• 71749 Citations
  • 119 h-Index
1984 …2019

Research output per year

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Research Output

2015

GABAA receptor-mediated input change on orexin neurons following sleep deprivation in mice

Matsuki, T., Takasu, M., Hirose, Y., Murakoshi, N., Sinton, C. M., Motoike, T. & Yanagisawa, M., Dec 1 2015, In : Neuroscience. 284, p. 217-224 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Hypothalamic orexin prevents hepatic insulin resistance via daily bidirectional regulation of autonomic nervous system in mice

Tsuneki, H., Tokai, E., Nakamura, Y., Takahashi, K., Fujita, M., Asaoka, T., Kon, K., Anzawa, Y., Wada, T., Takasaki, I., Kimura, K., Inoue, H., Yanagisawa, M., Sakurai, T. & Sasaoka, T., Feb 1 2015, In : Diabetes. 64, 2, p. 459-470 12 p.

Research output: Contribution to journalArticle

33 Scopus citations

Monitoring β-arrestin recruitment via β-lactamase enzyme fragment complementation: Purification of peptide E as a low-affinity ligand for mammalian bombesin receptors

Ikeda, Y., Kumagai, H., Okazaki, H., Fujishiro, M., Motozawa, Y., Nomura, S., Takeda, N., Toko, H., Takimoto, E., Akazawa, H., Morita, H., Suzuki, J. I., Yamazaki, T., Komuro, I. & Yanagisawa, M., Jun 1 2015, In : PLoS One. 10, 6, e0127445.

Research output: Contribution to journalArticle

5 Scopus citations

Neuromedin s-producing neurons act as essential pacemakers in the suprachiasmatic nucleus to couple clock neurons and dictate circadian rhythms

Lee, I. T., Chang, A. S., Manandhar, M., Shan, Y., Fan, J., Izumo, M., Ikeda, Y., Motoike, T., Dixon, S., Seinfeld, J. E., Takahashi, J. S. & Yanagisawa, M., Mar 4 2015, In : Neuron. 85, 5, p. 1086-1102 17 p.

Research output: Contribution to journalArticle

69 Scopus citations

Quantitative measurement of GPCR endocytosis via pulse-chase covalent labeling

Kumagai, H., Ikeda, Y., Motozawa, Y., Fujishiro, M., Okamura, T., Fujio, K., Okazaki, H., Nomura, S., Takeda, N., Harada, M., Toko, H., Takimoto, E., Akazawa, H., Morita, H., Suzuki, J. I., Yamazaki, T., Yamamoto, K., Komuro, I. & Yanagisawa, M., May 28 2015, In : PLoS One. 10, 5, e0129394.

Research output: Contribution to journalArticle

3 Scopus citations

Transient expression of neuropeptide W in postnatal mouse hypothalamus - A putative regulator of energy homeostasis

Motoike, T., Skach, A. G., Godwin, J. K., Sinton, C. M., Yamazaki, M., Abe, M., Natsume, R., Sakimura, K. & Yanagisawa, M., Aug 1 2015, In : Neuroscience. 301, p. 323-337 15 p.

Research output: Contribution to journalArticle

6 Scopus citations
2014

25 Years of endothelin research: The next generation

Emoto, N., Vignon-Zellweger, N., Lopes, R. A. M., Cacioppo, J., Desbiens, L., Kamato, D., Leurgans, T., Moorhouse, R., Straube, J., Wurm, R., Heiden, S., Ergul, A., Yanagisawa, M. & Barton, M., Nov 24 2014, In : Life Sciences. 118, 2, p. 77-86 10 p.

Research output: Contribution to journalReview article

5 Scopus citations

Correction to Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer's disease [The Journal of Experimental Medicine, 211, 13, (2014), 2487-2496]

Roh, J. H., Jiang, H., Finn, M. B., Stewart, F. R., Mahan, T. E., Cirrito, J. R., Heda, A., Joy Snider, B., Li, M., Yanagisawa, M., de Lecea, L. & Holtzman, D. M., Jan 1 2014, In : Journal of Experimental Medicine. 211, 13, p. 2487-2496 10 p.

