• 71926 Citations
  • 119 h-Index
1984 …2020

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Article
2010

Endothelial cell-derived endothelin-1 promotes cardiac fibrosis in diabetic hearts through stimulation of endothelial-to-mesenchymal transition

Widyantoro, B., Emoto, N., Nakayama, K., Anggrahini, D. W., Adiarto, S., Iwasa, N., Yagi, K., Miyagawa, K., Rikitake, Y., Suzuki, T., Kisanuki, Y. Y., Yanagisawa, M. & Hirata, K. I., Jun 8 2010, In : Circulation. 121, 22, p. 2407-2418 12 p.

Research output: Contribution to journalArticle

234 Scopus citations

Ghrelin Increases the Rewarding Value of High-Fat Diet in an Orexin-Dependent Manner

Perello, M., Sakata, I., Birnbaum, S. G., Chuang, J. C., Osborne-Lawrence, S., Rovinsky, S. A., Woloszyn, J., Yanagisawa, M., Lutter, M. & Zigman, J. M., May 1 2010, In : Biological Psychiatry. 67, 9, p. 880-886 7 p.

Research output: Contribution to journalArticle

245 Scopus citations

Histamine-1 receptor is not required as a downstream effector of orexin-2 receptor in maintenance of basal sleep/wake states

Hondo, M., Nagai, K., Ohno, K., Kisanuki, Y., Willie, J. T., Watanabe, T., Yanagisawa, M. & Sakurai, T., Mar 1 2010, In : Acta Physiologica. 198, 3, p. 287-294 8 p.

Research output: Contribution to journalArticle

40 Scopus citations

Loss of Goosecoid-like and DiGeorge syndrome critical region 14 in interpeduncular nucleus results in altered regulation of rapid eye movement sleep

Funato, H., Sato, M., Sinton, C. M., Gautron, L., Williams, S. C., Skach, A., Elmquist, J. K., Skoultchi, A. I. & Yanagisawa, M., Oct 19 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 42, p. 18155-18160 6 p.

Research output: Contribution to journalArticle

20 Scopus citations

Low blood pressure in endothelial cell-specific endothelin 1 knockout mice

Kisanuki, Y. Y., Emoto, N., Ohuchi, T., Widyantoro, B., Yagi, K., Nakayama, K., Kedzierski, R. M., Hammer, R. E., Yanagisawa, H., Williams, S. C., Richardson, J. A., Suzuki, T. & Yanagisawa, M., Jul 1 2010, In : Hypertension. 56, 1, p. 121-128 8 p.

Research output: Contribution to journalArticle

77 Scopus citations

Monoaminergic neuronal changes in orexin deficient mice

Mori, T., Ito, S., Kuwaki, T., Yanagisawa, M., Sakurai, T. & Sawaguchi, T., Mar 1 2010, In : Neuropharmacology. 58, 4-5, p. 826-832 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Narcoleptic orexin receptor knockout mice express enhanced cholinergic properties in laterodorsal tegmental neurons

Kalogiannis, M., Grupke, S. L., Potter, P. E., Edwards, J. G., Chemelli, R. M., Kisanuki, Y. Y., Yanagisawa, M. & Leonard, C. S., Jul 1 2010, In : European Journal of Neuroscience. 32, 1, p. 130-142 13 p.

Research output: Contribution to journalArticle

22 Scopus citations
2009

Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B

Irukayama-Tomobe, Y., Tanaka, H., Yokomizo, T., Hashidate-Yoshida, T., Yanagisawa, M. & Sakurai, T., Mar 10 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 10, p. 3930-3934 5 p.

Research output: Contribution to journalArticle

38 Scopus citations

COUP-TFII acts downstream of Wnt/β-catenin signal to silence PPARγ gene expression and repress adipogenesis

Okamura, M., Kudo, H., Wakabayashi, K. I., Tanaka, T., Nonaka, A., Uchida, A., Tsutsumi, S., Sakakibara, I., Naito, M., Osborne, T. F., Hamakubo, T., Ito, S., Aburatani, H., Yanagisawa, M., Kodama, T. & Sakai, J., Apr 7 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 14, p. 5819-5824 6 p.

