• 72322 Citations
  • 120 h-Index
1984 …2020

Research output per year

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Research Output

2006

A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice

Takayasu, S., Sakurai, T., Iwasaki, S., Teranishi, H., Yamanaka, A., Williams, S. C., Iguchi, H., Kawasawa, Y. I., Ikeda, Y., Sakakibara, I., Ohno, K., Ioka, R. X., Murakami, S., Dohmae, N., Xie, J., Suda, T., Motoike, T., Ohuchi, T., Yanagisawa, M. & Sakai, J., May 9 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 19, p. 7438-7443 6 p.

Research output: Contribution to journalArticle

111 Scopus citations

Deletion of endothelial cell endothelin B receptors does not affect blood pressure or sensitivity to salt

Bagnall, A. J., Kelland, N. F., Gulliver-Sloan, F., Davenport, A. P., Gray, G. A., Yanagisawa, M., Webb, D. J. & Kotelevtsev, Y. V., Aug 1 2006, In : Hypertension. 48, 2, p. 286-293 8 p.

Research output: Contribution to journalArticle

75 Scopus citations

Diabetic endothelin B receptor-deficient rats develop severe hypertension and progressive renal failure

Pfab, T., Thöne-Reineke, C., Theilig, F., Lange, I., Witt, H., Maser-Gluth, C., Bader, M., Stasch, J. P., Ruiz, P., Bachmann, S., Yanagisawa, M. & Hocher, B., Apr 1 2006, In : Journal of the American Society of Nephrology. 17, 4, p. 1082-1089 8 p.

Research output: Contribution to journalArticle

31 Scopus citations

Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine

Narita, M., Nagumo, Y., Hashimoto, S., Narita, M., Khotib, J., Miyatake, M., Sakurai, T., Yanagisawa, M., Nakamachi, T., Shioda, S. & Suzuki, T., Jan 11 2006, In : Journal of Neuroscience. 26, 2, p. 398-405 8 p.

Research output: Contribution to journalArticle

384 Scopus citations

Distribution of neuropeptide W immunoreactivity and mRNA in adult rat brain

Kitamura, Y., Tanaka, H., Motoike, T., Ishii, M., Williams, S. C., Yanagisawa, M. & Sakurai, T., Jun 6 2006, In : Brain Research. 1093, 1, p. 123-134 12 p.

Research output: Contribution to journalArticle

36 Scopus citations

Lessons from sleepy mice: Narcolepsy-cataplexy and the orexin neuropeptide system

Willie, J. T. & Yanagisawa, M., Jan 1 2006, Narcolepsy and Hypersomnia. CRC Press, p. 257-278 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Reduced expression of the endothelin receptor type B gene in piebald mice caused by insertion of a retroposon-like element in intron 1

Yamada, T., Ohtani, S., Sakurai, T., Tsuji, T., Kunieda, T. & Yanagisawa, M., Apr 21 2006, In : Journal of Biological Chemistry. 281, 16, p. 10799-10807 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Sex difference in body weight gain and leptin signaling in hypocretin/orexin deficient mouse models

Fujiki, N., Yoshida, Y., Zhang, S., Sakurai, T., Yanagisawa, M. & Nishino, S., Sep 1 2006, In : Peptides. 27, 9, p. 2326-2331 6 p.

Research output: Contribution to journalArticle

38 Scopus citations

The dorsomedial hypothalamic nucleus as a putative food-entrainable circadian pacemaker

Mieda, M., Williams, S. C., Richardson, J. A., Tanaka, K. & Yanagisawa, M., Aug 8 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 32, p. 12150-12155 6 p.

Research output: Contribution to journalArticle

219 Scopus citations

Uterine sensitization-associated gene-1 (USAG-1), a novel BMP antagonist expressed in the kidney, accelerates tubular injury

Yanagita, M., Okuda, T., Endo, S., Tanaka, M., Takahashi, K., Sugiyama, F., Kunita, S., Takahashi, S., Fukatsu, A., Yanagisawa, M., Kita, T. & Sakurai, T., Jan 1 2006, In : Journal of Clinical Investigation. 116, 1, p. 70-79 10 p.

