• 71926 Citations
  • 119 h-Index
1984 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2005

Increased sensitivity to acute and persistent pain in neuron-specific endothelin-1 knockout mice

Hasue, F., Kuwaki, T., Kisanuki, Y. Y., Yanagisawa, M., Moriya, H., Fukuda, Y. & Shimoyama, M., Jan 31 2005, In : Neuroscience. 130, 2, p. 349-358 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice

Sakurai, T., Nagata, R., Yamanaka, A., Kawamura, H., Tsujino, N., Muraki, Y., Kageyama, H., Kunita, S., Takahashi, S., Goto, K., Koyama, Y., Shioda, S. & Yanagisawa, M., Apr 21 2005, In : Neuron. 46, 2, p. 297-308 12 p.

Research output: Contribution to journalArticle

340 Scopus citations

Modafinil more effectively induces wakefulness in orexin-null mice than in wild-type littermates

Willie, J. T., Renthal, W., Chemelli, R. M., Miller, M. S., Scammell, T. E., Yanagisawa, M. & Sinton, C. M., Jan 24 2005, In : Neuroscience. 130, 4, p. 983-995 13 p.

Research output: Contribution to journalArticle

75 Scopus citations

Neuropeptide B-deficient mice demonstrate hyperalgesia in response to inflammatory pain

Kelly, M. A., Beuckmann, C. T., Williams, S. C., Sinton, C. M., Motoike, T., Richardson, J. A., Hammer, R. E., Garry, M. G. & Yanagisawa, M., Jul 12 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 28, p. 9942-9947 6 p.

Research output: Contribution to journalArticle

45 Scopus citations

Persistent pain and stress activate pain-inhibitory orexin pathways

Watanabe, S., Kuwaki, T., Yanagisawa, M., Fukuda, Y. & Shimoyama, M., Jan 19 2005, In : NeuroReport. 16, 1, p. 5-8 4 p.

Research output: Contribution to journalArticle

103 Scopus citations

Rodent models of human narcolepsy-cataplexy

Sakurai, T., Yanagisawa, M. & Mieda, M., Jan 1 2005, Hypocretins: Integrators of Physiological Functions. Springer US, p. 27-38 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Role of endothelin 1 in the pathogenesis of chronic chagasic heart disease

Tanowitz, H. B., Huang, H., Jelicks, L. A., Chandra, M., Loredo, M. L., Weiss, L. M., Factor, S. M., Shtutin, V., Mukherjee, S., Kitsis, R. N., Christ, G. J., Wittner, M., Shirani, J., Kisanuki, Y. Y. & Yanagisawa, M., Apr 1 2005, In : Infection and immunity. 73, 4, p. 2496-2503 8 p.

Research output: Contribution to journalArticle

69 Scopus citations

Roles of forkhead transcription factor Foxc2 (MFH-1) and endothelin receptor a in cardiovascular morphogenesis

Kanzaki-Kato, N., Tamakoshi, T., Fu, Y., Chandra, A., Itakura, T., Uezato, T., Tanaka, T., Clouthier, D. E., Sugiyama, T., Yanagisawa, M. & Miura, N., Feb 15 2005, In : Cardiovascular Research. 65, 3, p. 711-718 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

SOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice

Iguchi, H., Ikeda, Y., Okamura, M., Tanaka, T., Urashima, Y., Ohguchi, H., Takayasu, S., Kojima, N., Iwasaki, S., Ohashi, R., Jiang, S., Hasegawa, G., Ioka, R. X., Magoori, K., Sumi, K., Maejima, T., Uchida, A., Naito, M., Osborne, T. F., Yanagisawa, M. & 3 others, Yamamoto, T. T., Kodama, T. & Sakai, J., Nov 11 2005, In : Journal of Biological Chemistry. 280, 45, p. 37669-37680 12 p.

