• 3548 Citations
  • 26 h-Index
1986 …2019

Research output per year

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Research Output

  • 3548 Citations
  • 26 h-Index
  • 43 Article
  • 4 Chapter
  • 1 Short survey
2019

Oxygen triggers signal transduction in the DevS (DosS) sensor of Mycobacterium tuberculosis by modulating the quaternary structure

Lobão, J. B. D. S., Gondim, A. C. S., Guimarães, W. G., Gilles-Gonzalez, M-A., Lopes, L. G. D. F. & Sousa, E. H. S., Jan 1 2019, (Accepted/In press) In : FEBS Journal.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Drug discovery targeting heme-based sensors and their coupled activities

Sousa, E. H. S., Lopes, L. G. D. F., Gonzalez, G. & Gilles-Gonzalez, M. A., Feb 1 2017, In : Journal of Inorganic Biochemistry. 167, p. 12-20 9 p.

Research output: Contribution to journalShort survey

6 Scopus citations

Haem-Based Sensors of O2: Lessons and Perspectives

Sousa, E. H. S. & Gilles-Gonzalez, M. A., 2017, (Accepted/In press) In : Advances in Microbial Physiology.

Research output: Contribution to journalArticle

4 Scopus citations

Insights into signal transduction by a hybrid FixL: Denaturation study of on and off states of a multi-domain oxygen sensor

Guimarães, W. G., Gondim, A. C. S., Costa, P. M. D. S., Gilles-Gonzalez, M. A., Lopes, L. G. F., Carepo, M. S. P. & Sousa, E. H. S., Jul 1 2017, In : Journal of Inorganic Biochemistry. 172, p. 129-137 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Target DNA stabilizes Mycobacterium tuberculosis DevR/DosR phosphorylation by the full-length oxygen sensors DevS/DosS and DosT

Sousa, E. H. S., Gonzalez, G. & Gilles-Gonzalez, M. A., 2017, (Accepted/In press) In : FEBS Journal.

Research output: Contribution to journalArticle

3 Scopus citations
2013

Signal transduction and phosphoryl transfer by a FixL hybrid kinase with low oxygen affinity: Importance of the vicinal PAS domain and receiver aspartate

Sousa, E. H. S., Tuckerman, J. R., Gondim, A. C. S., Gonzalez, G. & Gilles-Gonzalez, M. A., Jan 22 2013, In : Biochemistry. 52, 3, p. 456-465 10 p.

Research output: Contribution to journalArticle

19 Scopus citations
2012

Novel FixL homologues in Chlamydomonas reinhardtii bind heme and O 2

Murthy, U. M. N., Wecker, M. S. A., Posewitz, M. C., Gilles-Gonzalez, M. A. & Ghirardi, M. L., Dec 14 2012, In : FEBS Letters. 586, 24, p. 4282-4288 7 p.

Research output: Contribution to journalArticle

6 Scopus citations
2011

Cyclic di-GMP activation of polynucleotide phosphorylase signal-dependent RNA processing

Tuckerman, J. R., Gonzalez, G. & Gilles-Gonzalez, M. A., Apr 15 2011, In : Journal of Molecular Biology. 407, 5, p. 633-639 7 p.

Research output: Contribution to journalArticle

89 Scopus citations

Hell's Gate globin I: An acid and thermostable bacterial hemoglobin resembling mammalian neuroglobin

Teh, A. H., Saito, J. A., Baharuddin, A., Tuckerman, J. R., Newhouse, J. S., Kanbe, M., Newhouse, E. I., Rahim, R. A., Favier, F., Didierjean, C., Sousa, E. H. S., Stott, M. B., Dunfield, P. F., Gonzalez, G., Gilles-Gonzalez, M. A., Najimudin, N. & Alam, M., Oct 20 2011, In : FEBS Letters. 585, 20, p. 3250-3258 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Making Sense of Oxygen

Gilles-Gonzalez, M. A., Mar 15 2011, Letters to a Young Chemist. Wiley Blackwell, p. 109-118 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2010

The PpaA/AerR regulators of photosynthesis gene expression from anoxygenic phototrophic proteobacteria contain heme-binding SCHIC domains

Moskvin, O. V., Gilles-Gonzalez, M. A. & Gomelsky, M., Oct 2010, In : Journal of Bacteriology. 192, 19, p. 5253-5256 4 p.