Research output: Contribution to journalArticle

112 Scopus citations
2005

A consensus sequence in the endothelin-B receptor second intracellular loop is required for NHE3 activation by endothelin-1

Laghmani, K., Sakamoto, A., Yanagisawa, M., Preisig, P. A. & Alpern, R. J., Apr 1 2005, In : American Journal of Physiology - Renal Physiology. 288, 4 57-4, p. F732-F739

Research output: Contribution to journalArticle

11 Scopus citations

Collecting duct-specific knockout of endothelin-1 alters vasopressin regulation of urine osmolality

Ge, Y., Ahn, D., Stricklett, P. K., Hughes, A. K., Yanagisawa, M., Verbalis, J. G. & Kohan, D. E., May 1 2005, In : American Journal of Physiology - Renal Physiology. 288, 5 57-5, p. F912-F920

Research output: Contribution to journalReview article

88 Scopus citations

Collecting duct-specific knockout of the endothelin A receptor alters renal vasopressin responsiveness, but not sodium excretion or blood pressure

Ge, Y., Stricklett, P. K., Hughes, A. K., Yanagisawa, M. & Kohan, D. E., Oct 1 2005, In : American Journal of Physiology - Renal Physiology. 289, 4 58-4, p. F692-F698

Research output: Contribution to journalArticle

80 Scopus citations

Deletion of the endothelin-A receptor gene within the developing mandible

Ruest, L. B., Kedzierski, R., Yanagisawa, M. & Clouthier, D. E., Mar 1 2005, In : Cell and Tissue Research. 319, 3, p. 447-453 7 p.

Research output: Contribution to journalArticle

20 Scopus citations
145 Scopus citations

Different contributions of endothelin-A and endothelin-B receptors in postischemic cardiac dysfunction and norepinephrine overflow in rat hearts

Yamamoto, S., Matsumoto, N., Kanazawa, M., Fujita, M., Takaoka, M., Gariepy, C. E., Yanagisawa, M. & Matsumura, Y., Jan 25 2005, In : Circulation. 111, 3, p. 302-309 8 p.

Research output: Contribution to journalArticle

33 Scopus citations

Endothelin B receptor-deficient mice develop endothelial dysfunction independently of salt loading

Quaschning, T., Rebhan, B., Wunderlich, C., Wanner, C., Richter, C. M., Pfab, T., Bauer, C., Kraemer-Guth, A., Galle, J., Yanagisawa, M. & Hocher, B., May 2005, In : Journal of hypertension. 23, 5, p. 979-985 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

Erratum: Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice (Neuron (April 21, 2005) 46 (297-308) PII: S0896-6273(05)00205-9 and DOI: 10.1016/j.neuron.2005.03.010)

Sakurai, T., Nagata, R., Yamanaka, A., Kawamura, H., Tsujino, N., Muraki, Y., Kageyama, H., Kunita, S., Takahashi, S., Goto, K., Koyama, Y., Shioda, S. & Yanagisawa, M., Jun 2 2005, In : Neuron. 46, 5, 1 p.

Research output: Contribution to journalComment/debate

Extrarenal ETB plays a significant role in controlling cardiovascular responses to high dietary sodium in rats

Ohkita, M., Wang, Y., Nguyen, N. D. T., Tsai, Y. H., Williams, S. C., Wiseman, R. C., Killen, P. D., Li, S., Yanagisawa, M. & Gariepy, C. E., May 1 2005, In : Hypertension. 45, 5, p. 940-946 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

Identification of N-arachidonylglycine, U18666A, and 4-androstene-3,17- dione as novel insulin Secretagogues

Ikeda, Y., Iguchi, H., Nakata, M., Ioka, R. X., Tanaka, T., Iwasaki, S., Magoori, K., Takayasu, S., Yamamoto, T. T., Kodama, T., Yada, T., Sakurai, T., Yanagisawa, M. & Sakai, J., Aug 5 2005, In : Biochemical and Biophysical Research Communications. 333, 3, p. 778-786 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Increased sensitivity to acute and persistent pain in neuron-specific endothelin-1 knockout mice

Hasue, F., Kuwaki, T., Kisanuki, Y. Y., Yanagisawa, M., Moriya, H., Fukuda, Y. & Shimoyama, M., Jan 31 2005, In : Neuroscience. 130, 2, p. 349-358 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice

Sakurai, T., Nagata, R., Yamanaka, A., Kawamura, H., Tsujino, N., Muraki, Y., Kageyama, H., Kunita, S., Takahashi, S., Goto, K., Koyama, Y., Shioda, S. & Yanagisawa, M., Apr 21 2005, In : Neuron. 46, 2, p. 297-308 12 p.