Research output: Contribution to journalArticle

56 Scopus citations

Vascular endothelium is critically involved in the hypotensive and hypovolemic actions of atrial natriuretic peptide

Sabrane, K., Kruse, M. N., Fabritz, L., Zetsche, B., Mitko, D., Skryabin, B. V., Zwiener, M., Baba, H. A., Yanagisawa, M. & Kuhn, M., Jun 1 2005, In : Journal of Clinical Investigation. 115, 6, p. 1666-1674 9 p.

Research output: Contribution to journalArticle

113 Scopus citations
2006

A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice

Takayasu, S., Sakurai, T., Iwasaki, S., Teranishi, H., Yamanaka, A., Williams, S. C., Iguchi, H., Kawasawa, Y. I., Ikeda, Y., Sakakibara, I., Ohno, K., Ioka, R. X., Murakami, S., Dohmae, N., Xie, J., Suda, T., Motoike, T., Ohuchi, T., Yanagisawa, M. & Sakai, J., May 9 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 19, p. 7438-7443 6 p.

Research output: Contribution to journalArticle

107 Scopus citations

Deletion of endothelial cell endothelin B receptors does not affect blood pressure or sensitivity to salt

Bagnall, A. J., Kelland, N. F., Gulliver-Sloan, F., Davenport, A. P., Gray, G. A., Yanagisawa, M., Webb, D. J. & Kotelevtsev, Y. V., Aug 1 2006, In : Hypertension. 48, 2, p. 286-293 8 p.

Research output: Contribution to journalArticle

75 Scopus citations

Diabetic endothelin B receptor-deficient rats develop severe hypertension and progressive renal failure

Pfab, T., Thöne-Reineke, C., Theilig, F., Lange, I., Witt, H., Maser-Gluth, C., Bader, M., Stasch, J. P., Ruiz, P., Bachmann, S., Yanagisawa, M. & Hocher, B., Apr 1 2006, In : Journal of the American Society of Nephrology. 17, 4, p. 1082-1089 8 p.

Research output: Contribution to journalArticle

31 Scopus citations

Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine

Narita, M., Nagumo, Y., Hashimoto, S., Narita, M., Khotib, J., Miyatake, M., Sakurai, T., Yanagisawa, M., Nakamachi, T., Shioda, S. & Suzuki, T., Jan 11 2006, In : Journal of Neuroscience. 26, 2, p. 398-405 8 p.

Research output: Contribution to journalArticle

384 Scopus citations

Distribution of neuropeptide W immunoreactivity and mRNA in adult rat brain

Kitamura, Y., Tanaka, H., Motoike, T., Ishii, M., Williams, S. C., Yanagisawa, M. & Sakurai, T., Jun 6 2006, In : Brain Research. 1093, 1, p. 123-134 12 p.

Research output: Contribution to journalArticle

36 Scopus citations

Lessons from sleepy mice: Narcolepsy-cataplexy and the orexin neuropeptide system

Willie, J. T. & Yanagisawa, M., Jan 1 2006, Narcolepsy and Hypersomnia. CRC Press, p. 257-278 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Reduced expression of the endothelin receptor type B gene in piebald mice caused by insertion of a retroposon-like element in intron 1

Yamada, T., Ohtani, S., Sakurai, T., Tsuji, T., Kunieda, T. & Yanagisawa, M., Apr 21 2006, In : Journal of Biological Chemistry. 281, 16, p. 10799-10807 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Sex difference in body weight gain and leptin signaling in hypocretin/orexin deficient mouse models

Fujiki, N., Yoshida, Y., Zhang, S., Sakurai, T., Yanagisawa, M. & Nishino, S., Sep 1 2006, In : Peptides. 27, 9, p. 2326-2331 6 p.

Research output: Contribution to journalArticle

38 Scopus citations

The dorsomedial hypothalamic nucleus as a putative food-entrainable circadian pacemaker

Mieda, M., Williams, S. C., Richardson, J. A., Tanaka, K. & Yanagisawa, M., Aug 8 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 32, p. 12150-12155 6 p.

