• 3537 Citations
  • 26 h-Index
1986 …2019
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Research Output 1986 2019

  • 3537 Citations
  • 26 h-Index
  • 43 Article
  • 4 Chapter
  • 1 Short survey
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Article
2019
Escherichia coli
Hemeproteins
Bacterial Genes
Phosphoric Diester Hydrolases
Second Messenger Systems
2 Citations (Scopus)

Oxygen triggers signal transduction in the DevS (DosS) sensor of Mycobacterium tuberculosis by modulating the quaternary structure

Lobão, J. B. D. S., Gondim, A. C. S., Guimarães, W. G., Gilles-Gonzalez, M-A., Lopes, L. G. D. F. & Sousa, E. H. S., Jan 1 2019, (Accepted/In press) In : FEBS Journal.

Research output: Contribution to journalArticle

Signal transduction
Heme
Mycobacterium tuberculosis
Histidine
Protein Kinases
2017
4 Citations (Scopus)

Haem-Based Sensors of O2: Lessons and Perspectives

Sousa, E. H. S. & Gilles-Gonzalez, M. A., 2017, (Accepted/In press) In : Advances in Microbial Physiology.

Research output: Contribution to journalArticle

Symbiosis
Chemotaxis
Carbon Monoxide
Biofilms
Heme
2 Citations (Scopus)

Insights into signal transduction by a hybrid FixL: Denaturation study of on and off states of a multi-domain oxygen sensor

Guimarães, W. G., Gondim, A. C. S., Costa, P. M. D. S., Gilles-Gonzalez, M. A., Lopes, L. G. F., Carepo, M. S. P. & Sousa, E. H. S., Jul 1 2017, In : Journal of Inorganic Biochemistry. 172, p. 129-137 9 p.

Research output: Contribution to journalArticle

Oxygen sensors
Signal transduction
Denaturation
Heme
Signal Transduction
3 Citations (Scopus)

Target DNA stabilizes Mycobacterium tuberculosis DevR/DosR phosphorylation by the full-length oxygen sensors DevS/DosS and DosT

Sousa, E. H. S., Gonzalez, G. & Gilles-Gonzalez, M. A., 2017, (Accepted/In press) In : FEBS Journal.

Research output: Contribution to journalArticle

Oxygen sensors
Phosphorylation
Mycobacterium tuberculosis
Oxygen
DNA
2013
19 Citations (Scopus)

Signal transduction and phosphoryl transfer by a FixL hybrid kinase with low oxygen affinity: Importance of the vicinal PAS domain and receiver aspartate

Sousa, E. H. S., Tuckerman, J. R., Gondim, A. C. S., Gonzalez, G. & Gilles-Gonzalez, M. A., Jan 22 2013, In : Biochemistry. 52, 3, p. 456-465 10 p.

Research output: Contribution to journalArticle

Signal transduction
Heme
Aspartic Acid
Signal Transduction
Phosphotransferases
2012
6 Citations (Scopus)

Novel FixL homologues in Chlamydomonas reinhardtii bind heme and O 2

Murthy, U. M. N., Wecker, M. S. A., Posewitz, M. C., Gilles-Gonzalez, M. A. & Ghirardi, M. L., Dec 14 2012, In : FEBS Letters. 586, 24, p. 4282-4288 7 p.

Research output: Contribution to journalArticle

Chlamydomonas reinhardtii
Heme
Ligands
Chlamydomonas
Proteins
2011
89 Citations (Scopus)

Cyclic di-GMP activation of polynucleotide phosphorylase signal-dependent RNA processing

Tuckerman, J. R., Gonzalez, G. & Gilles-Gonzalez, M. A., Apr 15 2011, In : Journal of Molecular Biology. 407, 5, p. 633-639 7 p.

Research output: Contribution to journalArticle

Polyribonucleotide Nucleotidyltransferase
RNA
Polyribonucleotides
Oxygen
Escherichia coli
20 Citations (Scopus)

Hell's Gate globin I: An acid and thermostable bacterial hemoglobin resembling mammalian neuroglobin

Teh, A. H., Saito, J. A., Baharuddin, A., Tuckerman, J. R., Newhouse, J. S., Kanbe, M., Newhouse, E. I., Rahim, R. A., Favier, F., Didierjean, C., Sousa, E. H. S., Stott, M. B., Dunfield, P. F., Gonzalez, G., Gilles-Gonzalez, M. A., Najimudin, N. & Alam, M., Oct 20 2011, In : FEBS Letters. 585, 20, p. 3250-3258 9 p.

