• 71213 Citations
  • 119 h-Index
1984 …2019
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Research Output 1984 2019

  • 71213 Citations
  • 119 h-Index
  • 451 Article
  • 3 Chapter
  • 3 Conference contribution
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Article
2019
1 Citation (Scopus)

A new mouse model of GLUT1 deficiency syndrome exhibits abnormal sleep-wake patterns and alterations of glucose kinetics in the brain

Furuse, T., Mizuma, H., Hirose, Y., Kushida, T., Yamada, I., Miura, I., Masuya, H., Funato, H., Yanagisawa, M., Onoe, H. & Wakana, S., Sep 12 2019, In : Disease models & mechanisms. 12, 9

Research output: Contribution to journalArticle

Open Access
Facilitative Glucose Transport Proteins
Brain
Sleep
Glucose
Electroencephalography

A novel rearrangement reaction of morphinan to arylmorphan skeletons and the pharmacologies of arylmorphan derivatives

Yata, M., Kutsumura, N., Nagumo, Y., Yamamoto, N., Saitoh, T., Ishikawa, Y., Irukayama-Tomobe, Y., Yanagisawa, M. & Nagase, H., Jan 1 2019, In : Heterocycles. p. 134-144 11 p.

Research output: Contribution to journalArticle

Morphinans
Opioid Receptors
Skeleton
Nitrogen
Orexin Receptors
2 Citations (Scopus)

Differential Roles of Each Orexin Receptor Signaling in Obesity

Kakizaki, M., Tsuneoka, Y., Takase, K., Kim, S. J., Choi, J., Ikkyu, A., Abe, M., Sakimura, K., Yanagisawa, M. & Funato, H., Oct 25 2019, In : iScience. 20, p. 1-13 13 p.

Research output: Contribution to journalArticle

Open Access
Orexin Receptors
Obesity
Endocrinology
1 Citation (Scopus)

Effects of 3 Weeks of Water Immersion and Restraint Stress on Sleep in Mice

Yasugaki, S., Liu, C. Y., Kashiwagi, M., Kanuka, M., Honda, T., Miyata, S., Yanagisawa, M. & Hayashi, Y., Oct 14 2019, In : Frontiers in Neuroscience. 13, 1072.

Research output: Contribution to journalArticle

Open Access
Immersion
Sleep
Water
Eye Movements
Depression
2 Citations (Scopus)

Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring

Yamamoto, N., Ohrui, S., Okada, T., Saitoh, T., Kutsumura, N., Nagumo, Y., Irukayama-Tomobe, Y., Ogawa, Y., Ishikawa, Y., Watanabe, Y., Hayakawa, D., Gouda, H., Yanagisawa, M. & Nagase, H., Jan 1 2019, In : Bioorganic and Medicinal Chemistry.

Research output: Contribution to journalArticle

Orexin Receptors
Morphinans
Derivatives
Amides
Assays
1 Citation (Scopus)

Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity

Saitoh, T., Seki, K., Nakajima, R., Yamamoto, N., Kutsumura, N., Nagumo, Y., Irukayama-Tomobe, Y., Ogawa, Y., Ishikawa, Y., Tanimura, R., Yanagisawa, M. & Nagase, H., Jan 1 2019, In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

Morphinans
Orexin Receptors
Sulfonamides
Scaffolds
Amides

MC-SleepNet: Large-scale Sleep Stage Scoring in Mice by Deep Neural Networks

Yamabe, M., Horie, K., Shiokawa, H., Funato, H., Yanagisawa, M. & Kitagawa, H., Dec 1 2019, In : Scientific reports. 9, 1, 15793.

Research output: Contribution to journalArticle

Open Access
Sleep Stages
Individuality
Noise
Research Design
Research

Methodology and theoretical basis of forward genetic screening for sleep/wakefulness in mice

Miyoshi, C., Kim, S. J., Ezaki, T., Ikkyu, A., Hotta-Hirashima, N., Kanno, S., Kakizaki, M., Yamada, M., Wakana, S., Yanagisawa, M. & Funato, H., Aug 6 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 32, p. 16062-16067 6 p.