Research output: Contribution to journalArticle

218 Scopus citations

Uterine sensitization-associated gene-1 (USAG-1), a novel BMP antagonist expressed in the kidney, accelerates tubular injury

Yanagita, M., Okuda, T., Endo, S., Tanaka, M., Takahashi, K., Sugiyama, F., Kunita, S., Takahashi, S., Fukatsu, A., Yanagisawa, M., Kita, T. & Sakurai, T., Jan 1 2006, In : Journal of Clinical Investigation. 116, 1, p. 70-79 10 p.

Research output: Contribution to journalArticle

111 Scopus citations
2007

Contribution of orexin in hypercapnic chemoreflex: Evidence from genetic and pharmacological disruption and supplementation studies in mice

Deng, B. S., Nakamura, A., Zhang, W., Yanagisawa, M., Fukuda, Y. & Kuwaki, T., Nov 1 2007, In : Journal of applied physiology. 103, 5, p. 1772-1779 8 p.

Research output: Contribution to journalArticle

82 Scopus citations

Progress report on the Hypertension Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP) study: Status at February 2004

Hosohata, K., Saito, S., Asayama, K., Ohkubo, T., Kikuya, M., Metoki, H., Obara, T., Kato, T., Hashimoto, J., Totsune, K., Miura, Y., Imai, Y., Arakawa, K., Fujishima, M., Fujii, J., Fukiyama, K., Hisamichi, S., Iimura, O., Ishii, M., Omae, T. & 526 others, Saruta, T., Yoshinaga, K., Abe, I., Abe, K., Abukawa, T., Ashida, T., Dohba, N., Etoh, T., Fujimura, A., Fujita, T., Fukui, A., Gotoh, T., Hama, H., Hano, T., Hayashi, H., Hayashida, N., Hayashi, M., Hiramori, K., Hirai, Y., Hirata, Y., Hiwada, K., Hora, K., Ichikawa, S., Iida, T., Ikeda, T., Imaizumi, T., Ishikawa, K., Ito, I., Ito, M., Ito, S., Iwaoka, D., Kanamasa, K., Katagiri, T., Katayama, S., Kawamura, H., Kawano, Y., Kida, H., Kikuchi, K., Kimura, G., Kimura, K., Kitaoka, H., Kobayashi, S., Kohara, K., Kojima, S., Komuro, I., Kumagai, H., Kumagai, Y., Kusano, E., Kushiro, T., Kuwajima, I., Maruyama, Y., Masani, F., Matsubara, H., Matsubara, T., Matsumoto, M., Matsuoka, H., Matsuura, H., Mishima, Y., Miura, M., Miyamori, I., Mori, H., Murakami, H., Muratani, H., Nakagawa, M., Nakao, K., Naruse, M., Nishio, I., Ogihara, T., Ohta, M., Ohtsuka, K., Ohtsuka, Y., Ohuchi, Y., Oikawa, S., Okabe, M., Okumura, K., Saitoh, I., Saitoh, H., Sakata, T., Saku, K., Sasaki, H., Seino, M., Senda, S., Shimada, K., Shimamoto, K., Shimizu, M., Shiomi, T., Shirato, K., Sone, M., Suzuki, H., Suzuki, S., Takahashi, H., Takada, M., Takeda, K., Takeda, N., Takeshita, A., Takishita, S., Tanaka, S., Toba, K., Tochikubo, O., Tomoike, H., Ueno, Y., Umemura, S., Urata, H., Watanabe, T., Yamada, K., Yamaguchi, T., Yamakado, M., Yamamoto, Y., Yamamoto, Y., Yamashina, A., Yokoyama, H., Yoshimura, M., Satoh, H., Oka, Y., Katagiri, H., Kondo, Y., Shishido, H., Kohinata, A., Kanno, Y., Ikeda, H., Takahira, Y., Takahashi, T., Kimura, A., Funahashi, J., Takada, N., Hanazawa, T., Suzuki, N., Osugi, M., Hashimoto, J., Ogawa, Y., Miyamura, T., Masuda, Y., Tanaka, S., Tanaka, S., Koizumi, M., Ando, T., Endo, T., Tsuchida, A., Nanba, M., Yonekura, S., Shiroishi, M., Nakagawa, M., Ito, K., Oda, K., Takahashi, K., Kanahara, I., Hirota, N., Tsutsui, M., Anzai, J., Hosoda, S., Shiiki, M., Takagawa, Y., Iida, M., Tada, M., Noto, T., Tanaka, H., Tajima, G., Kawamorita, K., Kikuchi, K., Suzuki, H., Suzuki, K., Komai, K., Seki, H., Omoto, A., Takahashi, H., Kitabayashi, A., Kimura, M., Kimura, Y., Yamamoto, H., Takahashi, K., Kimura, H., Kawamorita, Y., Emura, Y., Suzuki, Y., Ishikawa, Y., Nagai, K., Nagai, S., Ito, T., Nihei, K., Yamada, S., Goto, T., Yamamoto, N., Suzuki, Y., Ito, H., Ito, M., Fujita, T., Tominaga, Y., Tominaga, S., Suzuki, K., Ishibashi, K., Ando, Y., Sato, S., Morikawa, H., Kashima, S., Nakayama, D., Hayashi, Y., Ohta, K., Metoki, H., Fukami, K., Hayashi, T., Kishi, M., Tajima, J., Seino, J., Hoshi, H., Imai, Y., Kimura, H., Mori, R., Matsuo, K., Tanno, Y., Shibasaki, A., Yamagishi, T., Ohtomo, E., Ohtsuka, Y., Sasaki, S., Seino, M., Kurosawa, K., Ito, K., Takagi, Y., Kyogoku, S., Ito, K., Ono, Y., Watanabe, M., Watanabe, S., Hiwatashi, N., Yagi, C., Unakami, H., Asayama, K., Mouri, T., Watanabe, T., Kikuchi, K., Maruyama, N., Sone, M., Iwamoto, M., Naganuma, S., Mashiko, H., Ishii, H., Takaya, Y., Kamimoto, M., Shirai, A., Watanabe, R., Tohyama, Y., Araki, F., Sakuma, H., Amada, Y., Sato, E., Techigawara, M., Nakamura, K., Nakayama, T., Hasegawa, K., Hasegawa, K., Nagao, T., Minami, J., Kumagai, Y., Cho, T., Okamoto, K., Iguchi, T., Honzawa, T., Koitabashi, T., Yamada, T., Horikoshi, H., Nagao, T., Yoshimatsu, H., Seki, K., Akiyama, N., Suga, H., Matsunaga, R., Sinozaki, T., Ishimaru, Y., Yagi, N., Takikawa, H., Hukutome, T., Nakajima, C., Sato, H., Simizu, J., Arai, M., Koide, H., Takada, H., Sato, T., Umezu, T., Aoki, H., Nakamoto, H., Komahashi, K., Sekiya, S., Sugimoto, H., Arai, T., Suzuki, H., Inokuma, S., Funazaki, T., Yasuda, F., Kanouzawa, S., Yokota, C., Noguchi, Y., Hatano, M., Izumida, T., Hara, T., Muranaka, H., Suzuki, M., Ogawa, Y., Yabumoto, E., Matsushita, S., Kohzu, K., Sasaki, F., Hata, N., Yanagisawa, M., Ueda, T., Kurosawa, M., Doutare, S., Higashi, S., Kato, M., Hoshino, T., Fukuda, K., Ohtsuki, K., Ikeda, T., Kasatani, T., Yamada, T., Yatagai, S., Ohsuga, E., Yamakado, M., Kawamura, H., Mitsubayashi, H., Yamashina, S., Yamazaki, J., Nanjo, S., Ito, S., Teramoto, T., Gomi, T., Kato, S., Koekawa, N., Kuwaki, K., Ikeda, T., Hori, K., Arai, S., Koyama, H., Ichikawa, M., Hashimoto, A., Mori, H., Abe, S., Ohba, Y., Kurata, F., Miyakawa, M., Kimura, K., Hatori, Y., Ushiyama, M., Yamamoto, H., Adachi, M., Takayama, K., Shimizu, M., Iida, T., Asato, S., Uchiba, K., Watanabe, N., Kotani, M., Akaoka, F., Takahashi, S., Hirahara, K., Suzuki, S., Yamaguchi, Y., Ishikawa, S., Sasaki, K., Terada, Y., Ohhashi, S., Sakamaki, A., Hifumi, N., Ohno, T., Saeki, T., Suzaki, Y., Yamamoto, H., Nakagawa, T., Tomoda, F., Nishino, H., Ise, T., Takakuwa, H., Yokoyama, H., Kitakawa, S., Takasawa, K., Ohkura, T., Yamamoto, Y., Satake, K., Arai, Y., Nakayama, H., Sugiyama, S., Sugiura, K., Yokoyama, M., Ito, A., Okazaki, K., Saito, R., Mihara, J., Naito, A., Takahira, Y., Mori, T., Watanabe, M., Asai, S., Nojiri, O., Sakakura, K., Kozuka, M., Oyama, Y., Kawamura, Y., Inoko, T., Takeuchi, N., Tatematsu, H., Hayakawa, Y., Adachi, N., Tamagaki, N., Nakamura, T., Fukui, A., Amenomori, M., Kanaya, T., Masui, A., Hayashi, K., Nishi, S., Amari, M., Yoshida, K., Matsushita, Y., Sawada, S., Fujiwara, M., Ono, S., Tamai, K., Takemoto, Y., Kanemasa, T., Takenaka, T., Kitayama, K., Yasui, K., Fujita, S., Terayama, Y., Kato, N., Nagai, M., Takashima, H., Watanabe, K., Hirobe, N., Miyamoto, M., Sakamoto, N., Kurimoto, Y., Suzuki, N., Katsuya, S., Katsuya, T., Nagao, K., Nakamuta, K., Goto, S., Ueda, T., Imai, N., Sano, I., Ueda, H., Takahashi, N., Sada, T., Iwane, M., Suzuki, H., Yoshikawa, H., Tominaga, Y., Kamura, M., Ohtahara, A., Nakamura, Y., Osakada, M., Gen, M., Kahara, M., Yoshimoto, T., Mizuno, K., Furukawa, Y., Tokunaga, A., Sasaki, N., Matsumura, M., Furue, T., Iwasaki, K., Ichiki, K., Mizofuchi, S., Yokoi, T., Furumoto, W., Fukui, T., Fujino, K., Ohta, A., Ueda, S., Kitami, Y., Ohkura, T., Takeuchi, M., Yoshida, K., Nishiyama, S., Kawamoto, R., Kobaru, A., Endo, T., Kitano, K., Hirooka, Y., Tohaya, M., Miyazaki, Y., Onoyama, K., Miyagi, J., Kin, U., Fujishima, Y., Kuwahara, A., Shindo, R., Satake, Y., Moritsuka, T., Kuwahara, T., Hano, O., Takagi, Y., Suzuki, S., Abe, K., Sato, T., Kohno, M., Fujino, T., Wakayama, K., Aso, T., Goto, T., Ozaki, H., Ninomiya, K., Inobe, Y., Hamasaki, S., Inoue, J., Naomi, S., Iwaoka, T., Ono, T., Muta, Y., Endo, Y., Ohmori, H., Nagata, M., Wake, N., Kozawa, H., Tomino, Y., Ikeda, T., Yoshii, H., Nakamura, H., Fujimoto, N., Asato, T., Tozawa, M., Sunagawa, R., Nakamura, Y., Tomori, H. & Takashiba, K., Jan 1 2007, In : Clinical and Experimental Hypertension. 29, 1, p. 69-81 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

