• 71419 Citations
  • 119 h-Index
1984 …2019

Research output per year

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Research Output

  • 71419 Citations
  • 119 h-Index
  • 451 Article
  • 3 Chapter
  • 3 Conference contribution
2005

Deletion of the endothelin-A receptor gene within the developing mandible

Ruest, L. B., Kedzierski, R., Yanagisawa, M. & Clouthier, D. E., Mar 2005, In : Cell and Tissue Research. 319, 3, p. 447-453 7 p.

Research output: Contribution to journalArticle

20 Scopus citations
141 Scopus citations

Different contributions of endothelin-A and endothelin-B receptors in postischemic cardiac dysfunction and norepinephrine overflow in rat hearts

Yamamoto, S., Matsumoto, N., Kanazawa, M., Fujita, M., Takaoka, M., Gariepy, C. E., Yanagisawa, M. & Matsumura, Y., Jan 25 2005, In : Circulation. 111, 3, p. 302-309 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

Endothelin B receptor-deficient mice develop endothelial dysfunction independently of salt loading

Quaschning, T., Rebhan, B., Wunderlich, C., Wanner, C., Richter, C. M., Pfab, T., Bauer, C., Kraemer-Guth, A., Galle, J., Yanagisawa, M. & Hocher, B., May 2005, In : Journal of Hypertension. 23, 5, p. 979-985 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

Erratum: Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice (Neuron (April 21, 2005) 46 (297-308) PII: S0896-6273(05)00205-9 and DOI: 10.1016/j.neuron.2005.03.010)

Sakurai, T., Nagata, R., Yamanaka, A., Kawamura, H., Tsujino, N., Muraki, Y., Kageyama, H., Kunita, S., Takahashi, S., Goto, K., Koyama, Y., Shioda, S. & Yanagisawa, M., Jun 2 2005, In : Neuron. 46, 5, p. 837 1 p.

Research output: Contribution to journalArticle

Extrarenal ETB plays a significant role in controlling cardiovascular responses to high dietary sodium in rats

Ohkita, M., Wang, Y., Nguyen, N. D. T., Tsai, Y. H., Williams, S. C., Wiseman, R. C., Killen, P. D., Li, S., Yanagisawa, M. & Gariepy, C. E., May 2005, In : Hypertension. 45, 5, p. 940-946 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

Identification of N-arachidonylglycine, U18666A, and 4-androstene-3,17- dione as novel insulin Secretagogues

Ikeda, Y., Iguchi, H., Nakata, M., Ioka, R. X., Tanaka, T., Iwasaki, S., Magoori, K., Takayasu, S., Yamamoto, T. T., Kodama, T., Yada, T., Sakurai, T., Yanagisawa, M. & Sakai, J., Aug 5 2005, In : Biochemical and Biophysical Research Communications. 333, 3, p. 778-786 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Increased sensitivity to acute and persistent pain in neuron-specific endothelin-1 knockout mice

Hasue, F., Kuwaki, T., Kisanuki, Y. Y., Yanagisawa, M., Moriya, H., Fukuda, Y. & Shimoyama, M., 2005, In : Neuroscience. 130, 2, p. 349-358 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice

Sakurai, T., Nagata, R., Yamanaka, A., Kawamura, H., Tsujino, N., Muraki, Y., Kageyama, H., Kunita, S., Takahashi, S., Goto, K., Koyama, Y., Shioda, S. & Yanagisawa, M., Apr 21 2005, In : Neuron. 46, 2, p. 297-308 12 p.

Research output: Contribution to journalArticle

333 Scopus citations

Modafinil more effectively induces wakefulness in orexin-null mice than in wild-type littermates

Willie, J. T., Renthal, W., Chemelli, R. M., Miller, M. S., Scammell, T. E., Yanagisawa, M. & Sinton, C. M., 2005, In : Neuroscience. 130, 4, p. 983-995 13 p.

Research output: Contribution to journalArticle

74 Scopus citations

Neuropeptide B-deficient mice demonstrate hyperalgesia in response to inflammatory pain

Kelly, M. A., Beuckmann, C. T., Williams, S. C., Sinton, C. M., Motoike, T., Richardson, J. A., Hammer, R. E., Garry, M. G. & Yanagisawa, M., Jul 12 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 28, p. 9942-9947 6 p.