Research output: Contribution to journalArticle

Open Access
Wakefulness
Genetic Testing
Sleep
REM Sleep
Exome
MEF2 Transcription Factors
Suprachiasmatic Nucleus
Sleep
Brain
Proteins

Toward the mysteries of sleep

Yanagisawa, M., Jan 1 2019, In : Keio Journal of Medicine. 68, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Sleep
2018
3 Citations (Scopus)

Ablation of central serotonergic neurons decreased REM sleep and attenuated arousal response

Iwasaki, K., Komiya, H., Kakizaki, M., Miyoshi, C., Abe, M., Sakimura, K., Funato, H. & Yanagisawa, M., Aug 7 2018, In : Frontiers in Neuroscience. 12, AUG, 535.

Research output: Contribution to journalArticle

Serotonergic Neurons
REM Sleep
Arousal
Sleep
Serotonin
3 Citations (Scopus)

Acute pressor response to psychosocial stress is dependent on endothelium-derived endothelin-1

Fox, B. M., Becker, B. K., Loria, A. S., Hyndman, K. A., Jin, C., Clark, H., Johns, R., Yanagisawa, M., Pollock, D. M. & Pollock, J. S., Feb 1 2018, In : Journal of the American Heart Association. 7, 4, e007863.

Research output: Contribution to journalArticle

Endothelin-1
Endothelium
Vascular Endothelium
Knockout Mice
Endothelin A Receptors
5 Citations (Scopus)

A single phosphorylation site of SIK3 regulates daily sleep amounts and sleep need in mice

Honda, T., Fujiyama, T., Miyoshi, C., Ikkyu, A., Hotta-Hirashima, N., Kanno, S., Mizuno, S., Sugiyama, F., Takahashi, S., Funato, H. & Yanagisawa, M., Oct 9 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 41, p. 10458-10463 6 p.

Research output: Contribution to journalArticle

Sleep
Phosphorylation
Eye Movements
Disorders of Excessive Somnolence
Sequence Deletion
4 Citations (Scopus)

Continuous intrathecal orexin delivery inhibits cataplexy in a murine model of narcolepsy

Kaushik, M. K., Aritake, K., Imanishi, A., Kanbayashi, T., Ichikawa, T., Shimizu, T., Urade, Y. & Yanagisawa, M., Jun 5 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 23, p. 6046-6051 6 p.

Research output: Contribution to journalArticle

Cataplexy
Narcolepsy
Knockout Mice
Sleep
Implantable Infusion Pumps
2 Citations (Scopus)

Development of a Therapeutic Drug for Narcolepsy

Irukayama-Tomobe, Y. & Yanagisawa, M., Nov 1 2018, In : Brain and nerve = Shinkei kenkyu no shinpo. 70, 11, p. 1255-1263 9 p.

Research output: Contribution to journalArticle

Narcolepsy
Cataplexy
Orexin Receptors
Pharmaceutical Preparations
Therapeutics
1 Citation (Scopus)

Effects of the delta opioid receptor agonist KNT-127 on electroencephalographic activity in mice

Saitoh, A., Tominaga, H., Ogawa, Y., Irukayama-Tomobe, Y., Yamada, M., Yanagisawa, M. & Nagase, H., Apr 1 2018, In : Pharmacological Reports. 70, 2, p. 350-354 5 p.

