• 71419 Citations
  • 119 h-Index
1984 …2019

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

  • 71419 Citations
  • 119 h-Index
  • 451 Article
  • 3 Chapter
  • 3 Conference contribution
Filter
Article
2003

Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion

Fujino, T., Asaba, H., Kang, M. J., Ikeda, Y., Sone, H., Takada, S., Kim, D. H., Ioka, R. X., Ono, M., Tomoyori, H., Okubo, M., Murase, T., Kamataki, A., Yamamoto, J., Magoori, K., Takahashi, S., Miyamoto, Y., Oishi, H., Nose, M., Okazaki, M. & 5 others, Usui, S., Imaizumi, K., Yanagisawa, M., Sakai, J. & Yamamoto, T. T., Jan 7 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 1, p. 229-234 6 p.

Research output: Contribution to journalArticle

292 Scopus citations

N-type calcium channel α1B subunit (Cav2.2) Knock-out mice display hyperactivity and vigilance state differences

Beuckmann, C. T., Sinton, C. M., Miyamoto, N., Ino, M. & Yanagisawa, M., Jul 30 2003, In : Journal of Neuroscience. 23, 17, p. 6793-6797 5 p.

Research output: Contribution to journalArticle

51 Scopus citations

Orexin-immunoreactive inputs to rat sympathetic preganglionic neurons

Llewellyn-Smith, I. J., Martin, C. L., Marcus, J. N., Yanagisawa, M., Minson, J. B. & Scammell, T. E., Nov 13 2003, In : Neuroscience Letters. 351, 2, p. 115-119 5 p.

Research output: Contribution to journalArticle

47 Scopus citations

The embryo makes red blood cell progenitors in every tissue simultaneously with blood vessel morphogenesis

Sequeira Lopez, M. L. S., Cherñavvsky, D. R., Nomasa, T., Wall, L., Yanagisawa, M. & Gomez, R. A., Apr 1 2003, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 284, 4 53-4

Research output: Contribution to journalArticle

44 Scopus citations

The mapping of quantitative trait loci underlying strain differences in locomotor activity between 129S6 and C57Bl/6J mice

Kelly, M. A., Low, M. J., Phillips, T. J., Wakeland, E. K. & Yanagisawa, M., Oct 1 2003, In : Mammalian Genome. 14, 10, p. 692-702 11 p.

Research output: Contribution to journalArticle

34 Scopus citations

The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance

Vicent, D., Ilany, J., Kondo, T., Naruse, K., Fisher, S. J., Kisanuki, Y. Y., Bursell, S., Yanagisawa, M., King, G. L. & Kahn, C. R., May 2003, In : Journal of Clinical Investigation. 111, 9, p. 1373-1380 8 p.

Research output: Contribution to journalArticle

265 Scopus citations
2002

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs

Okazaki, Y., Furuno, M., Kasukawa, T., Adachi, J., Bono, H., Kondo, S., Nikaido, I., Osato, N., Saito, R., Suzuki, H., Yamanaka, I., Kiyosawa, H., Yagi, K., Tomaru, Y., Hasegawa, Y., Nogami, A., Schönbach, C., Gojobori, T., Baldarelli, R., Hill, D. P. & 117 others, Bult, C., Hume, D. A., Quackenbush, J., Schriml, L. M., Kanapin, A., Matsuda, H., Batalov, S., Beisel, K. W., Blake, J. A., Bradt, D., Brusic, V., Chothia, C., Corbani, L. E., Cousins, S., Dalla, E., Dragani, T. A., Fletcher, C. F., Forrest, A., Frazer, K. S., Gaasterland, T., Gariboldi, M., Gissi, C., Godzik, A., Gough, J., Grimmond, S., Gustincich, S., Hirokawa, N., Jackson, I. J., Jarvis, E. D., Kanai, A., Kawaji, H., Kawasawa, Y., Kedzierski, R. M., King, B. L., Konagaya, A., Kurochkin, I. V., Lee, Y., Lenhard, B., Lyons, P. A., Maglott, D. R., Maltais, L., Marchionni, L., McKenzie, L., Miki, H., Nagashima, T., Numata, K., Okido, T., Pavan, W. J., Pertea, G., Pesole, G., Petrovsky, N., Pillai, R., Pontius, J. U., Qi, D., Ramachandran, S., Ravasi, T., Reed, J. C., Reed, D. J., Reid, J., Ring, B. Z., Ringwald, M., Sandelin, A., Schneider, C., Semple, C. A. M., Setou, M., Shimada, K., Sultana, R., Takenaka, Y., Taylor, M. S., Teasdale, R. D., Tomita, M., Verardo, R., Wagner, L., Wahlestedt, C., Wang, Y., Watanabe, Y., Wells, C., Wilming, L. G., Wynshaw-Boris, A., Yanagisawa, M., Yang, I., Yang, L., Yuan, Z., Zavolan, M., Zhu, Y., Zimmer, A., Carninci, P., Hayatsu, N., Hirozane-Kishikawa, T., Konno, H., Nakamura, M., Sakazume, N., Sato, K., Shiraki, T., Waki, K., Kawai, J., Aizawa, K., Arakawa, T., Fukuda, S., Hara, A., Hashizume, W., Imotani, K., Ishii, Y., Itoh, M., Kagawa, I., Miyazaki, A., Sakai, K., Sasaki, D., Shibata, K., Shinagawa, A., Yasunishi, A., Yoshino, M., Waterston, R., Lander, E. S., Rogers, J., Birney, E. & Hayashizaki, Y., Dec 5 2002, In : Nature. 420, 6915, p. 563-573 11 p.