Research output: Contribution to journalArticle

45 Scopus citations

Persistent pain and stress activate pain-inhibitory orexin pathways

Watanabe, S., Kuwaki, T., Yanagisawa, M., Fukuda, Y. & Shimoyama, M., Jan 19 2005, In : NeuroReport. 16, 1, p. 5-8 4 p.

Research output: Contribution to journalArticle

99 Scopus citations

Rodent models of human narcolepsy-cataplexy

Sakurai, T., Yanagisawa, M. & Mieda, M., 2005, Hypocretins: Integrators of Physiological Functions. Springer US, p. 27-38 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Role of endothelin 1 in the pathogenesis of chronic chagasic heart disease

Tanowitz, H. B., Huang, H., Jelicks, L. A., Chandra, M., Loredo, M. L., Weiss, L. M., Factor, S. M., Shtutin, V., Mukherjee, S., Kitsis, R. N., Christ, G. J., Wittner, M., Shirani, J., Kisanuki, Y. Y. & Yanagisawa, M., Apr 2005, In : Infection and Immunity. 73, 4, p. 2496-2503 8 p.

Research output: Contribution to journalArticle

69 Scopus citations

Roles of forkhead transcription factor Foxc2 (MFH-1) and endothelin receptor a in cardiovascular morphogenesis

Kanzaki-Kato, N., Tamakoshi, T., Fu, Y., Chandra, A., Itakura, T., Uezato, T., Tanaka, T., Clouthier, D. E., Sugiyama, T., Yanagisawa, M. & Miura, N., Feb 15 2005, In : Cardiovascular Research. 65, 3, p. 711-718 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

SOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice

Iguchi, H., Ikeda, Y., Okamura, M., Tanaka, T., Urashima, Y., Ohguchi, H., Takayasu, S., Kojima, N., Iwasaki, S., Ohashi, R., Jiang, S., Hasegawa, G., Ioka, R. X., Magoori, K., Sumi, K., Maejima, T., Uchida, A., Naito, M., Osborne, T. F., Yanagisawa, M. & 3 others, Yamamoto, T. T., Kodama, T. & Sakai, J., Nov 11 2005, In : Journal of Biological Chemistry. 280, 45, p. 37669-37680 12 p.

Research output: Contribution to journalArticle

55 Scopus citations

Vascular endothelium is critically involved in the hypotensive and hypovolemic actions of atrial natriuretic peptide

Sabrane, K., Kruse, M. N., Fabritz, L., Zetsche, B., Mitko, D., Skryabin, B. V., Zwiener, M., Baba, H. A., Yanagisawa, M. & Kuhn, M., Jun 2005, In : Journal of Clinical Investigation. 115, 6, p. 1666-1674 9 p.

Research output: Contribution to journalArticle

111 Scopus citations
2004

A Krüppel-like factor KLF15 Contributes Fasting-induced Transcriptional Activation of Mitochondrial Acetyl-CoA Synthetase Gene AceCS2

Yamamoto, J., Ikeda, Y., Iguchi, H., Fujino, T., Tanaka, T., Asaba, H., Iwasaki, S., Ioka, R. X., Kaneko, I. W., Magoori, K., Takahashi, S., Mori, T., Sakaue, H., Kodama, T., Yanagisawa, M., Yamamoto, T. T., Ito, S. & Sakai, J., Apr 23 2004, In : Journal of Biological Chemistry. 279, 17, p. 16954-16962 9 p.

Research output: Contribution to journalArticle

58 Scopus citations

An autocrine role for endothelin-1 in the regulation of proximal tubule NHE3

Licht, C., Laghmani, K., Yanagisawa, M., Preisig, P. A. & Alpern, R. J., Apr 2004, In : Kidney International. 65, 4, p. 1320-1326 7 p.

Research output: Contribution to journalArticle

33 Scopus citations

Behavioral state instability in orexin knockout mice

Scammell, T. E., Crocker, A., McCormack, S., Yanagisawa, M., Sakurai, T. & Mochizuki, T., May 2004, In : Sleep and Biological Rhythms. 2, SUPPL. 1

Research output: Contribution to journalArticle

1 Scopus citations

Behavioral state instability in orexin knock-out mice

Mochizuki, T., Crocker, A., McCormack, S., Yanagisawa, M., Sakurai, T. & Scammell, T. E., Jul 14 2004, In : Journal of Neuroscience. 24, 28, p. 6291-6300 10 p.

