• 71926 Citations
  • 119 h-Index
1984 …2020

Research output per year

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Research Output

Mesolimbic neuropeptide W coordinates stress responses under novel environments

Motoike, T., Long, J. M., Tanaka, H., Sinton, C. M., Skach, A., Williams, S. C., Hammer, R. E., Sakurai, T. & Yanagisawa, M., May 24 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 21, p. 6023-6028 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Methodology and theoretical basis of forward genetic screening for sleep/wakefulness in mice

Miyoshi, C., Kim, S. J., Ezaki, T., Ikkyu, A., Hotta-Hirashima, N., Kanno, S., Kakizaki, M., Yamada, M., Wakana, S., Yanagisawa, M. & Funato, H., Aug 6 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 32, p. 16062-16067 6 p.

Research output: Contribution to journalArticle

Open Access

Mice with cardiomyocyte-specific disruption of the endothelin-1 gene are resistant to hyperthyroid cardiac hypertrophy

Shohet, R. V., Kisanuki, Y. Y., Zhao, X. S., Siddiquee, Z., Franco, F. & Yanagisawa, M., Feb 17 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 7, p. 2088-2093 6 p.

Research output: Contribution to journalArticle

72 Scopus citations

Modafinil more effectively induces wakefulness in orexin-null mice than in wild-type littermates

Willie, J. T., Renthal, W., Chemelli, R. M., Miller, M. S., Scammell, T. E., Yanagisawa, M. & Sinton, C. M., Jan 24 2005, In : Neuroscience. 130, 4, p. 983-995 13 p.

Research output: Contribution to journalArticle

75 Scopus citations

Modulation of circadian glucocorticoid oscillation via adrenal Opioid-CXCR7 Signaling alters emotional behavior

Ikeda, Y., Kumagai, H., Skach, A., Sato, M. & Yanagisawa, M., Dec 5 2013, In : Cell. 155, 6, p. 1323-1336 14 p.

Research output: Contribution to journalArticle

46 Scopus citations

Molecular and cellular mechanism of endothelin regulation: Implications for vascular function

Masaki, T., Kimura, S., Yanagisawa, M. & Goto, K., Oct 1991, In : Circulation. 84, 4, p. 1457-1468 12 p.

Research output: Contribution to journalArticle

Open Access
396 Scopus citations

Molecular biology and biochemistry of the endothelins

Masashi, Y. & Tomoh, M., Sep 1989, In : Trends in Pharmacological Sciences. 10, 9, p. 374-378 5 p.

Research output: Contribution to journalReview article

583 Scopus citations

Molecular characterization of endothelin receptors

Takeshi, S., Yanagisawa, M. & Tomoh, M., 1992, In : Trends in Pharmacological Sciences. 13, C, p. 103-108 6 p.

Research output: Contribution to journalReview article

594 Scopus citations

Monitoring β-arrestin recruitment via β-lactamase enzyme fragment complementation: Purification of peptide E as a low-affinity ligand for mammalian bombesin receptors

Ikeda, Y., Kumagai, H., Okazaki, H., Fujishiro, M., Motozawa, Y., Nomura, S., Takeda, N., Toko, H., Takimoto, E., Akazawa, H., Morita, H., Suzuki, J. I., Yamazaki, T., Komuro, I. & Yanagisawa, M., Jun 1 2015, In : PLoS One. 10, 6, e0127445.

Research output: Contribution to journalArticle

5 Scopus citations

Monoaminergic neuronal changes in orexin deficient mice

Mori, T., Ito, S., Kuwaki, T., Yanagisawa, M., Sakurai, T. & Sawaguchi, T., Mar 1 2010, In : Neuropharmacology. 58, 4-5, p. 826-832 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Monoclonal antibodies to endothelin: Application for sandwich immunoassays

Hamaoki, M., Kato, H., Sugi, M., Fujimoto, M., Kurihara, H., Yosizumi, M., Yanagisawa, M., Kimura, S., Masaki, T. & Yazaki, Y., Jan 1 1990, In : Hybridoma. 9, 1, p. 63-69 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

Narcolepsy in orexin knockout mice: Molecular genetics of sleep regulation

Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Clay Williams, S., Xiong, Y., Kisanuki, Y., Fitch, T. E., Nakazato, M., Hammer, R. E., Saper, C. B. & Yanagisawa, M., Aug 20 1999, In : Cell. 98, 4, p. 437-451 15 p.

