May-Yun Wang

  • 4663 Citations
  • 30 h-Index
1992 …2019

Research output per year

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Research Output

  • 4663 Citations
  • 30 h-Index
  • 37 Article
  • 3 Comment/debate
  • 2 Review article
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Article
2019

Dermal adipose tissue has high plasticity and undergoes reversible dedifferentiation in mice

Zhang, Z., Shao, M., Hepler, C., Zi, Z., Zhao, S., An, Y. A., Zhu, Y., Ghaben, A. L., May-Yun, W., Li, N., Onodera, T., Joffin, N., Crewe, C., Zhu, Q., Vishvanath, L., Kumar, A., Xing, C., Wang, Q. A., Gautron, L., Deng, Y. & 5 others, Gordillo, R., Kruglikov, I., Kusminski, C. M., Gupta, R. K. & Scherer, P. E., Dec 2 2019, In : Journal of Clinical Investigation. 129, 12, p. 5327-5342 16 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2018

Glucagon Receptor Antagonism Improves Glucose Metabolism and Cardiac Function by Promoting AMP-Mediated Protein Kinase in Diabetic Mice

Sharma, A. X., Quittner-Strom, E. B., Lee, Y. H., Johnson, J. A., Martin, S. A., Yu, X., Li, J., Lu, J., Cai, Z., Chen, S., Wang, M-Y., Zhang, Y., Pearson, M. J., Dorn, A. C., McDonald, J. G., Gordillo, R., Yan, H., Thai, D., Wang, Z., Unger, R. H. & 1 others, Holland, W. L., Feb 13 2018, In : Cell Reports. 22, 7, p. 1760-1773 14 p.

Research output: Contribution to journalArticle

12 Scopus citations
2017

Dapagliflozin suppresses glucagon signaling in rodent models of diabetes

Wang, M-Y., Yu, X., Lee, Y. H., McCorkle, S. K., Chen, S., Li, J., Wang, Z., Davidson, J. A., Scherer, P. E., Holland, W. L., Unger, R. H. & Roth, M. G., Jun 20 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 25, p. 6611-6616 6 p.

Research output: Contribution to journalArticle

10 Scopus citations
2015

Glucagon receptor antibody completely suppresses type 1 diabetes phenotype without insulin by disrupting a novel diabetogenic pathway

Wang, M-Y., Yan, H., Shi, Z., Evans, M. R., Yu, X., Lee, Y. H., Chen, S., Williams, A., Philippe, J., Roth, M. G. & Unger, R. H., Feb 24 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 8, p. 2503-2508 6 p.

Research output: Contribution to journalArticle

56 Scopus citations
2014

Hyperglycemia in rodent models of type 2 diabetes requires insulin-resistant alpha cells

Lee, Y. H., Berglund, E. D., Yu, X., Wang, M-Y., Evans, M. R., Scherer, P. E., Holland, W. L., Charron, M. J., Roth, M. G. & Unger, R. H., Jan 1 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 36, p. 13217-13222 6 p.

Research output: Contribution to journalArticle

48 Scopus citations
2013

Iatrogenic hyperinsulinemia in type 1 diabetes: Its effect on atherogenic risk markers

Wang, M-Y., Yu, X., Lee, Y. H., McCorkle, S. K., Clark, G. O., Strowig, S., Unger, R. H. & Raskin, P., Jan 1 2013, In : Journal of Diabetes and Its Complications. 27, 1, p. 70-74 5 p.

Research output: Contribution to journalArticle

19 Scopus citations
2012
87 Scopus citations
2011

Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice

Lee, Y. H., Wang, M-Y., Du, X. Q., Charron, M. J. & Unger, R. H., Feb 1 2011, In : Diabetes. 60, 2, p. 391-397 7 p.

Research output: Contribution to journalArticle

218 Scopus citations
2010

Leptin therapy in insulin-deficient type I diabetes

Wang, M-Y., Chen, L., Clark, G. O., Lee, Y. H., Stevens, R. D., Ilkayeva, O. R., Wenner, B. R., Bain, J. R., Charron, M. J., Newgard, C. B. & Unger, R. H., Mar 16 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 11, p. 4813-4819 7 p.