Research output: Contribution to journalArticle

15 Scopus citations
2009

An oxygen-sensing diguanylate cyclase and phosphodiesterase couple for c-di-GMP control

Tuckerman, J. R., Gonzalez, G., Sousa, E. H. S., Wan, X., Saito, J. A., Alam, M. & Gilles-Gonzalez, M. A., Oct 20 2009, In : Biochemistry. 48, 41, p. 9764-9774 11 p.

Research output: Contribution to journalArticle

132 Scopus citations

Globins Synthesize the Second Messenger Bis-(3′-5′)-Cyclic Diguanosine Monophosphate in Bacteria

Wan, X., Tuckerman, J. R., Saito, J. A., Freitas, T. A. K., Newhouse, J. S., Denery, J. R., Galperin, M. Y., Gonzalez, G., Gilles-Gonzalez, M. A. & Alam, M., May 1 2009, In : Journal of Molecular Biology. 388, 2, p. 262-270 9 p.

Research output: Contribution to journalArticle

59 Scopus citations
2008

A surfeit of biological heme-based sensors

Gilles-Gonzalez, M. A. & Gonzalez, G., 2008, The Smallest Biomolecules: Diatomics and their Interactions with Heme Proteins. Elsevier, p. 18-65 48 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Oxygen-Sensing Histidine-Protein Kinases: Assays of Ligand Binding and Turnover of Response-Regulator Substrates

Gilles-Gonzalez, M. A., Gonzalez, G., Sousa, E. H. S. & Tuckerman, J., 2008, In : Methods in Enzymology. 437, p. 173-189 17 p.

Research output: Contribution to journalArticle

14 Scopus citations

Soluble guanylyl cyclase and its evolutionary relatives

Sousa, E. H. S., Gonzalez, G. & Gilles-Gonzalez, M. A., 2008, The Smallest Biomolecules: Diatomics and their Interactions with Heme Proteins. Elsevier, p. 524-539 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
2007

A memory of oxygen binding explains the dose response of the heme-based sensor FixL

Sousa, E. H. S., Tuckerman, J. R., Gonzalez, G. & Gilles-Gonzalez, M. A., May 29 2007, In : Biochemistry. 46, 21, p. 6249-6257 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

DosT and DevS are oxygen-switched kinases in Mycobacterium tuberculosis

Sousa, E. H. S., Tuckerman, J. R., Gonzalez, G. & Gilles-Gonzalez, M. A., Aug 2007, In : Protein Science. 16, 8, p. 1708-1719 12 p.

Research output: Contribution to journalArticle

100 Scopus citations

Novel heme-based oxygen sensor with a revealing evolutionary history

Moskvin, O. V., Kaplan, S., Gilles-Gonzalez, M. A. & Gomelsky, M., Sep 28 2007, In : Journal of Biological Chemistry. 282, 39, p. 28740-28748 9 p.

Research output: Contribution to journalArticle

48 Scopus citations
2006

A Proximal Arginine R206 Participates in Switching of the Bradyrhizobium japonicum FixL Oxygen Sensor

Gilles-Gonzalez, M-A., Caceres, A. I., Sousa, E. H. S., Tomchick, D. R., Brautigam, C. A., Gonzalez, C. & Machius, M., Jun 30 2006, In : Journal of Molecular Biology. 360, 1, p. 80-89 10 p.

Research output: Contribution to journalArticle

26 Scopus citations
2005

Heme-based sensors: Defining characteristics, recent developments, and regulatory hypotheses

Gilles-Gonzalez, M. A. & Gonzalez, G., Jan 2005, In : Journal of Inorganic Biochemistry. 99, 1, p. 1-22 22 p.

Research output: Contribution to journalArticle

279 Scopus citations

Oxygen blocks the reaction of the FixL-FixJ complex with ATP but does not influence binding of FixJ or ATP to FixL

Silva Sousa, E. H., Gonzalez, G. & Gilles-Gonzalez, M. A., Nov 22 2005, In : Biochemistry. 44, 46, p. 15359-15365 7 p.

Research output: Contribution to journalArticle

25 Scopus citations
2004

Ancestral hemoglobins in Archaea

Freitas, T. A. K., Hou, S., Dioum, E. M., Saito, J. A., Newhouse, J., Gonzalez, G., Gilles-Gonzalez, M. A. & Alam, M., Apr 27 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 17, p. 6675-6680 6 p.

Research output: Contribution to journalArticle

73 Scopus citations

Signal transduction by heme-containing PAS-domain proteins

Gilles-Gonzalez, M. A. & Gonzalez, G., Feb 2004, In : Journal of Applied Physiology. 96, 2, p. 774-783 10 p.