Research output: Contribution to journalArticle

2353 Scopus citations

Narcoleptic orexin receptor knockout mice express enhanced cholinergic properties in laterodorsal tegmental neurons

Kalogiannis, M., Grupke, S. L., Potter, P. E., Edwards, J. G., Chemelli, R. M., Kisanuki, Y. Y., Yanagisawa, M. & Leonard, C. S., Jul 1 2010, In : European Journal of Neuroscience. 32, 1, p. 130-142 13 p.

Research output: Contribution to journalArticle

22 Scopus citations

Neuromedin s-producing neurons act as essential pacemakers in the suprachiasmatic nucleus to couple clock neurons and dictate circadian rhythms

Lee, I. T., Chang, A. S., Manandhar, M., Shan, Y., Fan, J., Izumo, M., Ikeda, Y., Motoike, T., Dixon, S., Seinfeld, J. E., Takahashi, J. S. & Yanagisawa, M., Mar 4 2015, In : Neuron. 85, 5, p. 1086-1102 17 p.

Research output: Contribution to journalArticle

70 Scopus citations

Neurons containing orexin in the lateral hypothalamic area of the adult rat brain are activated by insulin-induced acute hypoglycemia

Moriguchi, T., Sakurai, T., Nambu, T., Yanagisawa, M. & Goto, K., Apr 2 1999, In : Neuroscience Letters. 264, 1-3, p. 101-104 4 p.

Research output: Contribution to journalArticle

237 Scopus citations

Neuropeptide B-deficient mice demonstrate hyperalgesia in response to inflammatory pain

Kelly, M. A., Beuckmann, C. T., Williams, S. C., Sinton, C. M., Motoike, T., Richardson, J. A., Hammer, R. E., Garry, M. G. & Yanagisawa, M., Jul 12 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 28, p. 9942-9947 6 p.

Research output: Contribution to journalArticle

45 Scopus citations

Neurotensin Co-Expressed in Orexin-Producing Neurons in the Lateral Hypothalamus Plays an Important Role in Regulation of Sleep/Wakefulness States

Furutani, N., Hondo, M., Kageyama, H., Tsujino, N., Mieda, M., Yanagisawa, M., Shioda, S. & Sakurai, T., Apr 19 2013, In : PloS one. 8, 4, e62391.

Research output: Contribution to journalArticle

49 Scopus citations

Nighttime administration of nicotine improves hepatic glucose metabolism via the hypothalamic orexin system in mice

Tsuneki, H., Nagata, T., Fujita, M., Kon, K., Wu, N., Takatsuki, M., Yamaguchi, K., Wada, T., Nishijo, H., Yanagisawa, M., Sakurai, T. & Sasaoka, T., Jan 1 2016, In : Endocrinology. 157, 1, p. 195-206 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Nonpeptide Orexin-2 Receptor Agonist Attenuates Morphine-induced Sedative Effects in Rats

Toyama, S., Shimoyama, N., Tagaito, Y., Nagase, H., Saitoh, T., Yanagisawa, M. & Shimoyama, M., Jan 1 2018, In : Anesthesiology. 128, 5, p. 992-1003 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models

Irukayama-Tomobe, Y., Ogawa, Y., Tominaga, H., Ishikawa, Y., Hosokawa, N., Ambai, S., Kawabe, Y., Uchida, S., Nakajima, R., Saitoh, T., Kanda, T., Vogt, K., Sakurai, T., Nagase, H. & Yanagisawa, M., May 30 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 22, p. 5731-5736 6 p.

