• 71926 Citations
  • 119 h-Index
1984 …2020

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Endothelin-1 immunoreactivity and mRNA in the transplanted human heart

Giaid, A., Saleh, D., Yanagisawa, M. & Forbes, R. D. C., May 15 1995, In : Transplantation. 59, 9, p. 1308-1313 6 p.

Research output: Contribution to journalArticle

30 Scopus citations

Endothelin-1 impairs alveolar epithelial function via endothelial ET B receptor

Comellas, A. P., Briva, A., Dada, L. A., Butti, M. L., Trejo, H. E., Yshii, C., Azzam, Z. S., Litvan, J., Chen, J., Lecuona, E., Pesce, L. M., Yanagisawa, M. & Sznajder, J. I., Jan 15 2009, In : American journal of respiratory and critical care medicine. 179, 2, p. 113-122 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Endothelin-1 induces vasoconstriction through two functionally distinct pathways in porcine coronary artery: Contribution of phosphoinositide turnover

Kasuya, Y., Takuwa, Y., Yanagisawa, M., Kimura, S., Goto, K. & Masaki, T., Jun 30 1989, In : Biochemical and Biophysical Research Communications. 161, 3, p. 1049-1055 7 p.

Research output: Contribution to journalArticle

96 Scopus citations

Endothelin-1 in luteal tissue

Usuki, S., Suzuki, N., Matsumoto, H., Yanagisawa, M. & Masaki, T., Sep 1991, In : Molecular and Cellular Endocrinology. 80, 1-3, p. 147-151 5 p.

Research output: Contribution to journalArticle

37 Scopus citations

Endothelin-1 is an autocrine/paracrine growth factor for human cancer cell lines

Shichiri, M., Hirata, Y., Nakajima, T., Ando, K., Imai, T., Yanagisawa, M., Masaki, T. & Marumo, F., May 1991, In : Journal of Clinical Investigation. 87, 5, p. 1867-1871 5 p.

Research output: Contribution to journalArticle

Open Access
195 Scopus citations

Endothelin-1 is a transcriptional target of p53 in epidermal keratinocytes and regulates ultraviolet-induced melanocyte homeostasis

Hyter, S., Coleman, D. J., Ganguli-Indra, G., Merrill, G. F., Ma, S., Yanagisawa, M. & Indra, A. K., Mar 1 2013, In : Pigment Cell and Melanoma Research. 26, 2, p. 247-258 12 p.

Research output: Contribution to journalArticle

29 Scopus citations

Endothelin-1 Stimulates Leptin Production in Adipocytes

Xiong, Y., Tanaka, H., Richardson, J. A., Williams, S. C., Slaughter, C. A., Nakamura, M., Chen, J. L. & Yanagisawa, M., Jul 27 2001, In : Journal of Biological Chemistry. 276, 30, p. 28471-28477 7 p.

Research output: Contribution to journalArticle

47 Scopus citations

Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice

Chang, I., Bramall, A. N., Baynash, A. G., Rattner, A., Rakheja, D., Post, M., Joza, S., McKerlie, C., Stewart, D. J., McInnes, R. R. & Yanagisawa, M., Jun 3 2013, In : Journal of Clinical Investigation. 123, 6, p. 2643-2653 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Endothelin-2-Mediated Protection of Mutant Photoreceptors in Inherited Photoreceptor Degeneration

Bramall, A. N., Szego, M. J., Pacione, L. R., Chang, I., Diez, E., D'Orleans-Juste, P., Stewart, D. J., Hauswirth, W. W., Yanagisawa, M. & McInnes, R. R., Feb 28 2013, In : PloS one. 8, 2, e58023.

Research output: Contribution to journalArticle

16 Scopus citations

Endothelin-3 is a novel neuropeptide: Isolation and sequence determination of endothelin-1 and endothelin-3 in porcine brain

Shinmi, O., Kimura, S., Sawamura, T., Sugita, Y., Yoshizawa, T., Uchiyama, Y., Yanagisawa, M., Goto, K., Masaki, T. & Kanazawa, I., Oct 16 1989, In : Biochemical and Biophysical Research Communications. 164, 1, p. 587-593 7 p.