Research output: Contribution to journalArticle

141 Scopus citations
2003

A distal arginine in oxygen-sensing heme-PAS domains is essential to ligand binding, signal transduction, and structure

Dunham, C. M., Dioum, E. M., Tuckerman, J. R., Gonzalez, G., Scott, W. G. & Gilles-Gonzalez, M. A., Jul 1 2003, In : Biochemistry. 42, 25, p. 7701-7708 8 p.

Research output: Contribution to journalArticle

78 Scopus citations

Biochemistry and physiological importance of heme proteins as oxygen sensors

Gilles-Gonzalez, M-A., Jan 1 2003, Oxygen Sensing: Responses and Adaption to Hypoxia. CRC Press, p. 6-22 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations
2002

A comparative resonance raman analysis of heme-binding PAS domains: Heme iron coordination structures of the BjFixL, AxPDEA1, EcDoS, and MtDoS proteins

Tomita, T., Gonzalez, G., Chang, A. L., Ikeda-Saito, M. & Gilles-Gonzalez, M. A., Apr 16 2002, In : Biochemistry. 41, 15, p. 4819-4826 8 p.

Research output: Contribution to journalArticle

70 Scopus citations

Ligand and oxidation-state specific regulation of the heme-based oxygen sensor FixL from Sinorhizobium meliloti

Tuckerman, J. R., Gonzalez, G., Dioum, E. M. & Gilles-Gonzalez, M. A., May 14 2002, In : Biochemistry. 41, 19, p. 6170-6177 8 p.

Research output: Contribution to journalArticle

57 Scopus citations

Max Perutz never grew old.

Gilles-Gonzalez, M. A., Jul 2002, In : IUBMB Life. 54, 1, p. 41-42 2 p.

Research output: Contribution to journalArticle

Nature of the displaceable heme-axial residue in the EcDos protein, a heme-based sensor from Escherichia coli

Gonzalez, G., Dioum, E. M., Bertolucci, C. M., Tomita, T., Ikeda-Saito, M., Cheesman, M. R., Watmough, N. J. & Gilles-Gonzalez, M. A., Jul 2 2002, In : Biochemistry. 41, 26, p. 8414-8421 8 p.

Research output: Contribution to journalArticle

59 Scopus citations

NPAS2: A gas-responsive transcription factor

Dioum, E. M., Rutter, J., Tuckerman, J. R., Gonzalez, G., Gilles-Gonzalez, M. A. & McKnight, S. L., Dec 20 2002, In : Science. 298, 5602, p. 2385-2387 3 p.

Research output: Contribution to journalArticle

333 Scopus citations
2001

Complexation precedes phosphorylation for two-component regulatory system FixL/FixJ of Sinorhizobium meliloti

Tuckerman, J. R., Gonzalez, G. & Gilles-Gonzalez, M. A., May 4 2001, In : Journal of Molecular Biology. 308, 3, p. 449-455 7 p.

Research output: Contribution to journalArticle

41 Scopus citations

Oxygen signal transduction

Gilles-Gonzalez, M. A., 2001, In : IUBMB Life. 51, 3, p. 165-173 9 p.

Research output: Contribution to journalArticle

45 Scopus citations

Phosphodiesterase A1, a regulator of cellulose synthesis in Acetobacter xylinum, is a heme-based sensor

Chang, A. L., Tuckerman, J. R., Gonzalez, G., Mayer, R., Weinhouse, H., Volman, G., Amikam, D., Benziman, M. & Gilles-Gonzalez, M. A., Mar 27 2001, In : Biochemistry. 40, 12, p. 3420-3426 7 p.

Research output: Contribution to journalArticle

185 Scopus citations
2000

Dos, a heme-binding PAS protein from Escherichia coli, is a direct oxygen sensor

Delgado-Nixon, V. M., Gonzalez, G. & Gilles-Gonzalez, M. A., Mar 14 2000, In : Biochemistry. 39, 10, p. 2685-2691 7 p.

Research output: Contribution to journalArticle

212 Scopus citations
1998

Imidazole is a sensitive probe of steric hindrance in the distal pockets of oxygen-binding heme proteins

Mansy, S. S., Olson, J. S., Gonzalez, G. & Gilles-Gonzalez, M. A., Sep 8 1998, In : Biochemistry. 37, 36, p. 12452-12457 6 p.

