• 71926 Citations
  • 119 h-Index
1984 …2020

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Purification and characterization of putative endothelin converting enzyme in bovine adrenal medulla: Evidence for a cathepsin D-like enzyme

Sawamura, T., Kimura, S., Shinmi, O., Sugita, Y., Yanagisawa, M., Goto, K. & Masaki, T., May 16 1990, In : Biochemical and Biophysical Research Communications. 168, 3, p. 1230-1236 7 p.

Research output: Contribution to journalArticle

72 Scopus citations

QRFP-Deficient mice are hypophagic, lean, hypoactive and exhibit increased anxiety-Like behavior

Okamoto, K., Yamasaki, M., Takao, K., Soya, S., Iwasaki, M., Sasaki, K., Magoori, K., Sakakibara, I., Miyakawa, T., Mieda, M., Watanabe, M., Sakai, J., Yanagisawa, M. & Sakurai, T., Nov 2016, In : PloS one. 11, 11, e0164716.

Research output: Contribution to journalArticle

7 Scopus citations

Quantitative measurement of GPCR endocytosis via pulse-chase covalent labeling

Kumagai, H., Ikeda, Y., Motozawa, Y., Fujishiro, M., Okamura, T., Fujio, K., Okazaki, H., Nomura, S., Takeda, N., Harada, M., Toko, H., Takimoto, E., Akazawa, H., Morita, H., Suzuki, J. I., Yamazaki, T., Yamamoto, K., Komuro, I. & Yanagisawa, M., May 28 2015, In : PLoS One. 10, 5, e0129394.

Research output: Contribution to journalArticle

4 Scopus citations

Quantitative phosphoproteomic analysis of the molecular substrates of sleep need

Wang, Z., Ma, J., Miyoshi, C., Li, Y., Sato, M., Ogawa, Y., Lou, T., Ma, C., Gao, X., Lee, C., Fujiyama, T., Yang, X., Zhou, S., Hotta-Hirashima, N., Klewe-Nebenius, D., Ikkyu, A., Kakizaki, M., Kanno, S., Cao, L., Takahashi, S. & 5 others, Peng, J., Yu, Y., Funato, H., Yanagisawa, M. & Liu, Q., Jun 21 2018, In : Nature. 558, 7710, p. 435-439 5 p.

Research output: Contribution to journalArticle

38 Scopus citations

Rediscovering an endothelin antagonist (BQ-123): A self-deconvoluting cyclic pentapeptide library

Spatola, A. F., Crozet, Y., DeWit, D. & Yanagisawa, M., Sep 13 1996, In : Journal of Medicinal Chemistry. 39, 19, p. 3842-3846 5 p.

Research output: Contribution to journalArticle

51 Scopus citations
21 Scopus citations

Reduced expression of the endothelin receptor type B gene in piebald mice caused by insertion of a retroposon-like element in intron 1

Yamada, T., Ohtani, S., Sakurai, T., Tsuji, T., Kunieda, T. & Yanagisawa, M., Apr 21 2006, In : Journal of Biological Chemistry. 281, 16, p. 10799-10807 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Regulation of postnatal trabecular bone formation by the osteoblast endothelin A receptor

Clines, G. A., Mohammad, K. S., Grunda, J. M., Clines, K. L., Niewolna, M., McKenna, C. R., McKibbin, C. R., Yanagisawa, M., Suva, L. J., Chirgwin, J. M. & Guise, T. A., Oct 1 2011, In : Journal of Bone and Mineral Research. 26, 10, p. 2523-2536 14 p.

Research output: Contribution to journalArticle

23 Scopus citations

Regulation of vasculogenesis and angiogenesis by EphB/ephrin-B2 signaling between endothelial cells and surrounding mesenchymal cells

Oike, Y., Ito, Y., Hamada, K., Zhang, X. Q., Miyata, K., Arai, F., Inada, T., Araki, K., Nakagata, N., Takeya, M., Kisanuki, Y. Y., Yanagisawa, M., Gale, N. W. & Suda, T., Aug 15 2002, In : Blood. 100, 4, p. 1326-1333 8 p.