Research output: Contribution to journalArticle

1202 Scopus citations

Blood pressure of endothelin-3 null (-/-) knockout mice and endothelin A receptor null (-/-) knockout mice under anaesthesia

Kuwaki, T., Ishii, T., Ju, K., Yanagisawa, M. & Fukuda, Y., Aug 2002, In : Clinical Science. 103, SUPPL. 48

Research output: Contribution to journalArticle

11 Scopus citations

Elevated systemic levels of endothelin-1 and blood pressure correlate with blunted constrictor responses and downregulation of endothelinA, but not endothelinB, receptors in an animal model of hypertension

Télémaque-Potts, S., Kuc, R. E., Maguire, J. J., Ohlstein, E., Yanagisawa, M. & Davenport, A. P., Aug 2002, In : Clinical Science. 103, SUPPL. 48

Research output: Contribution to journalArticle

14 Scopus citations

ETB receptor protects the tubulointerstitium in experimental thrombotic microangiopathy

Nangaku, M., Yamada, K., Gariepy, C. E., Miyata, T., Inagi, R., Kurokawa, K., Yanagisawa, M., Fujita, T. & Johnson, R. J., 2002, In : Kidney International. 62, 3, p. 922-928 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Exaggerated hypoxic pulmonary hypertension in endothelin B receptor-deficient rats

Dunbar Ivy, D., Yanagisawa, M., Gariepy, C. E., Gebb, S. A., Colvin, K. L. & McMurtry, I. F., 2002, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 282, 4 26-4

Research output: Contribution to journalArticle

62 Scopus citations

Expression, purification and characterization of the monomeric and dimeric forms of soluble bovine endothelin converting enzyme-1a

Kulathila, R., Clark, K., Savage, P., Bowen, B. R., Emoto, N., Yanagisawa, M. & Jeng, A. Y., Aug 2002, In : Clinical Science. 103, SUPPL. 48

Research output: Contribution to journalArticle

3 Scopus citations

Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo

Yanagisawa, H., Davist, E. C., Starcher, B. C., Ouchi, T., Yanagisawa, M., Richardson, J. A. & Olson, E. N., Jan 10 2002, In : Nature. 415, 6868, p. 168-171 4 p.

Research output: Contribution to journalArticle

425 Scopus citations

Involvement of the serotonergic system in orexin-induced behavioral alterations in rats

Matsuzaki, I., Sakurai, T., Kunii, K., Nakamura, T., Yanagisawa, M. & Goto, K., Mar 15 2002, In : Regulatory Peptides. 104, 1-3, p. 119-123 5 p.

Research output: Contribution to journalArticle

42 Scopus citations

Orexins: From neuropeptides to energy homeostasis and sleep/wake regulation

Beuckmann, C. T. & Yanagisawa, M., 2002, In : Journal of Molecular Medicine. 80, 6, p. 329-342 14 p.

