• 72581 Citations
  • 120 h-Index
1984 …2020

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2016

Identification of mutations through dominant screening for obesity using C57BL/6 substrains

Hossain, M. S., Asano, F., Fujiyama, T., Miyoshi, C., Sato, M., Ikkyu, A., Kanno, S., Hotta, N., Kakizaki, M., Honda, T., Kim, S. J., Komiya, H., Miura, I., Suzuki, T., Kobayashi, K., Kaneda, H., Kumar, V., Takahashi, J. S., Wakana, S., Funato, H. & 1 others, Yanagisawa, M., Sep 2 2016, In : Scientific reports. 6, 32453.

Research output: Contribution to journalArticle

5 Scopus citations

Knockout of endothelin type B receptor signaling attenuates bleomycin-induced skin sclerosis in mice

Akashi, K., Saegusa, J., Sendo, S., Nishimura, K., Okano, T., Yagi, K., Yanagisawa, M., Emoto, N. & Morinobu, A., May 21 2016, In : Arthritis Research and Therapy. 18, 1, 113.

Research output: Contribution to journalArticle

8 Scopus citations

Mesolimbic neuropeptide W coordinates stress responses under novel environments

Motoike, T., Long, J. M., Tanaka, H., Sinton, C. M., Skach, A., Williams, S. C., Hammer, R. E., Sakurai, T. & Yanagisawa, M., May 24 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 21, p. 6023-6028 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Nighttime administration of nicotine improves hepatic glucose metabolism via the hypothalamic orexin system in mice

Tsuneki, H., Nagata, T., Fujita, M., Kon, K., Wu, N., Takatsuki, M., Yamaguchi, K., Wada, T., Nishijo, H., Yanagisawa, M., Sakurai, T. & Sasaoka, T., Jan 2016, In : Endocrinology. 157, 1, p. 195-206 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Peripherally administered orexin improves survival of mice with endotoxin shock

Ogawa, Y., Irukayama-Tomobe, Y., Murakoshi, N., Kiyama, M., Ishikawa, Y., Hosokawa, N., Tominaga, H., Uchida, S., Kimura, S., Kanuka, M., Morita, M., Hamada, M., Takahashi, S., Hayashi, Y. & Yanagisawa, M., Dec 30 2016, In : eLife. 5, DECEMBER2016, e21055.

Research output: Contribution to journalArticle

12 Scopus citations

QRFP-Deficient mice are hypophagic, lean, hypoactive and exhibit increased anxiety-Like behavior

Okamoto, K., Yamasaki, M., Takao, K., Soya, S., Iwasaki, M., Sasaki, K., Magoori, K., Sakakibara, I., Miyakawa, T., Mieda, M., Watanabe, M., Sakai, J., Yanagisawa, M. & Sakurai, T., Nov 2016, In : PloS one. 11, 11, e0164716.

Research output: Contribution to journalArticle

8 Scopus citations

Timed inhibition of orexin system by suvorexant improved sleep and glucose metabolism in type 2 diabetic db/db mice

Tsuneki, H., Kon, K., Ito, H., Yamazaki, M., Takahara, S., Toyooka, N., Ishii, Y., Sasahara, M., Wada, T., Yanagisawa, M., Sakurai, T. & Sasaoka, T., Nov 1 2016, In : Endocrinology. 157, 11, p. 4146-4157 12 p.

Research output: Contribution to journalArticle

12 Scopus citations
2015

Corrigendum to "Transient expression of neuropeptide W in postnatal mouse hypothalamus - A putative regulator of energy homeostasis" [Neuroscience, 301 (2015) 323-337]

Motoike, T., Skach, A. G., Godwin, J. K., Sinton, C. M., Yamazaki, M., Abe, M., Natsume, R., Sakimura, K. & Yanagisawa, M., Sep 1 2015, In : Neuroscience. 303, p. 630 1 p.

Research output: Contribution to journalArticle

Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists

Nagahara, T., Saitoh, T., Kutsumura, N., Irukayama-Tomobe, Y., Ogawa, Y., Kuroda, D., Gouda, H., Kumagai, H., Fujii, H., Yanagisawa, M. & Nagase, H., Aug 12 2015, In : Journal of Medicinal Chemistry. 58, 20, p. 7931-7937 7 p.