Research output: Contribution to journalArticle

Globins
Hemoglobins
Heme
Acids
X ray crystallography
2010
15 Citations (Scopus)

The PpaA/AerR regulators of photosynthesis gene expression from anoxygenic phototrophic proteobacteria contain heme-binding SCHIC domains

Moskvin, O. V., Gilles-Gonzalez, M. A. & Gomelsky, M., Oct 2010, In : Journal of Bacteriology. 192, 19, p. 5253-5256 4 p.

Research output: Contribution to journalArticle

Proteobacteria
Photosynthesis
Regulator Genes
Heme
Oxygen
2009
131 Citations (Scopus)

An oxygen-sensing diguanylate cyclase and phosphodiesterase couple for c-di-GMP control

Tuckerman, J. R., Gonzalez, G., Sousa, E. H. S., Wan, X., Saito, J. A., Alam, M. & Gilles-Gonzalez, M. A., Oct 20 2009, In : Biochemistry. 48, 41, p. 9764-9774 11 p.

Research output: Contribution to journalArticle

Phosphoric Diester Hydrolases
Oxygen
Ligands
Operon
Gene encoding
59 Citations (Scopus)

Globins Synthesize the Second Messenger Bis-(3′-5′)-Cyclic Diguanosine Monophosphate in Bacteria

Wan, X., Tuckerman, J. R., Saito, J. A., Freitas, T. A. K., Newhouse, J. S., Denery, J. R., Galperin, M. Y., Gonzalez, G., Gilles-Gonzalez, M. A. & Alam, M., May 1 2009, In : Journal of Molecular Biology. 388, 2, p. 262-270 9 p.

Research output: Contribution to journalArticle

Globins
Second Messenger Systems
Biofilms
Bacteria
Bordetella pertussis
2008
14 Citations (Scopus)

Oxygen-Sensing Histidine-Protein Kinases: Assays of Ligand Binding and Turnover of Response-Regulator Substrates

Gilles-Gonzalez, M. A., Gonzalez, G., Sousa, E. H. S. & Tuckerman, J., 2008, In : Methods in Enzymology. 437, p. 173-189 17 p.

Research output: Contribution to journalArticle

Heme
Histidine
Protein Kinases
Assays
Oxygen
2007
22 Citations (Scopus)

A memory of oxygen binding explains the dose response of the heme-based sensor FixL

Sousa, E. H. S., Tuckerman, J. R., Gonzalez, G. & Gilles-Gonzalez, M. A., May 29 2007, In : Biochemistry. 46, 21, p. 6249-6257 9 p.

Research output: Contribution to journalArticle

Heme
Oxygen
Data storage equipment
Phosphotransferases
Sensors
100 Citations (Scopus)

DosT and DevS are oxygen-switched kinases in Mycobacterium tuberculosis

Sousa, E. H. S., Tuckerman, J. R., Gonzalez, G. & Gilles-Gonzalez, M. A., Aug 2007, In : Protein Science. 16, 8, p. 1708-1719 12 p.

Research output: Contribution to journalArticle

Mycobacterium tuberculosis
Phosphotransferases
Oxygen
Ligands
Heme
48 Citations (Scopus)

Novel heme-based oxygen sensor with a revealing evolutionary history

Moskvin, O. V., Kaplan, S., Gilles-Gonzalez, M. A. & Gomelsky, M., Sep 28 2007, In : Journal of Biological Chemistry. 282, 39, p. 28740-28748 9 p.

Research output: Contribution to journalArticle

Oxygen sensors
Heme
History
Oxygen
Tetrapyrroles
2006
26 Citations (Scopus)

A Proximal Arginine R206 Participates in Switching of the Bradyrhizobium japonicum FixL Oxygen Sensor

Gilles-Gonzalez, M-A., Caceres, A. I., Sousa, E. H. S., Tomchick, D. R., Brautigam, C. A., Gonzalez, C. & Machius, M., Jun 30 2006, In : Journal of Molecular Biology. 360, 1, p. 80-89 10 p.