Research output: Contribution to journalArticle

265 Scopus citations

Collecting duct-specific knockout of endothelin-1 causes hypertension and sodium retention

Ahn, D., Ge, Y., Stricklett, P. K., Gill, P., Taylor, D., Hughes, A. K., Yanagisawa, M., Miller, L., Nelson, R. D. & Kohan, D. E., Aug 2004, In : Journal of Clinical Investigation. 114, 4, p. 504-511 8 p.

Research output: Contribution to journalArticle

208 Scopus citations

Emergence of clinical applications of endothelin system inhibitors

Goto, K., Miyauchi, T. & Yanagisawa, M., Nov 2004, In : Journal of Cardiovascular Pharmacology. 44, SUPPL. 1

Research output: Contribution to journalArticle

Endothelin B receptor deficient transgenic rescue rats: A rescue phenomenon in the brain

Riechers, C. C., Knabe, W., Sirén, A. L., Gariepy, C. E., Yanagisawa, M. & Ehrenreich, H., 2004, In : Neuroscience. 124, 4, p. 719-723 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

Exaggerated vascular and renal pathology in endothelin-B-receptor-deficient rats with subtotal nephrectomy

Tazawa, N., Okada, Y., Nakata, M., Izumoto, H., Takasu, M., Takaoka, M., Gariepy, C. E., Yanagisawa, M. & Matsumura, Y., Nov 2004, In : Journal of Cardiovascular Pharmacology. 44, SUPPL. 1

Research output: Contribution to journalArticle

8 Scopus citations

Expression of a Poly-Glutamine-Ataxin-3 Transgene in Orexin Neurons Induces Narcolepsy-Cataplexy in the Rat

Beuckmann, C. T., Sinton, C. M., Williams, S. C., Richardson, J. A., Hammer, R. E., Sakurai, T. & Yanagisawa, M., May 5 2004, In : Journal of Neuroscience. 24, 18, p. 4469-4477 9 p.

Research output: Contribution to journalArticle

139 Scopus citations

Expression of the poly-glutamine-ataxin-3 transgene causes loss of orexin expression: A rat model of narcolepsy

Beuckmann, C. T., Sinton, C. M., Williams, S. C., Richardson, J. A., Hammer, R. E., Sakurai, T. & Yanagisawa, M., May 2004, In : Sleep and Biological Rhythms. 2, SUPPL. 1

Research output: Contribution to journalArticle

Mast cells promote homeostasis by limiting endothelin-1-induced toxicity

Maurer, M., Wedemeyer, J., Metz, M., Piliponsky, A. M., Weller, K., Chatterjea, D., Clouthier, D. E., Yanagisawa, M. M., Tsai, M. & Galli, S. J., Nov 25 2004, In : Nature. 432, 7016, p. 512-516 5 p.

Research output: Contribution to journalArticle

226 Scopus citations

Mice with cardiomyocyte-specific disruption of the endothelin-1 gene are resistant to hyperthyroid cardiac hypertrophy

Shohet, R. V., Kisanuki, Y. Y., Zhao, X. S., Siddiquee, Z., Franco, F. & Yanagisawa, M., Feb 17 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 7, p. 2088-2093 6 p.

Research output: Contribution to journalArticle

72 Scopus citations

Orexin neurons function in an efferent pathway of a food-entrainable circadian oscillator in eliciting food-anticipatory activity and wakefulness

Mieda, M., Williams, S. C., Sinton, C. M., Richardson, J. A., Sakurai, T. & Yanagisawa, M., Nov 17 2004, In : Journal of Neuroscience. 24, 46, p. 10493-10501 9 p.

Research output: Contribution to journalArticle

152 Scopus citations

Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice

Mieda, M., Willie, J. T., Hara, J., Sinton, C. M., Sakurai, T. & Yanagisawa, M., Mar 30 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 13, p. 4649-4654 6 p.

