• 71926 Citations
  • 119 h-Index
1984 …2020

Research output per year

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Research Output

Entrainment of temperature and activity rhythms to restricted feeding in orexin knock out mice

Kaur, S., Thankachan, S., Begum, S., Blanco-Centurion, C., Sakurai, T., Yanagisawa, M. & Shiromani, P. J., Apr 18 2008, In : Brain Research. 1205, p. 47-54 8 p.

Research output: Contribution to journalArticle

47 Scopus citations

Erratum: Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice (Neuron (April 21, 2005) 46 (297-308) PII: S0896-6273(05)00205-9 and DOI: 10.1016/j.neuron.2005.03.010)

Sakurai, T., Nagata, R., Yamanaka, A., Kawamura, H., Tsujino, N., Muraki, Y., Kageyama, H., Kunita, S., Takahashi, S., Goto, K., Koyama, Y., Shioda, S. & Yanagisawa, M., Jun 2 2005, In : Neuron. 46, 5, 1 p.

Research output: Contribution to journalComment/debate

Erythromycin and clarithromycin attenuate cytokine-induced endothelin-1 expression in human bronchial epithelial cells

Takizawa, H., Desaki, M., Ohtoshi, T., Kawasaki, S., Kohyama, T., Sato, M., Nakajima, J., Yanagisawa, M. & Ito, K., Jul 1 1998, In : European Respiratory Journal. 12, 1, p. 57-63 7 p.

Research output: Contribution to journalArticle

49 Scopus citations

Essential role of sympathetic endothelin A receptors for adverse cardiac remodeling

Lehmann, L. H., Rostosky, J. S., Buss, S. J., Kreusser, M. M., Krebs, J., Mier, W., Enseleit, F., Spiger, K., Hardt, S. E., Wieland, T., Haass, M., Lüscher, T. F., Schneider, M. D., Parlato, R., Gröne, H. J., Haberkorn, U., Yanagisawa, M., Katus, H. A. & Backs, J., Sep 16 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 37, p. 13499-13504 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor

Yamamoto, N., Ohrui, S., Okada, T., Yata, M., Saitoh, T., Kutsumura, N., Nagumo, Y., Irukayama-Tomobe, Y., Ogawa, Y., Ishikawa, Y., Watanabe, Y., Hayakawa, D., Gouda, H., Yanagisawa, M. & Nagase, H., Sep 1 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 17, p. 4176-4179 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity

Ohrui, S., Yamamoto, N., Saitoh, T., Kutsumura, N., Nagumo, Y., Irukayama-Tomobe, Y., Ogawa, Y., Ishikawa, Y., Watanabe, Y., Hayakawa, D., Gouda, H., Yanagisawa, M. & Nagase, H., Jan 1 2018, (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

6 Scopus citations

Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring

Yamamoto, N., Ohrui, S., Okada, T., Saitoh, T., Kutsumura, N., Nagumo, Y., Irukayama-Tomobe, Y., Ogawa, Y., Ishikawa, Y., Watanabe, Y., Hayakawa, D., Gouda, H., Yanagisawa, M. & Nagase, H., Jan 1 2019, In : Bioorganic and Medicinal Chemistry.

Research output: Contribution to journalArticle

2 Scopus citations

Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity

Saitoh, T., Seki, K., Nakajima, R., Yamamoto, N., Kutsumura, N., Nagumo, Y., Irukayama-Tomobe, Y., Ogawa, Y., Ishikawa, Y., Tanimura, R., Yanagisawa, M. & Nagase, H., Jan 1 2019, In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

1 Scopus citations

Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group

Saitoh, T., Seki, K., Nakajima, R., Yamamoto, N., Kutsumura, N., Nagumo, Y., Irukayama-Tomobe, Y., Ogawa, Y., Ishikawa, Y., Yanagisawa, M. & Nagase, H., Feb 1 2020, In : Bioorganic and Medicinal Chemistry Letters. 30, 3, 126893.