Research output: Contribution to journalArticle

129 Scopus citations

Endothelial ETB limits vascular remodelling and development of pulmonary hypertension during hypoxia

Kelland, N. F., Bagnall, A. J., Morecroft, I., Gulliver-Sloan, F. H., Dempsie, Y., Nilsen, M., Yanagisawa, M., MacLean, M. R., Kotelevtsev, Y. V. & Webb, D. J., Jan 1 2009, In : Journal of Vascular Research. 47, 1, p. 16-22 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Endothelin-1 impairs alveolar epithelial function via endothelial ET B receptor

Comellas, A. P., Briva, A., Dada, L. A., Butti, M. L., Trejo, H. E., Yshii, C., Azzam, Z. S., Litvan, J., Chen, J., Lecuona, E., Pesce, L. M., Yanagisawa, M. & Sznajder, J. I., Jan 15 2009, In : American journal of respiratory and critical care medicine. 179, 2, p. 113-122 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Enhanced Orexin Receptor-2 Signaling Prevents Diet-Induced Obesity and Improves Leptin Sensitivity

Funato, H., Tsai, A. L., Willie, J. T., Kisanuki, Y., Williams, S. C., Sakurai, T. & Yanagisawa, M., Jan 7 2009, In : Cell Metabolism. 9, 1, p. 64-76 13 p.

Research output: Contribution to journalArticle

182 Scopus citations

Fasting-Induced Hypothermia and Reduced Energy Production in Mice Lacking Acetyl-CoA Synthetase 2

Sakakibara, I., Fujino, T., Ishii, M., Tanaka, T., Shimosawa, T., Miura, S., Zhang, W., Tokutake, Y., Yamamoto, J., Awano, M., Iwasaki, S., Motoike, T., Okamura, M., Inagaki, T., Kita, K., Ezaki, O., Naito, M., Kuwaki, T., Chohnan, S., Yamamoto, T. T. & 4 others, Hammer, R. E., Kodama, T., Yanagisawa, M. & Sakai, J., Feb 4 2009, In : Cell Metabolism. 9, 2, p. 191-202 12 p.

Research output: Contribution to journalArticle

54 Scopus citations

Halothane-induced hypnosis is not accompanied by inactivation of orexinergic output in rodents

Gompf, H., Chen, J., Sun, Y., Yanagisawa, M., Aston-Jones, G. & Kelz, M. B., Nov 2009, In : Anesthesiology. 111, 5, p. 1001-1009 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Hypothalamic Orexin Stimulates Feeding-Associated Glucose Utilization in Skeletal Muscle via Sympathetic Nervous System

Shiuchi, T., Haque, M. S., Okamoto, S., Inoue, T., Kageyama, H., Lee, S., Toda, C., Suzuki, A., Bachman, E. S., Kim, Y. B., Sakurai, T., Yanagisawa, M., Shioda, S., Imoto, K. & Minokoshi, Y., Dec 2 2009, In : Cell Metabolism. 10, 6, p. 466-480 15 p.

Research output: Contribution to journalArticle

149 Scopus citations

IGFBP3 colocalizes with and regulates hypocretin (orexin)

Honda, M., Eriksson, K. S., Zhang, S., Tanaka, S., Lin, L., Salehi, A., Hesla, P. E., Maehlen, J., Gaus, S. E., Yanagisawa, M., Sakurai, T., Taheri, S., Tsuchiya, K., Honda, Y. & Mignot, E., Jan 22 2009, In : PloS one. 4, 1, e4254.

Research output: Contribution to journalArticle

47 Scopus citations

Orexin/hypocretin and histamine: Distinct roles in the control of wakefulness demonstrated using knock-out mouse models

Anaclet, C., Parmentier, R., Ouk, K., Guidon, G., Buda, C., Sastre, J. P., Akaoka, H., Sergeeva, O. A., Yanagisawa, M., Ohtsu, H., Franco, P., Haas, H. L. & Lin, J. S., Nov 18 2009, In : Journal of Neuroscience. 29, 46, p. 14423-14438 16 p.