Research output: Contribution to journalArticle

238 Scopus citations

Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose-responsive neurons to regulate Ca2+ signaling in a reciprocal manner to leptin: Orexigenic neuronal pathways in the mediobasal hypothalamus

Muroya, S., Funahashi, H., Yamanaka, A., Kohno, D., Uramura, K., Nambu, T., Shibahara, M., Kuramochi, M., Takigawa, M., Yanagisawa, M., Sakurai, T., Shioda, S. & Yada, T., Mar 2004, In : European Journal of Neuroscience. 19, 6, p. 1524-1534 11 p.

Research output: Contribution to journalArticle

193 Scopus citations

Orexins acting at native OX1 receptor in colon cancer and neuroblastoma cells or at recombinant OX1 receptor suppress cell growth by inducing apoptosis

Rouet-Benzineb, P., Rouyer-Fessard, C., Jarry, A., Avondo, V., Pouzet, C., Yanagisawa, M., Laboisse, C., Laburthe, M. & Voisin, T., Oct 29 2004, In : Journal of Biological Chemistry. 279, 44, p. 45875-45886 12 p.

Research output: Contribution to journalArticle

75 Scopus citations

Role of endothelin ETB receptor in partial ablation-induced chronic renal failure in rats

Okada, Y., Nakata, M., Izumoto, H., Takasu, M., Tazawa, N., Takaoka, M., Gariepy, C. E., Yanagisawa, M. & Matsumura, Y., Jun 21 2004, In : European Journal of Pharmacology. 494, 1, p. 63-71 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Role of endothelin ET B receptor in the pathogenesis of monocrotaline-induced pulmonary hypertension in rats

Nishida, M., Okada, Y., Akiyoshi, K., Eshiro, K., Takaoka, M., Gariepy, C. E., Yanagisawa, M. & Matsumura, Y., Aug 2 2004, In : European Journal of Pharmacology. 496, 1-3, p. 159-165 7 p.

Research output: Contribution to journalArticle

25 Scopus citations

Role of hypothalamic orexin neurons in the regulation of arousal according to energy balance

Yamanaka, A., Beuckmann, C. T., Willie, J. T., Hara, J., Tsujino, N., Goto, K., Yanagisawa, M. & Sakurai, T., May 2004, In : Sleep and Biological Rhythms. 2, SUPPL. 1

Research output: Contribution to journalArticle

Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41

Xiong, Y., Miyamoto, N., Shibata, K., Valasek, M. A., Motoike, T., Kedzierski, R. M. & Yanagisawa, M., Jan 27 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 4, p. 1045-1050 6 p.

Research output: Contribution to journalArticle

390 Scopus citations

USAG-1: A bone morphogenetic protein antagonist abundantly expressed in the kidney

Yanagita, M., Oka, M., Watabe, T., Iguchi, H., Niida, A., Takahashi, S., Akiyama, T., Miyazono, K., Yanagisawa, M. & Sakurai, T., Apr 2 2004, In : Biochemical and Biophysical Research Communications. 316, 2, p. 490-500 11 p.

Research output: Contribution to journalArticle

103 Scopus citations

Variants of the orexin2/hcrt2 receptor gene identified in patients with excessive daytime sleepiness and patients with Tourette's syndrome comorbidity

Thompson, M. D., Comings, D. E., Abu-Ghazalah, R., Jereseh, Y., Lin, L., Wade, J., Sakurai, T., Tokita, S., Yoshida, T., Tanaka, H., Yanagisawa, M., Burnham, W. M. & Moldofsky, H., Aug 15 2004, In : American Journal of Medical Genetics - Neuropsychiatric Genetics. 129 B, 1, p. 69-75 7 p.

Research output: Contribution to journalArticle

32 Scopus citations
2003

Activation of peroxisome proliferator-activated receptor δ induces fatty acid β-oxidation in skeletal muscle and attenuates metabolic syndrome

Tanaka, T., Yamamoto, J., Iwasaki, S., Asaba, H., Hamura, H., Ikeda, Y., Watanabe, M., Magoori, K., Ioka, R. X., Tachibana, K., Watanabe, Y., Uchiyama, Y., Sumi, K., Iguchi, H., Ito, S., Doi, T., Hamakubo, T., Naito, M., Auwerx, J., Yanagisawa, M. & 2 others, Kodama, T. & Sakai, J., Dec 23 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 26, p. 15924-15929 6 p.