Research output: Contribution to journalArticle

340 Scopus citations

Modafinil more effectively induces wakefulness in orexin-null mice than in wild-type littermates

Willie, J. T., Renthal, W., Chemelli, R. M., Miller, M. S., Scammell, T. E., Yanagisawa, M. & Sinton, C. M., Jan 24 2005, In : Neuroscience. 130, 4, p. 983-995 13 p.

Research output: Contribution to journalArticle

76 Scopus citations

Neuropeptide B-deficient mice demonstrate hyperalgesia in response to inflammatory pain

Kelly, M. A., Beuckmann, C. T., Williams, S. C., Sinton, C. M., Motoike, T., Richardson, J. A., Hammer, R. E., Garry, M. G. & Yanagisawa, M., Jul 12 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 28, p. 9942-9947 6 p.

Research output: Contribution to journalArticle

45 Scopus citations

Persistent pain and stress activate pain-inhibitory orexin pathways

Watanabe, S., Kuwaki, T., Yanagisawa, M., Fukuda, Y. & Shimoyama, M., Jan 19 2005, In : NeuroReport. 16, 1, p. 5-8 4 p.

Research output: Contribution to journalArticle

104 Scopus citations

Rodent models of human narcolepsy-cataplexy

Sakurai, T., Yanagisawa, M. & Mieda, M., Jan 1 2005, Hypocretins: Integrators of Physiological Functions. Springer US, p. 27-38 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Role of endothelin 1 in the pathogenesis of chronic chagasic heart disease

Tanowitz, H. B., Huang, H., Jelicks, L. A., Chandra, M., Loredo, M. L., Weiss, L. M., Factor, S. M., Shtutin, V., Mukherjee, S., Kitsis, R. N., Christ, G. J., Wittner, M., Shirani, J., Kisanuki, Y. Y. & Yanagisawa, M., Apr 1 2005, In : Infection and immunity. 73, 4, p. 2496-2503 8 p.

Research output: Contribution to journalArticle

71 Scopus citations

Roles of forkhead transcription factor Foxc2 (MFH-1) and endothelin receptor a in cardiovascular morphogenesis

Kanzaki-Kato, N., Tamakoshi, T., Fu, Y., Chandra, A., Itakura, T., Uezato, T., Tanaka, T., Clouthier, D. E., Sugiyama, T., Yanagisawa, M. & Miura, N., Feb 15 2005, In : Cardiovascular Research. 65, 3, p. 711-718 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

SOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice

Iguchi, H., Ikeda, Y., Okamura, M., Tanaka, T., Urashima, Y., Ohguchi, H., Takayasu, S., Kojima, N., Iwasaki, S., Ohashi, R., Jiang, S., Hasegawa, G., Ioka, R. X., Magoori, K., Sumi, K., Maejima, T., Uchida, A., Naito, M., Osborne, T. F., Yanagisawa, M. & 3 others, Yamamoto, T. T., Kodama, T. & Sakai, J., Nov 11 2005, In : Journal of Biological Chemistry. 280, 45, p. 37669-37680 12 p.

Research output: Contribution to journalArticle

57 Scopus citations

Vascular endothelium is critically involved in the hypotensive and hypovolemic actions of atrial natriuretic peptide

Sabrane, K., Kruse, M. N., Fabritz, L., Zetsche, B., Mitko, D., Skryabin, B. V., Zwiener, M., Baba, H. A., Yanagisawa, M. & Kuhn, M., Jun 1 2005, In : Journal of Clinical Investigation. 115, 6, p. 1666-1674 9 p.

