• 4309 Citations
  • 37 h-Index
1980 …2019

Research output per year

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Research Output

2019

A bioactive mammalian disaccharide associated with autoimmunity activates STING-TBK1-dependent immune response

Fermaintt, C. S., Sano, K., Liu, Z., Ishii, N., Seino, J., Dobbs, N., Suzuki, T., Fu, Y. X., Lehrman, M. A., Matsuo, I. & Yan, N., Dec 1 2019, In : Nature communications. 10, 1, 2377.

Research output: Contribution to journalArticle

Open Access

Targeting STT3A-oligosaccharyltransferase with NGI-1 causes herpes simplex virus 1 dysfunction

Lu, H., Cherepanova, N. A., Gilmore, R., Contessa, J. N. & Lehrman, M. A., Jun 1 2019, In : FASEB Journal. 33, 6, p. 6801-6812 12 p.

Research output: Contribution to journalArticle

The Lec5 glycosylation mutant links homeobox genes with cholesterol and lipid-linked oligosaccharides

Lu, H., Sathe, A. A., Xing, C. & Lehrman, M. A., Feb 1 2019, In : Glycobiology. 29, 2, p. 106-109 4 p.

Research output: Contribution to journalArticle

2018

Mammalian STT3A/B oligosaccharyltransferases segregate N-glycosylation at the translocon from lipid-linked oligosaccharide hydrolysis

Lu, H., Fermaintt, C. S., Cherepanova, N. A., Reid, G., Yan, N. & Lehrman, M. A., Sep 18 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 38, p. 9557-9562 6 p.

Research output: Contribution to journalArticle

5 Scopus citations
2016

Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells

Lopez-Sambrooks, C., Shrimal, S., Khodier, C., Flaherty, D. P., Rinis, N., Charest, J. C., Gao, N., Zhao, P., Wells, L., Lewis, T. A., Lehrman, M. A., Gilmore, R., Golden, J. E. & Contessa, J. N., Oct 3 2016, (Accepted/In press) In : Nature Chemical Biology.

Research output: Contribution to journalArticle

28 Scopus citations

Trappc11 is required for protein glycosylation in zebrafish and humans

DeRossi, C., Vacaru, A., Rafiq, R., Cinaroglu, A., Imriea, D., Nayar, S., Baryshnikova, A., Milev, M. P., Stanga, D., Kadakia, D., Gao, N., Chu, J., Freeze, H. H., Lehrman, M. A., Sacher, M. & Sadler, K. C., Apr 15 2016, In : Molecular Biology of the Cell. 27, 8, p. 1220-1234 15 p.

Research output: Contribution to journalArticle

16 Scopus citations
2015

Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation

Hasan, M., Fermaintt, C. S., Gao, N., Sakai, T., Miyazaki, T., Jiang, S., Li, Q. Z., Atkinson, J. P., Morse, H. C., Lehrman, M. A. & Yan, N., Sep 15 2015, In : Immunity. 43, 3, p. 463-474 12 p., 3143.

Research output: Contribution to journalArticle

40 Scopus citations

Flipping a Lipid-Linked Oligosaccharide? You Must Whip It!

Lehrman, M. A., 2015, (Accepted/In press) In : Trends in Biochemical Sciences.

Research output: Contribution to journalArticle

2 Scopus citations

Mcl-1 downregulation leads to the heightened sensitivity exhibited by BCR-ABL positive ALL to induction of energy and ER-stress

Leclerc, G. J., DeSalvo, J., Du, J., Gao, N., Leclerc, G. M., Lehrman, M. A., Lampidis, T. J. & Barredo, J. C., May 13 2015, In : Leukemia Research. 39, 11, p. 1246-1254 9 p.

Research output: Contribution to journalArticle

5 Scopus citations
2014

Increased sensitivity to glucose starvation correlates with downregulation of glycogen phosphorylase isoform PYGB in tumor cell lines resistant to 2-deoxy-d-glucose

Philips, K. B., Kurtoglu, M., Leung, H. J., Liu, H., Gao, N., Lehrman, M. A., Murray, T. G. & Lampidis, T. J., Feb 2014, In : Cancer Chemotherapy and Pharmacology. 73, 2, p. 349-361 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

Spliced X-box binding protein 1 couples the unfolded protein response to hexosamine biosynthetic pathway

Wang, Z., Deng, Y., Gao, N., Pedrozo, Z., Li, D. L., Morales, C. R., Criollo, A., Luo, X., Tan, W., Jiang, N., Lehrman, M. A., Rothermel, B. A., Lee, A. H., Lavandero, S., Mammen, P. P., Ferdous, A., Gillette, T. G., Scherer, P. E. & Hill, J. A., Mar 13 2014, In : Cell. 156, 6, p. 1179-1192 14 p.