Research output: Contribution to journalArticle

117 Scopus citations

Regulation of vasculogenesis and angiogenesis by EphB/ephrin-B2 signaling between endothelial cells and surrounding mesenchymal cells

Oike, Y., Ito, Y., Hamada, K., Zhang, X. Q., Miyata, K., Arai, F., Inada, T., Araki, K., Nakagata, N., Takeya, M., Kisanuki, Y. Y., Yanagisawa, M., Gale, N. W. & Suda, T., Aug 15 2002, In : Blood. 100, 4, p. 1326-1333 8 p.

Research output: Contribution to journalArticle

101 Scopus citations

Role of cardiac myocyte-derived endothelin-1 in chagasic cardiomyopathy: Molecular genetic evidence

Huang, H., Yanagisawa, M., Kisanuki, Y. Y., Jelicks, L. A., Chandra, M., Factor, S. M., Wittner, M., Weiss, L. M., Pestell, R. G., Shtutin, V., Shirani, J. & Tanowitz, H. B., Aug 2002, In : Clinical Science. 103, SUPPL. 48

Research output: Contribution to journalArticle

20 Scopus citations

Role of endothelin ETB receptors in the renal hemodynamic and excretory responses to big endothelin-1

Konishi, F., Okada, Y., Takaoka, M., Gariepy, C. E., Yanagisawa, M. & Matsumura, Y., Sep 13 2002, In : European Journal of Pharmacology. 451, 2, p. 177-184 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Sleep, feeding, and neuropeptides: Roles of orexins and orexin receptors

Mieda, M. & Yanagisawa, M., Jun 1 2002, In : Current Opinion in Neurobiology. 12, 3, p. 339-345 7 p.

Research output: Contribution to journalArticle

84 Scopus citations

Vascular endothelin-B receptor system in vivo plays a favorable inhibitory role in vascular remodeling after injury revealed by endothelin-B receptor-knockout mice

Murakoshi, N., Miyauchi, T., Kakinuma, Y., Ohuchi, T., Goto, K., Yanagisawa, M. & Yamaguchi, I., Oct 8 2002, In : Circulation. 106, 15, p. 1991-1998 8 p.

Research output: Contribution to journalArticle

76 Scopus citations
2001

Differential expression of Orexin receptors 1 and 2 in the rat brain

Marcus, J. N., Aschkenasi, C. J., Lee, C. E., Chemelli, R. M., Saper, C. B., Yanagisawa, M. & Elmquist, J. K., Jun 18 2001, In : Journal of Comparative Neurology. 435, 1, p. 6-25 20 p.

Research output: Contribution to journalArticle

1121 Scopus citations

Distinct cellular localization and regulation of endothelin-1 and endothelin-converting enzyme-1 expression in the bovine corpus luteum: Implications for luteolysis

Levy, N., Gordin, M., Mamluk, R., Yanagisawa, M., Smith, M. F., Hampton, J. H. & Meidan, R., 2001, In : Endocrinology. 142, 12, p. 5254-5260 7 p.

Research output: Contribution to journalArticle

44 Scopus citations

Endothelin-1/endothelin-B receptor-mediated increases in NHE3 activity in chronic metabolic acidosis

Laghmani, K., Preisig, P. A., Moe, O. W., Yanagisawa, M. & Alpern, R. J., 2001, In : Journal of Clinical Investigation. 107, 12, p. 1563-1569 7 p.

Research output: Contribution to journalArticle

75 Scopus citations

Endothelin-1 Stimulates Leptin Production in Adipocytes

Xiong, Y., Tanaka, H., Richardson, J. A., Williams, S. C., Slaughter, C. A., Nakamura, M., Chen, J. L. & Yanagisawa, M., Jul 27 2001, In : Journal of Biological Chemistry. 276, 30, p. 28471-28477 7 p.

Research output: Contribution to journalArticle

47 Scopus citations

Endothelin B receptor deficiency potentiates ET-1 and hypoxic pulmonary vasoconstriction

Ivy, D. D., Mcmurtry, I. F., Yanagisawa, M., Gariepy, C. E., Le Cras, T. D., Gebb, S. A., Morris, K. G., Wiseman, R. C. & Abman, S. H., May 2001, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 280, 5 25-5

Research output: Contribution to journalArticle

68 Scopus citations

Endothelin system: The double-edged sword in health and disease

Kedzierski, R. M. & Yanagisawa, M., 2001, In : Annual Review of Pharmacology and Toxicology. 41, p. 851-876 26 p.