Research output: Contribution to journalArticle

Open Access
102 Scopus citations

Renal vasoconstriction by the endothelial cell-derived peptide endothelin in spontaneously hypertensive rats

Hirata, Y., Matsuoka, H., Kimura, K., Fukui, K., Hayakawa, H., Suzuki, E., Sugimoto, T., Sugimoto, T., Yanagisawa, M. & Masaki, T., Jan 1 1989, In : Circulation research. 65, 5, p. 1370-1379 10 p.

Research output: Contribution to journalArticle

Open Access
54 Scopus citations

Role of cardiac myocyte-derived endothelin-1 in chagasic cardiomyopathy: Molecular genetic evidence

Huang, H., Yanagisawa, M., Kisanuki, Y. Y., Jelicks, L. A., Chandra, M., Factor, S. M., Wittner, M., Weiss, L. M., Pestell, R. G., Shtutin, V., Shirani, J. & Tanowitz, H. B., Aug 1 2002, In : Clinical science. 103, SUPPL. 48, p. 263S-266S

Research output: Contribution to journalArticle

20 Scopus citations

Role of D1x6 in regulation of an endothelin-1-dependent, dHAND branchial arch enhancer

Charité, J., McFadden, D. G., Merlo, G., Levi, G., Clouthier, D. E., Yanagisawa, M., Richardson, J. A. & Olson, E. N., Nov 15 2001, In : Genes and Development. 15, 22, p. 3039-3049 11 p.

Research output: Contribution to journalArticle

98 Scopus citations

Role of endothelin-1/endothelin-A receptor-mediated signaling pathway in the aortic arch patterning in mice

Yanagisawa, H., Hammer, R. E., Richardson, J. A., Williams, S. C., Clouthier, D. E. & Yanagisawa, M., Jul 1 1998, In : Journal of Clinical Investigation. 102, 1, p. 22-33 12 p.

Research output: Contribution to journalArticle

Open Access
164 Scopus citations

Role of endothelin 1 in the pathogenesis of chronic chagasic heart disease

Tanowitz, H. B., Huang, H., Jelicks, L. A., Chandra, M., Loredo, M. L., Weiss, L. M., Factor, S. M., Shtutin, V., Mukherjee, S., Kitsis, R. N., Christ, G. J., Wittner, M., Shirani, J., Kisanuki, Y. Y. & Yanagisawa, M., Apr 1 2005, In : Infection and immunity. 73, 4, p. 2496-2503 8 p.

Research output: Contribution to journalArticle

69 Scopus citations

Role of endothelin ETB receptor in partial ablation-induced chronic renal failure in rats

Okada, Y., Nakata, M., Izumoto, H., Takasu, M., Tazawa, N., Takaoka, M., Gariepy, C. E., Yanagisawa, M. & Matsumura, Y., Jun 21 2004, In : European Journal of Pharmacology. 494, 1, p. 63-71 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Role of endothelin ET B receptor in the pathogenesis of monocrotaline-induced pulmonary hypertension in rats

Nishida, M., Okada, Y., Akiyoshi, K., Eshiro, K., Takaoka, M., Gariepy, C. E., Yanagisawa, M. & Matsumura, Y., Aug 2 2004, In : European Journal of Pharmacology. 496, 1-3, p. 159-165 7 p.

Research output: Contribution to journalArticle

25 Scopus citations

Role of endothelin ETB receptors in the renal hemodynamic and excretory responses to big endothelin-1

Konishi, F., Okada, Y., Takaoka, M., Gariepy, C. E., Yanagisawa, M. & Matsumura, Y., Sep 13 2002, In : European Journal of Pharmacology. 451, 2, p. 177-184 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Role of endothelin in mechanisms of local blood pressure control

Masaki, T., Yanagisawa, M., Goto, K. & Kimura, S., Dec 1 1990, In : Journal of hypertension. 8, SUPPL. 7, p. S107-S112