Research output: Contribution to journalArticle

644 Scopus citations

Attenuated defense response and low basal blood pressure in orexin knockout mice

Kayaba, Y., Nakamura, A., Kasuya, Y., Ohuchi, T., Yanagisawa, M., Komuro, I., Fukuda, Y. & Kuwaki, T., Sep 1 2003, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 285, 3 54-3

Research output: Contribution to journalArticle

260 Scopus citations

Cardiomyocyte-Specific Endothelin A Receptor Knockout Mice Have Normal Cardiac Function and an Unaltered Hypertrophic Response to Angiotensin II and Isoproterenol

Kedzierski, R. M., Grayburn, P. A., Kisanuki, Y. Y., Williams, C. S., Hammer, R. E., Richardson, J. A., Schneider, M. D. & Yanagisawa, M., Nov 2003, In : Molecular and Cellular Biology. 23, 22, p. 8226-8232 7 p.

Research output: Contribution to journalArticle

63 Scopus citations

Cell-autonomous and nonautonomous actions of endothelin-A receptor signaling in craniofacial and cardiovascular development

Clouthier, D. E., Williams, S. C., Hammer, R. E., Richardson, J. A. & Yanagisawa, M., Sep 15 2003, In : Developmental Biology. 261, 2, p. 506-519 14 p.

Research output: Contribution to journalArticle

44 Scopus citations

Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8

Tanaka, H., Yoshida, T., Miyamoto, N., Motoike, T., Kurosu, H., Shibata, K., Yamanaka, A., Williams, S. C., Richardson, J. A., Tsujino, N., Garry, M. G., Lerner, M. R., King, D. S., O'Dowd, B. F., Sakurai, T. & Yanagisawa, M., May 13 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 10, p. 6251-6256 6 p.

Research output: Contribution to journalArticle

142 Scopus citations

Colocalization of orexin a and glutamate immunoreactivity in axon terminals in the tuberomammillary nucleus in rats

Torrealba, F., Yanagisawa, M. & Saper, C. B., Jul 16 2003, In : Neuroscience. 119, 4, p. 1033-1044 12 p.

Research output: Contribution to journalArticle

146 Scopus citations

dHAND-Cre transgenic mice reveal specific potential functions of dHAND during craniofacial development

Ruest, L. B., Dager, M., Yanagisawa, H., Charité, J., Hammer, R. E., Olson, E. N., Yanagisawa, M. & Clouthier, D. E., May 15 2003, In : Developmental Biology. 257, 2, p. 263-277 15 p.

Research output: Contribution to journalArticle

34 Scopus citations

Distinct narcolepsy syndromes in orexin receptor-2 and orexin null mice: Molecular genetic dissection of non-REM and REM sleep regulatory processes

Willie, J. T., Chemelli, R. M., Sinton, C. M., Tokita, S., Williams, S. C., Kisanuki, Y. Y., Marcus, J. N., Lee, C., Elmquist, J. K., Kohlmeier, K. A., Leonard, C. S., Richardson, J. A., Hammer, R. E. & Yanagisawa, M., Jun 5 2003, In : Neuron. 38, 5, p. 715-730 16 p.

Research output: Contribution to journalArticle

458 Scopus citations

Dlx5/6-Enhancer Directed Expression of Cre Recombinase in the Pharyngeal Arches and Brain

Ruest, L. B., Hammer, R. E., Yanagisawa, M. & Clouthier, D. E., Dec 2003, In : Genesis. 37, 4, p. 188-194 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

Ece1 and Tbx1 define distinct pathways to aortic arch morphogenesis

Morishima, M., Yanagisawa, H., Yanagisawa, M. & Baldini, A., Sep 1 2003, In : Developmental Dynamics. 228, 1, p. 95-104 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Effects of orexin (hypocretin) on GIRK channels

Hoang, Q. V., Bajic, D., Yanagisawa, M., Nakajima, S. & Nakajima, Y., Aug 1 2003, In : Journal of Neurophysiology. 90, 2, p. 693-702 10 p.

Research output: Contribution to journalArticle

71 Scopus citations