Research output: Contribution to journalArticle

ET(B) receptor activation leads to activation and phosphorylation of NHE3

Peng, Y., Moe, O. W., Chu, T. S., Preisig, P. A., Yanagisawa, M. & Alpern, R. J., Jan 1 1999, In : American Journal of Physiology - Cell Physiology. 276, 4 45-4, p. C938-C945

Research output: Contribution to journalArticle

36 Scopus citations

ET-1 from endothelial cells is required for complete angiotensin II-induced cardiac fibrosis and hypertrophy

Adiarto, S., Heiden, S., Vignon-Zellweger, N., Nakayama, K., Yagi, K., Yanagisawa, M. & Emoto, N., Oct 15 2012, In : Life Sciences. 91, 13-14, p. 651-657 7 p.

Research output: Contribution to journalArticle

38 Scopus citations

ETB receptor activation causes exocytic insertion of NHE3 in OKP cells

Peng, Y., Amemiya, M., Yang, X., Fan, L., Moe, O. W., Yin, H. L., Preisig, P. A., Yanagisawa, M. & Alpern, R. J., Jan 2001, In : American Journal of Physiology - Renal Physiology. 280, 1 49-1, p. F34-F42

Research output: Contribution to journalArticle

60 Scopus citations

ETB receptor protects the tubulointerstitium in experimental thrombotic microangiopathy

Nangaku, M., Yamada, K., Gariepy, C. E., Miyata, T., Inagi, R., Kurokawa, K., Yanagisawa, M., Fujita, T. & Johnson, R. J., Jan 1 2002, In : Kidney international. 62, 3, p. 922-928 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Exaggerated hypoxic pulmonary hypertension in endothelin B receptor-deficient rats

Dunbar Ivy, D., Yanagisawa, M., Gariepy, C. E., Gebb, S. A., Colvin, K. L. & McMurtry, I. F., Jul 2 2002, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 282, 4 26-4, p. L703-L712

Research output: Contribution to journalArticle

63 Scopus citations

Exaggerated vascular and renal pathology in endothelin-B receptor-deficient rats with deoxycorticosterone acetate-salt hypertension

Matsumura, Y., Kuro, T., Kobayashi, Y., Konishi, F., Takaoka, M., Wessale, J. L., Opgenorth, T. J., Gariepy, C. E. & Yanagisawa, M., Nov 28 2000, In : Circulation. 102, 22, p. 2765-2773 9 p.

Research output: Contribution to journalArticle

Open Access
51 Scopus citations

Exaggerated vascular and renal pathology in endothelin-B-receptor-deficient rats with subtotal nephrectomy

Tazawa, N., Okada, Y., Nakata, M., Izumoto, H., Takasu, M., Takaoka, M., Gariepy, C. E., Yanagisawa, M. & Matsumura, Y., Nov 1 2004, In : Journal of Cardiovascular Pharmacology. 44, SUPPL. 1, p. S467-S470

Research output: Contribution to journalArticle

8 Scopus citations

Experimental bronchiolitis obliterans induced by in vivo HVJ-liposome- mediated endothelin-1 gene transfer

Takeda, S. I., Sawa, Y., Minami, M., Kaneda, Y., Fujii, Y., Shirakura, R., Yanagisawa, M. & Matsuda, H., Jun 1997, In : Annals of Thoracic Surgery. 63, 6, p. 1562-1567 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Expression, purification and characterization of the monomeric and dimeric forms of soluble bovine endothelin converting enzyme-1a

Kulathila, R., Clark, K., Savage, P., Bowen, B. R., Emoto, N., Yanagisawa, M. & Jeng, A. Y., Aug 1 2002, In : Clinical science. 103, SUPPL. 48, p. 94S-97S

Research output: Contribution to journalArticle

3 Scopus citations

Expression of a Poly-Glutamine-Ataxin-3 Transgene in Orexin Neurons Induces Narcolepsy-Cataplexy in the Rat

Beuckmann, C. T., Sinton, C. M., Williams, S. C., Richardson, J. A., Hammer, R. E., Sakurai, T. & Yanagisawa, M., May 5 2004, In : Journal of Neuroscience. 24, 18, p. 4469-4477 9 p.

Research output: Contribution to journalArticle

140 Scopus citations

Expression of endothelin-1 in pancreatic tissue of patients with chronic pancreatitis

Kakugawa, Y., Giaid, A., Yanagisawa, M., Baynash, A. G., Melnyk, P., Rosenberg, L. & Duguid, W. P., Feb 9 1996, In : Journal of Pathology. 178, 1, p. 78-83 6 p.