Research output: Contribution to journalArticle

32 Scopus citations

Role of endothelin in the development of dahl hypertension

Goligorsky, M. S., Iijima, K., Morgan, M., Yanagisawa, M., Masaki, T., Lin, L., Nasjletti, A., Kaskel, F., Frazer, M. & Badr, K. F., Jan 1 1991, In : Journal of Cardiovascular Pharmacology. 17, p. S484-S491

Research output: Contribution to journalArticle

25 Scopus citations

Role of hypothalamic orexin neurons in the regulation of arousal according to energy balance

Yamanaka, A., Beuckmann, C. T., Willie, J. T., Hara, J., Tsujino, N., Goto, K., Yanagisawa, M. & Sakurai, T., May 1 2004, In : Sleep and Biological Rhythms. 2, SUPPL. 1, p. S57

Research output: Contribution to journalArticle

Role of tyrosine kinase pathways in ET(B) receptor activation of NHE3

Chu, T. S., Tsuganezawa, H., Peng, Y., Cano, A., Yanagisawa, M. & Alpern, R. J., Sep 1 1996, In : American Journal of Physiology - Cell Physiology. 271, 3 40-3, p. C763-C771

Research output: Contribution to journalArticle

36 Scopus citations

Roles of forkhead transcription factor Foxc2 (MFH-1) and endothelin receptor a in cardiovascular morphogenesis

Kanzaki-Kato, N., Tamakoshi, T., Fu, Y., Chandra, A., Itakura, T., Uezato, T., Tanaka, T., Clouthier, D. E., Sugiyama, T., Yanagisawa, M. & Miura, N., Feb 15 2005, In : Cardiovascular Research. 65, 3, p. 711-718 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Salt-sensitive hypertension in endothelin-B receptor-deficient rats

Gariepy, C. E., Ohuchi, T., Williams, S. C., Richardson, J. A. & Yanagisawa, M., Apr 2000, In : Journal of Clinical Investigation. 105, 7, p. 925-933 9 p.

Research output: Contribution to journalArticle

Open Access
246 Scopus citations

Selective loss of GABAB receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture

Matsuki, T., Nomiyama, M., Takahira, H., Hirashima, N., Kunita, S., Takahashi, S., Yagami, K. I., Kilduff, T. S., Bettler, B., Yanagisawa, M. & Sakurai, T., Mar 17 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 11, p. 4459-4464 6 p.

Research output: Contribution to journalArticle

88 Scopus citations

Sensitivity of orexin-A binding to phospholipase C inhibitors, neuropeptide Y, and secretin

Kane, J. K., Tanaka, H., Parker, S. L., Yanagisawa, M. & Li, M. D., Jun 16 2000, In : Biochemical and Biophysical Research Communications. 272, 3, p. 959-965 7 p.

Research output: Contribution to journalArticle

39 Scopus citations

Sex difference in body weight gain and leptin signaling in hypocretin/orexin deficient mouse models

Fujiki, N., Yoshida, Y., Zhang, S., Sakurai, T., Yanagisawa, M. & Nishino, S., Sep 1 2006, In : Peptides. 27, 9, p. 2326-2331 6 p.

Research output: Contribution to journalArticle

38 Scopus citations

Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice

Kim, M. H., Kang, S. G., Park, J. H., Yanagisawa, M. & Kim, C. H., Aug 2013, In : Gastroenterology. 145, 2, p. 396-406.e10

Research output: Contribution to journalArticle

283 Scopus citations

Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41

Xiong, Y., Miyamoto, N., Shibata, K., Valasek, M. A., Motoike, T., Kedzierski, R. M. & Yanagisawa, M., Jan 27 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 4, p. 1045-1050 6 p.

Research output: Contribution to journalArticle

403 Scopus citations

Signaling pathways crucial for craniofacial development revealed by endothelin-A receptor-deficient mice

Clouthier, D. E., Williams, S. C., Yanagisawa, H., Wieduwilt, M., Richardson, J. A. & Yanagisawa, M., Jan 1 2000, In : Developmental Biology. 217, 1, p. 10-24 15 p.

