• 71926 Citations
  • 119 h-Index
1984 …2020

Research output per year

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Research Output

1990

Involvement of endothelin in the regulation of human vascular tonus - Potent vasoconstrictor effect and existence in endothelial cells

Miyauchi, T., Tomobe, Y., Shiba, R., Ishikawa, T., Yanagisawa, M., Kimura, S., Sugishita, Y., Ito, I., Goto, K. & Masaki, T., Jan 1 1990, In : Circulation. 81, 6, p. 1874-1880 7 p.

Research output: Contribution to journalArticle

Open Access
119 Scopus citations

Isolation of anti-endothelin receptor monoclonal antibodies for use in receptor characterization

Kondoh, M., Miyazaki, H., Watanabe, H., Shibata, T., Yanagisawa, M., Masaki, T. & Murakami, K., Oct 30 1990, In : Biochemical and Biophysical Research Communications. 172, 2, p. 503-510 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Mechanisms of increased sensitivity to endothelin-1 in aorta from spontaneously hypertensive rats

Tomobe, Y., Ishikawa, T., Yanagisawa, M., Kimura, S., Masaki, T. & Goto, K., Jan 1 1990, In : European Journal of Pharmacology. 183, 5, 1 p.

Research output: Contribution to journalArticle

4 Scopus citations

Monoclonal antibodies to endothelin: Application for sandwich immunoassays

Hamaoki, M., Kato, H., Sugi, M., Fujimoto, M., Kurihara, H., Yosizumi, M., Yanagisawa, M., Kimura, S., Masaki, T. & Yazaki, Y., Jan 1 1990, In : Hybridoma. 9, 1, p. 63-69 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

Production of endothelin-1 by rat cultured mesangial cells

Sakamoto, H., Sasaki, S., Hirata, Y., Imai, T., Ando, K., Ida, T., Sakurai, T., Yanagisawa, M., Masaki, T. & Marumo, F., Jun 15 1990, In : Biochemical and Biophysical Research Communications. 169, 2, p. 462-468 7 p.

Research output: Contribution to journalArticle

105 Scopus citations

Purification and characterization of putative endothelin converting enzyme in bovine adrenal medulla: Evidence for a cathepsin D-like enzyme

Sawamura, T., Kimura, S., Shinmi, O., Sugita, Y., Yanagisawa, M., Goto, K. & Masaki, T., May 16 1990, In : Biochemical and Biophysical Research Communications. 168, 3, p. 1230-1236 7 p.

Research output: Contribution to journalArticle

72 Scopus citations

Role of endothelin in mechanisms of local blood pressure control

Masaki, T., Yanagisawa, M., Goto, K. & Kimura, S., Dec 1 1990, In : Journal of hypertension. 8, SUPPL. 7, p. S107-S112

Research output: Contribution to journalArticle

32 Scopus citations

Study on the Endothelin Gene and its Expression

Masaki, T., Yanagisawa, M., Inoue, A., Kimura, S. & Goto, K., Jan 1 1990, In : JAPANESE CIRCULATION JOURNAL. 54, 9, p. 1221-1225 5 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

The human endothelin family: cDNA cloning, complete primary structure and differential tissue expression of the three precursors

Yanagtsawa, M., Inoue, A., Imai, T., Matsushita, Y. & Masaki, T., Jul 5 1990, In : European Journal of Pharmacology. 183, 5, p. 1628-1629 2 p.

Research output: Contribution to journalArticle

1989

Analysis of endothelin related peptides in culture supernatant of porcine aortic endothelial cells: Evidence for biosynthetic pathway of endothelin-1

Sawamura, T., Kimura, S., Shinmi, O., Sugita, Y., Yanagisawa, M. & Masaki, T., Aug 15 1989, In : Biochemical and Biophysical Research Communications. 162, 3, p. 1287-1294 8 p.

Research output: Contribution to journalArticle

84 Scopus citations

A novel vasoactive peptide endothelin stimulates mitogenesis through inositol lipid turnover in Swiss 3T3 fibroblasts

Takuwa, N., Takuwa, Y., Yanagisawa, M., Yamashita, K. & Masaki, T., Jan 1 1989, In : Journal of Biological Chemistry. 264, 14, p. 7856-7861 6 p.

Research output: Contribution to journalArticle

423 Scopus citations

Autoradiographic distribution in rat tissues of binding sites for endothelin: A neuropeptide?

Koseki, C., Imai, M., Hirata, Y., Yanagisawa, M. & Masaki, T., Jan 1 1989, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 256, 4, p. 25/4

Research output: Contribution to journalArticle

360 Scopus citations

Autoradiographic localization of [125I]-endothelin-1 binding sites in rat brain

Koseki, C., Imai, M., Hirata, Y., Yanagisawa, M. & Masaki, T., Aug 1989, In : Neuroscience Research. 6, 6, p. 581-585 5 p.