Research output: Contribution to journalArticle

delta Opioid Receptor
Seizures
Catalepsy
Implanted Electrodes
Psychotropic Drugs
6 Citations (Scopus)

Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity

Ohrui, S., Yamamoto, N., Saitoh, T., Kutsumura, N., Nagumo, Y., Irukayama-Tomobe, Y., Ogawa, Y., Ishikawa, Y., Watanabe, Y., Hayakawa, D., Gouda, H., Yanagisawa, M. & Nagase, H., Jan 1 2018, (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

Orexin Receptors
Dehydration
Derivatives
Sulfonamides
Amides
4 Citations (Scopus)

Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain

Fujiyama, T., Miyashita, S., Tsuneoka, Y., Kanemaru, K., Kakizaki, M., Kanno, S., Ishikawa, Y., Yamashita, M., Owa, T., Nagaoka, M., Kawaguchi, Y., Yanagawa, Y., Magnuson, M. A., Muratani, M., Shibuya, A., Nabeshima, Y. I., Yanagisawa, M., Funato, H. & Hoshino, M., Jul 3 2018, In : Cell Reports. 24, 1, p. 79-94 16 p.

Research output: Contribution to journalArticle

Sex Differentiation
Prosencephalon
Brain
Hypothalamus
Gonadal Hormones
10 Citations (Scopus)

Hypocretin/orexin deficiency decreases cocaine abuse liability

Steiner, N., Rossetti, C., Sakurai, T., Yanagisawa, M., de Lecea, L., Magistretti, P. J., Halfon, O. & Boutrel, B., May 1 2018, In : Neuropharmacology. 133, p. 395-403 9 p.

Research output: Contribution to journalArticle

Cocaine-Related Disorders
Cocaine
Reward
Orexins
Arousal
4 Citations (Scopus)

Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors

Wang, Y., Cao, L., Lee, C. Y., Matsuo, T., Wu, K., Asher, G., Tang, L., Saitoh, T., Russell, J. L., Klewe-Nebenius, D., Wang, L., Soya, S., Hasegawa, E., Chérasse, Y., Zhou, J., Li, Y., Wang, T., Zhan, X., Miyoshi, C., Irukayama, Y. & 13 others, Cao, J., Meeks, J., Gautron, L., Wang, Z., Sakurai, K., Funato, H., Sakurai, T., Yanagisawa, M., Nagase, H., Kobayakawa, R., Kobayakawa, K., Beutler, B. A. & Liu, Q., Dec 1 2018, In : Nature Communications. 9, 1, 4324.

Research output: Contribution to journalArticle

fear
Instinct
odors
predators
Genetic Testing
2 Citations (Scopus)

Localization of orexin B and orexin-2 receptor in the rat epididymis

Liguori, G., Tafuri, S., Miyoshi, C., Yanagisawa, M., Squillacioti, C., De Pasquale, V., Mirabella, N., Vittoria, A. & Costagliola, A., Jan 1 2018, (Accepted/In press) In : Acta Histochemica.

Research output: Contribution to journalArticle

Orexin Receptors
Epididymis
Hypothalamus
Orexins
Staining and Labeling
2 Citations (Scopus)

Nonpeptide Orexin-2 Receptor Agonist Attenuates Morphine-induced Sedative Effects in Rats

Toyama, S., Shimoyama, N., Tagaito, Y., Nagase, H., Saitoh, T., Yanagisawa, M. & Shimoyama, M., Jan 1 2018, In : Anesthesiology. 128, 5, p. 992-1003 12 p.

Research output: Contribution to journalArticle

Orexin Receptors
Hypnotics and Sedatives
Morphine
Startle Reflex
Electroencephalography
30 Citations (Scopus)

Quantitative phosphoproteomic analysis of the molecular substrates of sleep need

Wang, Z., Ma, J., Miyoshi, C., Li, Y., Sato, M., Ogawa, Y., Lou, T., Ma, C., Gao, X., Lee, C., Fujiyama, T., Yang, X., Zhou, S., Hotta-Hirashima, N., Klewe-Nebenius, D., Ikkyu, A., Kakizaki, M., Kanno, S., Cao, L., Takahashi, S. & 5 others, Peng, J., Yu, Y., Funato, H., Yanagisawa, M. & Liu, Q., Jun 21 2018, In : Nature. 558, 7710, p. 435-439 5 p.

