• 71926 Citations
  • 119 h-Index
1984 …2020

Research output per year

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Research Output

α-synuclein BAC transgenic mice exhibit RBD-like behaviour and hyposmia: A prodromal Parkinson's disease model

Taguchi, T., Ikuno, M., Hondo, M., Parajuli, L. K., Taguchi, K., Ueda, J., Sawamura, M., Okuda, S., Nakanishi, E., Hara, J., Uemura, N., Hatanaka, Y., Ayaki, T., Matsuzawa, S., Tanaka, M., El-Agnaf, O. M. A., Koike, M., Yanagisawa, M., Uemura, M. T., Yamakado, H. & 1 others, Takahashi, R., Jan 1 2020, In : Brain. 143, 1, p. 249-265 17 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Widespread distribution of orexin in rat brain and its regulation upon fasting

Mondal, M. S., Nakazato, M., Date, Y., Murakami, N., Yanagisawa, M. & Matsukura, S., Mar 24 1999, In : Biochemical and Biophysical Research Communications. 256, 3, p. 495-499 5 p.

Research output: Contribution to journalArticle

128 Scopus citations

Widely Distributed Neurotensinergic Neurons in the Brainstem Regulate NREM Sleep in Mice

Kashiwagi, M., Kanuka, M., Tatsuzawa, C., Suzuki, H., Morita, M., Tanaka, K., Kawano, T., Shin, J. W., Suzuki, H., Itohara, S., Yanagisawa, M. & Hayashi, Y., Mar 23 2020, In : Current Biology. 30, 6, p. 1002-1010.e4

Research output: Contribution to journalArticle

2 Scopus citations

Vigilance state-dependent attenuation of hypercapnic chemoreflex and exaggerated sleep apnea in orexin knockout mice

Nakamura, A., Zhang, W., Yanagisawa, M., Fukuda, Y. & Kuwaki, T., Jan 1 2007, In : Journal of applied physiology. 102, 1, p. 241-248 8 p.

Research output: Contribution to journalArticle

105 Scopus citations

Ventilatory long-term facilitation in mice can be observed during both sleep and wake periods and depends on orexin

Terada, J., Nakamura, A., Zhang, W., Yanagisawa, M., Kuriyama, T., Fukuda, Y. & Kuwaki, T., Feb 1 2008, In : Journal of applied physiology. 104, 2, p. 499-507 9 p.

Research output: Contribution to journalArticle

66 Scopus citations

Vasoconstrictor response of large cerebral arteries of cats to endothelin, an endothelium-derived vasoactive peptide

Saito, A., Shiba, R., Kimura, S., Yanagisawa, M., Goto, K. & Masaki, T., Mar 21 1989, In : European Journal of Pharmacology. 162, 2, p. 353-358 6 p.

Research output: Contribution to journalArticle

88 Scopus citations

Vascular endothelium is critically involved in the hypotensive and hypovolemic actions of atrial natriuretic peptide

Sabrane, K., Kruse, M. N., Fabritz, L., Zetsche, B., Mitko, D., Skryabin, B. V., Zwiener, M., Baba, H. A., Yanagisawa, M. & Kuhn, M., Jun 1 2005, In : Journal of Clinical Investigation. 115, 6, p. 1666-1674 9 p.

Research output: Contribution to journalArticle

113 Scopus citations

Vascular endothelium derived endothelin-1 is required for normal heart function after chronic pressure overload in mice

Heiden, S., Vignon-Zellweger, N., Masuda, S., Yagi, K., Nakayama, K., Yanagisawa, M. & Emoto, N., Feb 11 2014, In : PloS one. 9, 2, e88730.

Research output: Contribution to journalArticle

15 Scopus citations

Vascular endothelin-B receptor system in vivo plays a favorable inhibitory role in vascular remodeling after injury revealed by endothelin-B receptor-knockout mice

Murakoshi, N., Miyauchi, T., Kakinuma, Y., Ohuchi, T., Goto, K., Yanagisawa, M. & Yamaguchi, I., Oct 8 2002, In : Circulation. 106, 15, p. 1991-1998 8 p.

Research output: Contribution to journalArticle

76 Scopus citations

Vascular endothelial cell-derived endothelin-1 mediates vascular inflammation and neointima formation following blood flow cessation

Anggrahini, D. W., Emoto, N., Nakayama, K., Widyantoro, B., Adiarto, S., Iwasa, N., Nonaka, H., Rikitake, Y., Kisanuki, Y. Y., Yanagisawa, M. & Hirata, K. I., Apr 1 2009, In : Cardiovascular Research. 82, 1, p. 143-151 9 p.