Research output: Contribution to journalArticle

41 Scopus citations

Binding sites for endothelin-1 in rat tissues: An autoradiographic study

Koseki, C., Imai, M., Hirata, Y., Yanagisawa, M. & Masaki, T., Jan 1 1989, In : Journal of Cardiovascular Pharmacology. 13, p. S153-S154

Research output: Contribution to journalArticle

51 Scopus citations

Characteristics of pressor response to endothelin in spontaneously hypertensive and Wistar-Kyoto rats

Miyauchi, T., Ishikawa, T., Tomobe, Y., Yanagisawa, M., Kimura, S., Sugishita, Y., Ito, I., Goto, K. & Masaki, T., Jan 1 1989, In : Hypertension. 14, 4, p. 427-434 8 p.

Research output: Contribution to journalArticle

Open Access
99 Scopus citations

Conversion of big endothelin-1 to 21-residue endothelin-1 is essential for expression of full vasoconstrictor activity: Structure-activity relationships of big endothelin-1

Kimura, S., Kasuya, Y., Sawamura, T., Shinmi, O., Sugita, Y., Yanagisawa, M., Goto, K. & Masaki, T., Jan 1 1989, In : Journal of Cardiovascular Pharmacology. 13, p. S5-S7

Research output: Contribution to journalArticle

180 Scopus citations

Elimination of intravenously injected endothelin-1 from the circulation of the rat

Shiba, R., Yanagisawa, M., Miyauchi, T., Ishii, Y., Kimura, S., Uchiyama, Y., Masaki, T. & Goto, K., Jan 1 1989, In : Journal of Cardiovascular Pharmacology. 13, p. S98-S101

Research output: Contribution to journalArticle

104 Scopus citations
355 Scopus citations

Endothelin, its diverse biological activities and mechanisms of action

Takuwa, Y., Yanagisawa, M., Takuwa, N. & Masaki, T., 1989, In : Progress in Growth Factor Research. 1, 4, p. 195-206 12 p.

Research output: Contribution to journalArticle

36 Scopus citations

Endothelin 1, an endothelium-derived peptide, is expressed in neurons of the human spinal cord and dorsal root ganglia

Giaid, A., Gibson, S. J., Ibrahim, N. B. N., Legon, S., Bloom, S. R., Yanagisawa, M., Masaki, T., Varndell, I. M. & Polak, J. M., Jan 1 1989, In : Proceedings of the National Academy of Sciences of the United States of America. 86, 19, p. 7634-7638 5 p.

Research output: Contribution to journalArticle

Open Access
330 Scopus citations

Endothelin-1 acts in cerebral arteries from the adventitial but not from the luminal side

Shigeno, T., Mima, T., Takakura, K., Yanagisawa, M., Saito, A., Goto, K. & Masaki, T., Jan 1 1989, In : Journal of Cardiovascular Pharmacology. 13, p. S174-S176

Research output: Contribution to journalArticle

53 Scopus citations

Endothelin-1 depolarizes a ventral root potential in the newborn rat spinal cord

Yoshizawa, T., Kimura, S., Kanazawa, I., Yanagisawa, M. & Masaki, T., Jan 1 1989, In : Journal of Cardiovascular Pharmacology. 13, p. S216-S217

Research output: Contribution to journalArticle

26 Scopus citations

Endothelin-1 induces vasoconstriction through two functionally distinct pathways in porcine coronary artery: Contribution of phosphoinositide turnover

Kasuya, Y., Takuwa, Y., Yanagisawa, M., Kimura, S., Goto, K. & Masaki, T., Jun 30 1989, In : Biochemical and Biophysical Research Communications. 161, 3, p. 1049-1055 7 p.

Research output: Contribution to journalArticle

96 Scopus citations

Endothelin-3 is a novel neuropeptide: Isolation and sequence determination of endothelin-1 and endothelin-3 in porcine brain

Shinmi, O., Kimura, S., Sawamura, T., Sugita, Y., Yoshizawa, T., Uchiyama, Y., Yanagisawa, M., Goto, K., Masaki, T. & Kanazawa, I., Oct 16 1989, In : Biochemical and Biophysical Research Communications. 164, 1, p. 587-593 7 p.

Research output: Contribution to journalArticle

133 Scopus citations

Endothelin activates the dihydropyridine-sensitive, voltage-dependent Ca2+ channel in vascular smooth muscle

Goto, K., Kasuya, Y., Matsuki, N., Takuwa, Y., Kurihara, H., Ishikawa, T., Kimura, S., Yanagisawa, M. & Masaki, T., Jan 1 1989, In : Proceedings of the National Academy of Sciences of the United States of America. 86, 10, p. 3915-3918 4 p.