Research output: Contribution to journalArticle

Sleep
Phosphoproteins
Phosphorylation
Homeostasis
Brain
2 Citations (Scopus)

Sleep/Wake Behaviors in Mice during Pregnancy and Pregnancy-Associated Hypertensive Mice

Komiya, H., Miyoshi, C., Iwasaki, K., Hotta-Hirashima, N., Ikkyu, A., Kanno, S., Honda, T., Gosho, M., Hamada, H., Satoh, T., Fukamizu, A., Funato, H. & Yanagisawa, M., Mar 1 2018, In : Sleep. 41, 3

Research output: Contribution to journalArticle

Sleep
Pregnancy
Wakefulness
Inbred C57BL Mouse
Electroencephalography
2017
3 Citations (Scopus)

Anatomical and electrophysiological development of the hypothalamic orexin neurons from embryos to neonates

Ogawa, Y., Kanda, T., Vogt, K. & Yanagisawa, M., 2017, (Accepted/In press) In : Journal of Comparative Neurology.

Research output: Contribution to journalArticle

Embryonic Structures
Neurons
Sleep
Lateral Hypothalamic Area
Neuropeptides
15 Citations (Scopus)

Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies

Nagase, H., Yamamoto, N., Yata, M., Ohrui, S., Okada, T., Saitoh, T., Kutsumura, N., Nagumo, Y., Irukayama-Tomobe, Y., Ishikawa, Y., Ogawa, Y., Hirayama, S., Kuroda, D., Watanabe, Y., Gouda, H. & Yanagisawa, M., Feb 9 2017, In : Journal of Medicinal Chemistry. 60, 3, p. 1018-1040 23 p.

Research output: Contribution to journalArticle

Morphinans
Orexin Receptors
Skeleton
Acrylamide
Opioid Receptors
6 Citations (Scopus)

Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor

Yamamoto, N., Ohrui, S., Okada, T., Yata, M., Saitoh, T., Kutsumura, N., Nagumo, Y., Irukayama-Tomobe, Y., Ogawa, Y., Ishikawa, Y., Watanabe, Y., Hayakawa, D., Gouda, H., Yanagisawa, M. & Nagase, H., Sep 1 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 17, p. 4176-4179 4 p.

Research output: Contribution to journalArticle

Orexin Receptors
Amides
Sulfonamides
Opioid Receptors
Isomers
32 Citations (Scopus)

Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models

Irukayama-Tomobe, Y., Ogawa, Y., Tominaga, H., Ishikawa, Y., Hosokawa, N., Ambai, S., Kawabe, Y., Uchida, S., Nakajima, R., Saitoh, T., Kanda, T., Vogt, K., Sakurai, T., Nagase, H. & Yanagisawa, M., May 30 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 22, p. 5731-5736 6 p.

Research output: Contribution to journalArticle

Orexin Receptors
Cataplexy
Narcolepsy
Wakefulness
Neurons
6 Citations (Scopus)

Octacosanol restores stress-affected sleep in mice by alleviating stress

Kaushik, M. K., Aritake, K., Takeuchi, A., Yanagisawa, M. & Urade, Y., Dec 1 2017, In : Scientific Reports. 7, 1, 8892.

Research output: Contribution to journalArticle

Sleep
1-octacosanol
REM Sleep
Eye Movements
Corticosterone
4 Citations (Scopus)

T cells upon activation promote endothelin 1 production in monocytes via IFN-γ and TNF-α

Shinagawa, S., Okazaki, T., Ikeda, M., Yudoh, K., Kisanuki, Y. Y., Yanagisawa, M., Kawahata, K. & Ozaki, S., Dec 1 2017, In : Scientific Reports. 7, 1, 14500.

Research output: Contribution to journalArticle

Endothelin-1
Monocytes
T-Lymphocytes
Anti-Idiotypic Antibodies
Endothelial Cells
8 Citations (Scopus)

Triethylene glycol, an active component of Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction

Kaushik, M. K., Kaul, S. C., Wadhwa, R., Yanagisawa, M. & Urade, Y., Feb 1 2017, In : PLoS One. 12, 2, e0172508.

