• 72581 Citations
  • 120 h-Index
1984 …2020

Research output per year

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Research Output

Article

Ablation of 3-phosphoinositide-dependent protein kinase 1 (PDK1) in vascular endothelial cells enhances insulin sensitivity by reducing visceral fat and suppressing angiogenesis

Tawaramoto, K., Kotani, K., Hashiramoto, M., Kanda, Y., Nagare, T., Sakaue, H., Ogawa, W., Emoto, N., Yanagisawa, M., Noda, T., Kasuga, M. & Kaku, K., Jan 2012, In : Molecular Endocrinology. 26, 1, p. 95-109 15 p.

Research output: Contribution to journalArticle

6 Scopus citations

Ablation of central serotonergic neurons decreased REM sleep and attenuated arousal response

Iwasaki, K., Komiya, H., Kakizaki, M., Miyoshi, C., Abe, M., Sakimura, K., Funato, H. & Yanagisawa, M., Aug 7 2018, In : Frontiers in Neuroscience. 12, AUG, 535.

Research output: Contribution to journalArticle

8 Scopus citations

Abnormal response of melanin-concentrating hormone deficient mice to fasting: Hyperactivity and rapid eye movement sleep suppression

Willie, J. T., Sinton, C. M., Maratos-Flier, E. & Yanagisawa, M., Oct 28 2008, In : Neuroscience. 156, 4, p. 819-829 11 p.

Research output: Contribution to journalArticle

104 Scopus citations

Acid regulation of NaDC-1 requires a functional endothelin B receptor

Liu, L., Zacchia, M., Tian, X., Wan, L., Sakamoto, A., Yanagisawa, M., Alpern, R. J. & Preisig, P. A., Nov 2010, In : Kidney international. 78, 9, p. 895-904 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

A consensus sequence in the endothelin-B receptor second intracellular loop is required for NHE3 activation by endothelin-1

Laghmani, K., Sakamoto, A., Yanagisawa, M., Preisig, P. A. & Alpern, R. J., Apr 1 2005, In : American Journal of Physiology - Renal Physiology. 288, 4 57-4, p. F732-F739

Research output: Contribution to journalArticle

11 Scopus citations

Activation of peroxisome proliferator-activated receptor δ induces fatty acid β-oxidation in skeletal muscle and attenuates metabolic syndrome

Tanaka, T., Yamamoto, J., Iwasaki, S., Asaba, H., Hamura, H., Ikeda, Y., Watanabe, M., Magoori, K., Ioka, R. X., Tachibana, K., Watanabe, Y., Uchiyama, Y., Sumi, K., Iguchi, H., Ito, S., Doi, T., Hamakubo, T., Naito, M., Auwerx, J., Yanagisawa, M. & 2 others, Kodama, T. & Sakai, J., Dec 23 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 26, p. 15924-15929 6 p.

Research output: Contribution to journalArticle

657 Scopus citations

Acute pressor response to psychosocial stress is dependent on endothelium-derived endothelin-1

Fox, B. M., Becker, B. K., Loria, A. S., Hyndman, K. A., Jin, C., Clark, H., Johns, R., Yanagisawa, M., Pollock, D. M. & Pollock, J. S., Feb 1 2018, In : Journal of the American Heart Association. 7, 4, e007863.

Research output: Contribution to journalArticle

5 Scopus citations

A discrete neuronal circuit induces a hibernation-like state in rodents

Takahashi, T. M., Sunagawa, G. A., Soya, S., Abe, M., Sakurai, K., Ishikawa, K., Yanagisawa, M., Hama, H., Hasegawa, E., Miyawaki, A., Sakimura, K., Takahashi, M. & Sakurai, T., Jul 2 2020, In : Nature. 583, 7814, p. 109-114 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Affinity labelling of endothelin receptor and characterization of solubilized endothelin–endothelin‐receptor complex

Miyazaki, H., Kondoh, M., Watanabe, H., Masuda, Y., Murakami, K., Takahashi, M., Yanagisawa, M., Kimura, S., Goto, K. & Masaki, T., Jan 1990, In : European Journal of Biochemistry. 187, 1, p. 125-129 5 p.

Research output: Contribution to journalArticle

19 Scopus citations

Age- and sex-related variation of plasma endothelin-1 concentration in normal and hypertensive subjects

Miyauchi, T., Yanagisawa, M., Iida, K., Ajisaka, R., Suzuki, N., Fujino, M., Goto, K., Masaki, T. & Sugishita, Y., Apr 1992, In : American heart journal. 123, 4 PART 1, p. 1092-1093 2 p.