The development of hypocretin (OREXIN) deficiency in hypocretin/ataxin-3 transgenic rats

Zhang, S., Lin, L., Kaur, S., Thankachan, S., Blanco-Centurion, C., Yanagisawa, M., Mignot, E. & Shiromani, P. J., Aug 10 2007, In : Neuroscience. 148, 1, p. 34-43 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Vigilance state-dependent attenuation of hypercapnic chemoreflex and exaggerated sleep apnea in orexin knockout mice

Nakamura, A., Zhang, W., Yanagisawa, M., Fukuda, Y. & Kuwaki, T., Jan 1 2007, In : Journal of applied physiology. 102, 1, p. 241-248 8 p.

Research output: Contribution to journalArticle

105 Scopus citations
2008

Abnormal response of melanin-concentrating hormone deficient mice to fasting: Hyperactivity and rapid eye movement sleep suppression

Willie, J. T., Sinton, C. M., Maratos-Flier, E. & Yanagisawa, M., Oct 28 2008, In : Neuroscience. 156, 4, p. 819-829 11 p.

Research output: Contribution to journalArticle

103 Scopus citations

Age-related insulin resistance in hypothalamus and peripheral tissues of orexin knockout mice

Tsuneki, H., Murata, S., Anzawa, Y., Soeda, Y., Tokai, E., Wada, T., Kimura, I., Yanagisawa, M., Sakurai, T. & Sasaoka, T., Apr 1 2008, In : Diabetologia. 51, 4, p. 657-667 11 p.

Research output: Contribution to journalArticle

87 Scopus citations

An essential role for orexins in emergence from general anesthesia

Kelz, M. B., Sun, Y., Chen, J., Qing, C. M., Moore, J. T., Veasey, S. C., Dixon, S., Thornton, M., Funato, H. & Yanagisawa, M., Jan 29 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 4, p. 1309-1314 6 p.

Research output: Contribution to journalArticle

182 Scopus citations

Animals lacking endothelin-converting enzyme-2 are deficient in learning and memory

Rodriguiz, R. M., Gadnidze, K., Ragnauth, A., Dorr, N., Yanagisawa, M., Wetsel, W. C. & Devi, L. A., Jun 1 2008, In : Genes, Brain and Behavior. 7, 4, p. 418-426 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

An inverse agonist of the histamine H3 receptor improves wakefulness in narcolepsy: Studies in orexin-/- mice and patients

Lin, J. S., Dauvilliers, Y., Arnulf, I., Bastuji, H., Anaclet, C., Parmentier, R., Kocher, L., Yanagisawa, M., Lehert, P., Ligneau, X., Perrin, D., Robert, P., Roux, M., Lecomte, J. M. & Schwartz, J. C., Apr 1 2008, In : Neurobiology of Disease. 30, 1, p. 74-83 10 p.

Research output: Contribution to journalArticle

197 Scopus citations

Effect of neuropeptide B on feeding behavior is influenced by endogenous corticotropin-releasing factor activities

Aikawa, S., Ishii, M., Yanagisawa, M., Sakakibara, Y. & Sakurai, T., Nov 29 2008, In : Regulatory Peptides. 151, 1-3, p. 147-152 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41

Samuel, B. S., Shaito, A., Motoike, T., Rey, F. E., Backhed, F., Manchester, J. K., Hammer, R. E., Williams, S. C., Crowley, J., Yanagisawa, M. & Gordon, J. I., Oct 28 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 43, p. 16767-16772 6 p.

Research output: Contribution to journalArticle

808 Scopus citations

Endothelin: 20 Years from discovery to therapy

Barton, M. & Yanagisawa, M., Aug 1 2008, In : Canadian Journal of Physiology and Pharmacology. 86, 8, p. 485-498 14 p.

Research output: Contribution to journalReview article

204 Scopus citations

Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons

Makita, T., Sucov, H. M., Gariepy, C. E., Yanagisawa, M. & Ginty, D. D., Apr 10 2008, In : Nature. 452, 7188, p. 759-763 5 p.