Research output: Contribution to journalComment/debate

81 Scopus citations

Direct action of endothelin-1 on podocytes promotes diabetic glomerulosclerosis

Lenoir, O., Milon, M., Virsolvy, A., Hénique, C., Schmitt, A., Massé, J. M., Kotelevtsev, Y., Yanagisawa, M., Webb, D. J., Richard, S. & Tharaux, P. L., May 1 2014, In : Journal of the American Society of Nephrology. 25, 5, p. 1050-1062 13 p.

Research output: Contribution to journalArticle

47 Scopus citations

Endothelin XIII

Emoto, N., Masaki, T., Goto, K., Vanhoutte, P. M. & Yanagisawa, M., Nov 24 2014, In : Life Sciences. 118, 2, p. 47-50 4 p.

Research output: Contribution to journalEditorial

3 Scopus citations

Essential role of sympathetic endothelin A receptors for adverse cardiac remodeling

Lehmann, L. H., Rostosky, J. S., Buss, S. J., Kreusser, M. M., Krebs, J., Mier, W., Enseleit, F., Spiger, K., Hardt, S. E., Wieland, T., Haass, M., Lüscher, T. F., Schneider, M. D., Parlato, R., Gröne, H. J., Haberkorn, U., Yanagisawa, M., Katus, H. A. & Backs, J., Sep 16 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 37, p. 13499-13504 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Knockout of endothelial cell-derived endothelin-1 attenuates skin fibrosis but accelerates cutaneous wound healing

Makino, K., Jinnin, M., Aoi, J., Kajihara, I., Makino, T., Fukushima, S., Sakai, K., Nakayama, K., Emoto, N., Yanagisawa, M. & Ihn, H., May 22 2014, In : PloS one. 9, 5, e97972.

Research output: Contribution to journalArticle

16 Scopus citations

Loss of function of endothelin-2 leads to reduced ovulation and CL formation

Cacioppo, J. A., Oh, S. W., Kim, H. Y., Cho, J., Lin, P. C. P., Yanagisawa, M. & Ko, C., Apr 24 2014, In : PloS one. 9, 4, e96115.

Research output: Contribution to journalArticle

16 Scopus citations

Orexin/hypocretin activates mTOR complex 1 (mTORC1) via an Erk/Akt-independent and calcium-stimulated lysosome v-ATPase pathway

Wang, Z., Liu, S., Kakizaki, M., Hirose, Y., Ishikawa, Y., Funato, H., Yanagisawa, M., Yu, Y. & Liu, Q., Nov 14 2014, In : Journal of Biological Chemistry. 289, 46, p. 31950-31959 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Orexin neurons suppress narcolepsy via 2 distinct efferent pathways

Hasegawa, E., Yanagisawa, M., Sakurai, T. & Mieda, M., Feb 3 2014, In : Journal of Clinical Investigation. 124, 2, p. 604-616 13 p.

Research output: Contribution to journalArticle

87 Scopus citations

Orexin regulates bone remodeling via a dominant positive central action and a subordinate negative peripheral action

Wei, W., Motoike, T., Krzeszinski, J. Y., Jin, Z., Xie, X-J., Dechow, P. C., Yanagisawa, M. & Wan, Y., Jun 3 2014, In : Cell Metabolism. 19, 6, p. 927-940 14 p.

Research output: Contribution to journalArticle

15 Scopus citations
20 Scopus citations

The second tomoh masaki award (2013)

Emoto, N., Kasuya, Y. & Yanagisawa, M., Nov 24 2014, In : Life Sciences. 118, 2, p. 87-90 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

The thirteenth international conference on endothelin (ET-13), Tokyo, 2013

Emoto, N. & Yanagisawa, M., Nov 24 2014, In : Life Sciences. 118, 2, p. 70-76 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Vascular endothelium derived endothelin-1 is required for normal heart function after chronic pressure overload in mice

Heiden, S., Vignon-Zellweger, N., Masuda, S., Yagi, K., Nakayama, K., Yanagisawa, M. & Emoto, N., Feb 11 2014, In : PloS one. 9, 2, e88730.