Research output: Contribution to journalArticle

159 Scopus citations

Sleep/Wake Behaviors in Mice during Pregnancy and Pregnancy-Associated Hypertensive Mice

Komiya, H., Miyoshi, C., Iwasaki, K., Hotta-Hirashima, N., Ikkyu, A., Kanno, S., Honda, T., Gosho, M., Hamada, H., Satoh, T., Fukamizu, A., Funato, H. & Yanagisawa, M., Mar 1 2018, In : Sleep. 41, 3

Research output: Contribution to journalArticle

2 Scopus citations

SOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice

Iguchi, H., Ikeda, Y., Okamura, M., Tanaka, T., Urashima, Y., Ohguchi, H., Takayasu, S., Kojima, N., Iwasaki, S., Ohashi, R., Jiang, S., Hasegawa, G., Ioka, R. X., Magoori, K., Sumi, K., Maejima, T., Uchida, A., Naito, M., Osborne, T. F., Yanagisawa, M. & 3 others, Yamamoto, T. T., Kodama, T. & Sakai, J., Nov 11 2005, In : Journal of Biological Chemistry. 280, 45, p. 37669-37680 12 p.

Research output: Contribution to journalArticle

56 Scopus citations

Structure-activity relationships of endothelin: Importance of the C-terminal moiety

Kimura, S., Kasuya, Y., Sawamura, T., Shinmi, O., Sugita, Y., Yanagisawa, M., Goto, K. & Masaki, T., Nov 15 1988, In : Biochemical and Biophysical Research Communications. 156, 3, p. 1182-1186 5 p.

Research output: Contribution to journalArticle

206 Scopus citations

Structure and function of human prepro-orexin gene

Sakurai, T., Moriguchi, T., Furuya, K., Kajiwara, N., Nakamura, T., Yanagisawa, M. & Goto, K., Jun 18 1999, In : Journal of Biological Chemistry. 274, 25, p. 17771-17776 6 p.

Research output: Contribution to journalArticle

162 Scopus citations

Studies on endothelium-dependent vasorelaxation by hydralazine in porcine coronary artery

Wei, S., Kasuya, Y., Yanagisawa, M., Kimura, S., Masaki, T. & Goto, K., Mar 5 1997, In : European Journal of Pharmacology. 321, 3, p. 307-314 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Study on the Endothelin Gene and its Expression

Masaki, T., Yanagisawa, M., Inoue, A., Kimura, S. & Goto, K., Jan 1 1990, In : JAPANESE CIRCULATION JOURNAL. 54, 9, p. 1221-1225 5 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Systemic hypertension induced by hepatic overexpression of human preproendothelin-1 in rats

Niranjan, V., Télémaque, S., De Wit, D., Gerard, R. D. & Yanagisawa, M., Nov 15 1996, In : Journal of Clinical Investigation. 98, 10, p. 2364-2372 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

TaqI polymorphism at the human preproendothelin-1 gene (EDN1)

Watanabe, M., Yanagisawa, M., Hamaguchi, H., Kanazawa, I. & Masaki, T., Sep 25 1991, In : Nucleic acids research. 19, 18, 1 p.

Research output: Contribution to journalArticle

3 Scopus citations

Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice

Hosoda, K., Hammer, R. E., Richardson, J. A., Baynash, A. G., Cheung, J. C., Giaid, A. & Yanagisawa, M., Dec 30 1994, In : Cell. 79, 7, p. 1267-1276 10 p.

Research output: Contribution to journalArticle

830 Scopus citations

T cells upon activation promote endothelin 1 production in monocytes via IFN-γ and TNF-α

Shinagawa, S., Okazaki, T., Ikeda, M., Yudoh, K., Kisanuki, Y. Y., Yanagisawa, M., Kawahata, K. & Ozaki, S., Dec 1 2017, In : Scientific Reports. 7, 1, 14500.