Research output: Contribution to journalArticle

133 Scopus citations

Endothelin activates the dihydropyridine-sensitive, voltage-dependent Ca2+ channel in vascular smooth muscle

Goto, K., Kasuya, Y., Matsuki, N., Takuwa, Y., Kurihara, H., Ishikawa, T., Kimura, S., Yanagisawa, M. & Masaki, T., Jan 1 1989, In : Proceedings of the National Academy of Sciences of the United States of America. 86, 10, p. 3915-3918 4 p.

Research output: Contribution to journalArticle

Open Access
316 Scopus citations

Endothelin acts in feline and canine cerebral arteries from the adventitial side

Mima, T., Yanagisawa, M., Shigeno, T., Saito, A., Goto, K., Takakura, K. & Masaki, T., Nov 1989, In : Stroke. 20, 11, p. 1553-1556 4 p.

Research output: Contribution to journalArticle

Open Access
107 Scopus citations

Endothelin and its signaling - Genetic analysis in mice

Yanagisawa, M., Dec 1 1997, In : FASEB Journal. 11, 9, p. A1450

Research output: Contribution to journalArticle

Endothelin A receptor is necessary for O2 constriction but not closure of ductus arteriosus

Coceani, F., Liu, Y. A., Seidlitz, E., Kelsey, L., Kuwaki, T., Ackerley, C. & Yanagisawa, M., Oct 1999, In : American Journal of Physiology - Heart and Circulatory Physiology. 277, 4 46-4, p. H1521-H1531

Research output: Contribution to journalArticle

55 Scopus citations

EndothelinB receptor activates NHE-3 by a Ca2+ -dependent pathway in OKP cells

Chu, T. S., Peng, Y., Cano, A., Yanagisawa, M. & Alpern, R. J., Mar 15 1996, In : Journal of Clinical Investigation. 97, 6, p. 1454-1462 9 p.

Research output: Contribution to journalArticle

Open Access
65 Scopus citations

Endothelin B receptor deficiency potentiates ET-1 and hypoxic pulmonary vasoconstriction

Ivy, D. D., Mcmurtry, I. F., Yanagisawa, M., Gariepy, C. E., Le Cras, T. D., Gebb, S. A., Morris, K. G., Wiseman, R. C. & Abman, S. H., May 1 2001, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 280, 5 25-5, p. L1040-L1048

Research output: Contribution to journalArticle

69 Scopus citations

Endothelin B receptor-deficient mice develop endothelial dysfunction independently of salt loading

Quaschning, T., Rebhan, B., Wunderlich, C., Wanner, C., Richter, C. M., Pfab, T., Bauer, C., Kraemer-Guth, A., Galle, J., Yanagisawa, M. & Hocher, B., May 2005, In : Journal of hypertension. 23, 5, p. 979-985 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

Endothelin B receptor deficient transgenic rescue rats: A rescue phenomenon in the brain

Riechers, C. C., Knabe, W., Sirén, A. L., Gariepy, C. E., Yanagisawa, M. & Ehrenreich, H., Mar 22 2004, In : Neuroscience. 124, 4, p. 719-723 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

Endothelin B receptor is not required but necessary for finite regulation of ovulation

Cho, J., Kim, H., Kang, D. W., Yanagisawa, M. & Ko, C., Oct 15 2012, In : Life Sciences. 91, 13-14, p. 613-617 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon-sensitive metalloprotease with acidic pH optimum

Emoto, N. & Yanagisawa, M., Jun 23 1995, In : Journal of Biological Chemistry. 270, 25, p. 15262-15268 7 p.