Research output: Contribution to journalArticle

15 Scopus citations
2013
29 Scopus citations

Cardiomyocyte-specific deletion of endothelin receptor A rescues aging-associated cardiac hypertrophy and contractile dysfunction: Role of autophagy

Ceylan-Isik, A. F., Dong, M., Zhang, Y., Dong, F., Turdi, S., Nair, S., Yanagisawa, M. & Ren, J., Jan 1 2013, In : Basic Research in Cardiology. 108, 2, 335.

Research output: Contribution to journalArticle

41 Scopus citations

Differential actions of orexin receptors in brainstem cholinergic and monoaminergic neurons revealed by receptor knockouts: Implications for orexinergic signaling in arousal and narcolepsy

Kohlmeier, K. A., Tyler, C. J., Kalogiannis, M., Ishibashi, M., Kristensen, M. P., Gumenchuk, I., Chemelli, R. M., Kisanuki, Y. Y., Yanagisawa, M. & Leonard, C. S., Jan 1 2013, In : Frontiers in Neuroscience. 7 DEC, 246.

Research output: Contribution to journalArticle

35 Scopus citations

Dysregulation of Protease and Protease Inhibitors in a Mouse Model of Human Pelvic Organ Prolapse

Budatha, M., Silva, S., Montoya, T. I., Suzuki, A., Shah-Simpson, S., Wieslander, C. K., Yanagisawa, M., Word, R. A. & Yanagisawa, H., Feb 20 2013, In : PloS one. 8, 2, e56376.

Research output: Contribution to journalArticle

14 Scopus citations

Endothelin-1 is a transcriptional target of p53 in epidermal keratinocytes and regulates ultraviolet-induced melanocyte homeostasis

Hyter, S., Coleman, D. J., Ganguli-Indra, G., Merrill, G. F., Ma, S., Yanagisawa, M. & Indra, A. K., Mar 1 2013, In : Pigment Cell and Melanoma Research. 26, 2, p. 247-258 12 p.

Research output: Contribution to journalArticle

29 Scopus citations

Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice

Chang, I., Bramall, A. N., Baynash, A. G., Rattner, A., Rakheja, D., Post, M., Joza, S., McKerlie, C., Stewart, D. J., McInnes, R. R. & Yanagisawa, M., Jun 3 2013, In : Journal of Clinical Investigation. 123, 6, p. 2643-2653 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Endothelin-2-Mediated Protection of Mutant Photoreceptors in Inherited Photoreceptor Degeneration

Bramall, A. N., Szego, M. J., Pacione, L. R., Chang, I., Diez, E., D'Orleans-Juste, P., Stewart, D. J., Hauswirth, W. W., Yanagisawa, M. & McInnes, R. R., Feb 28 2013, In : PloS one. 8, 2, e58023.

Research output: Contribution to journalArticle

15 Scopus citations

Modulation of circadian glucocorticoid oscillation via adrenal Opioid-CXCR7 Signaling alters emotional behavior

Ikeda, Y., Kumagai, H., Skach, A., Sato, M. & Yanagisawa, M., Dec 5 2013, In : Cell. 155, 6, p. 1323-1336 14 p.

Research output: Contribution to journalArticle

46 Scopus citations

Neurotensin Co-Expressed in Orexin-Producing Neurons in the Lateral Hypothalamus Plays an Important Role in Regulation of Sleep/Wakefulness States

Furutani, N., Hondo, M., Kageyama, H., Tsujino, N., Mieda, M., Yanagisawa, M., Shioda, S. & Sakurai, T., Apr 19 2013, In : PloS one. 8, 4, e62391.

Research output: Contribution to journalArticle

49 Scopus citations

Olfactory receptor responding to gut microbiotaderived signals plays a role in renin secretion and blood pressure regulation

Pluznick, J. L., Protzko, R. J., Gevorgyan, H., Peterlin, Z., Sipos, A., Han, J., Brunet, I., Wan, L. X., Rey, F., Wang, T., Firestein, S. J., Yanagisawa, M., Gordon, J. I., Eichmann, A., Peti-Peterdi, J. & Caplan, M. J., Mar 12 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 11, p. 4410-4415 6 p.