Research output: Contribution to journalArticle

29 Scopus citations

Expression of Endothelin-1 in the Lungs of Patients with Pulmonary Hypertension

Giaid, A., Yanagisawa, M., Langleben, D., Michel, R. P., Levy, R., Shennib, H., Kimura, S., Masaki, T., Duguid, W. P. & Stewart, D. J., Jun 17 1993, In : New England Journal of Medicine. 328, 24, p. 1732-1739 8 p.

Research output: Contribution to journalArticle

1540 Scopus citations

Expression of endothelin-like peptide in the nervous system of the marine mollusk Aplysia

Giaid, A., Masaki, T., Ouimet, T., Yanagisawa, M., Gaspar, L., Cantin, M., Kimura, S. & Castellucci, V. F., Jan 1 1991, In : Journal of Cardiovascular Pharmacology. 17, p. S449-S451

Research output: Contribution to journalArticle

9 Scopus citations

Expression of multiple tau isoforms and microtubule bundle formation in fibroblasts transfected with a single tau cDNA

Kanai, Y., Takemura, R., Oshima, T., Mori, H., Ihara, Y., Yanagisawa, M., Masaki, T. & Hirokawa, N., Jan 1 1989, In : Journal of Cell Biology. 109, 3, p. 1173-1184 12 p.

Research output: Contribution to journalArticle

Open Access
280 Scopus citations

Expression of the poly-glutamine-ataxin-3 transgene causes loss of orexin expression: A rat model of narcolepsy

Beuckmann, C. T., Sinton, C. M., Williams, S. C., Richardson, J. A., Hammer, R. E., Sakurai, T. & Yanagisawa, M., May 1 2004, In : Sleep and Biological Rhythms. 2, SUPPL. 1, p. S44

Research output: Contribution to journalArticle

Extrarenal ETB plays a significant role in controlling cardiovascular responses to high dietary sodium in rats

Ohkita, M., Wang, Y., Nguyen, N. D. T., Tsai, Y. H., Williams, S. C., Wiseman, R. C., Killen, P. D., Li, S., Yanagisawa, M. & Gariepy, C. E., May 1 2005, In : Hypertension. 45, 5, p. 940-946 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

Fasting-Induced Hypothermia and Reduced Energy Production in Mice Lacking Acetyl-CoA Synthetase 2

Sakakibara, I., Fujino, T., Ishii, M., Tanaka, T., Shimosawa, T., Miura, S., Zhang, W., Tokutake, Y., Yamamoto, J., Awano, M., Iwasaki, S., Motoike, T., Okamura, M., Inagaki, T., Kita, K., Ezaki, O., Naito, M., Kuwaki, T., Chohnan, S., Yamamoto, T. T. & 4 others, Hammer, R. E., Kodama, T., Yanagisawa, M. & Sakai, J., Feb 4 2009, In : Cell Metabolism. 9, 2, p. 191-202 12 p.

Research output: Contribution to journalArticle

54 Scopus citations

Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo

Yanagisawa, H., Davist, E. C., Starcher, B. C., Ouchi, T., Yanagisawa, M., Richardson, J. A. & Olson, E. N., Jan 1 2002, In : Nature. 415, 6868, p. 168-171 4 p.

Research output: Contribution to journalLetter

429 Scopus citations

Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain

Fujiyama, T., Miyashita, S., Tsuneoka, Y., Kanemaru, K., Kakizaki, M., Kanno, S., Ishikawa, Y., Yamashita, M., Owa, T., Nagaoka, M., Kawaguchi, Y., Yanagawa, Y., Magnuson, M. A., Muratani, M., Shibuya, A., Nabeshima, Y. I., Yanagisawa, M., Funato, H. & Hoshino, M., Jul 3 2018, In : Cell Reports. 24, 1, p. 79-94 16 p.