Research output: Contribution to journalArticle

4 Scopus citations

The development of hypocretin (OREXIN) deficiency in hypocretin/ataxin-3 transgenic rats

Zhang, S., Lin, L., Kaur, S., Thankachan, S., Blanco-Centurion, C., Yanagisawa, M., Mignot, E. & Shiromani, P. J., Aug 10 2007, In : Neuroscience. 148, 1, p. 34-43 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

The dorsomedial hypothalamic nucleus as a putative food-entrainable circadian pacemaker

Mieda, M., Williams, S. C., Richardson, J. A., Tanaka, K. & Yanagisawa, M., Aug 8 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 32, p. 12150-12155 6 p.

Research output: Contribution to journalArticle

218 Scopus citations

The embryo makes red blood cell progenitors in every tissue simultaneously with blood vessel morphogenesis

Sequeira Lopez, M. L. S., Cherñavvsky, D. R., Nomasa, T., Wall, L., Yanagisawa, M. & Gomez, R. A., Apr 1 2003, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 284, 4 53-4, p. R1126-R1137

Research output: Contribution to journalArticle

44 Scopus citations

The expression pattern of endothelin 3 in the avian embryo

Nataf, V., Amemiya, A., Yanagisawa, M. & Le Douarin, N. M., May 1 1998, In : Mechanisms of Development. 73, 2, p. 217-220 4 p.

Research output: Contribution to journalArticle

48 Scopus citations

The expression patterns of endothelin-A receptor and endothelin 1 in the avian embryo

Nataf, V., Grapin-Botton, A., Champeval, D., Amemiya, A., Yanagisawa, M. & Le Douarin, N. M., Jul 1998, In : Mechanisms of Development. 75, 1-2, p. 145-149 5 p.

Research output: Contribution to journalArticle

30 Scopus citations

The human endothelin family: Three structurally and pharmacologically distinct isopeptides predicted by three separate genes

Inoue, A., Yanagisawa, M., Kimura, S., Kasuya, Y., Miyauchi, T., Goto, K. & Masaki, T., Jan 1 1989, In : Proceedings of the National Academy of Sciences of the United States of America. 86, 8, p. 2863-2867 5 p.

Research output: Contribution to journalArticle

Open Access
2459 Scopus citations

The human endothelin family: cDNA cloning, complete primary structure and differential tissue expression of the three precursors

Yanagtsawa, M., Inoue, A., Imai, T., Matsushita, Y. & Masaki, T., Jul 5 1990, In : European Journal of Pharmacology. 183, 5, p. 1628-1629 2 p.

Research output: Contribution to journalArticle

The human preproendothelin-1 gene: Possible regulation by endothelial phosphoinositide turnover signaling

Yanagisawa, M., Inoue, A., Takuwa, Y., Mitsui, Y., Kobayashi, M. & Masaki, T., Jan 1 1989, In : Journal of Cardiovascular Pharmacology. 13, p. S13-S17

Research output: Contribution to journalArticle

144 Scopus citations

The human preproendothelin-1 gene. Complete nucleotide sequence and regulation of expression

Inoue, A., Yanagisawa, M., Takuwa, Y., Mitsui, Y., Kobayashi, M. & Masaki, T., Jan 1 1989, In : Journal of Biological Chemistry. 264, 25, p. 14954-14959 6 p.

Research output: Contribution to journalArticle

388 Scopus citations

The ligand-receptor interactions of the endothelin systems are mediated by distinct 'message' and 'address' domains

Sakamoto, A., Yanagisawa, M., Sakurai, T., Nakao, K., Toyo-oka, T., Yano, M. & Masaki, T., Dec 1 1993, In : Journal of Cardiovascular Pharmacology. 22, SUPPL. 8, p. S113-S116

Research output: Contribution to journalArticle

13 Scopus citations

The mapping of quantitative trait loci underlying strain differences in locomotor activity between 129S6 and C57Bl/6J mice

Kelly, M. A., Low, M. J., Phillips, T. J., Wakeland, E. K. & Yanagisawa, M., Oct 1 2003, In : Mammalian Genome. 14, 10, p. 692-702 11 p.

Research output: Contribution to journalArticle

34 Scopus citations