Research output: Contribution to journalArticle

Withania
Withania somnifera
sleep
Sleep
Sleep Initiation and Maintenance Disorders
2016
35 Citations (Scopus)

An adenosine-mediated glial-neuronal circuit for homeostatic sleep

Bjorness, T., Dale, N., Mettlach, G., Sonneborn, A., Sahin, B., Fienberg, A. A., Yanagisawa, M., Bibb, J. A. & Greene, R., Mar 30 2016, In : Journal of Neuroscience. 36, 13, p. 3709-3721 13 p.

Research output: Contribution to journalArticle

Neuroglia
Adenosine
Sleep
Adenosine Kinase
Homeostasis
7 Citations (Scopus)

Attenuated cold defense responses in orexin neuron-ablated rats

Mohammed, M., Yanagisawa, M., Blessing, W. & Ootsuka, Y., Jul 2 2016, In : Temperature. 3, 3, p. 465-475 11 p.

Research output: Contribution to journalArticle

Open Access
Brown Adipose Tissue
Thermogenesis
Neurons
Vasoconstriction
Tail
68 Citations (Scopus)

Forward-genetics analysis of sleep in randomly mutagenized mice

Funato, H., Miyoshi, C., Fujiyama, T., Kanda, T., Sato, M., Wang, Z., Ma, J., Nakane, S., Tomita, J., Ikkyu, A., Kakizaki, M., Hotta-Hirashima, N., Kanno, S., Komiya, H., Asano, F., Honda, T., Kim, S. J., Harano, K., Muramoto, H., Yonezawa, T. & 17 others, Mizuno, S., Miyazaki, S., Connor, L., Kumar, V., Miura, I., Suzuki, T., Watanabe, A., Abe, M., Sugiyama, F., Takahashi, S., Sakimura, K., Hayashi, Y., Liu, Q., Kume, K., Wakana, S., Takahashi, J. S. & Yanagisawa, M., 2016, In : Nature. 539, 7629, p. 378-383 6 p.

Research output: Contribution to journalArticle

Sleep
REM Sleep
Mutation
Sleep Deprivation
Wakefulness
1 Citation (Scopus)

Functional ETA-ETB receptor cross-Talk in basilar artery in Situ from ETB receptor deficient rats

Yoon, S., Gariepy, C. E., Yanagisawa, M., Zuccarello, M. & Rapoport, R. M., Mar 1 2016, In : Journal of Cardiovascular Pharmacology. 67, 3, p. 212-217 6 p.

Research output: Contribution to journalArticle

Receptor Cross-Talk
Metrorrhagia
Basilar Artery
Endothelin-1
Constriction
16 Citations (Scopus)

Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney

Sato, Y., Mii, A., Hamazaki, Y., Fujita, H., Nakata, H., Masuda, K., Nishiyama, S., Shibuya, S., Haga, H., Ogawa, O., Shimizu, A., Narumiya, S., Kaisho, T., Arita, M., Yanagisawa, M., Miyasaka, M., Sharma, K., Minato, N., Kawamoto, H. & Yanagita, M., Jan 1 2016, In : JCI Insight. 1, 11, e87680.

Research output: Contribution to journalArticle

Open Access
Lymphoid Tissue
Fibroblasts
Kidney
Acute Kidney Injury
Nerve Growth Factor Receptor
7 Citations (Scopus)

High salt induces autocrine actions of ET-1 on inner medullary collecting duct NO production via upregulated ETB receptor expression

Hyndman, K. A., Dugas, C., Arguello, A. M., Goodchild, T. T., Buckley, K. M., Burch, M., Yanagisawa, M. & Pollock, J. S., Aug 1 2016, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 311, 2, p. R263-R271

Research output: Contribution to journalArticle

Endothelin B Receptors
Endothelin-1
Nitric Oxide
Salts
Nitric Oxide Synthase
5 Citations (Scopus)