Research output: Contribution to journalArticle

Open Access
424 Scopus citations

Endothelin-induced vasoconstriction of cerebral and peripheral arteries of dogs

Saito, A., Mima, T., Shigeno, T., Yanagisawa, M., Goto, K., Kimura, S. & Masaki, T., Jan 1 1990, In : European Journal of Pharmacology. 183, 5, p. 1803-1804 2 p.

Research output: Contribution to journalArticle

3 Scopus citations

Endothelin induces DNA polymerase α activity in ovaries of hypophysectomized estrogen-treated immature rats

Usuki, S., Otani, S., Goto, K., Matsumoto, H., Suzuki, N., Yanagisawa, M. & Masaki, T., Jan 1 1991, In : Hormone and Metabolic Research. 23, 12, p. 621-622 2 p.

Research output: Contribution to journalArticle

9 Scopus citations

Endothelin in perinatal pharmacology

Masaki, T., Usuki, S., Yanagisawa, M. & Suzuki, N., Feb 1991, In : Seminars in Perinatology. 15, 1, p. 27-29 3 p.

Research output: Contribution to journalArticle

13 Scopus citations

Endothelin in the central control of cardiovascular and respiratory functions

Kuwaki, T., Ling, G. Y., Onodera, M., Ishii, T., Nakamura, A., Ju, K. H., Cao, W. H., Kumada, M., Kurihara, H., Kurihara, Y., Yazaki, Y., Ohuchi, T., Yanagisawa, M. & Fukuda, Y., Dec 1 1999, In : Clinical and Experimental Pharmacology and Physiology. 26, 12, p. 989-994 6 p.

Research output: Contribution to journalArticle

43 Scopus citations

Endothelin is a potent secretagogue for atrial natriuretic peptide in cultured rat atrial myocytes

Fukuda, Y., Hirata, Y., Yoshimi, H., Kojima, T., Kobayashi, Y., Yanagisawa, M. & Masaki, T., Aug 30 1988, In : Biochemical and Biophysical Research Communications. 155, 1, p. 167-172 6 p.

Research output: Contribution to journalArticle

251 Scopus citations

Endothelin localizes in the dorsal horn and acts on the spinal neurones: Possible involvement of dihydropyridine-sensitive calcium channels and substance P release

Yoshizawa, T., Kimura, S., Kanazawa, I., Uchiyama, Y., Yanagisawa, M. & Masaki, T., Jul 31 1989, In : Neuroscience Letters. 102, 2-3, p. 179-184 6 p.

Research output: Contribution to journalArticle

119 Scopus citations

Endothelin receptor is coupled to phospholipase C via a pertussis toxin-insensitive guanine nucleotide-binding regulatory protein in vascular smooth muscle cells

Takuwa, Y., Kasuya, Y., Takuwa, N., Kudo, M., Yanagisawa, M., Goto, K., Masaki, T. & Yamashita, K., Mar 1990, In : Journal of Clinical Investigation. 85, 3, p. 653-658 6 p.

Research output: Contribution to journalArticle

Open Access
158 Scopus citations

Endothelin receptors in human parathyroid gland

Eguchi, S., Hirata, Y., Imai, T., Kanno, K., Akiba, T., Sakamoto, A., Yanagisawa, M., Masaki, T. & Marumo, F., May 15 1992, In : Biochemical and Biophysical Research Communications. 184, 3, p. 1448-1455 8 p.

Research output: Contribution to journalArticle

39 Scopus citations

Endothelins: vasoconstrictor effects and localization in canine cerebral arteries

Saito, A., Shiba, R., Yanagisawa, M., Masaki, T., Kimura, S., Yamada, K., Mima, T., Shigeno, T. & Goto, K., May 1991, In : British Journal of Pharmacology. 103, 1, p. 1129-1135 7 p.

Research output: Contribution to journalArticle

28 Scopus citations

Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons

Makita, T., Sucov, H. M., Gariepy, C. E., Yanagisawa, M. & Ginty, D. D., Apr 10 2008, In : Nature. 452, 7188, p. 759-763 5 p.

Research output: Contribution to journalArticle

127 Scopus citations

Endothelin-secreting tumor

Yokokawa, K., Tahara, H., Kohno, M., Murakawa -i., K., Yasunari, K., Nakagawa, K., Hamada, T., Otani, S., Yanagisawa, M. & Takeda, T., Jan 1 1991, In : Journal of Cardiovascular Pharmacology. 17, p. S398-S41

Research output: Contribution to journalArticle

12 Scopus citations

Endothelin XII

Barton, M., Yanagisawa, M., Vanhoutte, P. M. & Masaki, T., Oct 15 2012, In : Life Sciences. 91, 13-14, p. 449-451 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

Endothelium-specific loss of murine thrombomodulin disrupts the protein C anticoagulant pathway and causes juvenile-onset thrombosis

Isermann, B., Hendrickson, S. B., Zogg, M., Wing, M., Cummiskey, M., Kisanuki, Y. Y., Yanagisawa, M. & Weiler, H., Sep 3 2001, In : Journal of Clinical Investigation. 108, 4, p. 537-546 10 p.

Research output: Contribution to journalArticle

100 Scopus citations

Endotoxin and pro-inflammatory cytokines stimulate endothelin-1 expression and release by airway epithelial cells

Nakano, J., Takizawa, H., Ohtoshi, T., Shoji, S., Yamaguchi, M., Ishii, A., Yanagisawa, M. & Ito, K., Jun 27 1994, In : Clinical and Experimental Allergy. 24, 4, p. 330-336 7 p.

Research output: Contribution to journalArticle

80 Scopus citations

Enhanced blood pressure sensitivity to DOCA-salt treatment in endothelin ET(B) receptor-deficient rats

Matsumura, Y., Kuro, T., Konishi, F., Takaoka, M., Gariepy, C. E. & Yanagisawa, M., Jan 1 2000, In : British Journal of Pharmacology. 129, 6, p. 1060-1062 3 p.

Research output: Contribution to journalArticle

23 Scopus citations

Enhanced cortical responsiveness during natural sleep in freely behaving mice

Matsumoto, S., Ohyama, K., Díaz, J., Yanagisawa, M., Greene, R. W. & Vogt, K. E., Dec 1 2020, In : Scientific reports. 10, 1, 2278.

Research output: Contribution to journalArticle

Open Access

Enhanced Orexin Receptor-2 Signaling Prevents Diet-Induced Obesity and Improves Leptin Sensitivity

Funato, H., Tsai, A. L., Willie, J. T., Kisanuki, Y., Williams, S. C., Sakurai, T. & Yanagisawa, M., Jan 7 2009, In : Cell Metabolism. 9, 1, p. 64-76 13 p.

Research output: Contribution to journalArticle

182 Scopus citations

Entrainment of temperature and activity rhythms to restricted feeding in orexin knock out mice

Kaur, S., Thankachan, S., Begum, S., Blanco-Centurion, C., Sakurai, T., Yanagisawa, M. & Shiromani, P. J., Apr 18 2008, In : Brain Research. 1205, p. 47-54 8 p.

Research output: Contribution to journalArticle

47 Scopus citations

Erythromycin and clarithromycin attenuate cytokine-induced endothelin-1 expression in human bronchial epithelial cells

Takizawa, H., Desaki, M., Ohtoshi, T., Kawasaki, S., Kohyama, T., Sato, M., Nakajima, J., Yanagisawa, M. & Ito, K., Jul 1 1998, In : European Respiratory Journal. 12, 1, p. 57-63 7 p.

Research output: Contribution to journalArticle

49 Scopus citations

Essential role of sympathetic endothelin A receptors for adverse cardiac remodeling

Lehmann, L. H., Rostosky, J. S., Buss, S. J., Kreusser, M. M., Krebs, J., Mier, W., Enseleit, F., Spiger, K., Hardt, S. E., Wieland, T., Haass, M., Lüscher, T. F., Schneider, M. D., Parlato, R., Gröne, H. J., Haberkorn, U., Yanagisawa, M., Katus, H. A. & Backs, J., Sep 16 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 37, p. 13499-13504 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor

Yamamoto, N., Ohrui, S., Okada, T., Yata, M., Saitoh, T., Kutsumura, N., Nagumo, Y., Irukayama-Tomobe, Y., Ogawa, Y., Ishikawa, Y., Watanabe, Y., Hayakawa, D., Gouda, H., Yanagisawa, M. & Nagase, H., Sep 1 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 17, p. 4176-4179 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity

Ohrui, S., Yamamoto, N., Saitoh, T., Kutsumura, N., Nagumo, Y., Irukayama-Tomobe, Y., Ogawa, Y., Ishikawa, Y., Watanabe, Y., Hayakawa, D., Gouda, H., Yanagisawa, M. & Nagase, H., Jan 1 2018, (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

6 Scopus citations

Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring

Yamamoto, N., Ohrui, S., Okada, T., Saitoh, T., Kutsumura, N., Nagumo, Y., Irukayama-Tomobe, Y., Ogawa, Y., Ishikawa, Y., Watanabe, Y., Hayakawa, D., Gouda, H., Yanagisawa, M. & Nagase, H., Jan 1 2019, In : Bioorganic and Medicinal Chemistry.

Research output: Contribution to journalArticle

2 Scopus citations

Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity

Saitoh, T., Seki, K., Nakajima, R., Yamamoto, N., Kutsumura, N., Nagumo, Y., Irukayama-Tomobe, Y., Ogawa, Y., Ishikawa, Y., Tanimura, R., Yanagisawa, M. & Nagase, H., Jan 1 2019, In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

1 Scopus citations

Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group

Saitoh, T., Seki, K., Nakajima, R., Yamamoto, N., Kutsumura, N., Nagumo, Y., Irukayama-Tomobe, Y., Ogawa, Y., Ishikawa, Y., Yanagisawa, M. & Nagase, H., Feb 1 2020, In : Bioorganic and Medicinal Chemistry Letters. 30, 3, 126893.

Research output: Contribution to journalArticle

ET(B) receptor activation leads to activation and phosphorylation of NHE3

Peng, Y., Moe, O. W., Chu, T. S., Preisig, P. A., Yanagisawa, M. & Alpern, R. J., Jan 1 1999, In : American Journal of Physiology - Cell Physiology. 276, 4 45-4, p. C938-C945

Research output: Contribution to journalArticle

36 Scopus citations

ET-1 from endothelial cells is required for complete angiotensin II-induced cardiac fibrosis and hypertrophy

Adiarto, S., Heiden, S., Vignon-Zellweger, N., Nakayama, K., Yagi, K., Yanagisawa, M. & Emoto, N., Oct 15 2012, In : Life Sciences. 91, 13-14, p. 651-657 7 p.

Research output: Contribution to journalArticle

38 Scopus citations

ETB receptor activation causes exocytic insertion of NHE3 in OKP cells

Peng, Y., Amemiya, M., Yang, X., Fan, L., Moe, O. W., Yin, H. L., Preisig, P. A., Yanagisawa, M. & Alpern, R. J., Jan 2001, In : American Journal of Physiology - Renal Physiology. 280, 1 49-1, p. F34-F42

Research output: Contribution to journalArticle

60 Scopus citations

ETB receptor protects the tubulointerstitium in experimental thrombotic microangiopathy

Nangaku, M., Yamada, K., Gariepy, C. E., Miyata, T., Inagi, R., Kurokawa, K., Yanagisawa, M., Fujita, T. & Johnson, R. J., Jan 1 2002, In : Kidney international. 62, 3, p. 922-928 7 p.

Research output: Contribution to journalArticle

18 Scopus citations