Research output: Contribution to journalArticle

145 Scopus citations
2013

A zebrafish model of congenital disorders of glycosylation with phosphomannose isomerase deficiency reveals an early opportunity for corrective mannose supplementation

Chu, J., Mir, A., Gao, N., Rosa, S., Monson, C., Sharma, V., Steet, R., Freeze, H. H., Lehrman, M. A. & Sadler, K. C., Jan 1 2013, In : DMM Disease Models and Mechanisms. 6, 1, p. 95-105 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Glycoprotein biosynthesis in a eukaryote lacking the membrane protein Rft1

Jelk, J., Gao, N., Serricchio, M., Signorell, A., Schmidt, R. S., Bangs, J. D., Acosta-Serrano, A., Lehrman, M. A., Bütikofer, P. & Menon, A. K., Jul 12 2013, In : Journal of Biological Chemistry. 288, 28, p. 20616-20623 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Glycoproteins, N-Linked

Lehrman, M. A., Feb 15 2013, Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc., p. 457-464 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

High-throughput screening identifies aclacinomycin as a radiosensitizer of EGFR-mutant non-small cell lung cancer

Bennett, D. C., Charest, J., Sebolt, K., Lehrman, M., Rehemtulla, A. & Contessa, J. N., Jan 1 2013, In : Translational Oncology. 6, 3, p. 382-391 10 p.

Research output: Contribution to journalArticle

8 Scopus citations
6 Scopus citations

Mannose-6-phosphate: A regulator of LLO destruction

Gao, N. & Lehrman, M. A., Jul 25 2013, Glycosyltransferases: Methods and Protocols. p. 277-282 6 p. (Methods in Molecular Biology; vol. 1022).

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations

The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism

Deng, Y., Wang, Z., Tao, C., Gao, N., Holland, W. L., Ferdous, A., Repa, J., Liang, G., Ye, J., Lehrman, M. A., Hill, J. A., Horton, J. D. & Scherer, P. E., Jan 2 2013, In : Journal of Clinical Investigation. 123, 1, p. 455-468 14 p.

Research output: Contribution to journalArticle

78 Scopus citations
2012

5-thiomannosides block the biosynthesis of dolichol-linked oligosaccharides and mimic class I congenital disorders of glycosylation

Zandberg, W. F., Gao, N., Kumarasamy, J., Lehrman, M. A., Seidah, N. G. & Pinto, B. M., Feb 13 2012, In : ChemBioChem. 13, 3, p. 392-401 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

A zebrafish model of PMM2-CDG reveals altered neurogenesis and a substrate-accumulation mechanism for N-linked glycosylation deficiency

Cline, A., Gao, N., Flanagan-Steet, H., Sharma, V., Rosa, S., Sonon, R., Azadi, P., Sadler, K. C., Freeze, H. H., Lehrman, M. A. & Steet, R., Nov 1 2012, In : Molecular biology of the cell. 23, 21, p. 4175-4187 13 p.

Research output: Contribution to journalArticle

32 Scopus citations
2011

Mannose-6-phosphate regulates destruction of lipid-linked oligosaccharides

Gao, N., Shang, J., Huynh, D., Manthati, V. L., Arias, C., Harding, H. P., Kaufman, R. J., Mohr, I., Ron, D., Falck, J. R. & Lehrman, M. A., Sep 1 2011, In : Molecular biology of the cell. 22, 17, p. 2994-3009 16 p.

Research output: Contribution to journalArticle

24 Scopus citations

Nogo-B receptor is necessary for cellular dolichol biosynthesis and protein N-glycosylation

Harrison, K. D., Park, E. J., Gao, N., Kuo, A., Rush, J. S., Waechter, C. J., Lehrman, M. A. & Sessa, W. C., May 1 2011, In : EMBO Journal. 30, 12, p. 2490-2500 11 p.

Research output: Contribution to journalArticle

49 Scopus citations
2010

Antiangiogenic activity of 2-deoxy-D-glucose

Merchan, J. R., Kovács, K., Railsback, J. W., Kurtoglu, M., Jing, Y., Piña, Y., Gao, N., Murray, T. G., Lehrman, M. A. & Lampidis, T. J., Nov 17 2010, In : PloS one. 5, 10, e13699.

Research output: Contribution to journalArticle

68 Scopus citations
2009

Suppression of Rft1 expression does not impair the transbilayer movement of Man5GlcNAc2-P-P-dolichol in sealed microsomes from yeast

Rush, J. S., Gao, N., Lehrman, M. A., Matveev, S. & Waechter, C. J., Jul 24 2009, In : Journal of Biological Chemistry. 284, 30, p. 19835-19842 8 p.

Research output: Contribution to journalArticle

32 Scopus citations
2008

Recycling of dolichyl monophosphate to the cytoplasmic leaflet of the endoplasmic reticulum after the cleavage of dolichyl pyrophosphate on the lumenal monolayer

Rush, J. S., Gao, N., Lehrman, M. A. & Waechter, C. J., Feb 15 2008, In : Journal of Biological Chemistry. 283, 7, p. 4087-4093 7 p.