Research output: Contribution to journalArticle

Bradyrhizobium
Heme
Arginine
Oxygen
Ligands
2005
278 Citations (Scopus)

Heme-based sensors: Defining characteristics, recent developments, and regulatory hypotheses

Gilles-Gonzalez, M. A. & Gonzalez, G., Jan 2005, In : Journal of Inorganic Biochemistry. 99, 1, p. 1-22 22 p.

Research output: Contribution to journalArticle

Heme
Sensors
Guanylate Cyclase
Transmitters
Proteins
25 Citations (Scopus)

Oxygen blocks the reaction of the FixL-FixJ complex with ATP but does not influence binding of FixJ or ATP to FixL

Silva Sousa, E. H., Gonzalez, G. & Gilles-Gonzalez, M. A., Nov 22 2005, In : Biochemistry. 44, 46, p. 15359-15365 7 p.

Research output: Contribution to journalArticle

Adenosine Triphosphate
Oxygen
Phosphotransferases
Signal transduction
Heme
2004
73 Citations (Scopus)

Ancestral hemoglobins in Archaea

Freitas, T. A. K., Hou, S., Dioum, E. M., Saito, J. A., Newhouse, J., Gonzalez, G., Gilles-Gonzalez, M. A. & Alam, M., Apr 27 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 17, p. 6675-6680 6 p.

Research output: Contribution to journalArticle

Globins
Archaea
Hemoglobins
Heme
Histidine
141 Citations (Scopus)

Signal transduction by heme-containing PAS-domain proteins

Gilles-Gonzalez, M. A. & Gonzalez, G., Feb 2004, In : Journal of Applied Physiology. 96, 2, p. 774-783 10 p.

Research output: Contribution to journalArticle

Heme
Signal Transduction
Carbon Monoxide
Oxygen
Nitrogen Fixation
2003
78 Citations (Scopus)

A distal arginine in oxygen-sensing heme-PAS domains is essential to ligand binding, signal transduction, and structure

Dunham, C. M., Dioum, E. M., Tuckerman, J. R., Gonzalez, G., Scott, W. G. & Gilles-Gonzalez, M. A., Jul 1 2003, In : Biochemistry. 42, 25, p. 7701-7708 8 p.

Research output: Contribution to journalArticle

Signal transduction
Heme
Arginine
Signal Transduction
Oxygen
2002
70 Citations (Scopus)

A comparative resonance raman analysis of heme-binding PAS domains: Heme iron coordination structures of the BjFixL, AxPDEA1, EcDoS, and MtDoS proteins

Tomita, T., Gonzalez, G., Chang, A. L., Ikeda-Saito, M. & Gilles-Gonzalez, M. A., Apr 16 2002, In : Biochemistry. 41, 15, p. 4819-4826 8 p.

Research output: Contribution to journalArticle

Heme
Iron
Proteins
Carbon Monoxide
Sinorhizobium meliloti
57 Citations (Scopus)

Ligand and oxidation-state specific regulation of the heme-based oxygen sensor FixL from Sinorhizobium meliloti

Tuckerman, J. R., Gonzalez, G., Dioum, E. M. & Gilles-Gonzalez, M. A., May 14 2002, In : Biochemistry. 41, 19, p. 6170-6177 8 p.

Research output: Contribution to journalArticle

Sinorhizobium meliloti
Oxygen sensors
Heme
Adenosine Triphosphate
Oxygen

Max Perutz never grew old.

Gilles-Gonzalez, M. A., Jul 2002, In : IUBMB Life. 54, 1, p. 41-42 2 p.

Research output: Contribution to journalArticle

20th Century History
Austria
England
Biochemistry
58 Citations (Scopus)

Nature of the displaceable heme-axial residue in the EcDos protein, a heme-based sensor from Escherichia coli

Gonzalez, G., Dioum, E. M., Bertolucci, C. M., Tomita, T., Ikeda-Saito, M., Cheesman, M. R., Watmough, N. J. & Gilles-Gonzalez, M. A., Jul 2 2002, In : Biochemistry. 41, 26, p. 8414-8421 8 p.