Research output: Contribution to journalArticle

148 Scopus citations

Selective loss of GABAB receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture

Matsuki, T., Nomiyama, M., Takahira, H., Hirashima, N., Kunita, S., Takahashi, S., Yagami, K. I., Kilduff, T. S., Bettler, B., Yanagisawa, M. & Sakurai, T., Mar 17 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 11, p. 4459-4464 6 p.

Research output: Contribution to journalArticle

88 Scopus citations

Vascular endothelial cell-derived endothelin-1 mediates vascular inflammation and neointima formation following blood flow cessation

Anggrahini, D. W., Emoto, N., Nakayama, K., Widyantoro, B., Adiarto, S., Iwasa, N., Nonaka, H., Rikitake, Y., Kisanuki, Y. Y., Yanagisawa, M. & Hirata, K. I., Apr 1 2009, In : Cardiovascular Research. 82, 1, p. 143-151 9 p.

Research output: Contribution to journalArticle

67 Scopus citations
2008

Abnormal response of melanin-concentrating hormone deficient mice to fasting: Hyperactivity and rapid eye movement sleep suppression

Willie, J. T., Sinton, C. M., Maratos-Flier, E. & Yanagisawa, M., Oct 28 2008, In : Neuroscience. 156, 4, p. 819-829 11 p.

Research output: Contribution to journalArticle

103 Scopus citations

Age-related insulin resistance in hypothalamus and peripheral tissues of orexin knockout mice

Tsuneki, H., Murata, S., Anzawa, Y., Soeda, Y., Tokai, E., Wada, T., Kimura, I., Yanagisawa, M., Sakurai, T. & Sasaoka, T., Apr 1 2008, In : Diabetologia. 51, 4, p. 657-667 11 p.

Research output: Contribution to journalArticle

87 Scopus citations

An essential role for orexins in emergence from general anesthesia

Kelz, M. B., Sun, Y., Chen, J., Qing, C. M., Moore, J. T., Veasey, S. C., Dixon, S., Thornton, M., Funato, H. & Yanagisawa, M., Jan 29 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 4, p. 1309-1314 6 p.

Research output: Contribution to journalArticle

182 Scopus citations

Animals lacking endothelin-converting enzyme-2 are deficient in learning and memory

Rodriguiz, R. M., Gadnidze, K., Ragnauth, A., Dorr, N., Yanagisawa, M., Wetsel, W. C. & Devi, L. A., Jun 1 2008, In : Genes, Brain and Behavior. 7, 4, p. 418-426 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

An inverse agonist of the histamine H3 receptor improves wakefulness in narcolepsy: Studies in orexin-/- mice and patients

Lin, J. S., Dauvilliers, Y., Arnulf, I., Bastuji, H., Anaclet, C., Parmentier, R., Kocher, L., Yanagisawa, M., Lehert, P., Ligneau, X., Perrin, D., Robert, P., Roux, M., Lecomte, J. M. & Schwartz, J. C., Apr 1 2008, In : Neurobiology of Disease. 30, 1, p. 74-83 10 p.

Research output: Contribution to journalArticle

197 Scopus citations

Effect of neuropeptide B on feeding behavior is influenced by endogenous corticotropin-releasing factor activities

Aikawa, S., Ishii, M., Yanagisawa, M., Sakakibara, Y. & Sakurai, T., Nov 29 2008, In : Regulatory Peptides. 151, 1-3, p. 147-152 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41

Samuel, B. S., Shaito, A., Motoike, T., Rey, F. E., Backhed, F., Manchester, J. K., Hammer, R. E., Williams, S. C., Crowley, J., Yanagisawa, M. & Gordon, J. I., Oct 28 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 43, p. 16767-16772 6 p.