Research output: Contribution to journalArticle

220 Scopus citations

Regeneration of pancreatic islets in vivo by ultrasound-targeted gene therapy

Chen, S., Shimoda, M., Wang, M. Y., Ding, J., Noguchi, H., Matsumoto, S. & Grayburn, P. A., Nov 1 2010, In : Gene Therapy. 17, 11, p. 1411-1420 10 p.

Research output: Contribution to journalArticle

43 Scopus citations
2008

Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome

Wang, M-Y., Grayburn, P., Chen, S., Ravazzola, M., Orci, L. & Unger, R. H., Apr 22 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 16, p. 6139-6144 6 p.

Research output: Contribution to journalArticle

99 Scopus citations

Making insulin-deficient type 1 diabetic rodents thrive without insulin

Yu, X., Park, B. H., Wang, M-Y., Wang, Z. & Unger, R. H., Sep 16 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 37, p. 14070-14075 6 p.

Research output: Contribution to journalArticle

160 Scopus citations
2006

Combined leptin actions on adipose tissue and hypothalamus are required to deplete adipocyte fat in lean rats: Implications for obesity treatment

Park, B. H., Wang, M-Y., Lee, Y. H., Yu, X., Ravazzola, M., Orci, L. & Unger, R. H., Dec 29 2006, In : Journal of Biological Chemistry. 281, 52, p. 40283-40291 9 p.

Research output: Contribution to journalArticle

22 Scopus citations
2005
116 Scopus citations
67 Scopus citations
2004

Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue

Boucher, A., Lu, D., Burgess, S. C., Telemaque-Potts, S., Jensen, M. V., Mulder, H., Wang, M-Y., Unger, R. H., Sherry, D. & Newgard, C. B., Jun 25 2004, In : Journal of Biological Chemistry. 279, 26, p. 27263-27271 9 p.

Research output: Contribution to journalArticle

91 Scopus citations
86 Scopus citations

Increased expression and activity of 11β-HSD-1 in diabetic islets and prevention with troglitazone

Duplomb, L., Lee, Y. H., Wang, M-Y., Park, B. H., Takaishi, K., Agarwal, A. K. & Unger, R. H., Jan 16 2004, In : Biochemical and Biophysical Research Communications. 313, 3, p. 594-599 6 p.

Research output: Contribution to journalArticle

34 Scopus citations

Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: Prevention of diabetes and ectopic lipid deposition

Yu, X., McCorkle, S., Wang, M-Y., Lee, Y. H., Li, J., Saha, A. K., Unger, R. H. & Ruderman, N. B., Nov 1 2004, In : Diabetologia. 47, 11, p. 2012-2021 10 p.

Research output: Contribution to journalArticle

118 Scopus citations

Rapid transformation of white adipocytes into fat-oxidizing machines

Orci, L., Cook, W. S., Ravazzola, M., Wang, M. Y., Park, B. H., Montesano, R. & Ungert, R. H., Feb 17 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 7, p. 2058-2063 6 p.

Research output: Contribution to journalArticle

197 Scopus citations
2002

PPARα is necessary for the lipopenic action of hyperleptinemia on white adipose and liver tissue

Lee, Y. H., Yu, X., Gonzales, F., Mangelsdorf, D. J., Wang, M-Y., Richardson, C., Witters, L. A. & Unger, R. H., Sep 3 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 18, p. 11848-11853 6 p.

Research output: Contribution to journalArticle

144 Scopus citations
2001

Liporegulation in Diet-induced Obesity: The antisteatotic role of hyperleptinemia

Lee, Y. H., Wang, M-Y., Kakuma, T., Wang, Z. W., Babcock, E. E., McCorkle, K., Higa, M., Zhou, Y. T. & Unger, R. H., Feb 23 2001, In : Journal of Biological Chemistry. 276, 8, p. 5629-5635 7 p.

Research output: Contribution to journalArticle

218 Scopus citations
1999

Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves β- cell function

Wang, M-Y., Shimabukuro, M., Lee, Y. H., Trinh, K. Y., Chen, J. L., Newgard, C. B. & Unger, R. H., May 25 1999, In : Diabetes. 48, 5, p. 1020-1025 6 p.

Research output: Contribution to journalArticle

67 Scopus citations

Novel form of lipolysis induced by leptin

Wang, M-Y., Lee, Y. H. & Unger, R. H., Jun 18 1999, In : Journal of Biological Chemistry. 274, 25, p. 17541-17544 4 p.