Research output: Contribution to journalArticle

113 Scopus citations
2004

A Krüppel-like factor KLF15 Contributes Fasting-induced Transcriptional Activation of Mitochondrial Acetyl-CoA Synthetase Gene AceCS2

Yamamoto, J., Ikeda, Y., Iguchi, H., Fujino, T., Tanaka, T., Asaba, H., Iwasaki, S., Ioka, R. X., Kaneko, I. W., Magoori, K., Takahashi, S., Mori, T., Sakaue, H., Kodama, T., Yanagisawa, M., Yamamoto, T. T., Ito, S. & Sakai, J., Apr 23 2004, In : Journal of Biological Chemistry. 279, 17, p. 16954-16962 9 p.

Research output: Contribution to journalArticle

59 Scopus citations

An autocrine role for endothelin-1 in the regulation of proximal tubule NHE3

Licht, C., Laghmani, K., Yanagisawa, M., Preisig, P. A. & Alpern, R. J., Apr 2004, In : Kidney international. 65, 4, p. 1320-1326 7 p.

Research output: Contribution to journalArticle

33 Scopus citations

Behavioral state instability in orexin knockout mice

Scammell, T. E., Crocker, A., McCormack, S., Yanagisawa, M., Sakurai, T. & Mochizuki, T., May 1 2004, In : Sleep and Biological Rhythms. 2, SUPPL. 1, p. S13-S14

Research output: Contribution to journalArticle

1 Scopus citations

Behavioral state instability in orexin knock-out mice

Mochizuki, T., Crocker, A., McCormack, S., Yanagisawa, M., Sakurai, T. & Scammell, T. E., Jul 14 2004, In : Journal of Neuroscience. 24, 28, p. 6291-6300 10 p.

Research output: Contribution to journalArticle

267 Scopus citations

Collecting duct-specific knockout of endothelin-1 causes hypertension and sodium retention

Ahn, D., Ge, Y., Stricklett, P. K., Gill, P., Taylor, D., Hughes, A. K., Yanagisawa, M., Miller, L., Nelson, R. D. & Kohan, D. E., Aug 1 2004, In : Journal of Clinical Investigation. 114, 4, p. 504-511 8 p.

Research output: Contribution to journalArticle

211 Scopus citations

Emergence of clinical applications of endothelin system inhibitors

Goto, K., Miyauchi, T. & Yanagisawa, M., Nov 1 2004, In : Journal of Cardiovascular Pharmacology. 44, SUPPL. 1, p. xiii-xiv

Research output: Contribution to journalArticle

Endothelin B receptor deficient transgenic rescue rats: A rescue phenomenon in the brain

Riechers, C. C., Knabe, W., Sirén, A. L., Gariepy, C. E., Yanagisawa, M. & Ehrenreich, H., Mar 22 2004, In : Neuroscience. 124, 4, p. 719-723 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

Exaggerated vascular and renal pathology in endothelin-B-receptor-deficient rats with subtotal nephrectomy

Tazawa, N., Okada, Y., Nakata, M., Izumoto, H., Takasu, M., Takaoka, M., Gariepy, C. E., Yanagisawa, M. & Matsumura, Y., Nov 1 2004, In : Journal of Cardiovascular Pharmacology. 44, SUPPL. 1, p. S467-S470

Research output: Contribution to journalArticle

8 Scopus citations

Expression of a Poly-Glutamine-Ataxin-3 Transgene in Orexin Neurons Induces Narcolepsy-Cataplexy in the Rat

Beuckmann, C. T., Sinton, C. M., Williams, S. C., Richardson, J. A., Hammer, R. E., Sakurai, T. & Yanagisawa, M., May 5 2004, In : Journal of Neuroscience. 24, 18, p. 4469-4477 9 p.

Research output: Contribution to journalArticle

140 Scopus citations

Expression of the poly-glutamine-ataxin-3 transgene causes loss of orexin expression: A rat model of narcolepsy

Beuckmann, C. T., Sinton, C. M., Williams, S. C., Richardson, J. A., Hammer, R. E., Sakurai, T. & Yanagisawa, M., May 1 2004, In : Sleep and Biological Rhythms. 2, SUPPL. 1, p. S44

Research output: Contribution to journalArticle

Mast cells promote homeostasis by limiting endothelin-1-induced toxicity

Maurer, M., Wedemeyer, J., Metz, M., Piliponsky, A. M., Weller, K., Chatterjea, D., Clouthier, D. E., Yanagisawa, M. M., Tsai, M. & Galli, S. J., Nov 25 2004, In : Nature. 432, 7016, p. 512-516 5 p.