Research output: Contribution to journalArticle

25 Scopus citations

Unexpected basis for impaired Glc3Man9 GlcNAc2-P-P-dolichol biosynthesis by elevated expression of GlcNAc-1-P transferase

Gao, N., Shang, J. & Lehrman, M. A., Jan 1 2008, In : Glycobiology. 18, 1, p. 125-134 10 p.

Research output: Contribution to journalArticle

5 Scopus citations
2007

Teaching dolichol-linked oligosaccharides more tricks with alternatives to metabolic radiolabeling

Lehrman, M. A., Aug 1 2007, In : Glycobiology. 17, 8, p. 75R-85R

Research output: Contribution to journalReview article

14 Scopus citations

Translation attenuation by PERK balances ER glycoprotein synthesis with lipid-linked oligosaccharide flux

Shang, J., Gao, N., Kaufman, R. J., Ron, D., Harding, H. P. & Lehrman, M. A., Feb 26 2007, In : Journal of Cell Biology. 176, 5, p. 605-616 12 p.

Research output: Contribution to journalArticle

31 Scopus citations

Under normoxia, 2-deoxy-D-glucose elicits cell death in select tumor types not by inhibition of glycolysis but by interfering with N-linked glycosylation

Kurtoglu, M., Gao, N., Shang, J., Maher, J. C., Lehrman, M. A., Wangpaichitr, M., Savaraj, N., Lane, A. N. & Lampidis, T. J., Nov 1 2007, In : Molecular Cancer Therapeutics. 6, 11, p. 3049-3058 10 p.

Research output: Contribution to journalArticle

142 Scopus citations
32 Scopus citations
15 Scopus citations
2005
37 Scopus citations

Characterization of lipid-linked oligosaccharide accumulation in mouse models of Batten disease

Cho, S. K., Gao, N., Pearce, D. A., Lehrman, M. A. & Hofmann, S. L., Sep 6 2005, In : Glycobiology. 15, 6, p. 637-648 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Overview: A sugary view of endoplasmic reticulum function

Lehrman, M. A., Apr 2005, In : Methods. 35, 4, 1 p.

Research output: Contribution to journalEditorial

2004
27 Scopus citations

Discordance of UPR signaling by ATF6 and Ire1p-XBP1 with levels of target transcripts

Shang, J. & Lehrman, M. A., Apr 30 2004, In : Biochemical and Biophysical Research Communications. 317, 2, p. 390-396 7 p.

Research output: Contribution to journalArticle

60 Scopus citations
8 Scopus citations

Metformin-stimulated Mannose Transport in Dermal Fibroblasts

Shang, J. & Lehrman, M. A., Mar 12 2004, In : Journal of Biological Chemistry. 279, 11, p. 9703-9712 10 p.

Research output: Contribution to journalArticle

20 Scopus citations
2003

Alternative and sources of reagents and supplies of fluorophore-assisted carbohydrate electrophoresis(FACE).

Lehrman, M. A. & Gao, N., Jan 2003, In : Glycobiology. 13, 1, p. 1G-3G

Research output: Contribution to journalArticle

8 Scopus citations
15 Scopus citations
2002
Open Access
37 Scopus citations
23 Scopus citations
Open Access
39 Scopus citations

Rapid activation of glycogen phosphorylase by the endoplasmic reticulum unfolded protein response

Gill, A., Gao, N. & Lehrman, M. A., Nov 22 2002, In : Journal of Biological Chemistry. 277, 47, p. 44747-44753 7 p.

Research output: Contribution to journalArticle

11 Scopus citations
2001

A mutation in the human MPDU1 gene causes congenital disorder of glycosylation type If (CDG-If)

Kranz, C., Denecke, J., Lehrman, M. A., Ray, S., Kienz, P., Kreissel, G., Sagi, D., Peter-Katalinic, J., Freeze, H. H., Schmid, T., Jackowski-Dohrmann, S., Harms, E. & Marquardt, T., Jan 1 2001, In : Journal of Clinical Investigation. 108, 11, p. 1613-1619 7 p.

Research output: Contribution to journalArticle

Open Access
96 Scopus citations

Oligosaccharide-based Information in Endoplasmic Reticulum Quality Control and Other Biological Systems

Lehrman, M. A., Mar 23 2001, In : Journal of Biological Chemistry. 276, 12, p. 8623-8626 4 p.

Research output: Contribution to journalShort survey

57 Scopus citations

Requirement of the Lec35 gene for all known classes of monosaccharide-P-dolichol-dependent glycosyltransferase reactions in mammals

Anand, M., Rush, J. S., Ray, S., Doucey, M. A., Weik, J., Ware, F. E., Hofsteenge, J., Waechter, C. J. & Lehrman, M. A., Jan 1 2001, In : Molecular biology of the cell. 12, 2, p. 487-501 15 p.

Research output: Contribution to journalArticle

68 Scopus citations
2000
3 Scopus citations