Research output: Contribution to journalArticle

119 Scopus citations

Age-related insulin resistance in hypothalamus and peripheral tissues of orexin knockout mice

Tsuneki, H., Murata, S., Anzawa, Y., Soeda, Y., Tokai, E., Wada, T., Kimura, I., Yanagisawa, M., Sakurai, T. & Sasaoka, T., Apr 1 2008, In : Diabetologia. 51, 4, p. 657-667 11 p.

Research output: Contribution to journalArticle

87 Scopus citations

A Krüppel-like factor KLF15 Contributes Fasting-induced Transcriptional Activation of Mitochondrial Acetyl-CoA Synthetase Gene AceCS2

Yamamoto, J., Ikeda, Y., Iguchi, H., Fujino, T., Tanaka, T., Asaba, H., Iwasaki, S., Ioka, R. X., Kaneko, I. W., Magoori, K., Takahashi, S., Mori, T., Sakaue, H., Kodama, T., Yanagisawa, M., Yamamoto, T. T., Ito, S. & Sakai, J., Apr 23 2004, In : Journal of Biological Chemistry. 279, 17, p. 16954-16962 9 p.

Research output: Contribution to journalArticle

59 Scopus citations

A missense mutation of the endothelin-B receptor gene in multigenic hirschsprung's disease

Puffenberger, E. G., Hosoda, K., Washington, S. S., Nakao, K., deWit, D., Yanagisawa, M. & Chakravarti, A., Dec 30 1994, In : Cell. 79, 7, p. 1257-1266 10 p.

Research output: Contribution to journalArticle

734 Scopus citations

An adenosine-mediated glial-neuronal circuit for homeostatic sleep

Bjorness, T., Dale, N., Mettlach, G., Sonneborn, A., Sahin, B., Fienberg, A. A., Yanagisawa, M., Bibb, J. A. & Greene, R., Mar 30 2016, In : Journal of Neuroscience. 36, 13, p. 3709-3721 13 p.

Research output: Contribution to journalArticle

41 Scopus citations

Analysis of big endothelin-1 digestion by cathepsin D

Sawamura, T., Shinmi, O., Kishi, N., Sugita, Y., Yanagisawa, M., Goto, K., Masaki, T. & Kimura, S., Oct 30 1990, In : Biochemical and Biophysical Research Communications. 172, 2, p. 883-889 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

Analysis of C5a receptor by monoclonal antibody

Watanabe, H., Kuraya, M., Kasukawa, R., Yanagisawa, H., Yanagisawa, M. & Fujita, T., Sep 11 1995, In : Journal of Immunological Methods. 185, 1, p. 19-29 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Analysis of endothelin related peptides in culture supernatant of porcine aortic endothelial cells: Evidence for biosynthetic pathway of endothelin-1

Sawamura, T., Kimura, S., Shinmi, O., Sugita, Y., Yanagisawa, M. & Masaki, T., Aug 15 1989, In : Biochemical and Biophysical Research Communications. 162, 3, p. 1287-1294 8 p.