Research output: Contribution to journalArticle

380 Scopus citations

Orexin receptor-1 in the locus coeruleus plays an important role in cue-dependent fear memory consolidation

Soya, S., Shoji, H., Hasegawa, E., Hondo, M., Miyakawa, T., Yanagisawa, M., Mieda, M. & Sakurai, T., Sep 9 2013, In : Journal of Neuroscience. 33, 36, p. 14549-14557 9 p.

Research output: Contribution to journalArticle

58 Scopus citations

Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice

Kim, M. H., Kang, S. G., Park, J. H., Yanagisawa, M. & Kim, C. H., Aug 2013, In : Gastroenterology. 145, 2, p. 396-406.e10

Research output: Contribution to journalArticle

278 Scopus citations
2012

Ablation of 3-phosphoinositide-dependent protein kinase 1 (PDK1) in vascular endothelial cells enhances insulin sensitivity by reducing visceral fat and suppressing angiogenesis

Tawaramoto, K., Kotani, K., Hashiramoto, M., Kanda, Y., Nagare, T., Sakaue, H., Ogawa, W., Emoto, N., Yanagisawa, M., Noda, T., Kasuga, M. & Kaku, K., Jan 1 2012, In : Molecular Endocrinology. 26, 1, p. 95-109 15 p.

Research output: Contribution to journalArticle

6 Scopus citations

Cardiac-specific knockout of ET A receptor mitigates low ambient temperature-induced cardiac hypertrophy and contractile dysfunction

Zhang, Y., Li, L., Hua, Y., Nunn, J. M., Dong, F., Yanagisawa, M. & Ren, J., Apr 1 2012, In : Journal of molecular cell biology. 4, 2, p. 97-107 11 p.

Research output: Contribution to journalArticle

36 Scopus citations

Endothelin B receptor is not required but necessary for finite regulation of ovulation

Cho, J., Kim, H., Kang, D. W., Yanagisawa, M. & Ko, C., Oct 15 2012, In : Life Sciences. 91, 13-14, p. 613-617 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Endothelin XII

Barton, M., Yanagisawa, M., Vanhoutte, P. M. & Masaki, T., Oct 15 2012, In : Life Sciences. 91, 13-14, p. 449-451 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

ET-1 from endothelial cells is required for complete angiotensin II-induced cardiac fibrosis and hypertrophy

Adiarto, S., Heiden, S., Vignon-Zellweger, N., Nakayama, K., Yagi, K., Yanagisawa, M. & Emoto, N., Oct 15 2012, In : Life Sciences. 91, 13-14, p. 651-657 7 p.

Research output: Contribution to journalArticle

38 Scopus citations
2011

Cholinergic modulation of narcoleptic attacks in double orexin receptor knockout mice

Kalogiannis, M., Hsu, E., Willie, J. T., Chemelli, R. M., Kisanuki, Y. Y., Yanagisawa, M. & Leonard, C. S., Apr 22 2011, In : PloS one. 6, 4, e18697.

Research output: Contribution to journalArticle

34 Scopus citations

Critical role of neuropeptides B/W receptor 1 signaling in social behavior and fear memory

Nagata-Kuroiwa, R., Furutani, N., Hara, J., Hondo, M., Ishii, M., Abe, T., Mieda, M., Tsujino, N., Motoike, T., Yanagawa, Y., Kuwaki, T., Yamamoto, M., Yanagisawa, M. & Sakurai, T., Mar 4 2011, In : PloS one. 6, 2, e16972.

Research output: Contribution to journalArticle

19 Scopus citations

Decreased intake of sucrose solutions in orexin knockout mice

Matsuo, E., Mochizuki, A., Nakayama, K., Nakamura, S., Yamamoto, T., Shioda, S., Sakurai, T., Yanagisawa, M., Shiuchi, T., Minokoshi, Y. & Inoue, T., Feb 1 2011, In : Journal of Molecular Neuroscience. 43, 2, p. 217-224 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Differential roles of orexin receptor-1 and -2 in the regulation of Non-REM and REM sleep

Mieda, M., Hasegawa, E., Kisanuki, Y. Y., Sinton, C. M., Yanagisawa, M. & Sakurai, T., Apr 27 2011, In : Journal of Neuroscience. 31, 17, p. 6518-6526 9 p.