Research output: Contribution to journalArticle

232 Scopus citations

Mice with cardiomyocyte-specific disruption of the endothelin-1 gene are resistant to hyperthyroid cardiac hypertrophy

Shohet, R. V., Kisanuki, Y. Y., Zhao, X. S., Siddiquee, Z., Franco, F. & Yanagisawa, M., Feb 17 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 7, p. 2088-2093 6 p.

Research output: Contribution to journalArticle

72 Scopus citations

Orexin neurons function in an efferent pathway of a food-entrainable circadian oscillator in eliciting food-anticipatory activity and wakefulness

Mieda, M., Williams, S. C., Sinton, C. M., Richardson, J. A., Sakurai, T. & Yanagisawa, M., Nov 17 2004, In : Journal of Neuroscience. 24, 46, p. 10493-10501 9 p.

Research output: Contribution to journalArticle

157 Scopus citations

Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice

Mieda, M., Willie, J. T., Hara, J., Sinton, C. M., Sakurai, T. & Yanagisawa, M., Mar 30 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 13, p. 4649-4654 6 p.

Research output: Contribution to journalArticle

245 Scopus citations

Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose-responsive neurons to regulate Ca2+ signaling in a reciprocal manner to leptin: Orexigenic neuronal pathways in the mediobasal hypothalamus

Muroya, S., Funahashi, H., Yamanaka, A., Kohno, D., Uramura, K., Nambu, T., Shibahara, M., Kuramochi, M., Takigawa, M., Yanagisawa, M., Sakurai, T., Shioda, S. & Yada, T., Mar 1 2004, In : European Journal of Neuroscience. 19, 6, p. 1524-1534 11 p.

Research output: Contribution to journalArticle

198 Scopus citations

Orexins acting at native OX1 receptor in colon cancer and neuroblastoma cells or at recombinant OX1 receptor suppress cell growth by inducing apoptosis

Rouet-Benzineb, P., Rouyer-Fessard, C., Jarry, A., Avondo, V., Pouzet, C., Yanagisawa, M., Laboisse, C., Laburthe, M. & Voisin, T., Oct 29 2004, In : Journal of Biological Chemistry. 279, 44, p. 45875-45886 12 p.

Research output: Contribution to journalArticle

76 Scopus citations

Role of endothelin ETB receptor in partial ablation-induced chronic renal failure in rats

Okada, Y., Nakata, M., Izumoto, H., Takasu, M., Tazawa, N., Takaoka, M., Gariepy, C. E., Yanagisawa, M. & Matsumura, Y., Jun 21 2004, In : European Journal of Pharmacology. 494, 1, p. 63-71 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Role of endothelin ET B receptor in the pathogenesis of monocrotaline-induced pulmonary hypertension in rats

Nishida, M., Okada, Y., Akiyoshi, K., Eshiro, K., Takaoka, M., Gariepy, C. E., Yanagisawa, M. & Matsumura, Y., Aug 2 2004, In : European Journal of Pharmacology. 496, 1-3, p. 159-165 7 p.

Research output: Contribution to journalArticle

25 Scopus citations

Role of hypothalamic orexin neurons in the regulation of arousal according to energy balance

Yamanaka, A., Beuckmann, C. T., Willie, J. T., Hara, J., Tsujino, N., Goto, K., Yanagisawa, M. & Sakurai, T., May 1 2004, In : Sleep and Biological Rhythms. 2, SUPPL. 1, p. S57

Research output: Contribution to journalArticle

Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41

Xiong, Y., Miyamoto, N., Shibata, K., Valasek, M. A., Motoike, T., Kedzierski, R. M. & Yanagisawa, M., Jan 27 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 4, p. 1045-1050 6 p.

Research output: Contribution to journalArticle

410 Scopus citations