Research output: Contribution to journalArticle

808 Scopus citations

Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons

Makita, T., Sucov, H. M., Gariepy, C. E., Yanagisawa, M. & Ginty, D. D., Apr 10 2008, In : Nature. 452, 7188, p. 759-763 5 p.

Research output: Contribution to journalArticle

127 Scopus citations

Entrainment of temperature and activity rhythms to restricted feeding in orexin knock out mice

Kaur, S., Thankachan, S., Begum, S., Blanco-Centurion, C., Sakurai, T., Yanagisawa, M. & Shiromani, P. J., Apr 18 2008, In : Brain Research. 1205, p. 47-54 8 p.

Research output: Contribution to journalArticle

47 Scopus citations

Orexin (hypocretin) gene transfer diminishes narcoleptic sleep behavior in mice

Liu, M., Thankachan, S., Kaur, S., Begum, S., Blanco-Centurion, C., Sakurai, T., Yanagisawa, M., Neve, R. & Shiromani, P. J., Oct 1 2008, In : European Journal of Neuroscience. 28, 7, p. 1382-1393 12 p.

Research output: Contribution to journalArticle

56 Scopus citations

The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress

Lutter, M., Sakata, I., Osborne-Lawrence, S., Rovinsky, S. A., Anderson, J. G., Jung, S., Birnbaum, S. G., Yanagisawa, M., Elmquist, J. K., Nestler, E. J. & Zigman, J. M., Jul 1 2008, In : Nature neuroscience. 11, 7, p. 752-753 2 p.

Research output: Contribution to journalArticle

380 Scopus citations

Urinary protein profiling with surface-enhanced laser desorption/ionization time-of-flight mass spectrometry in etB receptor-deficient rats1

Raila, J., Kalk, P., Pfab, T., Thöne-Reineke, C., Godes, M., Yanagisawa, M., Schweigert, F. J. & Hocher, B., Aug 1 2008, In : Canadian Journal of Physiology and Pharmacology. 86, 8, p. 566-570 5 p.

Research output: Contribution to journalArticle

Ventilatory long-term facilitation in mice can be observed during both sleep and wake periods and depends on orexin

Terada, J., Nakamura, A., Zhang, W., Yanagisawa, M., Kuriyama, T., Fukuda, Y. & Kuwaki, T., Feb 1 2008, In : Journal of applied physiology. 104, 2, p. 499-507 9 p.

Research output: Contribution to journalArticle

66 Scopus citations
2007

Contribution of orexin in hypercapnic chemoreflex: Evidence from genetic and pharmacological disruption and supplementation studies in mice

Deng, B. S., Nakamura, A., Zhang, W., Yanagisawa, M., Fukuda, Y. & Kuwaki, T., Nov 1 2007, In : Journal of applied physiology. 103, 5, p. 1772-1779 8 p.

Research output: Contribution to journalArticle

82 Scopus citations

Progress report on the Hypertension Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP) study: Status at February 2004