Research output: Contribution to journalArticle

84 Scopus citations

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs

Okazaki, Y., Furuno, M., Kasukawa, T., Adachi, J., Bono, H., Kondo, S., Nikaido, I., Osato, N., Saito, R., Suzuki, H., Yamanaka, I., Kiyosawa, H., Yagi, K., Tomaru, Y., Hasegawa, Y., Nogami, A., Schönbach, C., Gojobori, T., Baldarelli, R., Hill, D. P. & 117 others, Bult, C., Hume, D. A., Quackenbush, J., Schriml, L. M., Kanapin, A., Matsuda, H., Batalov, S., Beisel, K. W., Blake, J. A., Bradt, D., Brusic, V., Chothia, C., Corbani, L. E., Cousins, S., Dalla, E., Dragani, T. A., Fletcher, C. F., Forrest, A., Frazer, K. S., Gaasterland, T., Gariboldi, M., Gissi, C., Godzik, A., Gough, J., Grimmond, S., Gustincich, S., Hirokawa, N., Jackson, I. J., Jarvis, E. D., Kanai, A., Kawaji, H., Kawasawa, Y., Kedzierski, R. M., King, B. L., Konagaya, A., Kurochkin, I. V., Lee, Y., Lenhard, B., Lyons, P. A., Maglott, D. R., Maltais, L., Marchionni, L., McKenzie, L., Miki, H., Nagashima, T., Numata, K., Okido, T., Pavan, W. J., Pertea, G., Pesole, G., Petrovsky, N., Pillai, R., Pontius, J. U., Qi, D., Ramachandran, S., Ravasi, T., Reed, J. C., Reed, D. J., Reid, J., Ring, B. Z., Ringwald, M., Sandelin, A., Schneider, C., Semple, C. A. M., Setou, M., Shimada, K., Sultana, R., Takenaka, Y., Taylor, M. S., Teasdale, R. D., Tomita, M., Verardo, R., Wagner, L., Wahlestedt, C., Wang, Y., Watanabe, Y., Wells, C., Wilming, L. G., Wynshaw-Boris, A., Yanagisawa, M., Yang, I., Yang, L., Yuan, Z., Zavolan, M., Zhu, Y., Zimmer, A., Carninci, P., Hayatsu, N., Hirozane-Kishikawa, T., Konno, H., Nakamura, M., Sakazume, N., Sato, K., Shiraki, T., Waki, K., Kawai, J., Aizawa, K., Arakawa, T., Fukuda, S., Hara, A., Hashizume, W., Imotani, K., Ishii, Y., Itoh, M., Kagawa, I., Miyazaki, A., Sakai, K., Sasaki, D., Shibata, K., Shinagawa, A., Yasunishi, A., Yoshino, M., Waterston, R., Lander, E. S., Rogers, J., Birney, E. & Hayashizaki, Y., Dec 5 2002, In : Nature. 420, 6915, p. 563-573 11 p.

Research output: Contribution to journalArticle

1222 Scopus citations

Analysis of two pharmacologically predicted endothelin B receptor subtypes by using the endothelin B receptor gene knockout mouse

Mizuguchi, T., Nishiyama, M., Moroi, K., Tanaka, H., Saito, T., Masuda, Y., Masaki, T., De Wit, D., Yanagisawa, M. & Kimura, S., Jan 1 1997, In : British Journal of Pharmacology. 120, 8, p. 1427-1430 4 p.

Research output: Contribution to journalArticle

49 Scopus citations

Anatomical and electrophysiological development of the hypothalamic orexin neurons from embryos to neonates

Ogawa, Y., Kanda, T., Vogt, K. & Yanagisawa, M., Dec 15 2017, In : Journal of Comparative Neurology. 525, 18, p. 3809-3820 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

An autocrine role for endothelin-1 in the regulation of proximal tubule NHE3

Licht, C., Laghmani, K., Yanagisawa, M., Preisig, P. A. & Alpern, R. J., Apr 2004, In : Kidney international. 65, 4, p. 1320-1326 7 p.

Research output: Contribution to journalArticle

33 Scopus citations

An essential role for orexins in emergence from general anesthesia

Kelz, M. B., Sun, Y., Chen, J., Qing, C. M., Moore, J. T., Veasey, S. C., Dixon, S., Thornton, M., Funato, H. & Yanagisawa, M., Jan 29 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 4, p. 1309-1314 6 p.

Research output: Contribution to journalArticle

188 Scopus citations

A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice

Takayasu, S., Sakurai, T., Iwasaki, S., Teranishi, H., Yamanaka, A., Williams, S. C., Iguchi, H., Kawasawa, Y. I., Ikeda, Y., Sakakibara, I., Ohno, K., Ioka, R. X., Murakami, S., Dohmae, N., Xie, J., Suda, T., Motoike, T., Ohuchi, T., Yanagisawa, M. & Sakai, J., May 9 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 19, p. 7438-7443 6 p.

Research output: Contribution to journalArticle

112 Scopus citations

A new mouse model of GLUT1 deficiency syndrome exhibits abnormal sleep-wake patterns and alterations of glucose kinetics in the brain

Furuse, T., Mizuma, H., Hirose, Y., Kushida, T., Yamada, I., Miura, I., Masuya, H., Funato, H., Yanagisawa, M., Onoe, H. & Wakana, S., 2019, In : DMM Disease Models and Mechanisms. 12, 9, dmm038828.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Animals lacking endothelin-converting enzyme-2 are deficient in learning and memory

Rodriguiz, R. M., Gadnidze, K., Ragnauth, A., Dorr, N., Yanagisawa, M., Wetsel, W. C. & Devi, L. A., Jun 1 2008, In : Genes, Brain and Behavior. 7, 4, p. 418-426 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

An inverse agonist of the histamine H3 receptor improves wakefulness in narcolepsy: Studies in orexin-/- mice and patients

Lin, J. S., Dauvilliers, Y., Arnulf, I., Bastuji, H., Anaclet, C., Parmentier, R., Kocher, L., Yanagisawa, M., Lehert, P., Ligneau, X., Perrin, D., Robert, P., Roux, M., Lecomte, J. M. & Schwartz, J. C., Apr 1 2008, In : Neurobiology of Disease. 30, 1, p. 74-83 10 p.