Research output: Contribution to journalArticle

145 Scopus citations

Ectopic overexpression of orexin alters sleep/wakefulness states and muscle tone regulation during REM sleep in mice

Willie, J. T., Takahira, H., Shibahara, M., Hara, J., Nomiyama, M., Yanagisawa, M. & Sakurai, T., Feb 1 2011, In : Journal of Molecular Neuroscience. 43, 2, p. 155-161 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

Hypothalamic orexin system: From orphan GPCR to therapeutic target

Yanagisawa, M., Jul 1 2011, In : Experimental Animals. 60, SUPPL. 3, 1 p.

Research output: Contribution to journalArticle

2 Scopus citations

Orexin gene transfer into zona incerta neurons suppresses muscle paralysis in narcoleptic mice

Liu, M., Blanco-Centurion, C., Konadhode, R., Begum, S., Pelluru, D., Gerashchenko, D., Sakurai, T., Yanagisawa, M., van den Pol, A. N. & Shiromani, P. J., Apr 20 2011, In : Journal of Neuroscience. 31, 16, p. 6028-6040 13 p.

Research output: Contribution to journalArticle

53 Scopus citations

Partial requirement of endothelin receptor B in spiral ganglion neurons for postnatal development of hearing

Ida-Eto, M., Ohgami, N., Iida, M., Yajima, I., Kumasaka, M. Y., Takaiwa, K., Kimitsuki, T., Sone, M., Nakashima, T., Tsuzuki, T., Komune, S., Yanagisawa, M. & Kato, M., Aug 26 2011, In : Journal of Biological Chemistry. 286, 34, p. 29621-29626 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Regulation of postnatal trabecular bone formation by the osteoblast endothelin A receptor

Clines, G. A., Mohammad, K. S., Grunda, J. M., Clines, K. L., Niewolna, M., McKenna, C. R., McKibbin, C. R., Yanagisawa, M., Suva, L. J., Chirgwin, J. M. & Guise, T. A., Oct 1 2011, In : Journal of Bone and Mineral Research. 26, 10, p. 2523-2536 14 p.

Research output: Contribution to journalArticle

23 Scopus citations
2010

Acid regulation of NaDC-1 requires a functional endothelin B receptor

Liu, L., Zacchia, M., Tian, X., Wan, L., Sakamoto, A., Yanagisawa, M., Alpern, R. J. & Preisig, P. A., Nov 2010, In : Kidney international. 78, 9, p. 895-904 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

A novel mouse model for de novo melanoma

Kumasaka, M. Y., Yajima, I., Hossain, K., Iida, M., Tsuzuki, T., Ohno, T., Takahashi, M., Yanagisawa, M. & Kato, M., Jan 1 2010, In : Cancer Research. 70, 1, p. 24-29 6 p.

Research output: Contribution to journalArticle

20 Scopus citations

Dissecting the functional significance of endothelin A receptors in peripheral nociceptors in vivo via conditional gene deletion

Stösser, S., Agarwal, N., Tappe-Theodor, A., Yanagisawa, M. & Kuner, R., Feb 1 2010, In : Pain. 148, 2, p. 206-214 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Endothelial cell-derived endothelin-1 promotes cardiac fibrosis in diabetic hearts through stimulation of endothelial-to-mesenchymal transition

Widyantoro, B., Emoto, N., Nakayama, K., Anggrahini, D. W., Adiarto, S., Iwasa, N., Yagi, K., Miyagawa, K., Rikitake, Y., Suzuki, T., Kisanuki, Y. Y., Yanagisawa, M. & Hirata, K. I., Jun 8 2010, In : Circulation. 121, 22, p. 2407-2418 12 p.

Research output: Contribution to journalArticle

231 Scopus citations