Research output: Contribution to journalArticle

39 Scopus citations

Normal ventilation and ventilatory responses to chemical stimuli in juvenile mutant mice deficient in endothelin-3

Nakamura, A., Kuwaki, T., Kuriyama, T., Yanagisawa, M. & Fukuda, Y., Nov 27 2000, In : Respiration Physiology. 124, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Novel mutations of the endothelin B receptor gene in patients with Hirschsprung's disease and their characterization

Tanaka, H., Moroi, K., Iwai, J., Takahashi, H., Ohnuma, N., Hori, S., Takimoto, M., Nishiyama, M., Masaki, T., Yanagisawa, M., Sekiya, S. & Kimura, S., May 1 1998, In : Journal of Biological Chemistry. 273, 18, p. 11378-11383 6 p.

Research output: Contribution to journalArticle

81 Scopus citations

Novel quinazoline endothelin converting enzyme inhibitors

Ahn, K., Sisneros, A. M., Pan, S., Hupe, D., Kam, S. N., Lee, C., Doherty, A., Kaw, S., Emoto, N. & Yanagisawa, M., Dec 1 1996, In : FASEB Journal. 10, 6, p. A1404

Research output: Contribution to journalArticle

1 Scopus citations

Novel selective quinazoline inhibitors of endothelin converting enzyme-1

Ahn, K., Sisneros, A. M., Herman, S. B., Pan, S. M., Hupe, D., Lee, C., Nikam, S., Cheng, X. M., Doherty, A. M., Schroeder, R. L., Haleen, S. J., Kaw, S., Emoto, N. & Yanagisawa, M., Feb 4 1998, In : Biochemical and Biophysical Research Communications. 243, 1, p. 184-190 7 p.

Research output: Contribution to journalArticle

51 Scopus citations

N-type calcium channel α1B subunit (Cav2.2) Knock-out mice display hyperactivity and vigilance state differences

Beuckmann, C. T., Sinton, C. M., Miyamoto, N., Ino, M. & Yanagisawa, M., Jul 30 2003, In : Journal of Neuroscience. 23, 17, p. 6793-6797 5 p.

Research output: Contribution to journalArticle

51 Scopus citations
172 Scopus citations

Octacosanol restores stress-affected sleep in mice by alleviating stress

Kaushik, M. K., Aritake, K., Takeuchi, A., Yanagisawa, M. & Urade, Y., Dec 1 2017, In : Scientific reports. 7, 1, 8892.

Research output: Contribution to journalArticle

6 Scopus citations

Olfactory receptor responding to gut microbiotaderived signals plays a role in renin secretion and blood pressure regulation

Pluznick, J. L., Protzko, R. J., Gevorgyan, H., Peterlin, Z., Sipos, A., Han, J., Brunet, I., Wan, L. X., Rey, F., Wang, T., Firestein, S. J., Yanagisawa, M., Gordon, J. I., Eichmann, A., Peti-Peterdi, J. & Caplan, M. J., Mar 12 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 11, p. 4410-4415 6 p.

Research output: Contribution to journalArticle

389 Scopus citations

Orexin/hypocretin activates mTOR complex 1 (mTORC1) via an Erk/Akt-independent and calcium-stimulated lysosome v-ATPase pathway

Wang, Z., Liu, S., Kakizaki, M., Hirose, Y., Ishikawa, Y., Funato, H., Yanagisawa, M., Yu, Y. & Liu, Q., Nov 14 2014, In : Journal of Biological Chemistry. 289, 46, p. 31950-31959 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Orexin/hypocretin and histamine: Distinct roles in the control of wakefulness demonstrated using knock-out mouse models

Anaclet, C., Parmentier, R., Ouk, K., Guidon, G., Buda, C., Sastre, J. P., Akaoka, H., Sergeeva, O. A., Yanagisawa, M., Ohtsu, H., Franco, P., Haas, H. L. & Lin, J. S., Nov 18 2009, In : Journal of Neuroscience. 29, 46, p. 14423-14438 16 p.

Research output: Contribution to journalArticle

148 Scopus citations

Orexin (hypocretin) gene transfer diminishes narcoleptic sleep behavior in mice

Liu, M., Thankachan, S., Kaur, S., Begum, S., Blanco-Centurion, C., Sakurai, T., Yanagisawa, M., Neve, R. & Shiromani, P. J., Oct 1 2008, In : European Journal of Neuroscience. 28, 7, p. 1382-1393 12 p.

Research output: Contribution to journalArticle

56 Scopus citations

Orexin (hypocretin) neurons contain dynorphin.

Chou, T. C., Lee, C. E., Lu, J., Elmquist, J. K., Hara, J., Willie, J. T., Beuckmann, C. T., Chemelli, R. M., Sakurai, T., Yanagisawa, M., Saper, C. B. & Scammell, T. E., Oct 1 2001, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 21, 19, p. RC168

Research output: Contribution to journalArticle

306 Scopus citations

Orexin gene transfer into zona incerta neurons suppresses muscle paralysis in narcoleptic mice

Liu, M., Blanco-Centurion, C., Konadhode, R., Begum, S., Pelluru, D., Gerashchenko, D., Sakurai, T., Yanagisawa, M., van den Pol, A. N. & Shiromani, P. J., Apr 20 2011, In : Journal of Neuroscience. 31, 16, p. 6028-6040 13 p.

Research output: Contribution to journalArticle

53 Scopus citations

Orexin-immunoreactive inputs to rat sympathetic preganglionic neurons

Llewellyn-Smith, I. J., Martin, C. L., Marcus, J. N., Yanagisawa, M., Minson, J. B. & Scammell, T. E., Nov 13 2003, In : Neuroscience Letters. 351, 2, p. 115-119 5 p.

Research output: Contribution to journalArticle

48 Scopus citations

Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system

Nakamura, T., Uramura, K., Nambu, T., Yada, T., Goto, K., Yanagisawa, M. & Sakurai, T., Aug 4 2000, In : Brain Research. 873, 1, p. 181-187 7 p.

Research output: Contribution to journalArticle

286 Scopus citations

Orexin neurons function in an efferent pathway of a food-entrainable circadian oscillator in eliciting food-anticipatory activity and wakefulness

Mieda, M., Williams, S. C., Sinton, C. M., Richardson, J. A., Sakurai, T. & Yanagisawa, M., Nov 17 2004, In : Journal of Neuroscience. 24, 46, p. 10493-10501 9 p.

Research output: Contribution to journalArticle

157 Scopus citations

Orexin neurons suppress narcolepsy via 2 distinct efferent pathways

Hasegawa, E., Yanagisawa, M., Sakurai, T. & Mieda, M., Feb 3 2014, In : Journal of Clinical Investigation. 124, 2, p. 604-616 13 p.

Research output: Contribution to journalArticle

87 Scopus citations

Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice

Mieda, M., Willie, J. T., Hara, J., Sinton, C. M., Sakurai, T. & Yanagisawa, M., Mar 30 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 13, p. 4649-4654 6 p.

Research output: Contribution to journalArticle

241 Scopus citations

Orexin receptor-1 in the locus coeruleus plays an important role in cue-dependent fear memory consolidation

Soya, S., Shoji, H., Hasegawa, E., Hondo, M., Miyakawa, T., Yanagisawa, M., Mieda, M. & Sakurai, T., Sep 9 2013, In : Journal of Neuroscience. 33, 36, p. 14549-14557 9 p.

Research output: Contribution to journalArticle

58 Scopus citations

Orexin regulates bone remodeling via a dominant positive central action and a subordinate negative peripheral action

Wei, W., Motoike, T., Krzeszinski, J. Y., Jin, Z., Xie, X-J., Dechow, P. C., Yanagisawa, M. & Wan, Y., Jun 3 2014, In : Cell Metabolism. 19, 6, p. 927-940 14 p.

Research output: Contribution to journalArticle

18 Scopus citations

Orexins: From neuropeptides to energy homeostasis and sleep/wake regulation

Beuckmann, C. T. & Yanagisawa, M., Jul 25 2002, In : Journal of Molecular Medicine. 80, 6, p. 329-342 14 p.

Research output: Contribution to journalReview article

117 Scopus citations

Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems

Date, Y., Ueta, Y., Yamashita, H., Yamaguchi, H., Matsukura, S., Kangawa, K., Sakurai, T., Yanagisawa, M. & Nakazato, M., Jan 19 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 2, p. 748-753 6 p.

Research output: Contribution to journalArticle

879 Scopus citations

Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose-responsive neurons to regulate Ca2+ signaling in a reciprocal manner to leptin: Orexigenic neuronal pathways in the mediobasal hypothalamus

Muroya, S., Funahashi, H., Yamanaka, A., Kohno, D., Uramura, K., Nambu, T., Shibahara, M., Kuramochi, M., Takigawa, M., Yanagisawa, M., Sakurai, T., Shioda, S. & Yada, T., Mar 1 2004, In : European Journal of Neuroscience. 19, 6, p. 1524-1534 11 p.

Research output: Contribution to journalArticle

197 Scopus citations

Orexins acting at native OX1 receptor in colon cancer and neuroblastoma cells or at recombinant OX1 receptor suppress cell growth by inducing apoptosis

Rouet-Benzineb, P., Rouyer-Fessard, C., Jarry, A., Avondo, V., Pouzet, C., Yanagisawa, M., Laboisse, C., Laburthe, M. & Voisin, T., Oct 29 2004, In : Journal of Biological Chemistry. 279, 44, p. 45875-45886 12 p.

Research output: Contribution to journalArticle

76 Scopus citations

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.

Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richarson, J. A., Kozlowski, G. P., Wilson, S., Arch, J. R., Buckingham, R. E., Haynes, A. C., Carr, S. A., Annan, R. S., McNulty, D. E., Liu, W. S., Terrett, J. A., Elshourbagy, N. A., Bergsma, D. J. & 1 others, Yanagisawa, M., Mar 6 1998, In : Cell. 92, 5, p. 1 page following 696

Research output: Contribution to journalComment/debate

1457 Scopus citations

Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., Arch, J. R. S., Buckingham, R. E., Haynes, A. C., Carr, S. A., Annan, R. S., McNulty, D. E., Liu, W. S., Terrett, J. A., Elshourbagy, N. A., Bergsma, D. J. & 1 others, Yanagisawa, M., Feb 20 1998, In : Cell. 92, 4, p. 573-585 13 p.

Research output: Contribution to journalArticle

2611 Scopus citations

Partial requirement of endothelin receptor B in spiral ganglion neurons for postnatal development of hearing

Ida-Eto, M., Ohgami, N., Iida, M., Yajima, I., Kumasaka, M. Y., Takaiwa, K., Kimitsuki, T., Sone, M., Nakashima, T., Tsuzuki, T., Komune, S., Yanagisawa, M. & Kato, M., Aug 26 2011, In : Journal of Biological Chemistry. 286, 34, p. 29621-29626 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Peripherally administered orexin improves survival of mice with endotoxin shock

Ogawa, Y., Irukayama-Tomobe, Y., Murakoshi, N., Kiyama, M., Ishikawa, Y., Hosokawa, N., Tominaga, H., Uchida, S., Kimura, S., Kanuka, M., Morita, M., Hamada, M., Takahashi, S., Hayashi, Y. & Yanagisawa, M., Dec 30 2016, In : eLife. 5, DECEMBER2016, e21055.

Research output: Contribution to journalArticle

12 Scopus citations

Persistent pain and stress activate pain-inhibitory orexin pathways

Watanabe, S., Kuwaki, T., Yanagisawa, M., Fukuda, Y. & Shimoyama, M., Jan 19 2005, In : NeuroReport. 16, 1, p. 5-8 4 p.

Research output: Contribution to journalArticle

103 Scopus citations