Research output: Contribution to journalArticle

48 Scopus citations

Endothelin-1 as a master regulator of whole-body Na+ homeostasis

Speed, J. S., Heimlich, J. B., Hyndman, K. A., Fox, B. M., Patel, V., Yanagisawa, M., Pollock, J. S., Titze, J. M. & Pollock, D. M., Dec 1 2015, In : FASEB Journal. 29, 12, p. 4937-4944 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

GABAA receptor-mediated input change on orexin neurons following sleep deprivation in mice

Matsuki, T., Takasu, M., Hirose, Y., Murakoshi, N., Sinton, C. M., Motoike, T. & Yanagisawa, M., Dec 1 2015, In : Neuroscience. 284, p. 217-224 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Hypothalamic orexin prevents hepatic insulin resistance via daily bidirectional regulation of autonomic nervous system in mice

Tsuneki, H., Tokai, E., Nakamura, Y., Takahashi, K., Fujita, M., Asaoka, T., Kon, K., Anzawa, Y., Wada, T., Takasaki, I., Kimura, K., Inoue, H., Yanagisawa, M., Sakurai, T. & Sasaoka, T., Feb 1 2015, In : Diabetes. 64, 2, p. 459-470 12 p.

Research output: Contribution to journalArticle

33 Scopus citations

Monitoring β-arrestin recruitment via β-lactamase enzyme fragment complementation: Purification of peptide E as a low-affinity ligand for mammalian bombesin receptors

Ikeda, Y., Kumagai, H., Okazaki, H., Fujishiro, M., Motozawa, Y., Nomura, S., Takeda, N., Toko, H., Takimoto, E., Akazawa, H., Morita, H., Suzuki, J. I., Yamazaki, T., Komuro, I. & Yanagisawa, M., Jun 1 2015, In : PloS one. 10, 6, e0127445.

Research output: Contribution to journalArticle

5 Scopus citations

Neuromedin s-producing neurons act as essential pacemakers in the suprachiasmatic nucleus to couple clock neurons and dictate circadian rhythms

Lee, I. T., Chang, A. S., Manandhar, M., Shan, Y., Fan, J., Izumo, M., Ikeda, Y., Motoike, T., Dixon, S., Seinfeld, J. E., Takahashi, J. S. & Yanagisawa, M., Mar 4 2015, In : Neuron. 85, 5, p. 1086-1102 17 p.

Research output: Contribution to journalArticle

75 Scopus citations

Quantitative measurement of GPCR endocytosis via pulse-chase covalent labeling

Kumagai, H., Ikeda, Y., Motozawa, Y., Fujishiro, M., Okamura, T., Fujio, K., Okazaki, H., Nomura, S., Takeda, N., Harada, M., Toko, H., Takimoto, E., Akazawa, H., Morita, H., Suzuki, J. I., Yamazaki, T., Yamamoto, K., Komuro, I. & Yanagisawa, M., May 28 2015, In : PloS one. 10, 5, e0129394.

Research output: Contribution to journalArticle

6 Scopus citations

Transient expression of neuropeptide W in postnatal mouse hypothalamus - A putative regulator of energy homeostasis

Motoike, T., Skach, A. G., Godwin, J. K., Sinton, C. M., Yamazaki, M., Abe, M., Natsume, R., Sakimura, K. & Yanagisawa, M., Aug 1 2015, In : Neuroscience. 301, p. 323-337 15 p.

Research output: Contribution to journalArticle

7 Scopus citations
2014

Direct action of endothelin-1 on podocytes promotes diabetic glomerulosclerosis

Lenoir, O., Milon, M., Virsolvy, A., Hénique, C., Schmitt, A., Massé, J. M., Kotelevtsev, Y., Yanagisawa, M., Webb, D. J., Richard, S. & Tharaux, P. L., May 1 2014, In : Journal of the American Society of Nephrology. 25, 5, p. 1050-1062 13 p.