Research output: Contribution to journalArticle

Open Access
316 Scopus citations

Endothelin acts in feline and canine cerebral arteries from the adventitial side

Mima, T., Yanagisawa, M., Shigeno, T., Saito, A., Goto, K., Takakura, K. & Masaki, T., Nov 1989, In : Stroke. 20, 11, p. 1553-1556 4 p.

Research output: Contribution to journalArticle

Open Access
107 Scopus citations

Endothelin localizes in the dorsal horn and acts on the spinal neurones: Possible involvement of dihydropyridine-sensitive calcium channels and substance P release

Yoshizawa, T., Kimura, S., Kanazawa, I., Uchiyama, Y., Yanagisawa, M. & Masaki, T., Jul 31 1989, In : Neuroscience Letters. 102, 2-3, p. 179-184 6 p.

Research output: Contribution to journalArticle

119 Scopus citations

Expression of multiple tau isoforms and microtubule bundle formation in fibroblasts transfected with a single tau cDNA

Kanai, Y., Takemura, R., Oshima, T., Mori, H., Ihara, Y., Yanagisawa, M., Masaki, T. & Hirokawa, N., Jan 1 1989, In : Journal of Cell Biology. 109, 3, p. 1173-1184 12 p.

Research output: Contribution to journalArticle

Open Access
280 Scopus citations

Hemodynamic shear stress stimulates endothelin production by cultured endothelial cells

Yoshizumi, M., Kurihara, H., Sugiyama, T., Takaku, F., Yanagisawa, M., Masaki, T. & Yazaki, Y., Jun 15 1989, In : Biochemical and Biophysical Research Communications. 161, 2, p. 859-864 6 p.

Research output: Contribution to journalArticle

441 Scopus citations

Identification of the endothelin-1 receptor in the chick heart

Miyazaki, H., Kondoh, M., Watanabe, H., Hayashi, T., Murakami, K., Takahashi, M., Yanagisawa, M., Kimura, S., Goto, K. & Masaki, T., Jan 1 1989, In : Journal of Cardiovascular Pharmacology. 13, p. S155-S156

Research output: Contribution to journalArticle

17 Scopus citations

Immunoreactive endothelin-1 in plasma detected by a sandwich-type enzyme immunoassay

Suzuki, N., Matsumoto, H., Kitada, C., Yanagisawa, M., Miyauchi, T., Masaki, T. & Fujino, M., Jan 1 1989, In : Journal of Cardiovascular Pharmacology. 13, p. S151-S152

Research output: Contribution to journalArticle

45 Scopus citations

INCREASED PLASMA CONCENTRATIONS OF ENDOTHELIN-1 AND BIG ENDOTHELIN-1 IN ACUTE MYOCARDIAL INFARCTION

Miyauchi, T., Yanagisawa, M., Tomizawa, T., Sugishita, Y., Suzuki, N., Fujino, M., Ajisaka, R., Goto, K. & Masaki, T., Jul 1 1989, In : The Lancet. 334, 8653, p. 53-54 2 p.

Research output: Contribution to journalLetter

542 Scopus citations

Mechanism of contraction to endothelin in isolated porcine coronary artery

Kasuya, Y., Ishikawa, T., Yanagisawa, M., Kimura, S., Goto, K. & Masaki, T., Dec 1 1989, In : American Journal of Physiology - Heart and Circulatory Physiology. 257, 6, p. 26/6

Research output: Contribution to journalArticle

57 Scopus citations

Molecular biology and biochemistry of the endothelins

Masashi, Y. & Tomoh, M., Sep 1989, In : Trends in Pharmacological Sciences. 10, 9, p. 374-378 5 p.

Research output: Contribution to journalReview article

583 Scopus citations

Presence of endothelin-1 in porcine spinal cord: Isolation and sequence determination

Shinmi, O., Kimura, S., Yoshizawa, T., Sawamura, T., Uchiyama, Y., Sugita, Y., Kanazawa, I., Yanagisawa, M., Goto, K. & Masaki, T., Jul 14 1989, In : Biochemical and Biophysical Research Communications. 162, 1, p. 340-346 7 p.

Research output: Contribution to journalArticle

97 Scopus citations

Renal vasoconstriction by the endothelial cell-derived peptide endothelin in spontaneously hypertensive rats

Hirata, Y., Matsuoka, H., Kimura, K., Fukui, K., Hayakawa, H., Suzuki, E., Sugimoto, T., Sugimoto, T., Yanagisawa, M. & Masaki, T., Jan 1 1989, In : Circulation research. 65, 5, p. 1370-1379 10 p.

Research output: Contribution to journalArticle

Open Access
54 Scopus citations

The human endothelin family: Three structurally and pharmacologically distinct isopeptides predicted by three separate genes

Inoue, A., Yanagisawa, M., Kimura, S., Kasuya, Y., Miyauchi, T., Goto, K. & Masaki, T., Jan 1 1989, In : Proceedings of the National Academy of Sciences of the United States of America. 86, 8, p. 2863-2867 5 p.