Hosohata, K., Saito, S., Asayama, K., Ohkubo, T., Kikuya, M., Metoki, H., Obara, T., Kato, T., Hashimoto, J., Totsune, K., Miura, Y., Imai, Y., Arakawa, K., Fujishima, M., Fujii, J., Fukiyama, K., Hisamichi, S., Iimura, O., Ishii, M., Omae, T. & 526 others, Saruta, T., Yoshinaga, K., Abe, I., Abe, K., Abukawa, T., Ashida, T., Dohba, N., Etoh, T., Fujimura, A., Fujita, T., Fukui, A., Gotoh, T., Hama, H., Hano, T., Hayashi, H., Hayashida, N., Hayashi, M., Hiramori, K., Hirai, Y., Hirata, Y., Hiwada, K., Hora, K., Ichikawa, S., Iida, T., Ikeda, T., Imaizumi, T., Ishikawa, K., Ito, I., Ito, M., Ito, S., Iwaoka, D., Kanamasa, K., Katagiri, T., Katayama, S., Kawamura, H., Kawano, Y., Kida, H., Kikuchi, K., Kimura, G., Kimura, K., Kitaoka, H., Kobayashi, S., Kohara, K., Kojima, S., Komuro, I., Kumagai, H., Kumagai, Y., Kusano, E., Kushiro, T., Kuwajima, I., Maruyama, Y., Masani, F., Matsubara, H., Matsubara, T., Matsumoto, M., Matsuoka, H., Matsuura, H., Mishima, Y., Miura, M., Miyamori, I., Mori, H., Murakami, H., Muratani, H., Nakagawa, M., Nakao, K., Naruse, M., Nishio, I., Ogihara, T., Ohta, M., Ohtsuka, K., Ohtsuka, Y., Ohuchi, Y., Oikawa, S., Okabe, M., Okumura, K., Saitoh, I., Saitoh, H., Sakata, T., Saku, K., Sasaki, H., Seino, M., Senda, S., Shimada, K., Shimamoto, K., Shimizu, M., Shiomi, T., Shirato, K., Sone, M., Suzuki, H., Suzuki, S., Takahashi, H., Takada, M., Takeda, K., Takeda, N., Takeshita, A., Takishita, S., Tanaka, S., Toba, K., Tochikubo, O., Tomoike, H., Ueno, Y., Umemura, S., Urata, H., Watanabe, T., Yamada, K., Yamaguchi, T., Yamakado, M., Yamamoto, Y., Yamamoto, Y., Yamashina, A., Yokoyama, H., Yoshimura, M., Satoh, H., Oka, Y., Katagiri, H., Kondo, Y., Shishido, H., Kohinata, A., Kanno, Y., Ikeda, H., Takahira, Y., Takahashi, T., Kimura, A., Funahashi, J., Takada, N., Hanazawa, T., Suzuki, N., Osugi, M., Hashimoto, J., Ogawa, Y., Miyamura, T., Masuda, Y., Tanaka, S., Tanaka, S., Koizumi, M., Ando, T., Endo, T., Tsuchida, A., Nanba, M., Yonekura, S., Shiroishi, M., Nakagawa, M., Ito, K., Oda, K., Takahashi, K., Kanahara, I., Hirota, N., Tsutsui, M., Anzai, J., Hosoda, S., Shiiki, M., Takagawa, Y., Iida, M., Tada, M., Noto, T., Tanaka, H., Tajima, G., Kawamorita, K., Kikuchi, K., Suzuki, H., Suzuki, K., Komai, K., Seki, H., Omoto, A., Takahashi, H., Kitabayashi, A., Kimura, M., Kimura, Y., Yamamoto, H., Takahashi, K., Kimura, H., Kawamorita, Y., Emura, Y., Suzuki, Y., Ishikawa, Y., Nagai, K., Nagai, S., Ito, T., Nihei, K., Yamada, S., Goto, T., Yamamoto, N., Suzuki, Y., Ito, H., Ito, M., Fujita, T., Tominaga, Y., Tominaga, S., Suzuki, K., Ishibashi, K., Ando, Y., Sato, S., Morikawa, H., Kashima, S., Nakayama, D., Hayashi, Y., Ohta, K., Metoki, H., Fukami, K., Hayashi, T., Kishi, M., Tajima, J., Seino, J., Hoshi, H., Imai, Y., Kimura, H., Mori, R., Matsuo, K., Tanno, Y., Shibasaki, A., Yamagishi, T., Ohtomo, E., Ohtsuka, Y., Sasaki, S., Seino, M., Kurosawa, K., Ito, K., Takagi, Y., Kyogoku, S., Ito, K., Ono, Y., Watanabe, M., Watanabe, S., Hiwatashi, N., Yagi, C., Unakami, H., Asayama, K., Mouri, T., Watanabe, T., Kikuchi, K., Maruyama, N., Sone, M., Iwamoto, M., Naganuma, S., Mashiko, H., Ishii, H., Takaya, Y., Kamimoto, M., Shirai, A., Watanabe, R., Tohyama, Y., Araki, F., Sakuma, H., Amada, Y., Sato, E., Techigawara, M., Nakamura, K., Nakayama, T., Hasegawa, K., Hasegawa, K., Nagao, T., Minami, J., Kumagai, Y., Cho, T., Okamoto, K., Iguchi, T., Honzawa, T., Koitabashi, T., Yamada, T., Horikoshi, H., Nagao, T., Yoshimatsu, H., Seki, K., Akiyama, N., Suga, H., Matsunaga, R., Sinozaki, T., Ishimaru, Y., Yagi, N., Takikawa, H., Hukutome, T., Nakajima, C., Sato, H., Simizu, J., Arai, M., Koide, H., Takada, H., Sato, T., Umezu, T., Aoki, H., Nakamoto, H., Komahashi, K., Sekiya, S., Sugimoto, H., Arai, T., Suzuki, H., Inokuma, S., Funazaki, T., Yasuda, F., Kanouzawa, S., Yokota, C., Noguchi, Y., Hatano, M., Izumida, T., Hara, T., Muranaka, H., Suzuki, M., Ogawa, Y., Yabumoto, E., Matsushita, S., Kohzu, K., Sasaki, F., Hata, N., Yanagisawa, M., Ueda, T., Kurosawa, M., Doutare, S., Higashi, S., Kato, M., Hoshino, T., Fukuda, K., Ohtsuki, K., Ikeda, T., Kasatani, T., Yamada, T., Yatagai, S., Ohsuga, E., Yamakado, M., Kawamura, H., Mitsubayashi, H., Yamashina, S., Yamazaki, J., Nanjo, S., Ito, S., Teramoto, T., Gomi, T., Kato, S., Koekawa, N., Kuwaki, K., Ikeda, T., Hori, K., Arai, S., Koyama, H., Ichikawa, M., Hashimoto, A., Mori, H., Abe, S., Ohba, Y., Kurata, F., Miyakawa, M., Kimura, K., Hatori, Y., Ushiyama, M., Yamamoto, H., Adachi, M., Takayama, K., Shimizu, M., Iida, T., Asato, S., Uchiba, K., Watanabe, N., Kotani, M., Akaoka, F., Takahashi, S., Hirahara, K., Suzuki, S., Yamaguchi, Y., Ishikawa, S., Sasaki, K., Terada, Y., Ohhashi, S., Sakamaki, A., Hifumi, N., Ohno, T., Saeki, T., Suzaki, Y., Yamamoto, H., Nakagawa, T., Tomoda, F., Nishino, H., Ise, T., Takakuwa, H., Yokoyama, H., Kitakawa, S., Takasawa, K., Ohkura, T., Yamamoto, Y., Satake, K., Arai, Y., Nakayama, H., Sugiyama, S., Sugiura, K., Yokoyama, M., Ito, A., Okazaki, K., Saito, R., Mihara, J., Naito, A., Takahira, Y., Mori, T., Watanabe, M., Asai, S., Nojiri, O., Sakakura, K., Kozuka, M., Oyama, Y., Kawamura, Y., Inoko, T., Takeuchi, N., Tatematsu, H., Hayakawa, Y., Adachi, N., Tamagaki, N., Nakamura, T., Fukui, A., Amenomori, M., Kanaya, T., Masui, A., Hayashi, K., Nishi, S., Amari, M., Yoshida, K., Matsushita, Y., Sawada, S., Fujiwara, M., Ono, S., Tamai, K., Takemoto, Y., Kanemasa, T., Takenaka, T., Kitayama, K., Yasui, K., Fujita, S., Terayama, Y., Kato, N., Nagai, M., Takashima, H., Watanabe, K., Hirobe, N., Miyamoto, M., Sakamoto, N., Kurimoto, Y., Suzuki, N., Katsuya, S., Katsuya, T., Nagao, K., Nakamuta, K., Goto, S., Ueda, T., Imai, N., Sano, I., Ueda, H., Takahashi, N., Sada, T., Iwane, M., Suzuki, H., Yoshikawa, H., Tominaga, Y., Kamura, M., Ohtahara, A., Nakamura, Y., Osakada, M., Gen, M., Kahara, M., Yoshimoto, T., Mizuno, K., Furukawa, Y., Tokunaga, A., Sasaki, N., Matsumura, M., Furue, T., Iwasaki, K., Ichiki, K., Mizofuchi, S., Yokoi, T., Furumoto, W., Fukui, T., Fujino, K., Ohta, A., Ueda, S., Kitami, Y., Ohkura, T., Takeuchi, M., Yoshida, K., Nishiyama, S., Kawamoto, R., Kobaru, A., Endo, T., Kitano, K., Hirooka, Y., Tohaya, M., Miyazaki, Y., Onoyama, K., Miyagi, J., Kin, U., Fujishima, Y., Kuwahara, A., Shindo, R., Satake, Y., Moritsuka, T., Kuwahara, T., Hano, O., Takagi, Y., Suzuki, S., Abe, K., Sato, T., Kohno, M., Fujino, T., Wakayama, K., Aso, T., Goto, T., Ozaki, H., Ninomiya, K., Inobe, Y., Hamasaki, S., Inoue, J., Naomi, S., Iwaoka, T., Ono, T., Muta, Y., Endo, Y., Ohmori, H., Nagata, M., Wake, N., Kozawa, H., Tomino, Y., Ikeda, T., Yoshii, H., Nakamura, H., Fujimoto, N., Asato, T., Tozawa, M., Sunagawa, R., Nakamura, Y., Tomori, H. & Takashiba, K., Jan 1 2007, In : Clinical and Experimental Hypertension. 29, 1, p. 69-81 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