Research output: Contribution to journalArticle

Heme
Escherichia coli
Sensors
Ligands
Carbon Monoxide
331 Citations (Scopus)

NPAS2: A gas-responsive transcription factor

Dioum, E. M., Rutter, J., Tuckerman, J. R., Gonzalez, G., Gilles-Gonzalez, M. A. & McKnight, S. L., Dec 20 2002, In : Science. 298, 5602, p. 2385-2387 3 p.

Research output: Contribution to journalArticle

Transcription Factors
Gases
Heme
ARNTL Transcription Factors
DNA
2001
41 Citations (Scopus)

Complexation precedes phosphorylation for two-component regulatory system FixL/FixJ of Sinorhizobium meliloti

Tuckerman, J. R., Gonzalez, G. & Gilles-Gonzalez, M. A., May 4 2001, In : Journal of Molecular Biology. 308, 3, p. 449-455 7 p.

Research output: Contribution to journalArticle

Sinorhizobium meliloti
Phosphorylation
Adenosine Triphosphate
Nitrogen Fixation
Heme
45 Citations (Scopus)

Oxygen signal transduction

Gilles-Gonzalez, M. A., 2001, In : IUBMB Life. 51, 3, p. 165-173 9 p.

Research output: Contribution to journalArticle

Signal transduction
Signal Transduction
Oxygen
Molecular oxygen
Sensors
182 Citations (Scopus)

Phosphodiesterase A1, a regulator of cellulose synthesis in Acetobacter xylinum, is a heme-based sensor

Chang, A. L., Tuckerman, J. R., Gonzalez, G., Mayer, R., Weinhouse, H., Volman, G., Amikam, D., Benziman, M. & Gilles-Gonzalez, M. A., Mar 27 2001, In : Biochemistry. 40, 12, p. 3420-3426 7 p.

Research output: Contribution to journalArticle

Gluconacetobacter xylinus
Acetobacter
Phosphoric Diester Hydrolases
Heme
Cellulose
2000
211 Citations (Scopus)

Dos, a heme-binding PAS protein from Escherichia coli, is a direct oxygen sensor

Delgado-Nixon, V. M., Gonzalez, G. & Gilles-Gonzalez, M. A., Mar 14 2000, In : Biochemistry. 39, 10, p. 2685-2691 7 p.

Research output: Contribution to journalArticle

Oxygen sensors
Escherichia coli Proteins
Heme
Carbon Monoxide
Oxygen
1998
35 Citations (Scopus)

Imidazole is a sensitive probe of steric hindrance in the distal pockets of oxygen-binding heme proteins

Mansy, S. S., Olson, J. S., Gonzalez, G. & Gilles-Gonzalez, M. A., Sep 8 1998, In : Biochemistry. 37, 36, p. 12452-12457 6 p.

Research output: Contribution to journalArticle

Myoglobin
Sperm Whale
Oxygen
Rate constants
Glutamine
29 Citations (Scopus)

Mechanisms of autoxidation of the oxygen sensor FixL and Aplysia myoglobin: Implications for oxygen-binding heme proteins

Gonzalez, G., Gilles-Gonzalez, M. A., Rybak-Akimova, E. V., Buchalova, M. & Busch, D. H., Jul 14 1998, In : Biochemistry. 37, 28, p. 10188-10194 7 p.

Research output: Contribution to journalArticle

Aplysia
Oxygen sensors
Myoglobin
Oxygen
Heme
316 Citations (Scopus)

Structure of a biological oxygen sensor: A new mechanism for heme- driven signal transduction

Gong, W., Hao, B., Mansy, S. S., Gonzalez, G., Gilles-Gonzalez, M. A. & Chan, M. K., 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 26, p. 15177-15182 6 p.

Research output: Contribution to journalArticle

Heme
Signal Transduction
Oxygen
Ligands
Phosphotransferases
1996
25 Citations (Scopus)

Assignment of the hyperfine-shifted 1H-NMR signals of the heme in the oxygen sensor FixL from Rhizobium meliloti

Bertolucci, C., Ming, L. J., Gonzalez, G. & Gilles-Gonzalez, M. A., Jul 1996, In : Chemistry and Biology. 3, 7, p. 561-566 6 p.