Research output: Contribution to journalArticle

127 Scopus citations

Entrainment of temperature and activity rhythms to restricted feeding in orexin knock out mice

Kaur, S., Thankachan, S., Begum, S., Blanco-Centurion, C., Sakurai, T., Yanagisawa, M. & Shiromani, P. J., Apr 18 2008, In : Brain Research. 1205, p. 47-54 8 p.

Research output: Contribution to journalArticle

47 Scopus citations

Orexin (hypocretin) gene transfer diminishes narcoleptic sleep behavior in mice

Liu, M., Thankachan, S., Kaur, S., Begum, S., Blanco-Centurion, C., Sakurai, T., Yanagisawa, M., Neve, R. & Shiromani, P. J., Oct 1 2008, In : European Journal of Neuroscience. 28, 7, p. 1382-1393 12 p.

Research output: Contribution to journalArticle

56 Scopus citations

The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress

Lutter, M., Sakata, I., Osborne-Lawrence, S., Rovinsky, S. A., Anderson, J. G., Jung, S., Birnbaum, S. G., Yanagisawa, M., Elmquist, J. K., Nestler, E. J. & Zigman, J. M., Jul 1 2008, In : Nature neuroscience. 11, 7, p. 752-753 2 p.

Research output: Contribution to journalArticle

380 Scopus citations

Urinary protein profiling with surface-enhanced laser desorption/ionization time-of-flight mass spectrometry in etB receptor-deficient rats1

Raila, J., Kalk, P., Pfab, T., Thöne-Reineke, C., Godes, M., Yanagisawa, M., Schweigert, F. J. & Hocher, B., Aug 1 2008, In : Canadian Journal of Physiology and Pharmacology. 86, 8, p. 566-570 5 p.

Research output: Contribution to journalArticle

Ventilatory long-term facilitation in mice can be observed during both sleep and wake periods and depends on orexin

Terada, J., Nakamura, A., Zhang, W., Yanagisawa, M., Kuriyama, T., Fukuda, Y. & Kuwaki, T., Feb 1 2008, In : Journal of applied physiology. 104, 2, p. 499-507 9 p.

Research output: Contribution to journalArticle

66 Scopus citations
2009

Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B

Irukayama-Tomobe, Y., Tanaka, H., Yokomizo, T., Hashidate-Yoshida, T., Yanagisawa, M. & Sakurai, T., Mar 10 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 10, p. 3930-3934 5 p.

Research output: Contribution to journalArticle

38 Scopus citations

COUP-TFII acts downstream of Wnt/β-catenin signal to silence PPARγ gene expression and repress adipogenesis

Okamura, M., Kudo, H., Wakabayashi, K. I., Tanaka, T., Nonaka, A., Uchida, A., Tsutsumi, S., Sakakibara, I., Naito, M., Osborne, T. F., Hamakubo, T., Ito, S., Aburatani, H., Yanagisawa, M., Kodama, T. & Sakai, J., Apr 7 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 14, p. 5819-5824 6 p.

Research output: Contribution to journalArticle

129 Scopus citations

Endothelial ETB limits vascular remodelling and development of pulmonary hypertension during hypoxia

Kelland, N. F., Bagnall, A. J., Morecroft, I., Gulliver-Sloan, F. H., Dempsie, Y., Nilsen, M., Yanagisawa, M., MacLean, M. R., Kotelevtsev, Y. V. & Webb, D. J., Jan 1 2009, In : Journal of Vascular Research. 47, 1, p. 16-22 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Endothelin-1 impairs alveolar epithelial function via endothelial ET B receptor

Comellas, A. P., Briva, A., Dada, L. A., Butti, M. L., Trejo, H. E., Yshii, C., Azzam, Z. S., Litvan, J., Chen, J., Lecuona, E., Pesce, L. M., Yanagisawa, M. & Sznajder, J. I., Jan 15 2009, In : American journal of respiratory and critical care medicine. 179, 2, p. 113-122 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Enhanced Orexin Receptor-2 Signaling Prevents Diet-Induced Obesity and Improves Leptin Sensitivity

Funato, H., Tsai, A. L., Willie, J. T., Kisanuki, Y., Williams, S. C., Sakurai, T. & Yanagisawa, M., Jan 7 2009, In : Cell Metabolism. 9, 1, p. 64-76 13 p.