Research output: Contribution to journalArticle

5 Scopus citations

Forward-genetics analysis of sleep in randomly mutagenized mice

Funato, H., Miyoshi, C., Fujiyama, T., Kanda, T., Sato, M., Wang, Z., Ma, J., Nakane, S., Tomita, J., Ikkyu, A., Kakizaki, M., Hotta-Hirashima, N., Kanno, S., Komiya, H., Asano, F., Honda, T., Kim, S. J., Harano, K., Muramoto, H., Yonezawa, T. & 17 others, Mizuno, S., Miyazaki, S., Connor, L., Kumar, V., Miura, I., Suzuki, T., Watanabe, A., Abe, M., Sugiyama, F., Takahashi, S., Sakimura, K., Hayashi, Y., Liu, Q., Kume, K., Wakana, S., Takahashi, J. S. & Yanagisawa, M., 2016, In : Nature. 539, 7629, p. 378-383 6 p.

Research output: Contribution to journalArticle

75 Scopus citations

Fos expression in orexin neurons varies with behavioral state

Estabrooke, I. V., McCarthy, M. T., Ko, E., Chou, T. C., Chemelli, R. M., Yanagisawa, M., Saper, C. B. & Scammell, T. E., Mar 1 2001, In : Journal of Neuroscience. 21, 5, p. 1656-1662 7 p.

Research output: Contribution to journalArticle

517 Scopus citations

Functional analysis of five endothelin-B receptor mutations found in human hirschsprung disease patients

Abe, Y., Sakurai, T., Yamada, T., Nakamura, T., Yanagisawa, M. & Goto, K., Aug 28 2000, In : Biochemical and Biophysical Research Communications. 275, 2, p. 524-531 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Functional ETA-ETB receptor cross-Talk in basilar artery in Situ from ETB receptor deficient rats

Yoon, S., Gariepy, C. E., Yanagisawa, M., Zuccarello, M. & Rapoport, R. M., Mar 1 2016, In : Journal of Cardiovascular Pharmacology. 67, 3, p. 212-217 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

GABAA receptor-mediated input change on orexin neurons following sleep deprivation in mice

Matsuki, T., Takasu, M., Hirose, Y., Murakoshi, N., Sinton, C. M., Motoike, T. & Yanagisawa, M., Dec 1 2015, In : Neuroscience. 284, p. 217-224 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Gene therapy for Hirschsprung disease?

Kapur, R. P., Yanagisawa, M., Yanagisawa, H. & Rice, J., Dec 1 1997, In : Pediatric Pathology and Laboratory Medicine. 17, 3, p. 516-517 2 p.

Research output: Contribution to journalArticle

Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity

Hara, J., Beuckmann, C. T., Nambu, T., Willie, J. T., Chemelli, R. M., Sinton, C. M., Sugiyama, F., Yagami, K. I., Goto, K., Yanagisawa, M. & Sakurai, T., Jan 1 2001, In : Neuron. 30, 2, p. 345-354 10 p.

Research output: Contribution to journalArticle

1030 Scopus citations

Ghrelin Increases the Rewarding Value of High-Fat Diet in an Orexin-Dependent Manner

Perello, M., Sakata, I., Birnbaum, S. G., Chuang, J. C., Osborne-Lawrence, S., Rovinsky, S. A., Woloszyn, J., Yanagisawa, M., Lutter, M. & Zigman, J. M., May 1 2010, In : Biological Psychiatry. 67, 9, p. 880-886 7 p.

Research output: Contribution to journalArticle

245 Scopus citations

G protein-coupled receptor genes in the FANTOM2 database

Kawasawa, Y., McKenzie, L. M., Hill, D. P., Bono, H., Arakawa, T., Carninci, P., Kawai, J., Hayashizaki, Y. & Yanagisawa, M., Jun 1 2003, In : Genome Research. 13, 6 B, p. 1466-1477 12 p.

Research output: Contribution to journalArticle

25 Scopus citations

Halothane-induced hypnosis is not accompanied by inactivation of orexinergic output in rodents

Gompf, H., Chen, J., Sun, Y., Yanagisawa, M., Aston-Jones, G. & Kelz, M. B., Nov 2009, In : Anesthesiology. 111, 5, p. 1001-1009 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Hemodynamic shear stress stimulates endothelin production by cultured endothelial cells

Yoshizumi, M., Kurihara, H., Sugiyama, T., Takaku, F., Yanagisawa, M., Masaki, T. & Yazaki, Y., Jun 15 1989, In : Biochemical and Biophysical Research Communications. 161, 2, p. 859-864 6 p.