Research output: Contribution to journalArticle

52 Scopus citations

Essential role of sympathetic endothelin A receptors for adverse cardiac remodeling

Lehmann, L. H., Rostosky, J. S., Buss, S. J., Kreusser, M. M., Krebs, J., Mier, W., Enseleit, F., Spiger, K., Hardt, S. E., Wieland, T., Haass, M., Lüscher, T. F., Schneider, M. D., Parlato, R., Gröne, H. J., Haberkorn, U., Yanagisawa, M., Katus, H. A. & Backs, J., Sep 16 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 37, p. 13499-13504 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Knockout of endothelial cell-derived endothelin-1 attenuates skin fibrosis but accelerates cutaneous wound healing

Makino, K., Jinnin, M., Aoi, J., Kajihara, I., Makino, T., Fukushima, S., Sakai, K., Nakayama, K., Emoto, N., Yanagisawa, M. & Ihn, H., May 22 2014, In : PloS one. 9, 5, e97972.

Research output: Contribution to journalArticle

17 Scopus citations

Loss of function of endothelin-2 leads to reduced ovulation and CL formation

Cacioppo, J. A., Oh, S. W., Kim, H. Y., Cho, J., Lin, P. C. P., Yanagisawa, M. & Ko, C., Apr 24 2014, In : PloS one. 9, 4, e96115.

Research output: Contribution to journalArticle

16 Scopus citations

Orexin/hypocretin activates mTOR complex 1 (mTORC1) via an Erk/Akt-independent and calcium-stimulated lysosome v-ATPase pathway

Wang, Z., Liu, S., Kakizaki, M., Hirose, Y., Ishikawa, Y., Funato, H., Yanagisawa, M., Yu, Y. & Liu, Q., Nov 14 2014, In : Journal of Biological Chemistry. 289, 46, p. 31950-31959 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Orexin neurons suppress narcolepsy via 2 distinct efferent pathways

Hasegawa, E., Yanagisawa, M., Sakurai, T. & Mieda, M., Feb 3 2014, In : Journal of Clinical Investigation. 124, 2, p. 604-616 13 p.

Research output: Contribution to journalArticle

92 Scopus citations

Orexin regulates bone remodeling via a dominant positive central action and a subordinate negative peripheral action

Wei, W., Motoike, T., Krzeszinski, J. Y., Jin, Z., Xie, X-J., Dechow, P. C., Yanagisawa, M. & Wan, Y., Jun 3 2014, In : Cell Metabolism. 19, 6, p. 927-940 14 p.

Research output: Contribution to journalArticle

20 Scopus citations
21 Scopus citations

The second tomoh masaki award (2013)

Emoto, N., Kasuya, Y. & Yanagisawa, M., Nov 24 2014, In : Life Sciences. 118, 2, p. 87-90 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

The thirteenth international conference on endothelin (ET-13), Tokyo, 2013

Emoto, N. & Yanagisawa, M., Nov 24 2014, In : Life Sciences. 118, 2, p. 70-76 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Vascular endothelium derived endothelin-1 is required for normal heart function after chronic pressure overload in mice

Heiden, S., Vignon-Zellweger, N., Masuda, S., Yagi, K., Nakayama, K., Yanagisawa, M. & Emoto, N., Feb 11 2014, In : PloS one. 9, 2, e88730.

Research output: Contribution to journalArticle

15 Scopus citations
2013
33 Scopus citations

Cardiomyocyte-specific deletion of endothelin receptor A rescues aging-associated cardiac hypertrophy and contractile dysfunction: Role of autophagy

Ceylan-Isik, A. F., Dong, M., Zhang, Y., Dong, F., Turdi, S., Nair, S., Yanagisawa, M. & Ren, J., Jan 1 2013, In : Basic Research in Cardiology. 108, 2, 335.

Research output: Contribution to journalArticle

44 Scopus citations

Differential actions of orexin receptors in brainstem cholinergic and monoaminergic neurons revealed by receptor knockouts: Implications for orexinergic signaling in arousal and narcolepsy

Kohlmeier, K. A., Tyler, C. J., Kalogiannis, M., Ishibashi, M., Kristensen, M. P., Gumenchuk, I., Chemelli, R. M., Kisanuki, Y. Y., Yanagisawa, M. & Leonard, C. S., 2013, In : Frontiers in Neuroscience. 7 DEC, 246.