Research output: Contribution to journalArticle

182 Scopus citations

Fasting-Induced Hypothermia and Reduced Energy Production in Mice Lacking Acetyl-CoA Synthetase 2

Sakakibara, I., Fujino, T., Ishii, M., Tanaka, T., Shimosawa, T., Miura, S., Zhang, W., Tokutake, Y., Yamamoto, J., Awano, M., Iwasaki, S., Motoike, T., Okamura, M., Inagaki, T., Kita, K., Ezaki, O., Naito, M., Kuwaki, T., Chohnan, S., Yamamoto, T. T. & 4 others, Hammer, R. E., Kodama, T., Yanagisawa, M. & Sakai, J., Feb 4 2009, In : Cell Metabolism. 9, 2, p. 191-202 12 p.

Research output: Contribution to journalArticle

54 Scopus citations

Halothane-induced hypnosis is not accompanied by inactivation of orexinergic output in rodents

Gompf, H., Chen, J., Sun, Y., Yanagisawa, M., Aston-Jones, G. & Kelz, M. B., Nov 2009, In : Anesthesiology. 111, 5, p. 1001-1009 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Hypothalamic Orexin Stimulates Feeding-Associated Glucose Utilization in Skeletal Muscle via Sympathetic Nervous System

Shiuchi, T., Haque, M. S., Okamoto, S., Inoue, T., Kageyama, H., Lee, S., Toda, C., Suzuki, A., Bachman, E. S., Kim, Y. B., Sakurai, T., Yanagisawa, M., Shioda, S., Imoto, K. & Minokoshi, Y., Dec 2 2009, In : Cell Metabolism. 10, 6, p. 466-480 15 p.

Research output: Contribution to journalArticle

149 Scopus citations

IGFBP3 colocalizes with and regulates hypocretin (orexin)

Honda, M., Eriksson, K. S., Zhang, S., Tanaka, S., Lin, L., Salehi, A., Hesla, P. E., Maehlen, J., Gaus, S. E., Yanagisawa, M., Sakurai, T., Taheri, S., Tsuchiya, K., Honda, Y. & Mignot, E., Jan 22 2009, In : PloS one. 4, 1, e4254.

Research output: Contribution to journalArticle

47 Scopus citations

Orexin/hypocretin and histamine: Distinct roles in the control of wakefulness demonstrated using knock-out mouse models

Anaclet, C., Parmentier, R., Ouk, K., Guidon, G., Buda, C., Sastre, J. P., Akaoka, H., Sergeeva, O. A., Yanagisawa, M., Ohtsu, H., Franco, P., Haas, H. L. & Lin, J. S., Nov 18 2009, In : Journal of Neuroscience. 29, 46, p. 14423-14438 16 p.

Research output: Contribution to journalArticle

148 Scopus citations

Selective loss of GABAB receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture

Matsuki, T., Nomiyama, M., Takahira, H., Hirashima, N., Kunita, S., Takahashi, S., Yagami, K. I., Kilduff, T. S., Bettler, B., Yanagisawa, M. & Sakurai, T., Mar 17 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 11, p. 4459-4464 6 p.

Research output: Contribution to journalArticle

88 Scopus citations

Selective loss of GABAB receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture (Proceedings of the National Academy of Sciences of the United States of America (2009) 106, 11, (4459-4464) DOI: 10.1073/pnas.0811126106)

Matsuki, T., Nomiyama, M., Takahira, H., Hirashima, N., Kunita, S., Takahashi, S., Yagami, K. I., Kilduff, T. S., Bettler, B., Yanagisawa, M. & Sakurai, T., May 26 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 21, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations