• 71926 Citations
  • 119 h-Index
1984 …2020

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Increased plasma concentrations of endothelin-1 during and after pulmonary surgery

Onizuka, M., Miyauchi, T., Morita, R., Akaogi, E., Mitsui, K., Suzuki, N., Fujino, M., Yanagisawa, M., Goto, K., Masaki, T. & Hori, M., Jan 1 1991, In : Journal of Cardiovascular Pharmacology. 17, p. S402-S403

Research output: Contribution to journalArticle

10 Scopus citations

Increased plasma level of endothelin-1 and coronary spasm induction in patients with vasospastic angina pectoris

Toyo-oka, T., Aizawa, T., Suzuki, N., Hirata, Y., Miyauchi, T., Shin, W. S., Yanagisawa, M., Masaki, T. & Sugimoto, T., Jan 1 1991, In : Circulation. 83, 2, p. 476-483 8 p.

Research output: Contribution to journalArticle

Open Access
226 Scopus citations

Increased sensitivity to acute and persistent pain in neuron-specific endothelin-1 knockout mice

Hasue, F., Kuwaki, T., Kisanuki, Y. Y., Yanagisawa, M., Moriya, H., Fukuda, Y. & Shimoyama, M., Jan 31 2005, In : Neuroscience. 130, 2, p. 349-358 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Increased susceptibility to deoxycorticosterone acetate-salt-induced hypertension in endothelin-B-receptor-deficient rats

Matsumura, Y., Kuro, T., Kobayashi, Y., Konishi, F., Takaoka, M., Wessale, J. L., Opgenorth, T. J., Gariepy, C. E. & Yanagisawa, M., Jan 1 2000, In : Journal of Cardiovascular Pharmacology. 36, 5 SUPPL. 1, p. S86-S89

Research output: Contribution to journalArticle

5 Scopus citations

Induction of endothelin-1 gene by angiotensin and vasopressin in endothelial cells

Imai, T., Hirata, Y., Emori, T., Yanagisawa, M., Masaki, T. & Marumo, F., Jun 1992, In : Hypertension. 19, 6, p. 753-757 5 p.

Research output: Contribution to journalArticle

Open Access
328 Scopus citations

Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice

Sakurai, T., Nagata, R., Yamanaka, A., Kawamura, H., Tsujino, N., Muraki, Y., Kageyama, H., Kunita, S., Takahashi, S., Goto, K., Koyama, Y., Shioda, S. & Yanagisawa, M., Apr 21 2005, In : Neuron. 46, 2, p. 297-308 12 p.

Research output: Contribution to journalArticle

340 Scopus citations

Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons

Baynash, A. G., Hosoda, K., Giaid, A., Richardson, J. A., Emoto, N., Hammer, R. E. & Yanagisawa, M., Dec 30 1994, In : Cell. 79, 7, p. 1277-1285 9 p.

Research output: Contribution to journalArticle

768 Scopus citations

Interleukin 1 increases the production of endothelin-1 by cultured endothelial cells

Yoshizumi, M., Kurihara, H., Morita, T., Yamashita, T., Oh-hashi, Y., Sugiyama, T., Takaku, F., Yanagisawa, M., Masaki, T. & Yazaki, Y., Jan 15 1990, In : Biochemical and Biophysical Research Communications. 166, 1, p. 324-329 6 p.

Research output: Contribution to journalArticle

245 Scopus citations

Interleukin-2 Suppresses Endothelin-1 Secretion of Cultured Endothelial Cells

Taniguchi, K., Morimoto, S., Fukuo, K., Ogihara, T., Yanagisawa, M., Masaki, T. & Suzuki, N., 1992, In : Hypertension Research. 15, p. 171-175 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Intracellular localization of membrane-bound endothelin-converting enzyme from rat lung

Gui, G., Xu, D., Emoto, N. & Yanagisawa, M., Dec 1 1993, In : Journal of Cardiovascular Pharmacology. 22, SUPPL. 8, p. S53-S56

Research output: Contribution to journalArticle

24 Scopus citations

In vivo role of endothelin-converting enzyme-1 as examined by adenovirus-mediated overexpression in rats

Télémaque, S., Emoto, N., DeWit, D. & Yanagisawa, M., Jan 1 1998, In : Journal of Cardiovascular Pharmacology. 31, SUPPL. 1, p. S548-S550

Research output: Contribution to journalArticle

18 Scopus citations

Involvement of endothelin in the regulation of human vascular tonus - Potent vasoconstrictor effect and existence in endothelial cells

Miyauchi, T., Tomobe, Y., Shiba, R., Ishikawa, T., Yanagisawa, M., Kimura, S., Sugishita, Y., Ito, I., Goto, K. & Masaki, T., Jan 1 1990, In : Circulation. 81, 6, p. 1874-1880 7 p.

Research output: Contribution to journalArticle

Open Access
119 Scopus citations

Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawal

Georgescu, D., Zachariou, V., Barrot, M., Mieda, M., Willie, J. T., Eisch, A. J., Yanagisawa, M., Nestler, E. J. & DiLeone, R. J., Apr 15 2003, In : Journal of Neuroscience. 23, 8, p. 3106-3111 6 p.

Research output: Contribution to journalArticle

269 Scopus citations

Involvement of the serotonergic system in orexin-induced behavioral alterations in rats

Matsuzaki, I., Sakurai, T., Kunii, K., Nakamura, T., Yanagisawa, M. & Goto, K., Mar 15 2002, In : Regulatory Peptides. 104, 1-3, p. 119-123 5 p.

Research output: Contribution to journalArticle

42 Scopus citations

Isolation of anti-endothelin receptor monoclonal antibodies for use in receptor characterization

Kondoh, M., Miyazaki, H., Watanabe, H., Shibata, T., Yanagisawa, M., Masaki, T. & Murakami, K., Oct 30 1990, In : Biochemical and Biophysical Research Communications. 172, 2, p. 503-510 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Knockout of endothelial cell-derived endothelin-1 attenuates skin fibrosis but accelerates cutaneous wound healing

Makino, K., Jinnin, M., Aoi, J., Kajihara, I., Makino, T., Fukushima, S., Sakai, K., Nakayama, K., Emoto, N., Yanagisawa, M. & Ihn, H., May 22 2014, In : PloS one. 9, 5, e97972.

Research output: Contribution to journalArticle

17 Scopus citations

Knockout of endothelin type B receptor signaling attenuates bleomycin-induced skin sclerosis in mice

Akashi, K., Saegusa, J., Sendo, S., Nishimura, K., Okano, T., Yagi, K., Yanagisawa, M., Emoto, N. & Morinobu, A., May 21 2016, In : Arthritis Research and Therapy. 18, 1, 113.

Research output: Contribution to journalArticle

8 Scopus citations

Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization

Kondo, T., Vicent, D., Suzuma, K., Yanagisawa, M., King, G. L., Holzenberger, M. & Kahn, C. R., Jun 1 2003, In : Journal of Clinical Investigation. 111, 12, p. 1835-1842 8 p.

Research output: Contribution to journalArticle

180 Scopus citations

Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors

Wang, Y., Cao, L., Lee, C. Y., Matsuo, T., Wu, K., Asher, G., Tang, L., Saitoh, T., Russell, J. L., Klewe-Nebenius, D., Wang, L., Soya, S., Hasegawa, E., Chérasse, Y., Zhou, J., Li, Y., Wang, T., Zhan, X., Miyoshi, C., Irukayama, Y. & 13 others, Cao, J., Meeks, J., Gautron, L., Wang, Z., Sakurai, K., Funato, H., Sakurai, T., Yanagisawa, M., Nagase, H., Kobayakawa, R., Kobayakawa, K., Beutler, B. A. & Liu, Q., Dec 1 2018, In : Nature communications. 9, 1, 4324.

Research output: Contribution to journalArticle

4 Scopus citations

Leptin receptor- and STAT3-immunoreactivities in hypocretin/orexin neurones of the lateral hypothalamus

Håkansson, M. L., De Lecea, L., Sutcliffe, J. G., Yanagisawa, M. & Meister, B., Jul 29 1999, In : Journal of Neuroendocrinology. 11, 8, p. 653-663 11 p.

Research output: Contribution to journalArticle

204 Scopus citations

Localization of endothelin-converting enzyme-1 in human kidney

Pupilli, C., Romagnani, P., Lasagni, L., Bellini, F., Misciglia, N., Emoto, N., Yanagisawa, M., Rizzo, M., Mannelli, M. & Serio, M., Dec 9 1997, In : American Journal of Physiology - Renal Physiology. 273, 5 42-5, p. F749-F756

Research output: Contribution to journalArticle

27 Scopus citations

Localization of orexin B and orexin-2 receptor in the rat epididymis

Liguori, G., Tafuri, S., Miyoshi, C., Yanagisawa, M., Squillacioti, C., De Pasquale, V., Mirabella, N., Vittoria, A. & Costagliola, A., Jan 1 2018, (Accepted/In press) In : Acta Histochemica.

Research output: Contribution to journalArticle

2 Scopus citations

Loss of function of endothelin-2 leads to reduced ovulation and CL formation

Cacioppo, J. A., Oh, S. W., Kim, H. Y., Cho, J., Lin, P. C. P., Yanagisawa, M. & Ko, C., Apr 24 2014, In : PloS one. 9, 4, e96115.

Research output: Contribution to journalArticle

16 Scopus citations

Loss of Goosecoid-like and DiGeorge syndrome critical region 14 in interpeduncular nucleus results in altered regulation of rapid eye movement sleep

Funato, H., Sato, M., Sinton, C. M., Gautron, L., Williams, S. C., Skach, A., Elmquist, J. K., Skoultchi, A. I. & Yanagisawa, M., Oct 19 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 42, p. 18155-18160 6 p.

Research output: Contribution to journalArticle

20 Scopus citations

Low blood pressure in endothelial cell-specific endothelin 1 knockout mice

Kisanuki, Y. Y., Emoto, N., Ohuchi, T., Widyantoro, B., Yagi, K., Nakayama, K., Kedzierski, R. M., Hammer, R. E., Yanagisawa, H., Williams, S. C., Richardson, J. A., Suzuki, T. & Yanagisawa, M., Jul 1 2010, In : Hypertension. 56, 1, p. 121-128 8 p.

Research output: Contribution to journalArticle

77 Scopus citations

Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion

Fujino, T., Asaba, H., Kang, M. J., Ikeda, Y., Sone, H., Takada, S., Kim, D. H., Ioka, R. X., Ono, M., Tomoyori, H., Okubo, M., Murase, T., Kamataki, A., Yamamoto, J., Magoori, K., Takahashi, S., Miyamoto, Y., Oishi, H., Nose, M., Okazaki, M. & 5 others, Usui, S., Imaizumi, K., Yanagisawa, M., Sakai, J. & Yamamoto, T. T., Jan 7 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 1, p. 229-234 6 p.

Research output: Contribution to journalArticle

295 Scopus citations

Mast cells promote homeostasis by limiting endothelin-1-induced toxicity

Maurer, M., Wedemeyer, J., Metz, M., Piliponsky, A. M., Weller, K., Chatterjea, D., Clouthier, D. E., Yanagisawa, M. M., Tsai, M. & Galli, S. J., Nov 25 2004, In : Nature. 432, 7016, p. 512-516 5 p.

Research output: Contribution to journalArticle

228 Scopus citations

MC-SleepNet: Large-scale Sleep Stage Scoring in Mice by Deep Neural Networks

Yamabe, M., Horie, K., Shiokawa, H., Funato, H., Yanagisawa, M. & Kitagawa, H., Dec 1 2019, In : Scientific reports. 9, 1, 15793.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Mechanism of contraction to endothelin in isolated porcine coronary artery

Kasuya, Y., Ishikawa, T., Yanagisawa, M., Kimura, S., Goto, K. & Masaki, T., Dec 1 1989, In : American Journal of Physiology - Heart and Circulatory Physiology. 257, 6, p. 26/6

Research output: Contribution to journalArticle

57 Scopus citations

Mechanisms of altered sensitivity to endothelin-1 between aortic smooth muscles of spontaneously hypertensive and Wistar-Kyoto rats

Tomobe, Y., Ishikawa, T., Yanagisawa, M., Kimura, S., Masaki, T. & Goto, K., Jan 1 1991, In : Journal of Pharmacology and Experimental Therapeutics. 257, 2, p. 555-561 7 p.

Research output: Contribution to journalArticle

49 Scopus citations

Mechanisms of endothelin-1 mRNA and peptides induction by TGF-β and TPA in MDCK cells

Horie, M., Uchida, S., Yanagisawa, M., Matsushita, Y., Kurokawa, K. & Ogata, E., Jan 1 1991, In : Journal of Cardiovascular Pharmacology. 17, p. S222-S225

Research output: Contribution to journalArticle

16 Scopus citations

Mechanisms of increased sensitivity to endothelin-1 in aorta from spontaneously hypertensive rats

Tomobe, Y., Ishikawa, T., Yanagisawa, M., Kimura, S., Masaki, T. & Goto, K., Jan 1 1990, In : European Journal of Pharmacology. 183, 5, 1 p.

Research output: Contribution to journalArticle

4 Scopus citations

Mesolimbic neuropeptide W coordinates stress responses under novel environments

Motoike, T., Long, J. M., Tanaka, H., Sinton, C. M., Skach, A., Williams, S. C., Hammer, R. E., Sakurai, T. & Yanagisawa, M., May 24 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 21, p. 6023-6028 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Methodology and theoretical basis of forward genetic screening for sleep/wakefulness in mice

Miyoshi, C., Kim, S. J., Ezaki, T., Ikkyu, A., Hotta-Hirashima, N., Kanno, S., Kakizaki, M., Yamada, M., Wakana, S., Yanagisawa, M. & Funato, H., Aug 6 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 32, p. 16062-16067 6 p.

Research output: Contribution to journalArticle

Open Access

Mice with cardiomyocyte-specific disruption of the endothelin-1 gene are resistant to hyperthyroid cardiac hypertrophy

Shohet, R. V., Kisanuki, Y. Y., Zhao, X. S., Siddiquee, Z., Franco, F. & Yanagisawa, M., Feb 17 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 7, p. 2088-2093 6 p.

Research output: Contribution to journalArticle

72 Scopus citations

Modafinil more effectively induces wakefulness in orexin-null mice than in wild-type littermates

Willie, J. T., Renthal, W., Chemelli, R. M., Miller, M. S., Scammell, T. E., Yanagisawa, M. & Sinton, C. M., Jan 24 2005, In : Neuroscience. 130, 4, p. 983-995 13 p.

Research output: Contribution to journalArticle

75 Scopus citations

Modulation of circadian glucocorticoid oscillation via adrenal Opioid-CXCR7 Signaling alters emotional behavior

Ikeda, Y., Kumagai, H., Skach, A., Sato, M. & Yanagisawa, M., Dec 5 2013, In : Cell. 155, 6, p. 1323-1336 14 p.

Research output: Contribution to journalArticle

46 Scopus citations

Molecular and cellular mechanism of endothelin regulation: Implications for vascular function

Masaki, T., Kimura, S., Yanagisawa, M. & Goto, K., Oct 1991, In : Circulation. 84, 4, p. 1457-1468 12 p.

Research output: Contribution to journalArticle

Open Access
396 Scopus citations

Monitoring β-arrestin recruitment via β-lactamase enzyme fragment complementation: Purification of peptide E as a low-affinity ligand for mammalian bombesin receptors

Ikeda, Y., Kumagai, H., Okazaki, H., Fujishiro, M., Motozawa, Y., Nomura, S., Takeda, N., Toko, H., Takimoto, E., Akazawa, H., Morita, H., Suzuki, J. I., Yamazaki, T., Komuro, I. & Yanagisawa, M., Jun 1 2015, In : PLoS One. 10, 6, e0127445.

Research output: Contribution to journalArticle

5 Scopus citations

Monoaminergic neuronal changes in orexin deficient mice

Mori, T., Ito, S., Kuwaki, T., Yanagisawa, M., Sakurai, T. & Sawaguchi, T., Mar 1 2010, In : Neuropharmacology. 58, 4-5, p. 826-832 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Monoclonal antibodies to endothelin: Application for sandwich immunoassays

Hamaoki, M., Kato, H., Sugi, M., Fujimoto, M., Kurihara, H., Yosizumi, M., Yanagisawa, M., Kimura, S., Masaki, T. & Yazaki, Y., Jan 1 1990, In : Hybridoma. 9, 1, p. 63-69 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

Narcolepsy in orexin knockout mice: Molecular genetics of sleep regulation

Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Clay Williams, S., Xiong, Y., Kisanuki, Y., Fitch, T. E., Nakazato, M., Hammer, R. E., Saper, C. B. & Yanagisawa, M., Aug 20 1999, In : Cell. 98, 4, p. 437-451 15 p.

Research output: Contribution to journalArticle

2353 Scopus citations

Narcoleptic orexin receptor knockout mice express enhanced cholinergic properties in laterodorsal tegmental neurons

Kalogiannis, M., Grupke, S. L., Potter, P. E., Edwards, J. G., Chemelli, R. M., Kisanuki, Y. Y., Yanagisawa, M. & Leonard, C. S., Jul 1 2010, In : European Journal of Neuroscience. 32, 1, p. 130-142 13 p.

Research output: Contribution to journalArticle

22 Scopus citations

Neuromedin s-producing neurons act as essential pacemakers in the suprachiasmatic nucleus to couple clock neurons and dictate circadian rhythms

Lee, I. T., Chang, A. S., Manandhar, M., Shan, Y., Fan, J., Izumo, M., Ikeda, Y., Motoike, T., Dixon, S., Seinfeld, J. E., Takahashi, J. S. & Yanagisawa, M., Mar 4 2015, In : Neuron. 85, 5, p. 1086-1102 17 p.

Research output: Contribution to journalArticle

70 Scopus citations

Neurons containing orexin in the lateral hypothalamic area of the adult rat brain are activated by insulin-induced acute hypoglycemia

Moriguchi, T., Sakurai, T., Nambu, T., Yanagisawa, M. & Goto, K., Apr 2 1999, In : Neuroscience Letters. 264, 1-3, p. 101-104 4 p.

Research output: Contribution to journalArticle

237 Scopus citations

Neuropeptide B-deficient mice demonstrate hyperalgesia in response to inflammatory pain

Kelly, M. A., Beuckmann, C. T., Williams, S. C., Sinton, C. M., Motoike, T., Richardson, J. A., Hammer, R. E., Garry, M. G. & Yanagisawa, M., Jul 12 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 28, p. 9942-9947 6 p.

Research output: Contribution to journalArticle

45 Scopus citations

Neurotensin Co-Expressed in Orexin-Producing Neurons in the Lateral Hypothalamus Plays an Important Role in Regulation of Sleep/Wakefulness States

Furutani, N., Hondo, M., Kageyama, H., Tsujino, N., Mieda, M., Yanagisawa, M., Shioda, S. & Sakurai, T., Apr 19 2013, In : PloS one. 8, 4, e62391.

Research output: Contribution to journalArticle

49 Scopus citations

Nighttime administration of nicotine improves hepatic glucose metabolism via the hypothalamic orexin system in mice

Tsuneki, H., Nagata, T., Fujita, M., Kon, K., Wu, N., Takatsuki, M., Yamaguchi, K., Wada, T., Nishijo, H., Yanagisawa, M., Sakurai, T. & Sasaoka, T., Jan 1 2016, In : Endocrinology. 157, 1, p. 195-206 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Nonpeptide Orexin-2 Receptor Agonist Attenuates Morphine-induced Sedative Effects in Rats

Toyama, S., Shimoyama, N., Tagaito, Y., Nagase, H., Saitoh, T., Yanagisawa, M. & Shimoyama, M., Jan 1 2018, In : Anesthesiology. 128, 5, p. 992-1003 12 p.

Research output: Contribution to journalArticle

3 Scopus citations