The development of hypocretin (OREXIN) deficiency in hypocretin/ataxin-3 transgenic rats

Zhang, S., Lin, L., Kaur, S., Thankachan, S., Blanco-Centurion, C., Yanagisawa, M., Mignot, E. & Shiromani, P. J., Aug 10 2007, In : Neuroscience. 148, 1, p. 34-43 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Vigilance state-dependent attenuation of hypercapnic chemoreflex and exaggerated sleep apnea in orexin knockout mice

Nakamura, A., Zhang, W., Yanagisawa, M., Fukuda, Y. & Kuwaki, T., Jan 1 2007, In : Journal of applied physiology. 102, 1, p. 241-248 8 p.

Research output: Contribution to journalArticle

105 Scopus citations
2006

A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice

Takayasu, S., Sakurai, T., Iwasaki, S., Teranishi, H., Yamanaka, A., Williams, S. C., Iguchi, H., Kawasawa, Y. I., Ikeda, Y., Sakakibara, I., Ohno, K., Ioka, R. X., Murakami, S., Dohmae, N., Xie, J., Suda, T., Motoike, T., Ohuchi, T., Yanagisawa, M. & Sakai, J., May 9 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 19, p. 7438-7443 6 p.

Research output: Contribution to journalArticle

107 Scopus citations

Deletion of endothelial cell endothelin B receptors does not affect blood pressure or sensitivity to salt

Bagnall, A. J., Kelland, N. F., Gulliver-Sloan, F., Davenport, A. P., Gray, G. A., Yanagisawa, M., Webb, D. J. & Kotelevtsev, Y. V., Aug 1 2006, In : Hypertension. 48, 2, p. 286-293 8 p.

Research output: Contribution to journalArticle

75 Scopus citations

Diabetic endothelin B receptor-deficient rats develop severe hypertension and progressive renal failure

Pfab, T., Thöne-Reineke, C., Theilig, F., Lange, I., Witt, H., Maser-Gluth, C., Bader, M., Stasch, J. P., Ruiz, P., Bachmann, S., Yanagisawa, M. & Hocher, B., Apr 1 2006, In : Journal of the American Society of Nephrology. 17, 4, p. 1082-1089 8 p.