Research output: Contribution to journalArticle

35 Scopus citations

Mechanisms of autoxidation of the oxygen sensor FixL and Aplysia myoglobin: Implications for oxygen-binding heme proteins

Gonzalez, G., Gilles-Gonzalez, M. A., Rybak-Akimova, E. V., Buchalova, M. & Busch, D. H., Jul 14 1998, In : Biochemistry. 37, 28, p. 10188-10194 7 p.

Research output: Contribution to journalArticle

29 Scopus citations

Structure of a biological oxygen sensor: A new mechanism for heme- driven signal transduction

Gong, W., Hao, B., Mansy, S. S., Gonzalez, G., Gilles-Gonzalez, M. A. & Chan, M. K., 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 26, p. 15177-15182 6 p.

Research output: Contribution to journalArticle

317 Scopus citations
1996

Assignment of the hyperfine-shifted 1H-NMR signals of the heme in the oxygen sensor FixL from Rhizobium meliloti

Bertolucci, C., Ming, L. J., Gonzalez, G. & Gilles-Gonzalez, M. A., Jul 1996, In : Chemistry and Biology. 3, 7, p. 561-566 6 p.

Research output: Contribution to journalArticle

25 Scopus citations

Nonsteric factors dominate binding of nitric oxide, azide, imidazole, cyanide, and fluoride to the rhizobial heme-based oxygen sensor FixL

Winkler, W. C., Gonzalez, G., Wittenberg, J. B., Hille, R., Dakappagari, N., Jacob, A., Gonzalez, L. A. & Gilles-Gonzalez, M. A., Oct 1996, In : Chemistry and Biology. 3, 10, p. 841-850 10 p.

Research output: Contribution to journalArticle

52 Scopus citations
1995

Kinase activity of oxygen sensor fixl depends on the spin state of its heme iron

Gilles-González, M. A., 1995, In : Biochemistry®. 34, 1, p. 232-236 5 p.

Research output: Contribution to journalArticle

120 Scopus citations
1994

Heme-based sensors, exemplified by the kinase FixL, are a new class of heme protein with distinctive ligand binding and autoxidation

Gilles-Gonzalez, M. A., Gonzalez, G., Perutz, M. F., Kiger, L., Marden, M. C. & Poyart, C., 1994, In : Biochemistry. 33, 26, p. 8067-8073 7 p.

Research output: Contribution to journalArticle

237 Scopus citations
1993

Regulation of the kinase activity of heme protein FixL from the two-component system FixL/FixJ of Rhizobium meliloti

Gilles-Gonzalez, M. A. & Gonzalez, G., Aug 5 1993, In : Journal of Biological Chemistry. 268, 22, p. 16293-16297 5 p.

Research output: Contribution to journalArticle

105 Scopus citations
1991

A haemoprotein with kinase activity encoded by the oxygen sensor of Rhizobium meliloti

Gilles-Gonzalez, M. A., Ditta, G. S. & Helinski, D. R., Mar 14 1991, In : Nature. 350, 6314, p. 170-172 3 p.

Research output: Contribution to journalArticle

398 Scopus citations

Structure-function studies of bacteriorhodopsin XV: Effects of deletions in loops B-C and E-F on bacteriorhodopsin chromophore and structure

Gilles-Gonzalez, M. A., Engelman, D. M. & Khorana, H. G., May 5 1991, In : Journal of Biological Chemistry. 266, 13, p. 8545-8550 6 p.

Research output: Contribution to journalArticle

41 Scopus citations
1988

Studies on light transduction by bacteriorhodopsin and rhodopsin

Braiman, M., Bubis, J., Doi, T., Chen, H. B., Flitsch, S. L., Franke, R. R., Gilles-Gonzalez, M. A., Graham, R. M., Karnik, S. S., Khorana, H. G., Knox, B. E., Krebs, M. P., Marti, T., Mogi, T., Nakayama, T., Oprian, D. D., Puckett, K. L., Sakmar, T. P. & Stern, L. J., 1988, In : Cold Spring Harbor Symposia on Quantitative Biology. 53, 1, p. 355-364 10 p.

Research output: Contribution to journalArticle

4 Scopus citations
1986

Methods for mutagenesis of the bacterioopsin gene

Gilles-Gonzalez, M. A., Hackett, N. R. & Jones, S. J., 1986, In : Methods in Enzymology. VOL. 125, p. 190-214 25 p.

Research output: Contribution to journalArticle

9 Scopus citations