Research output: Contribution to journalArticle

Open Access
2459 Scopus citations

The human preproendothelin-1 gene: Possible regulation by endothelial phosphoinositide turnover signaling

Yanagisawa, M., Inoue, A., Takuwa, Y., Mitsui, Y., Kobayashi, M. & Masaki, T., Jan 1 1989, In : Journal of Cardiovascular Pharmacology. 13, p. S13-S17

Research output: Contribution to journalArticle

144 Scopus citations

The human preproendothelin-1 gene. Complete nucleotide sequence and regulation of expression

Inoue, A., Yanagisawa, M., Takuwa, Y., Mitsui, Y., Kobayashi, M. & Masaki, T., Jan 1 1989, In : Journal of Biological Chemistry. 264, 25, p. 14954-14959 6 p.

Research output: Contribution to journalArticle

388 Scopus citations

The possible role of endothelin-1 in the pathogenesis of coronary vasospasm

Kurihara, H., Yoshizumi, M., Sugiyama, T., Yamaoki, K., Nagai, R., Takaku, F., Satoh, H., Inui, J., Yanagisawa, M., Masaki, T. & Yazaki, Y., Jan 1 1989, In : Journal of Cardiovascular Pharmacology. 13, p. S132-S137

Research output: Contribution to journalArticle

81 Scopus citations

Transforming growth factor-β stimulates the expression of endothelin mRNA by vascular endothelial cells

Kurihara, H., Yoshizumi, M., Sugiyama, T., Takaku, F., Yanagisawa, M., Masaki, T., Hamaoki, M., Kato, H. & Yazaki, Y., Mar 31 1989, In : Biochemical and Biophysical Research Communications. 159, 3, p. 1435-1440 6 p.

Research output: Contribution to journalArticle

370 Scopus citations

Two different forms of endothelin receptors in rat lung

Masuda, Y., Miyazaki, H., Kondoh, M., Watanabe, H., Yanagisawa, M., Masaki, T. & Murakami, K., Nov 6 1989, In : FEBS Letters. 257, 2, p. 208-210 3 p.

Research output: Contribution to journalArticle

107 Scopus citations
111 Scopus citations

Two distinct types of endothelin receptors are present on chick cardiac membranes

Watanabe, H., Miyazaki, H., Kondoh, M., Masuda, Y., Kimura, S., Yanagisawa, M., Masaki, T. & Murakami, K., Jun 30 1989, In : Biochemical and Biophysical Research Communications. 161, 3, p. 1252-1259 8 p.

Research output: Contribution to journalArticle

164 Scopus citations

Two isoforms of smooth muscle myosin regulatory light chain in chicken gizzard

Inoue, A., Yanagisawa, M., Takano-Ohmuro, H. & Masaki, T., Aug 1989, In : European Journal of Biochemistry. 183, 3, p. 645-651 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Two problems on smooth muscle contraction in relation to calcium ion

Masaki, T., Yanagisawa, M., Kurihara, H., Goto, K., Kimura, S., Katoch, S. & Tanaka, T., Jan 1 1989, In : Journal of Pharmacobio-Dynamics. 12, 4, p. S-105

Research output: Contribution to journalArticle

Vasoconstrictor response of large cerebral arteries of cats to endothelin, an endothelium-derived vasoactive peptide

Saito, A., Shiba, R., Kimura, S., Yanagisawa, M., Goto, K. & Masaki, T., Mar 21 1989, In : European Journal of Pharmacology. 162, 2, p. 353-358 6 p.

Research output: Contribution to journalArticle

88 Scopus citations
1988

A novel peptide vasoconstrictor, endothelin, is produced by vascular endothelium and modulates smooth muscle ca2+channels

Yanagisawa, M., Kurihara, H., Kimura, S., Goto, K. & Masaki, T., Dec 1988, In : Journal of Hypertension, Supplement. 6, 4, p. s188-s191

Research output: Contribution to journalArticle

227 Scopus citations

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

Yanagisawa, M., Kurihara, H., Kimura, S., Tomobe, Y., Kobayashi, M., Mitsui, Y., Yazaki, Y., Goto, K. & Masaki, T., Jan 1 1988, In : Nature. 332, 6163, p. 411-415 5 p.

Research output: Contribution to journalArticle

9722 Scopus citations

Binding and receptor down-regulation of a novel vasoconstrictor endothelin in cultured rat vascular smooth muscle cells

Hirata, Y., Yoshimi, H., Takaichi, S., Yanagisawa, M. & Masaki, T., Oct 24 1988, In : FEBS Letters. 239, 1, p. 13-17 5 p.

Research output: Contribution to journalArticle

210 Scopus citations