Research output: Contribution to journalArticle

67 Scopus citations

Variants of the orexin2/hcrt2 receptor gene identified in patients with excessive daytime sleepiness and patients with Tourette's syndrome comorbidity

Thompson, M. D., Comings, D. E., Abu-Ghazalah, R., Jereseh, Y., Lin, L., Wade, J., Sakurai, T., Tokita, S., Yoshida, T., Tanaka, H., Yanagisawa, M., Burnham, W. M. & Moldofsky, H., Aug 15 2004, In : American Journal of Medical Genetics - Neuropsychiatric Genetics. 129 B, 1, p. 69-75 7 p.

Research output: Contribution to journalArticle

33 Scopus citations

Uterine sensitization-associated gene-1 (USAG-1), a novel BMP antagonist expressed in the kidney, accelerates tubular injury

Yanagita, M., Okuda, T., Endo, S., Tanaka, M., Takahashi, K., Sugiyama, F., Kunita, S., Takahashi, S., Fukatsu, A., Yanagisawa, M., Kita, T. & Sakurai, T., Jan 1 2006, In : Journal of Clinical Investigation. 116, 1, p. 70-79 10 p.

Research output: Contribution to journalArticle

111 Scopus citations

USAG-1: A bone morphogenetic protein antagonist abundantly expressed in the kidney

Yanagita, M., Oka, M., Watabe, T., Iguchi, H., Niida, A., Takahashi, S., Akiyama, T., Miyazono, K., Yanagisawa, M. & Sakurai, T., Apr 2 2004, In : Biochemical and Biophysical Research Communications. 316, 2, p. 490-500 11 p.

Research output: Contribution to journalArticle

103 Scopus citations

Urinary protein profiling with surface-enhanced laser desorption/ionization time-of-flight mass spectrometry in etB receptor-deficient rats1

Raila, J., Kalk, P., Pfab, T., Thöne-Reineke, C., Godes, M., Yanagisawa, M., Schweigert, F. J. & Hocher, B., Aug 1 2008, In : Canadian Journal of Physiology and Pharmacology. 86, 8, p. 566-570 5 p.

Research output: Contribution to journalArticle

Two problems on smooth muscle contraction in relation to calcium ion

Masaki, T., Yanagisawa, M., Kurihara, H., Goto, K., Kimura, S., Katoch, S. & Tanaka, T., Jan 1 1989, In : Journal of Pharmacobio-Dynamics. 12, 4, p. S-105

Research output: Contribution to journalArticle

Two isoforms of smooth muscle myosin regulatory light chain in chicken gizzard

Inoue, A., Yanagisawa, M., Takano-Ohmuro, H. & Masaki, T., Aug 1989, In : European Journal of Biochemistry. 183, 3, p. 645-651 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Two distinct types of endothelin receptors are present on chick cardiac membranes

Watanabe, H., Miyazaki, H., Kondoh, M., Masuda, Y., Kimura, S., Yanagisawa, M., Masaki, T. & Murakami, K., Jun 30 1989, In : Biochemical and Biophysical Research Communications. 161, 3, p. 1252-1259 8 p.

Research output: Contribution to journalArticle

164 Scopus citations
111 Scopus citations

Two different forms of endothelin receptors in rat lung

Masuda, Y., Miyazaki, H., Kondoh, M., Watanabe, H., Yanagisawa, M., Masaki, T. & Murakami, K., Nov 6 1989, In : FEBS Letters. 257, 2, p. 208-210 3 p.

Research output: Contribution to journalArticle

107 Scopus citations

Triethylene glycol, an active component of Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction

Kaushik, M. K., Kaul, S. C., Wadhwa, R., Yanagisawa, M. & Urade, Y., Feb 2017, In : PloS one. 12, 2, e0172508.

Research output: Contribution to journalArticle

8 Scopus citations

Transient expression of neuropeptide W in postnatal mouse hypothalamus - A putative regulator of energy homeostasis

Motoike, T., Skach, A. G., Godwin, J. K., Sinton, C. M., Yamazaki, M., Abe, M., Natsume, R., Sakimura, K. & Yanagisawa, M., Aug 1 2015, In : Neuroscience. 301, p. 323-337 15 p.

Research output: Contribution to journalArticle

6 Scopus citations

Transgenic rescue of aganglionosis and piebaldism in lethal spotted mice

Rice, J., Doggett, B., Sweetser, D. A., Yanagisawa, H., Yanagisawa, M. & Kapur, R. P., Jan 19 2000, In : Developmental Dynamics. 217, 1, p. 120-132 13 p.

Research output: Contribution to journalArticle

34 Scopus citations
Open Access
145 Scopus citations

Transforming growth factor-β stimulates the expression of endothelin mRNA by vascular endothelial cells

Kurihara, H., Yoshizumi, M., Sugiyama, T., Takaku, F., Yanagisawa, M., Masaki, T., Hamaoki, M., Kato, H. & Yazaki, Y., Mar 31 1989, In : Biochemical and Biophysical Research Communications. 159, 3, p. 1435-1440 6 p.

Research output: Contribution to journalArticle

370 Scopus citations

Toward the mysteries of sleep

Yanagisawa, M., Jan 1 2019, In : Keio Journal of Medicine. 68, 1, 1 p.

Research output: Contribution to journalArticle

Open Access

Topographical localisation of endothelin mRNA and peptide immunoreactivity in neurones of the human brain

Giaid, A., Gibson, S. J., Herrero, M. T., Gentleman, S., Legon, S., Yanagisawa, M., Masaki, T., Ibrahim, N. B. N., Roberts, G. W., Rossi, M. L. & Polak, J. M., Jan 1 1991, In : Histochemistry. 95, 3, p. 303-314 12 p.

Research output: Contribution to journalArticle

146 Scopus citations

To eat or to sleep? Orexin in the regulation of feeding and wakefulness

Willie, J. T., Chemelli, R. M., Sinton, C. M. & Yanagisawa, M., Aug 11 2001, In : Annual Review of Neuroscience. 24, p. 429-458 30 p.

Research output: Contribution to journalReview article

607 Scopus citations

Tissue-specific modulation of endothelin receptors in a rat model of hypertension

Telemaque-Potts, S., Kuc, R. E., Yanagisawa, M. & Davenport, A. P., Jan 1 2000, In : Journal of Cardiovascular Pharmacology. 36, 5 SUPPL. 1, p. S122-S123

Research output: Contribution to journalArticle

5 Scopus citations

Timed inhibition of orexin system by suvorexant improved sleep and glucose metabolism in type 2 diabetic db/db mice

Tsuneki, H., Kon, K., Ito, H., Yamazaki, M., Takahara, S., Toyooka, N., Ishii, Y., Sasahara, M., Wada, T., Yanagisawa, M., Sakurai, T. & Sasaoka, T., Nov 1 2016, In : Endocrinology. 157, 11, p. 4146-4157 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Tie2-Cre transgenic mice: A new model for endothelial cell-lineage analysis in vivo

Kisanuki, Y. Y., Hammer, R. E., Miyazaki, J. I., Williams, S. C., Richardson, J. A. & Yanagisawa, M., Feb 15 2001, In : Developmental Biology. 230, 2, p. 230-242 13 p.

Research output: Contribution to journalArticle

786 Scopus citations

The thirteenth international conference on endothelin (ET-13), Tokyo, 2013

Emoto, N. & Yanagisawa, M., Nov 24 2014, In : Life Sciences. 118, 2, p. 70-76 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

The second tomoh masaki award (2013)

Emoto, N., Kasuya, Y. & Yanagisawa, M., Nov 24 2014, In : Life Sciences. 118, 2, p. 87-90 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance

Vicent, D., Ilany, J., Kondo, T., Naruse, K., Fisher, S. J., Kisanuki, Y. Y., Bursell, S., Yanagisawa, M., King, G. L. & Kahn, C. R., May 2003, In : Journal of Clinical Investigation. 111, 9, p. 1373-1380 8 p.

Research output: Contribution to journalArticle

Open Access
267 Scopus citations

The possible role of endothelin-1 in the pathogenesis of coronary vasospasm

Kurihara, H., Yoshizumi, M., Sugiyama, T., Yamaoki, K., Nagai, R., Takaku, F., Satoh, H., Inui, J., Yanagisawa, M., Masaki, T. & Yazaki, Y., Jan 1 1989, In : Journal of Cardiovascular Pharmacology. 13, p. S132-S137

Research output: Contribution to journalArticle

81 Scopus citations

The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress

Lutter, M., Sakata, I., Osborne-Lawrence, S., Rovinsky, S. A., Anderson, J. G., Jung, S., Birnbaum, S. G., Yanagisawa, M., Elmquist, J. K., Nestler, E. J. & Zigman, J. M., Jul 1 2008, In : Nature neuroscience. 11, 7, p. 752-753 2 p.

Research output: Contribution to journalArticle

380 Scopus citations

The mapping of quantitative trait loci underlying strain differences in locomotor activity between 129S6 and C57Bl/6J mice

Kelly, M. A., Low, M. J., Phillips, T. J., Wakeland, E. K. & Yanagisawa, M., Oct 1 2003, In : Mammalian Genome. 14, 10, p. 692-702 11 p.

Research output: Contribution to journalArticle

34 Scopus citations

The ligand-receptor interactions of the endothelin systems are mediated by distinct 'message' and 'address' domains

Sakamoto, A., Yanagisawa, M., Sakurai, T., Nakao, K., Toyo-oka, T., Yano, M. & Masaki, T., Dec 1 1993, In : Journal of Cardiovascular Pharmacology. 22, SUPPL. 8, p. S113-S116

Research output: Contribution to journalArticle

13 Scopus citations

The human preproendothelin-1 gene. Complete nucleotide sequence and regulation of expression

Inoue, A., Yanagisawa, M., Takuwa, Y., Mitsui, Y., Kobayashi, M. & Masaki, T., Jan 1 1989, In : Journal of Biological Chemistry. 264, 25, p. 14954-14959 6 p.

Research output: Contribution to journalArticle

388 Scopus citations

The human preproendothelin-1 gene: Possible regulation by endothelial phosphoinositide turnover signaling

Yanagisawa, M., Inoue, A., Takuwa, Y., Mitsui, Y., Kobayashi, M. & Masaki, T., Jan 1 1989, In : Journal of Cardiovascular Pharmacology. 13, p. S13-S17

Research output: Contribution to journalArticle

144 Scopus citations

The human endothelin family: Three structurally and pharmacologically distinct isopeptides predicted by three separate genes

Inoue, A., Yanagisawa, M., Kimura, S., Kasuya, Y., Miyauchi, T., Goto, K. & Masaki, T., Jan 1 1989, In : Proceedings of the National Academy of Sciences of the United States of America. 86, 8, p. 2863-2867 5 p.

Research output: Contribution to journalArticle

Open Access
2459 Scopus citations

The human endothelin family: cDNA cloning, complete primary structure and differential tissue expression of the three precursors

Yanagtsawa, M., Inoue, A., Imai, T., Matsushita, Y. & Masaki, T., Jul 5 1990, In : European Journal of Pharmacology. 183, 5, p. 1628-1629 2 p.

Research output: Contribution to journalArticle

The expression patterns of endothelin-A receptor and endothelin 1 in the avian embryo

Nataf, V., Grapin-Botton, A., Champeval, D., Amemiya, A., Yanagisawa, M. & Le Douarin, N. M., Jul 1998, In : Mechanisms of Development. 75, 1-2, p. 145-149 5 p.

Research output: Contribution to journalArticle

30 Scopus citations

The expression pattern of endothelin 3 in the avian embryo

Nataf, V., Amemiya, A., Yanagisawa, M. & Le Douarin, N. M., May 1 1998, In : Mechanisms of Development. 73, 2, p. 217-220 4 p.

Research output: Contribution to journalArticle

48 Scopus citations

The endothelin system: A new target for therapeutic intervention

Yanagisawa, M., Jan 1 1994, In : Circulation. 89, 3, p. 1320-1322 3 p.

Research output: Contribution to journalEditorial

Open Access
183 Scopus citations

The embryo makes red blood cell progenitors in every tissue simultaneously with blood vessel morphogenesis

Sequeira Lopez, M. L. S., Cherñavvsky, D. R., Nomasa, T., Wall, L., Yanagisawa, M. & Gomez, R. A., Apr 1 2003, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 284, 4 53-4, p. R1126-R1137

Research output: Contribution to journalArticle

44 Scopus citations

The dorsomedial hypothalamic nucleus as a putative food-entrainable circadian pacemaker

Mieda, M., Williams, S. C., Richardson, J. A., Tanaka, K. & Yanagisawa, M., Aug 8 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 32, p. 12150-12155 6 p.

Research output: Contribution to journalArticle

218 Scopus citations

The development of hypocretin (OREXIN) deficiency in hypocretin/ataxin-3 transgenic rats

Zhang, S., Lin, L., Kaur, S., Thankachan, S., Blanco-Centurion, C., Yanagisawa, M., Mignot, E. & Shiromani, P. J., Aug 10 2007, In : Neuroscience. 148, 1, p. 34-43 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

T cells upon activation promote endothelin 1 production in monocytes via IFN-γ and TNF-α

Shinagawa, S., Okazaki, T., Ikeda, M., Yudoh, K., Kisanuki, Y. Y., Yanagisawa, M., Kawahata, K. & Ozaki, S., Dec 1 2017, In : Scientific Reports. 7, 1, 14500.

Research output: Contribution to journalArticle

4 Scopus citations

Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice

Hosoda, K., Hammer, R. E., Richardson, J. A., Baynash, A. G., Cheung, J. C., Giaid, A. & Yanagisawa, M., Dec 30 1994, In : Cell. 79, 7, p. 1267-1276 10 p.

Research output: Contribution to journalArticle

830 Scopus citations

TaqI polymorphism at the human preproendothelin-1 gene (EDN1)

Watanabe, M., Yanagisawa, M., Hamaguchi, H., Kanazawa, I. & Masaki, T., Sep 25 1991, In : Nucleic acids research. 19, 18, 1 p.

Research output: Contribution to journalArticle

3 Scopus citations