Identification of mutations through dominant screening for obesity using C57BL/6 substrains

Hossain, M. S., Asano, F., Fujiyama, T., Miyoshi, C., Sato, M., Ikkyu, A., Kanno, S., Hotta, N., Kakizaki, M., Honda, T., Kim, S. J., Komiya, H., Miura, I., Suzuki, T., Kobayashi, K., Kaneda, H., Kumar, V., Takahashi, J. S., Wakana, S., Funato, H. & 1 others, Yanagisawa, M., Sep 2 2016, In : Scientific Reports. 6, 32453.

Research output: Contribution to journalArticle

Obesity
Mutation
Pedigree
Neuropeptides
Exome
8 Citations (Scopus)

Knockout of endothelin type B receptor signaling attenuates bleomycin-induced skin sclerosis in mice

Akashi, K., Saegusa, J., Sendo, S., Nishimura, K., Okano, T., Yagi, K., Yanagisawa, M., Emoto, N. & Morinobu, A., May 21 2016, In : Arthritis Research and Therapy. 18, 1, 113.

Research output: Contribution to journalArticle

Endothelin B Receptors
Bleomycin
Sclerosis
Endothelin-1
Skin
5 Citations (Scopus)

Mesolimbic neuropeptide W coordinates stress responses under novel environments

Motoike, T., Long, J. M., Tanaka, H., Sinton, C. M., Skach, A., Williams, S. C., Hammer, R. E., Sakurai, T. & Yanagisawa, M., May 24 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 21, p. 6023-6028 6 p.

Research output: Contribution to journalArticle

Neuropeptides
Neurons
Septal Nuclei
Limbic System
Dopaminergic Neurons
10 Citations (Scopus)

Nighttime administration of nicotine improves hepatic glucose metabolism via the hypothalamic orexin system in mice

Tsuneki, H., Nagata, T., Fujita, M., Kon, K., Wu, N., Takatsuki, M., Yamaguchi, K., Wada, T., Nishijo, H., Yanagisawa, M., Sakurai, T. & Sasaoka, T., Jan 1 2016, In : Endocrinology. 157, 1, p. 195-206 12 p.

Research output: Contribution to journalArticle

Nicotine
Glucose
Liver
Blood Glucose
Gluconeogenesis
10 Citations (Scopus)

Peripherally administered orexin improves survival of mice with endotoxin shock

Ogawa, Y., Irukayama-Tomobe, Y., Murakoshi, N., Kiyama, M., Ishikawa, Y., Hosokawa, N., Tominaga, H., Uchida, S., Kimura, S., Kanuka, M., Morita, M., Hamada, M., Takahashi, S., Hayashi, Y. & Yanagisawa, M., Dec 30 2016, In : eLife. 5, DECEMBER2016, e21055.

Research output: Contribution to journalArticle

Neurology
Septic Shock
Endotoxins
Lipopolysaccharides
Shock
7 Citations (Scopus)

QRFP-Deficient mice are hypophagic, lean, hypoactive and exhibit increased anxiety-Like behavior

Okamoto, K., Yamasaki, M., Takao, K., Soya, S., Iwasaki, M., Sasaki, K., Magoori, K., Sakakibara, I., Miyakawa, T., Mieda, M., Watanabe, M., Sakai, J., Yanagisawa, M. & Sakurai, T., Nov 1 2016, In : PLoS One. 11, 11, e0164716.

Research output: Contribution to journalArticle

Arcuate Nucleus of Hypothalamus
Wakefulness
Feeding Behavior
anxiety
feeding behavior
10 Citations (Scopus)

Timed inhibition of orexin system by suvorexant improved sleep and glucose metabolism in type 2 diabetic db/db mice

Tsuneki, H., Kon, K., Ito, H., Yamazaki, M., Takahara, S., Toyooka, N., Ishii, Y., Sasahara, M., Wada, T., Yanagisawa, M., Sakurai, T. & Sasaoka, T., Nov 1 2016, In : Endocrinology. 157, 11, p. 4146-4157 12 p.