Research output: Contribution to journalArticle

564 Scopus citations

Endothelium-specific loss of murine thrombomodulin disrupts the protein C anticoagulant pathway and causes juvenile-onset thrombosis

Isermann, B., Hendrickson, S. B., Zogg, M., Wing, M., Cummiskey, M., Kisanuki, Y. Y., Yanagisawa, M. & Weiler, H., 2001, In : Journal of Clinical Investigation. 108, 4, p. 537-546 10 p.

Research output: Contribution to journalArticle

100 Scopus citations

ETB receptor activation causes exocytic insertion of NHE3 in OKP cells

Peng, Y., Amemiya, M., Yang, X., Fan, L., Moe, O. W., Yin, H. L., Preisig, P. A., Yanagisawa, M. & Alpern, R. J., Jan 2001, In : American Journal of Physiology - Renal Physiology. 280, 1 49-1

Research output: Contribution to journalArticle

60 Scopus citations

Fos expression in orexin neurons varies with behavioral state

Estabrooke, I. V., McCarthy, M. T., Ko, E., Chou, T. C., Chemelli, R. M., Yanagisawa, M., Saper, C. B. & Scammell, T. E., Mar 1 2001, In : Journal of Neuroscience. 21, 5, p. 1656-1662 7 p.

Research output: Contribution to journalArticle

512 Scopus citations

Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity

Hara, J., Beuckmann, C. T., Nambu, T., Willie, J. T., Chemelli, R. M., Sinton, C. M., Sugiyama, F., Yagami, K. I., Goto, K., Yanagisawa, M. & Sakurai, T., 2001, In : Neuron. 30, 2, p. 345-354 10 p.

Research output: Contribution to journalArticle

1018 Scopus citations

Impaired ventilatory responses to hypoxia in mice deficient in endothelin-converting-enzyme-1

Renolleau, S., Dauger, S., Vardon, G., Levacher, B., Simonneau, M., Yanagisawa, M., Gaultier, C. & Gallego, J., 2001, In : Pediatric Research. 49, 5, p. 705-712 8 p.

Research output: Contribution to journalArticle

34 Scopus citations

Orexin (hypocretin) neurons contain dynorphin.

Chou, T. C., Lee, C. E., Lu, J., Elmquist, J. K., Hara, J., Willie, J. T., Beuckmann, C. T., Chemelli, R. M., Sakurai, T., Yanagisawa, M., Saper, C. B. & Scammell, T. E., 2001, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 21, 19

Research output: Contribution to journalArticle

300 Scopus citations

Role of D1x6 in regulation of an endothelin-1-dependent, dHAND branchial arch enhancer

Charité, J., McFadden, D. G., Merlo, G., Levi, G., Clouthier, D. E., Yanagisawa, M., Richardson, J. A. & Olson, E. N., Nov 15 2001, In : Genes and Development. 15, 22, p. 3039-3049 11 p.

Research output: Contribution to journalArticle

97 Scopus citations

Tie2-Cre transgenic mice: A new model for endothelial cell-lineage analysis in vivo

Kisanuki, Y. Y., Hammer, R. E., Miyazaki, J. I., Williams, S. C., Richardson, J. A. & Yanagisawa, M., Feb 15 2001, In : Developmental Biology. 230, 2, p. 230-242 13 p.

Research output: Contribution to journalArticle

776 Scopus citations

To eat or to sleep? Orexin in the regulation of feeding and wakefulness

Willie, J. T., Chemelli, R. M., Sinton, C. M. & Yanagisawa, M., 2001, In : Annual Review of Neuroscience. 24, p. 429-458 30 p.