Research output: Contribution to journalArticle

285 Scopus citations
1998

Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression

Shimabukuro, M., Higa, M., Zhou, Y. T., Wang, M-Y., Newgard, C. B. & Unger, R. H., Dec 4 1998, In : Journal of Biological Chemistry. 273, 49, p. 32487-32490 4 p.

Research output: Contribution to journalArticle

309 Scopus citations

OB-Rb gene transfer to leptin-resistant islets reverses diabetogenic phenotype

Wang, M. Y., Koyama, K., Shimabukuro, M., Newgard, C. B. & Uncer, R. H., Jan 20 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 2, p. 714-718 5 p.

Research output: Contribution to journalArticle

88 Scopus citations
80 Scopus citations

Protection against lipoapoptosis of β cells through leptin-dependent maintenance of Bcl-2 expression

Shimabukuro, M., Wang, M-Y., Zhou, Y. T., Newgard, C. B. & Unger, R. H., Aug 4 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 16, p. 9558-9561 4 p.

Research output: Contribution to journalArticle

198 Scopus citations

Resistance to adenovirally induced hyperleptinemia in rats: Comparison of ventromedial hypothalamic lesions and mutated leptin receptors

Koyama, K., Shimabukuro, M., Chen, G., Wang, M-Y., Lee, Y. H., Kalra, P. S., Dube, M. G., Kalra, S. P., Newgard, C. B. & Unger, R. H., Aug 15 1998, In : Journal of Clinical Investigation. 102, 4, p. 728-733 6 p.

Research output: Contribution to journalArticle

Open Access
48 Scopus citations

Role of peroxisome proliferator-activated receptor α in disease of pancreatic β cells

Zhou, Y. T., Shimabukuro, M., Wang, M-Y., Lee, Y. H., Higa, M., Milburn Jr., J. L., Newgard, C. B. & Unger, R. H., Jul 21 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 15, p. 8898-8903 6 p.

Research output: Contribution to journalArticle

160 Scopus citations
1997

Direct antidiabetic effect of leptin through triglyceride depletion of tissues

Shimabukuro, M., Koyama, K., Chen, G., Wang, M-Y., Trieu, F., Lee, Y. H., Newgard, C. B. & Unger, R. H., Apr 29 1997, In : Proceedings of the National Academy of Sciences of the United States of America. 94, 9, p. 4637-4641 5 p.

Research output: Contribution to journalArticle

593 Scopus citations

Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation

Zhou, Y. T., Shimabukuro, M., Koyama, K., Lee, Y. H., Wang, M-Y., Trieu, F., Newgard, C. B. & Unger, R. H., Jun 10 1997, In : Proceedings of the National Academy of Sciences of the United States of America. 94, 12, p. 6386-6390 5 p.

Research output: Contribution to journalArticle

367 Scopus citations

β-Cell function in normal rats made chronically hyperleptinemic by adenovirus-leptin gene therapy

Koyama, K., Chen, G., Wang, M-Y., Lee, Y. H., Shimabukuro, M., Newgard, C. B. & Unger, R. H., Aug 7 1997, In : Diabetes. 46, 8, p. 1276-1280 5 p.

Research output: Contribution to journalArticle

122 Scopus citations
1996

A novel leptin receptor isoform in rat

Wang, M-Y., Zhou, Y. T., Newgard, C. B. & Unger, R. H., Aug 26 1996, In : FEBS Letters. 392, 2, p. 87-90 4 p.

Research output: Contribution to journalArticle

168 Scopus citations
1994

Identification of chicken liver glucose transporter

Wang, M. Y., Tsai, M. Y. & Wang, C., Apr 1994, In : Archives of Biochemistry and Biophysics. 310, 1, p. 172-179 8 p.

Research output: Contribution to journalArticle

28 Scopus citations
1993

Characterization of glucose transport system in Drosophila Kc cells

Wang, M. Y. & Wang, C., Feb 15 1993, In : FEBS Letters. 317, 3, p. 241-244 4 p.

Research output: Contribution to journalArticle

10 Scopus citations
1992

Inhibition of tonoplast ATPase by 2′,3′-dialdehyde derivative of ATP

Chow, W. M., Tzeng, C. M., Chen, C. S., Kuo, S. Y., Wang, M. Y. & Pan, R. L., Jan 1 1992, In : Plant Physiology. 98, 1, p. 44-52 9 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations