enzymes
7 Citations (Scopus)

Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study

Llanos-Cuentas, A., Casapia, M., Chuquiyauri, R., Hinojosa, J. C., Kerr, N., Rosario, M., Toovey, S., Arch, R. H., Phillips, M. A., Rozenberg, F. D., Bath, J., Ng, C. L., Cowell, A. N., Winzeler, E. A., Fidock, D. A., Baker, M., Möhrle, J. J., Hooft van Huijsduijnen, R., Gobeau, N., Araeipour, N. & 3 othersAndenmatten, N., Rückle, T. & Duparc, S., Jan 1 2018, (Accepted/In press) In : The Lancet Infectious Diseases.

Research output: Contribution to journalArticle

Vivax Malaria
Plasmodium
Antimalarials
Plasmodium falciparum
Infection
4 Citations (Scopus)

Assessing drug efficacy against Plasmodium falciparum liver stages in vivo

Flannery, E. L., Foquet, L., Chuenchob, V., Fishbaugher, M., Billman, Z., Navarro, M. J., Betz, W., Olsen, T. M., Lee, J., Camargo, N., Nguyen, T., Schafer, C., Sack, B. K., Wilson, E. M., Saunders, J., Bial, J., Campo, B., Charman, S. A., Murphy, S. C., Phillips, M. A. & 2 othersKappe, S. H. & Mikolajczak, S. A., Jan 11 2018, In : JCI insight. 3, 1

Research output: Contribution to journalArticle

Open Access
Plasmodium falciparum
Liver
Pharmaceutical Preparations
Antimalarials
Parasites

Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265

White, J., Dhingra, S. K., Deng, X., El Mazouni, F., Lee, M. C. S., Afanador, G. A., Lawong, A., Tomchick, D. R., Ng, C. L., Bath, J., Rathod, P. K., Fidock, D. A. & Phillips, M. A., Jan 1 2018, (Accepted/In press) In : ACS Infectious Diseases.

Research output: Contribution to journalArticle

Plasmodium falciparum
Point Mutation
Parasites
Malaria
Mutation
4 Citations (Scopus)

Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity

Kokkonda, S., El Mazouni, F., White, K. L., White, J., Shackleford, D. M., Lafuente-Monasterio, M. J., Rowland, P., Manjalanagara, K., Joseph, J. T., Garcia-Pérez, A., Fernandez, J., Gamo, F. J., Waterson, D., Burrows, J. N., Palmer, M. J., Charman, S. A., Rathod, P. K. & Phillips, M. A., Aug 31 2018, In : ACS Omega. 3, 8, p. 9227-9240 14 p.

Research output: Contribution to journalArticle

Antimalarials
Pharmacokinetics
Pharmaceutical Preparations
Lead
dihydroorotate dehydrogenase