Research output: Contribution to journalArticle

604 Scopus citations
2000

Arterial pressure response to endothelin-1 and sarafotoxin 6c in rescued endothelin-B-deficient rats

Pollock, D. M., Portik-Dobos, V., Procter, C., Gariepy, C. E. & Yanagisawa, M., 2000, In : Journal of Cardiovascular Pharmacology. 36, 5 SUPPL. 1

Research output: Contribution to journalArticle

13 Scopus citations
13 Scopus citations

Deletion of the endothelin-A-receptor suppresses oxygen-induced constriction but not postnatal closure of the ductus arteriosus

Coceani, F., Liu, Y. A., Seidlitz, E., Kelsey, L., Kuwaki, T., Ackerley, C. & Yanagisawa, M., 2000, In : Journal of Cardiovascular Pharmacology. 36, 5 SUPPL. 1

Research output: Contribution to journalArticle

11 Scopus citations

Disruption of ECE-1 and ECE-2 reveals a role for endothelin-converting enzyme-2 in murine cardiac development

Yanagisawa, H., Hammer, R. E., Richardson, J. A., Emoto, N., Clay Williams, S., Takeda, S. I., Clouthier, D. E. & Yanagisawa, M., May 2000, In : Journal of Clinical Investigation. 105, 10, p. 1373-1382 10 p.

Research output: Contribution to journalArticle

163 Scopus citations

Enhanced blood pressure sensitivity to DOCA-salt treatment in endothelin ET(B) receptor-deficient rats

Matsumura, Y., Kuro, T., Konishi, F., Takaoka, M., Gariepy, C. E. & Yanagisawa, M., 2000, In : British Journal of Pharmacology. 129, 6, p. 1060-1062 3 p.

Research output: Contribution to journalArticle

22 Scopus citations

Exaggerated vascular and renal pathology in endothelin-B receptor-deficient rats with deoxycorticosterone acetate-salt hypertension

Matsumura, Y., Kuro, T., Kobayashi, Y., Konishi, F., Takaoka, M., Wessale, J. L., Opgenorth, T. J., Gariepy, C. E. & Yanagisawa, M., Nov 28 2000, In : Circulation. 102, 22, p. 2765-2773 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

Functional analysis of five endothelin-B receptor mutations found in human hirschsprung disease patients

Abe, Y., Sakurai, T., Yamada, T., Nakamura, T., Yanagisawa, M. & Goto, K., Aug 28 2000, In : Biochemical and Biophysical Research Communications. 275, 2, p. 524-531 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Heterozygous knock-out of ET(B) receptors induces BQ-123-sensitive hypertension in the mouse

Berthiaume, N., Yanagisawa, M., Labonté, J. & D'Orléans-Juste, P., 2000, In : Hypertension. 36, 6, p. 1002-1007 6 p.

Research output: Contribution to journalArticle

46 Scopus citations

Hypothalamic arousal regions are activated during modafinil-induced wakefulness

Scammell, T. E., Estabrooke, I. V., McCarthy, M. T., Chemelli, R. M., Yanagisawa, M., Miller, M. S. & Saper, C. B., Nov 15 2000, In : Journal of Neuroscience. 20, 22, p. 8620-8628 9 p.

Research output: Contribution to journalArticle

416 Scopus citations

Increased susceptibility to deoxycorticosterone acetate-salt-induced hypertension in endothelin-B-receptor-deficient rats

Matsumura, Y., Kuro, T., Kobayashi, Y., Konishi, F., Takaoka, M., Wessale, J. L., Opgenorth, T. J., Gariepy, C. E. & Yanagisawa, M., 2000, In : Journal of Cardiovascular Pharmacology. 36, 5 SUPPL. 1

Research output: Contribution to journalArticle

5 Scopus citations

Normal ventilation and ventilatory responses to chemical stimuli in juvenile mutant mice deficient in endothelin-3

Nakamura, A., Kuwaki, T., Kuriyama, T., Yanagisawa, M. & Fukuda, Y., 2000, In : Respiration Physiology. 124, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system

Nakamura, T., Uramura, K., Nambu, T., Yada, T., Goto, K., Yanagisawa, M. & Sakurai, T., Aug 4 2000, In : Brain Research. 873, 1, p. 181-187 7 p.

Research output: Contribution to journalArticle

283 Scopus citations
26 Scopus citations

Salt-sensitive hypertension in endothelin-B receptor-deficient rats

Gariepy, C. E., Ohuchi, T., Williams, S. C., Richardson, J. A. & Yanagisawa, M., Apr 2000, In : Journal of Clinical Investigation. 105, 7, p. 925-933 9 p.

Research output: Contribution to journalArticle

244 Scopus citations