Research output: Contribution to journalArticle

441 Scopus citations

Heparin regulates endothelin production through endothelium-derived nitric oxide in human endothelial cells

Yokokawa, K., Tahara, H., Kohno, M., Mandal, A. K., Yanagisawa, M. & Takeda, T., Jan 1 1993, In : Journal of Clinical Investigation. 92, 4, p. 2080-2085 6 p.

Research output: Contribution to journalArticle

Open Access
112 Scopus citations

Heparin suppresses endothelin-1 peptide and mRNA expression in cultured endothelial cells of spontaneously hypertensive rats

Yokokawa, K., Kohne, M., Mandal, A. K., Tahara, H., Yanagisawa, M. & Takeda, T., Mar 1 1994, In : Journal of the American Society of Nephrology. 4, 9, p. 1683-1689 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney

Sato, Y., Mii, A., Hamazaki, Y., Fujita, H., Nakata, H., Masuda, K., Nishiyama, S., Shibuya, S., Haga, H., Ogawa, O., Shimizu, A., Narumiya, S., Kaisho, T., Arita, M., Yanagisawa, M., Miyasaka, M., Sharma, K., Minato, N., Kawamoto, H. & Yanagita, M., Jan 1 2016, In : JCI Insight. 1, 11, e87680.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

Heterozygous knock-out of ET(B) receptors induces BQ-123-sensitive hypertension in the mouse

Berthiaume, N., Yanagisawa, M., Labonté, J. & D'Orléans-Juste, P., Jan 1 2000, In : Hypertension. 36, 6, p. 1002-1007 6 p.

Research output: Contribution to journalArticle

Open Access
46 Scopus citations

High salt induces autocrine actions of ET-1 on inner medullary collecting duct NO production via upregulated ETB receptor expression

Hyndman, K. A., Dugas, C., Arguello, A. M., Goodchild, T. T., Buckley, K. M., Burch, M., Yanagisawa, M. & Pollock, J. S., Aug 2016, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 311, 2, p. R263-R271

Research output: Contribution to journalArticle

7 Scopus citations

Histamine-1 receptor is not required as a downstream effector of orexin-2 receptor in maintenance of basal sleep/wake states

Hondo, M., Nagai, K., Ohno, K., Kisanuki, Y., Willie, J. T., Watanabe, T., Yanagisawa, M. & Sakurai, T., Mar 1 2010, In : Acta Physiologica. 198, 3, p. 287-294 8 p.

Research output: Contribution to journalArticle

40 Scopus citations

Human melanoma cells express functional endothelin-1 receptors

Yohn, J. J., Smith, C., Stevens, T., Hoffman, T. A., Morelli, J. G., Hurt, D. L., Yanagisawa, M., Kane, M. A. & Zamora, M. R., May 30 1994, In : Biochemical and Biophysical Research Communications. 201, 1, p. 449-457 9 p.

Research output: Contribution to journalArticle

53 Scopus citations

Human smooth muscle myosin heavy chain gene mapped to chromosomal region 16q12

Matsuoka, R., Yoshida, M. C., Furutani, Y., Imamura, S. I., Kanda, N., Yanagisawa, M., Masaki, T. & Takao, A., Jan 1 1993, In : American Journal of Medical Genetics. 46, 1, p. 61-67 7 p.

Research output: Contribution to journalArticle

47 Scopus citations

Hypertension associated with endothelin-secreting malignant hemangioendothelioma

Yokokawa, K., Tahara, H., Kohno, M., Murakawa, K. I., Yasunari, K., Nakagawa, K., Hamada, T., Otani, S., Yanagisawa, M. & Takeda, T., Jan 1 1991, In : Annals of internal medicine. 114, 3, p. 213-215 3 p.

Research output: Contribution to journalArticle

156 Scopus citations

Hypocretin/orexin deficiency decreases cocaine abuse liability

Steiner, N., Rossetti, C., Sakurai, T., Yanagisawa, M., de Lecea, L., Magistretti, P. J., Halfon, O. & Boutrel, B., May 1 2018, In : Neuropharmacology. 133, p. 395-403 9 p.

Research output: Contribution to journalArticle

10 Scopus citations