Research output: Contribution to journalArticle

Sleep
Glucose
Liver
Type 2 Diabetes Mellitus
Peroxisome Proliferator-Activated Receptors
2015
1 Citation (Scopus)

Correction to Potential role of orexin and sleep modulation in the pathogenesis of alzheimer's disease [The Journal of Experimental Medicine, 211, 13, (2014), 2487-2496]

Roh, J. H., Jiang, H., Finn, M. B., Stewart, F. R., Mahan, T. E., Cirrito, J. R., Heda, A., Joy Snider, B., Li, M., Yanagisawa, M., de Lecea, L. & Holtzman, D. M., 2015, In : Journal of Experimental Medicine. 212, 1, p. 121 1 p.

Research output: Contribution to journalArticle

Corrigendum to "Transient expression of neuropeptide W in postnatal mouse hypothalamus - A putative regulator of energy homeostasis" [Neuroscience, 301 (2015) 323-337]

Motoike, T., Skach, A. G., Godwin, J. K., Sinton, C. M., Yamazaki, M., Abe, M., Natsume, R., Sakimura, K. & Yanagisawa, M., Sep 1 2015, In : Neuroscience. 303, p. 630 1 p.

Research output: Contribution to journalArticle

Neurosciences
Neuropeptides
Hypothalamus
Homeostasis
corrigendum
46 Citations (Scopus)

Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists

Nagahara, T., Saitoh, T., Kutsumura, N., Irukayama-Tomobe, Y., Ogawa, Y., Kuroda, D., Gouda, H., Kumagai, H., Fujii, H., Yanagisawa, M. & Nagase, H., Aug 12 2015, In : Journal of Medicinal Chemistry. 58, 20, p. 7931-7937 7 p.

Research output: Contribution to journalArticle

Orexin Receptors
Cataplexy
Narcolepsy
Wakefulness
G-Protein-Coupled Receptors
14 Citations (Scopus)

Endothelin-1 as a master regulator of whole-body Na+ homeostasis

Speed, J. S., Heimlich, J. B., Hyndman, K. A., Fox, B. M., Patel, V., Yanagisawa, M., Pollock, J. S., Titze, J. M. & Pollock, D. M., Dec 1 2015, In : FASEB Journal. 29, 12, p. 4937-4944 8 p.

Research output: Contribution to journalArticle

Endothelin-1
Homeostasis
Skin
Osmolar Concentration
Endothelial cells
32 Citations (Scopus)

Hypothalamic orexin prevents hepatic insulin resistance via daily bidirectional regulation of autonomic nervous system in mice

Tsuneki, H., Tokai, E., Nakamura, Y., Takahashi, K., Fujita, M., Asaoka, T., Kon, K., Anzawa, Y., Wada, T., Takasaki, I., Kimura, K., Inoue, H., Yanagisawa, M., Sakurai, T. & Sasaoka, T., Feb 1 2015, In : Diabetes. 64, 2, p. 459-470 12 p.

Research output: Contribution to journalArticle

Autonomic Nervous System
Insulin Resistance
Liver
Blood Glucose
Glucose
5 Citations (Scopus)

Monitoring β-arrestin recruitment via β-lactamase enzyme fragment complementation: Purification of peptide E as a low-affinity ligand for mammalian bombesin receptors

Ikeda, Y., Kumagai, H., Okazaki, H., Fujishiro, M., Motozawa, Y., Nomura, S., Takeda, N., Toko, H., Takimoto, E., Akazawa, H., Morita, H., Suzuki, J. I., Yamazaki, T., Komuro, I. & Yanagisawa, M., Jun 1 2015, In : PLoS One. 10, 6, e0127445.

Research output: Contribution to journalArticle

arrestins
Bombesin Receptors
Arrestin
G-Protein-Coupled Receptors
Purification