Research output: Contribution to journalArticle

36 Scopus citations

Dysregulation of Protease and Protease Inhibitors in a Mouse Model of Human Pelvic Organ Prolapse

Budatha, M., Silva, S., Montoya, T. I., Suzuki, A., Shah-Simpson, S., Wieslander, C. K., Yanagisawa, M., Word, R. A. & Yanagisawa, H., Feb 20 2013, In : PloS one. 8, 2, e56376.

Research output: Contribution to journalArticle

15 Scopus citations

Endothelin-1 is a transcriptional target of p53 in epidermal keratinocytes and regulates ultraviolet-induced melanocyte homeostasis

Hyter, S., Coleman, D. J., Ganguli-Indra, G., Merrill, G. F., Ma, S., Yanagisawa, M. & Indra, A. K., Mar 1 2013, In : Pigment Cell and Melanoma Research. 26, 2, p. 247-258 12 p.

Research output: Contribution to journalArticle

30 Scopus citations

Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice

Chang, I., Bramall, A. N., Baynash, A. G., Rattner, A., Rakheja, D., Post, M., Joza, S., McKerlie, C., Stewart, D. J., McInnes, R. R. & Yanagisawa, M., Jun 3 2013, In : Journal of Clinical Investigation. 123, 6, p. 2643-2653 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Endothelin-2-Mediated Protection of Mutant Photoreceptors in Inherited Photoreceptor Degeneration

Bramall, A. N., Szego, M. J., Pacione, L. R., Chang, I., Diez, E., D'Orleans-Juste, P., Stewart, D. J., Hauswirth, W. W., Yanagisawa, M. & McInnes, R. R., Feb 28 2013, In : PloS one. 8, 2, e58023.

Research output: Contribution to journalArticle

18 Scopus citations

Modulation of circadian glucocorticoid oscillation via adrenal Opioid-CXCR7 Signaling alters emotional behavior

Ikeda, Y., Kumagai, H., Skach, A., Sato, M. & Yanagisawa, M., Dec 5 2013, In : Cell. 155, 6, p. 1323-1336 14 p.

Research output: Contribution to journalArticle

48 Scopus citations

Neurotensin Co-Expressed in Orexin-Producing Neurons in the Lateral Hypothalamus Plays an Important Role in Regulation of Sleep/Wakefulness States

Furutani, N., Hondo, M., Kageyama, H., Tsujino, N., Mieda, M., Yanagisawa, M., Shioda, S. & Sakurai, T., Apr 19 2013, In : PloS one. 8, 4, e62391.

Research output: Contribution to journalArticle

49 Scopus citations

Olfactory receptor responding to gut microbiotaderived signals plays a role in renin secretion and blood pressure regulation

Pluznick, J. L., Protzko, R. J., Gevorgyan, H., Peterlin, Z., Sipos, A., Han, J., Brunet, I., Wan, L. X., Rey, F., Wang, T., Firestein, S. J., Yanagisawa, M., Gordon, J. I., Eichmann, A., Peti-Peterdi, J. & Caplan, M. J., Mar 12 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 11, p. 4410-4415 6 p.

Research output: Contribution to journalArticle

411 Scopus citations

Orexin receptor-1 in the locus coeruleus plays an important role in cue-dependent fear memory consolidation

Soya, S., Shoji, H., Hasegawa, E., Hondo, M., Miyakawa, T., Yanagisawa, M., Mieda, M. & Sakurai, T., Sep 9 2013, In : Journal of Neuroscience. 33, 36, p. 14549-14557 9 p.

Research output: Contribution to journalArticle

62 Scopus citations

Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice

Kim, M. H., Kang, S. G., Park, J. H., Yanagisawa, M. & Kim, C. H., Aug 2013, In : Gastroenterology. 145, 2, p. 396-406.e10

Research output: Contribution to journalArticle

303 Scopus citations
2012

Ablation of 3-phosphoinositide-dependent protein kinase 1 (PDK1) in vascular endothelial cells enhances insulin sensitivity by reducing visceral fat and suppressing angiogenesis

Tawaramoto, K., Kotani, K., Hashiramoto, M., Kanda, Y., Nagare, T., Sakaue, H., Ogawa, W., Emoto, N., Yanagisawa, M., Noda, T., Kasuga, M. & Kaku, K., Jan 2012, In : Molecular Endocrinology. 26, 1, p. 95-109 15 p.