Research output: Contribution to journalArticle

31 Scopus citations

Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine

Narita, M., Nagumo, Y., Hashimoto, S., Narita, M., Khotib, J., Miyatake, M., Sakurai, T., Yanagisawa, M., Nakamachi, T., Shioda, S. & Suzuki, T., Jan 11 2006, In : Journal of Neuroscience. 26, 2, p. 398-405 8 p.

Research output: Contribution to journalArticle

384 Scopus citations

Distribution of neuropeptide W immunoreactivity and mRNA in adult rat brain

Kitamura, Y., Tanaka, H., Motoike, T., Ishii, M., Williams, S. C., Yanagisawa, M. & Sakurai, T., Jun 6 2006, In : Brain Research. 1093, 1, p. 123-134 12 p.

Research output: Contribution to journalArticle

36 Scopus citations

Reduced expression of the endothelin receptor type B gene in piebald mice caused by insertion of a retroposon-like element in intron 1

Yamada, T., Ohtani, S., Sakurai, T., Tsuji, T., Kunieda, T. & Yanagisawa, M., Apr 21 2006, In : Journal of Biological Chemistry. 281, 16, p. 10799-10807 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Sex difference in body weight gain and leptin signaling in hypocretin/orexin deficient mouse models

Fujiki, N., Yoshida, Y., Zhang, S., Sakurai, T., Yanagisawa, M. & Nishino, S., Sep 1 2006, In : Peptides. 27, 9, p. 2326-2331 6 p.

Research output: Contribution to journalArticle

38 Scopus citations

The dorsomedial hypothalamic nucleus as a putative food-entrainable circadian pacemaker

Mieda, M., Williams, S. C., Richardson, J. A., Tanaka, K. & Yanagisawa, M., Aug 8 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 32, p. 12150-12155 6 p.

Research output: Contribution to journalArticle

218 Scopus citations

Uterine sensitization-associated gene-1 (USAG-1), a novel BMP antagonist expressed in the kidney, accelerates tubular injury

Yanagita, M., Okuda, T., Endo, S., Tanaka, M., Takahashi, K., Sugiyama, F., Kunita, S., Takahashi, S., Fukatsu, A., Yanagisawa, M., Kita, T. & Sakurai, T., Jan 1 2006, In : Journal of Clinical Investigation. 116, 1, p. 70-79 10 p.

Research output: Contribution to journalArticle

111 Scopus citations
2005

A consensus sequence in the endothelin-B receptor second intracellular loop is required for NHE3 activation by endothelin-1

Laghmani, K., Sakamoto, A., Yanagisawa, M., Preisig, P. A. & Alpern, R. J., Apr 1 2005, In : American Journal of Physiology - Renal Physiology. 288, 4 57-4, p. F732-F739

Research output: Contribution to journalArticle

11 Scopus citations

Collecting duct-specific knockout of the endothelin A receptor alters renal vasopressin responsiveness, but not sodium excretion or blood pressure

Ge, Y., Stricklett, P. K., Hughes, A. K., Yanagisawa, M. & Kohan, D. E., Oct 1 2005, In : American Journal of Physiology - Renal Physiology. 289, 4 58-4, p. F692-F698

Research output: Contribution to journalArticle

79 Scopus citations

Deletion of the endothelin-A receptor gene within the developing mandible

Ruest, L. B., Kedzierski, R., Yanagisawa, M. & Clouthier, D. E., Mar 1 2005, In : Cell and Tissue Research. 319, 3, p. 447-453 7 p.

Research output: Contribution to journalArticle

20 Scopus citations
144 Scopus citations

Different contributions of endothelin-A and endothelin-B receptors in postischemic cardiac dysfunction and norepinephrine overflow in rat hearts

Yamamoto, S., Matsumoto, N., Kanazawa, M., Fujita, M., Takaoka, M., Gariepy, C. E., Yanagisawa, M. & Matsumura, Y., Jan 25 2005, In : Circulation. 111, 3, p. 302-309 8 p.

Research output: Contribution to journalArticle

33 Scopus citations