Research output: Contribution to journalArticle

Sinorhizobium meliloti
Oxygen sensors
Heme
Nuclear magnetic resonance
Oxygen
52 Citations (Scopus)

Nonsteric factors dominate binding of nitric oxide, azide, imidazole, cyanide, and fluoride to the rhizobial heme-based oxygen sensor FixL

Winkler, W. C., Gonzalez, G., Wittenberg, J. B., Hille, R., Dakappagari, N., Jacob, A., Gonzalez, L. A. & Gilles-Gonzalez, M. A., Oct 1996, In : Chemistry and Biology. 3, 10, p. 841-850 10 p.

Research output: Contribution to journalArticle

Oxygen sensors
Azides
Cyanides
Heme
Fluorides
1995
120 Citations (Scopus)

Kinase activity of oxygen sensor fixl depends on the spin state of its heme iron

Gilles-González, M. A., 1995, In : Biochemistry®. 34, 1, p. 232-236 5 p.

Research output: Contribution to journalArticle

Oxygen sensors
Heme
Phosphotransferases
Iron
Oxygen
1994
237 Citations (Scopus)

Heme-based sensors, exemplified by the kinase FixL, are a new class of heme protein with distinctive ligand binding and autoxidation

Gilles-Gonzalez, M. A., Gonzalez, G., Perutz, M. F., Kiger, L., Marden, M. C. & Poyart, C., 1994, In : Biochemistry. 33, 26, p. 8067-8073 7 p.

Research output: Contribution to journalArticle

Hemeproteins
Heme
Carbon Monoxide
Phosphotransferases
Oxygen
1993
105 Citations (Scopus)

Regulation of the kinase activity of heme protein FixL from the two-component system FixL/FixJ of Rhizobium meliloti

Gilles-Gonzalez, M. A. & Gonzalez, G., Aug 5 1993, In : Journal of Biological Chemistry. 268, 22, p. 16293-16297 5 p.

Research output: Contribution to journalArticle

Hemeproteins
Sinorhizobium meliloti
Phosphotransferases
Oxygen
Nitrogen fixation
1991
398 Citations (Scopus)

A haemoprotein with kinase activity encoded by the oxygen sensor of Rhizobium meliloti

Gilles-Gonzalez, M. A., Ditta, G. S. & Helinski, D. R., Mar 14 1991, In : Nature. 350, 6314, p. 170-172 3 p.

Research output: Contribution to journalArticle

Sinorhizobium meliloti
Phosphotransferases
Oxygen
Phosphorylation
Phosphates
41 Citations (Scopus)

Structure-function studies of bacteriorhodopsin XV: Effects of deletions in loops B-C and E-F on bacteriorhodopsin chromophore and structure

Gilles-Gonzalez, M. A., Engelman, D. M. & Khorana, H. G., May 5 1991, In : Journal of Biological Chemistry. 266, 13, p. 8545-8550 6 p.

Research output: Contribution to journalArticle

Bacteriorhodopsins
Chromophores
Mutant Proteins
Hydroxylamine
Denaturation
1988
4 Citations (Scopus)

Studies on light transduction by bacteriorhodopsin and rhodopsin

Braiman, M., Bubis, J., Doi, T., Chen, H. B., Flitsch, S. L., Franke, R. R., Gilles-Gonzalez, M. A., Graham, R. M., Karnik, S. S., Khorana, H. G., Knox, B. E., Krebs, M. P., Marti, T., Mogi, T., Nakayama, T., Oprian, D. D., Puckett, K. L., Sakmar, T. P. & Stern, L. J., 1988, In : Cold Spring Harbor Symposia on Quantitative Biology. 53, 1, p. 355-364 10 p.

Research output: Contribution to journalArticle

Transducin
Bacteriorhodopsins
Signal transduction
Retinal Pigments
Rhodopsin
1986
9 Citations (Scopus)

Methods for mutagenesis of the bacterioopsin gene

Gilles-Gonzalez, M. A., Hackett, N. R. & Jones, S. J., 1986, In : Methods in Enzymology. VOL. 125, p. 190-214 25 p.

Research output: Contribution to journalArticle