Research output: Contribution to journalArticle

6 Scopus citations

Cardiac-specific knockout of ET A receptor mitigates low ambient temperature-induced cardiac hypertrophy and contractile dysfunction

Zhang, Y., Li, L., Hua, Y., Nunn, J. M., Dong, F., Yanagisawa, M. & Ren, J., Apr 1 2012, In : Journal of molecular cell biology. 4, 2, p. 97-107 11 p.

Research output: Contribution to journalArticle

36 Scopus citations

Endothelin B receptor is not required but necessary for finite regulation of ovulation

Cho, J., Kim, H., Kang, D. W., Yanagisawa, M. & Ko, C., Oct 15 2012, In : Life Sciences. 91, 13-14, p. 613-617 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Endothelin XII

Barton, M., Yanagisawa, M., Vanhoutte, P. M. & Masaki, T., Oct 15 2012, In : Life Sciences. 91, 13-14, p. 449-451 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

ET-1 from endothelial cells is required for complete angiotensin II-induced cardiac fibrosis and hypertrophy

Adiarto, S., Heiden, S., Vignon-Zellweger, N., Nakayama, K., Yagi, K., Yanagisawa, M. & Emoto, N., Oct 15 2012, In : Life Sciences. 91, 13-14, p. 651-657 7 p.

Research output: Contribution to journalArticle

38 Scopus citations
2011

Cholinergic modulation of narcoleptic attacks in double orexin receptor knockout mice

Kalogiannis, M., Hsu, E., Willie, J. T., Chemelli, R. M., Kisanuki, Y. Y., Yanagisawa, M. & Leonard, C. S., 2011, In : PloS one. 6, 4, e18697.

Research output: Contribution to journalArticle

34 Scopus citations

Critical role of neuropeptides B/W receptor 1 signaling in social behavior and fear memory

Nagata-Kuroiwa, R., Furutani, N., Hara, J., Hondo, M., Ishii, M., Abe, T., Mieda, M., Tsujino, N., Motoike, T., Yanagawa, Y., Kuwaki, T., Yamamoto, M., Yanagisawa, M. & Sakurai, T., 2011, In : PloS one. 6, 2, e16972.

Research output: Contribution to journalArticle

19 Scopus citations

Decreased intake of sucrose solutions in orexin knockout mice

Matsuo, E., Mochizuki, A., Nakayama, K., Nakamura, S., Yamamoto, T., Shioda, S., Sakurai, T., Yanagisawa, M., Shiuchi, T., Minokoshi, Y. & Inoue, T., Feb 1 2011, In : Journal of Molecular Neuroscience. 43, 2, p. 217-224 8 p.

Research output: Contribution to journalArticle

25 Scopus citations

Differential roles of orexin receptor-1 and -2 in the regulation of Non-REM and REM sleep

Mieda, M., Hasegawa, E., Kisanuki, Y. Y., Sinton, C. M., Yanagisawa, M. & Sakurai, T., Apr 27 2011, In : Journal of Neuroscience. 31, 17, p. 6518-6526 9 p.

Research output: Contribution to journalArticle

150 Scopus citations

Ectopic overexpression of orexin alters sleep/wakefulness states and muscle tone regulation during REM sleep in mice

Willie, J. T., Takahira, H., Shibahara, M., Hara, J., Nomiyama, M., Yanagisawa, M. & Sakurai, T., Feb 2011, In : Journal of Molecular Neuroscience. 43, 2, p. 155-161 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

Hypothalamic orexin system: From orphan GPCR to therapeutic target

Yanagisawa, M., Jul 1 2011, In : Experimental Animals. 60, SUPPL. 3, 1 p.

Research output: Contribution to journalArticle

2 Scopus citations