Research output: Contribution to journalArticle

200 Scopus citations

A novel mouse model for de novo melanoma

Kumasaka, M. Y., Yajima, I., Hossain, K., Iida, M., Tsuzuki, T., Ohno, T., Takahashi, M., Yanagisawa, M. & Kato, M., Jan 1 2010, In : Cancer research. 70, 1, p. 24-29 6 p.

Research output: Contribution to journalArticle

23 Scopus citations

A novel peptide vasoconstrictor, endothelin, is produced by vascular endothelium and modulates smooth muscle ca2+channels

Yanagisawa, M., Kurihara, H., Kimura, S., Goto, K. & Masaki, T., Dec 1988, In : Journal of Hypertension, Supplement. 6, 4, p. s188-s191

Research output: Contribution to journalArticle

228 Scopus citations

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

Yanagisawa, M., Kurihara, H., Kimura, S., Tomobe, Y., Kobayashi, M., Mitsui, Y., Yazaki, Y., Goto, K. & Masaki, T., 1988, In : Nature. 332, 6163, p. 411-415 5 p.

Research output: Contribution to journalArticle

9764 Scopus citations

A novel rearrangement reaction of morphinan to arylmorphan skeletons and the pharmacologies of arylmorphan derivatives

Yata, M., Kutsumura, N., Nagumo, Y., Yamamoto, N., Saitoh, T., Ishikawa, Y., Irukayama-Tomobe, Y., Yanagisawa, M. & Nagase, H., Jan 1 2019, In : Heterocycles. p. 134-144 11 p.

Research output: Contribution to journalArticle

A novel vasoactive peptide endothelin stimulates mitogenesis through inositol lipid turnover in Swiss 3T3 fibroblasts

Takuwa, N., Takuwa, Y., Yanagisawa, M., Yamashita, K. & Masaki, T., Jan 1 1989, In : Journal of Biological Chemistry. 264, 14, p. 7856-7861 6 p.

Research output: Contribution to journalArticle

425 Scopus citations

A pertussis toxin‐sensitive mechanism of endothelin action in porcine coronary artery smooth muscle

Kasuya, Y., Takuwa, Y., Yanagisawa, M., Masaki, T. & Goto, K., Oct 1992, In : British Journal of Pharmacology. 107, 2, p. 456-462 7 p.

Research output: Contribution to journalArticle

36 Scopus citations

Arginine-vasopressin increases the release of ET-1 into perfusate of rat mesenteric artery

Tomobe, Y., Yanagisawa, M., Fujimori, A., Masaki, T. & Goto, K., Mar 15 1993, In : Biochemical and Biophysical Research Communications. 191, 2, p. 654-661 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B

Irukayama-Tomobe, Y., Tanaka, H., Yokomizo, T., Hashidate-Yoshida, T., Yanagisawa, M. & Sakurai, T., Mar 10 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 10, p. 3930-3934 5 p.

Research output: Contribution to journalArticle

38 Scopus citations

Arterial pressure response to endothelin-1 and sarafotoxin 6c in rescued endothelin-B-deficient rats

Pollock, D. M., Portik-Dobos, V., Procter, C., Gariepy, C. E. & Yanagisawa, M., Jan 1 2000, In : Journal of Cardiovascular Pharmacology. 36, 5 SUPPL. 1, p. S82-S85

Research output: Contribution to journalArticle

13 Scopus citations

A single phosphorylation site of SIK3 regulates daily sleep amounts and sleep need in mice

Honda, T., Fujiyama, T., Miyoshi, C., Ikkyu, A., Hotta-Hirashima, N., Kanno, S., Mizuno, S., Sugiyama, F., Takahashi, S., Funato, H. & Yanagisawa, M., Oct 9 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 41, p. 10458-10463 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Attenuated cold defense responses in orexin neuron-ablated rats

Mohammed, M., Yanagisawa, M., Blessing, W. & Ootsuka, Y., Jul 2 2016, In : Temperature. 3, 3, p. 465-475 11 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Attenuated defense response and low basal blood pressure in orexin knockout mice

Kayaba, Y., Nakamura, A., Kasuya, Y., Ohuchi, T., Yanagisawa, M., Komuro, I., Fukuda, Y. & Kuwaki, T., Sep 1 2003, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 285, 3 54-3, p. R581-R593

Research output: Contribution to journalArticle

266 Scopus citations

Autoradiographic distribution in rat tissues of binding sites for endothelin: A neuropeptide?

Koseki, C., Imai, M., Hirata, Y., Yanagisawa, M. & Masaki, T., Jan 1 1989, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 256, 4, p. 25/4

Research output: Contribution to journalArticle

362 Scopus citations

Autoradiographic localization of [125I]-endothelin-1 binding sites in rat brain

Koseki, C., Imai, M., Hirata, Y., Yanagisawa, M. & Masaki, T., Aug 1989, In : Neuroscience Research. 6, 6, p. 581-585 5 p.

Research output: Contribution to journalArticle

41 Scopus citations

Autoregulation of endothelin-1 secretion by cultured human keratinocytes via the endothelin B receptor

Yohn, J. J., Smith, C., Stevens, T., Morelli, J. G., Shurnas, L. R., Walchak, S. J., Hoffman, T. A., Kelley, K. K., Escobedo-Morse, A., Yanagisawa, M., Kane, M. A. & Zamora, M. R., Dec 30 1994, In : BBA - Molecular Cell Research. 1224, 3, p. 454-458 5 p.

Research output: Contribution to journalArticle

23 Scopus citations
33 Scopus citations

Behavioral state instability in orexin knockout mice

Scammell, T. E., Crocker, A., McCormack, S., Yanagisawa, M., Sakurai, T. & Mochizuki, T., May 1 2004, In : Sleep and Biological Rhythms. 2, SUPPL. 1, p. S13-S14

Research output: Contribution to journalArticle

1 Scopus citations

Behavioral state instability in orexin knock-out mice

Mochizuki, T., Crocker, A., McCormack, S., Yanagisawa, M., Sakurai, T. & Scammell, T. E., Jul 14 2004, In : Journal of Neuroscience. 24, 28, p. 6291-6300 10 p.

Research output: Contribution to journalArticle

269 Scopus citations

Binding and receptor down-regulation of a novel vasoconstrictor endothelin in cultured rat vascular smooth muscle cells

Hirata, Y., Yoshimi, H., Takaichi, S., Yanagisawa, M. & Masaki, T., Oct 24 1988, In : FEBS Letters. 239, 1, p. 13-17 5 p.

Research output: Contribution to journalArticle

211 Scopus citations

Binding sites for endothelin-1 in rat tissues: An autoradiographic study

Koseki, C., Imai, M., Hirata, Y., Yanagisawa, M. & Masaki, T., 1989, In : Journal of Cardiovascular Pharmacology. 13, p. S153-S154

Research output: Contribution to journalArticle

51 Scopus citations

Blood pressure of endothelin-3 null (-/-) knockout mice and endothelin A receptor null (-/-) knockout mice under anaesthesia

Kuwaki, T., Ishii, T., Ju, K., Yanagisawa, M. & Fukuda, Y., Aug 1 2002, In : Clinical science. 103, SUPPL. 48, p. 48S-52S

Research output: Contribution to journalArticle

11 Scopus citations

Cardiac-specific knockout of ET A receptor mitigates low ambient temperature-induced cardiac hypertrophy and contractile dysfunction

Zhang, Y., Li, L., Hua, Y., Nunn, J. M., Dong, F., Yanagisawa, M. & Ren, J., Apr 1 2012, In : Journal of molecular cell biology. 4, 2, p. 97-107 11 p.

Research output: Contribution to journalArticle

36 Scopus citations

Cardiomyocyte-specific deletion of endothelin receptor A rescues aging-associated cardiac hypertrophy and contractile dysfunction: Role of autophagy

Ceylan-Isik, A. F., Dong, M., Zhang, Y., Dong, F., Turdi, S., Nair, S., Yanagisawa, M. & Ren, J., Jan 1 2013, In : Basic Research in Cardiology. 108, 2, 335.

Research output: Contribution to journalArticle

44 Scopus citations

Cardiomyocyte-Specific Endothelin A Receptor Knockout Mice Have Normal Cardiac Function and an Unaltered Hypertrophic Response to Angiotensin II and Isoproterenol

Kedzierski, R. M., Grayburn, P. A., Kisanuki, Y. Y., Williams, C. S., Hammer, R. E., Richardson, J. A., Schneider, M. D. & Yanagisawa, M., Nov 1 2003, In : Molecular and cellular biology. 23, 22, p. 8226-8232 7 p.

Research output: Contribution to journalArticle

63 Scopus citations